Abstract：
:A major problem in cyclosporine A (CsA) therapy is its nephrotoxicity, characterized by a marked fall in glomerular filtration rate (GFR). Since the glomerular ultrafiltration area is an important determinant of GFR and has been proposed to be regulated by mesangial (MS) cell contraction, we examined the effect of CsA on arginine vasopressin (AVP)-induced Ca2+ mobilization and contraction in cultured MS cells. Intracellular Ca2+, [Ca2+]i, concentrations were measured using quin 2. Basal levels were not affected by CsA (151.1 +/- 6.2 vs. 145.2 +/- 5.8 nM, NS), but 10 micrograms/ml CsA significantly augmented the 10(-8) M AVP-induced increase of [Ca2+]i (delta 94.5 +/- 6.6 vs delta 167.3 +/- 8.4 nM, P less than 0.01). This effect was also seen in Ca2+-free medium (P less than 0.01). The effect of CsA on [Ca2+]i was not due to an inhibition of 45Ca2+ efflux, since AVP-induced increase of 45Ca2+ efflux at 30 seconds was enhanced in cells pretreated with CsA (1630 +/- 185 vs. 3646 +/- 197 cpm/mg prot/30 sec, P less than 0.01). As compared to control, CsA increased 45Ca2+ uptake in MS cells (7924 +/- 414 vs. 11928 +/- 760 cpm/mg prot/5 min, P less than 0.05); this effect was not affected by the Ca2+ channel blocker verapamil (5 X 10(-5) M, P less than 0.05). MS cell contraction was evaluated by a digital imaging analysis system.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Kidney Intjournal_title
Kidney internationalauthors
Meyer-Lehnert H,Schrier RWdoi
10.1038/ki.1988.149subject
Has Abstractpub_date
1988-07-01 00:00:00pages
89-97issue
1eissn
0085-2538issn
1523-1755pii
S0085-2538(15)34322-2journal_volume
34pub_type
杂志文章abstract：:Lysophosphatidic acid (LPA) is known to regulate various biological responses by binding to LPA receptors. The serum level of LPA is elevated in diabetes, but the involvement of LPA in the development of diabetes and its complications remains unknown. Therefore, we studied LPA signaling in diabetic nephropathy and the...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2016.11.010
更新日期：2017-06-01 00:00:00
abstract：UNLABELLED:A non-nucleotide-bridged DNA decoy inhibits renal epithelial nitric oxide synthase expression. BACKGROUND:The expression of inducible nitric oxide synthase (iNOS) is subject to strict tissue-specific transcriptional control. In mouse renal epithelium, an interferon-gamma (IFN-gamma)-induced signaling protei...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2000.00809.x
更新日期：2000-01-01 00:00:00
abstract：:The parathyroid hormone (PTH) response to hypocalcemia was studied in 18 hemodialysis patients with osteitis fibrosa, and the relationship with PTH and bone histology in 26 hemodialysis patients. Hypocalcemia was produced during hemodialysis by the use of a dialysate devoid of calcium. Both amino (N) (P less than 0.05...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1984.37
更新日期：1984-02-01 00:00:00
abstract：:The distribution of precursor nitrogen between urea and glutamine was studied in control and acidotic rats. Acidosis, either acutely induced with hydrochloric acid or chronically induced with ammonium chloride, resulted in a rise in ammonia and a fall in urinary urea excretion; the percent of urinary nitrogen excreted...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1981.182
更新日期：1981-11-01 00:00:00
abstract：BACKGROUND:Advanced glycation end products (AGEs) accumulate in patients with diabetes, particularly at sites of vascular damage and within atherosclerotic lesions, but whether they have direct actions on vascular smooth muscle cells (VSMCs) is controversial. METHODS:AGEs were constructed and characterized by protein ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2005.00746.x
更新日期：2005-12-01 00:00:00
abstract：:Among patients with proteinuric chronic kidney disease (CKD), current guideline recommendations mandate the use of agents blocking the renin angiotensin aldosterone system (RAAS) as first-line antihypertensive therapy based on randomized trials demonstrating that RAAS inhibitors are superior to other antihypertensive ...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1016/j.kint.2017.08.038
更新日期：2018-02-01 00:00:00
abstract：:Substantial evidence implicates impaired renal excretion of sodium as the major culprit in the pathogenesis of hypertension. The key question is: How does the impairment of Na+ excretion lead to increased peripheral vascular resistance and elevation of the blood pressure? Here we describe the evidence that elevated le...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/ki.1996.260
更新日期：1996-06-01 00:00:00
abstract：:Experiments were performed using a variety of methods to assess the functional status of different nephron populations following 45 min of renal ischemia in the rat. Micropuncture techniques revealed that SNGFR and reabsorption in the surface nephrons are only modestly reduced after ischemia, whