Predominant synthesis of IgA with lambda light chain in IgA nephropathy.

abstract：:We describe a rat model of renal failure that separates catabolic and anabolic states from each other. Muscle protein synthesis was compared during the anabolic period between sham (S) operated and renal failure (RF) rats that were fed different levels of dietary protein. Male rats weighing between 60 and 80 g first h...

journal_title：Kidney international

authors： Baliga R,George VT,Ray PE,Holliday MA

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:We have recently demonstrated an increase in apoptosis in Han:SPRD rat kidneys with autosomal-dominant polycystic kidney disease (ADPKD). Caspase-3 and caspase-7 are major mediators of apoptosis. There are two pathways of caspase-3 and caspase-7-mediated apoptosis: (1) the "extrinsic" pathway involving the d...

journal_title：Kidney international

authors： Tao Y,Kim J,Stanley M,He Z,Faubel S,Schrier RW,Edelstein CL

更新日期：2005-03-01 00:00:00

abstract：:Glutamine accumulation in rat kidney was investigated by giving large loads of gluta, mate and aspartate and measuring glutamine changes in seven completely defined portions of the nephron and in small patches from the thin limb area and from the papilla. Both glutamate and aspartate (which is partly coverted to gluta...

journal_title：Kidney international

authors： Burch HB,Chan AW,Alvey TR,Lowry OH

更新日期：1978-11-01 00:00:00

abstract：:Progression of diabetic nephropathy appears directly related to renal tubulointerstitial injury, but the involved genes are incompletely delineated. To identify such genes, DNA microarray analysis was performed with RNA from renal proximal tubules (RPTs) of streptozotocin-induced diabetic Wistar rats, spontaneously di...

journal_title：Kidney international

authors： Hsieh TJ,Chen R,Zhang SL,Liu F,Brezniceanu ML,Whiteside CI,Fantus IG,Ingelfinger JR,Hamet P,Chan JS

更新日期：2006-03-01 00:00:00

abstract：:The biological action of calcitriol is mediated through a hormone-receptor complex interacting with nuclear chromatin. Interaction of the calcitriol receptor (VDR) with VDR response elements produces bioactive proteins which carry out the physiological actions of calcitriol. Since biological response to calcitriol app...

journal_title：Kidney international

authors： Patel SR,Ke HQ,Vanholder R,Hsu CH

更新日期：1994-07-01 00:00:00

abstract：:In studying the metabolic effects of diet potassium (K+) variation in normal humans, we noted that varying diet K+ within its normal range influenced inorganic phosphorus (Pi) homeostasis and serum calcitriol (1,25-dihydroxyvitamin D) levels. In six men who ingested a constant whole-foods diet containing (per 70 kg bo...

journal_title：Kidney international

authors： Sebastian A,Hernandez RE,Portale AA,Colman J,Tatsuno J,Morris RC Jr

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:Urine is supersaturated in calcium oxalate, which means that it will contain calcium oxalate crystals that form spontaneously. Their size must be controlled to prevent retention in ducts and the eventual development of a lithiasis. This is achieved, in part, by specific inhibitors of crystal growth. We inves...

journal_title：Kidney international

authors： Cerini C,Geider S,Dussol B,Hennequin C,Daudon M,Veesler S,Nitsche S,Boistelle R,Berthézène P,Dupuy P,Vazi A,Berland Y,Dagorn JC,Verdier JM

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Gene expression profiling of nephropathies may facilitate development of diagnostic strategies for complex renal diseases as well as provide insight into the molecular pathogenesis of kidney diseases. To test molecular based renal disease categorization, differential gene expression profiles were compared be...

journal_title：Kidney international

authors： Henger A,Kretzler M,Doran P,Bonrouhi M,Schmid H,Kiss E,Cohen CD,Madden S,Porubsky S,Gröne EF,Schlöndorff D,Nelson PJ,Gröne HJ

更新日期：2004-03-01 00:00:00

abstract：:Fibrates, the PPAR alpha ligand-like compounds increase the expression of proximal tubule liver fatty acid binding protein (L-FABP) and significantly decrease cisplatin-induced acute kidney injury. To study whether the bezafibrate-mediated upregulation of renal L-FABP was involved in this cytoprotective effect we trea...

journal_title：Kidney international

authors： Negishi K,Noiri E,Maeda R,Portilla D,Sugaya T,Fujita T

更新日期：2008-06-01 00:00:00

abstract：:We compared the effects of calcitriol and doxercalciferol, in combination with either calcium carbonate or sevelamer, on bone, mineral, and fibroblast growth factor-23 (FGF-23) metabolism in patients with secondary hyperparathyroidism. A total of 60 pediatric patients treated with peritoneal dialysis were randomized t...

journal_title：Kidney international

authors： Wesseling-Perry K,Pereira RC,Sahney S,Gales B,Wang HJ,Elashoff R,Jüppner H,Salusky IB

更新日期：2011-01-01 00:00:00

abstract：:The present studies were undertaken to assess the effects of 5'-N-ethylcarboxamideadenosine (NECA), an adenosine analogue, on erythropoietin (Epo) production. NECA (0.05 and 0.1 mumol/kg i.v.) produced significant increases in serum Epo levels (368.8 +/- 56.1 and 384.6 +/- 45.9 mU/ml, respectively) in exhypoxic polycy...

journal_title：Kidney international

authors： Nakashima J,Ohigashi T,Brookins JW,Beckman BS,Agrawal KC,Fisher JW

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:Adiponectin is an adipocyte-derived cytokine that has anti-inflammatory properties. A preliminary proteomic evaluation of urine for biomarkers of systemic lupus erythematosus (SLE) nephritis demonstrated high levels of adiponectin in SLE urine. This prompted investigation of adiponectin expression in human S...

journal_title：Kidney international

authors： Rovin BH,Song H,Hebert LA,Nadasdy T,Nadasdy G,Birmingham DJ,Yung Yu C,Nagaraja HN

更新日期：2005-10-01 00:00:00

abstract：:Steroid Resistant Nephrotic Syndrome (SRNS) in children and young adults has differing etiologies with monogenic disease accounting for 2.9-30% in selected series. Using whole exome sequencing we sought to stratify a national population of children with SRNS into monogenic and non-monogenic forms, and further define t...

journal_title：Kidney international

authors： Bierzynska A,McCarthy HJ,Soderquest K,Sen ES,Colby E,Ding WY,Nabhan MM,Kerecuk L,Hegde S,Hughes D,Marks S,Feather S,Jones C,Webb NJ,Ognjanovic M,Christian M,Gilbert RD,Sinha MD,Lord GM,Simpson M,Koziell AB,Welsh

更新日期：2017-04-01 00:00:00

abstract：:Urinary peptidomics focuses on endogenous urinary peptide content. Many studies now show the usefulness of this approach for the discovery and validation of biomarkers in kidney diseases that are as varied as chronic kidney disease, acute kidney injury, congenital anomalies of the kidney and the urinary tract, and pol...

journal_title：Kidney international

authors： Klein J,Bascands JL,Mischak H,Schanstra JP

更新日期：2016-03-01 00:00:00

abstract：:Previous work has documented an acceleration of proteolysis and branched-chain amino acid oxidation when muscles from rats with chronic metabolic acidosis were incubated in vitro. The present study examines the impact of chronic metabolic acidosis on whole body amino acid turnover and oxidation in chronically catheter...

journal_title：Kidney international

authors： May RC,Masud T,Logue B,Bailey J,England B

更新日期：1992-06-01 00:00:00

abstract：:To investigate the cause and the mechanisms responsible of the compulsive thirst and excessive fluid intake observed in many patients on chronic dialysis treatment, we measured plasma antidiuretic hormone (ADH), angiotensin II (Ang II) and some hemodynamic parameters in seven polydipsic and in six normodipsic patients...

journal_title：Kidney international

authors： Graziani G,Badalamenti S,Del Bo A,Marabini M,Gazzano G,Como G,Viganò E,Ambroso G,Morganti A

更新日期：1993-07-01 00:00:00

abstract：:The Standardized Outcomes in Nephrology (SONG) initiative is designed to improve research productivity by building consensus. Stakeholders involved with peritoneal dialysis (PD) have put life participation on top of their list, along with treatment-related infection, cardiovascular complications, and patient and techn...

journal_title：Kidney international

authors： Davies SJ

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Although atherosclerotic renovascular disease is increasingly recognized in chronic kidney disease, few national level studies have examined its clinical epidemiology. METHODS:Claims data from a 5% random sample of the United States Medicare population were used to select patients without atherosclerotic re...

journal_title：Kidney international

authors： Kalra PA,Guo H,Kausz AT,Gilbertson DT,Liu J,Chen SC,Ishani A,Collins AJ,Foley RN

更新日期：2005-07-01 00:00:00

abstract：:A strong influence of urinary kallikrein excretion on the salt sensitivity of blood pressure has been recently suggested in normotensive patients. To evaluate the relationship between kallikrein and salt sensitivity in essential hypertension, active kallikrein excretion, plasma renin activity, atrial natriuretic pepti...

journal_title：Kidney international

authors： Ferri C,Bellini C,Carlomagno A,Perrone A,Santucci A

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Regular access monitoring is recommended to detect and treat access stenosis in order to prevent access thrombosis and failure. METHODS:In 1999, we instituted monthly access blood flow monitoring using the ultrasound dilution technique (UDT). In a sequential observational trial, 222 patients were studied fo...

journal_title：Kidney international

authors： Shahin H,Reddy G,Sharafuddin M,Katz D,Franzwa BS,Dixon BS

更新日期：2005-11-01 00:00:00

abstract：:Donor pretreatment of 100 mg/kg each of cyclophosphamide (CY) and methylprednisolone (P) infused 5 hours before nephrectomy invariably prolongs the survival of DLA mismatched, MLC incompatible nonlittermate Beagle renal allografts as well as the survival of mongrel renal allografts. The effect of donor pretreatment ap...

journal_title：Kidney international

authors： Brom HL,van Breda Vriesman PJ,Terpstra JL

更新日期：1982-02-01 00:00:00

abstract：:Most epidemiologic data, thus far, have focused on short-term outcomes of acute kidney injury (AKI). Lo et al. correlate AKI with long-term outcomes. The concept of 'uremic memory' sheds light on the importance of AKI and its permanent imprint. The focus of research should be on prevention of an episode of AKI, when p...

journal_title：Kidney international

authors： Golestaneh L,Melamed ML,Hostetter TH

更新日期：2009-10-01 00:00:00

abstract：:Ambient glucose concentrations alter type 1 angiotensin II receptor (AT1R) expression in renal tissues. The direction of change in AT1R density may depend on the specific cell type and the capacity for that cell type to use glucose as an energy substrate. Given the effects of angiotensin II (Ang II) in proximal tubule...

journal_title：Kidney international

authors： Becker BN,Kondo S,Cheng HF,Harris RC

更新日期：1997-07-01 00:00:00

abstract：:The metabolism of phenylalanine and tyrosine was evaluated in six normal men, five chronically uremic men, and three men undergoing maintenance hemodialysis. Phenylalanine, tyrosine, and 13 acidic metabolites of those amino acids were measured in plasma postabsorptively and in plasma and urine after a phenylalanine lo...

journal_title：Kidney international

authors： Jones MR,Kopple JD,Swendseid ME

更新日期：1978-08-01 00:00:00

abstract：:A major problem in cyclosporine A (CsA) therapy is its nephrotoxicity, characterized by a marked fall in glomerular filtration rate (GFR). Since the glomerular ultrafiltration area is an important determinant of GFR and has been proposed to be regulated by mesangial (MS) cell contraction, we examined the effect of CsA...

journal_title：Kidney international

authors： Meyer-Lehnert H,Schrier RW

更新日期：1988-07-01 00:00:00

abstract：:Toward an etiological classification of developmental disorders of the kidney and upper urinary tract. There are a large number of developmental disorders and syndromes that affect the kidney and upper urinary tract. These have generally been classified according to morphological criteria established decades ago. Alth...

journal_title：Kidney international

authors： Pohl M,Bhatnagar V,Mendoza SA,Nigam SK

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Previous experiments from our laboratory have demonstrated that HKalpha(2) coimmunoprecipitated with beta(1)-Na(+),K(+)-ATPase. Although HKalpha(2) is expressed abundantly in the apical membrane of distal colon, the demonstration that beta(1) localizes to this same membrane in distal colon has not been demon...

journal_title：Kidney international

authors： Li J,Codina J,Petroske E,Werle MJ,Willingham MC,DuBose TD Jr

更新日期：2004-09-01 00:00:00

abstract：:The effects of chronic respiratory alkalosis on divalent ion homeostasis have not been reported in any species. We studied four normal male subjects during a four-day control period (residence at 500 m), during six days of chronic respiratory alkalosis induced by hypobaric hypoxia (residence at 3450 m), followed by a ...

journal_title：Kidney international

authors： Krapf R,Jaeger P,Hulter HN

更新日期：1992-09-01 00:00:00

abstract：:Adenosine is known to be a potent inhibitor of renin release from the kidneys. The aim of this study was to investigate the transmembrane signalling avenue that the second messenger of adenosine causes inhibition of renal renin release. Using short term cultures of juxtaglomerular cells isolated from rat kidneys, we f...

journal_title：Kidney international

authors： Kurtz A,Della Bruna R,Pfeilschifter J,Bauer C

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:Genetic polymorphisms of the angiotensinogen (AGT) and angiotensin-converting enzyme (ACE) genes are associated with increased risk of hypertension and left ventricular hypertrophy (LVH) in hypertensive subjects. However, the extent to which these polymorphisms are related to LVH and remodeling in dialysis p...

journal_title：Kidney international

authors： Wang AY,Chan JC,Wang M,Poon E,Lui SF,Li PK,Sanderson J

更新日期：2003-05-01 00:00:00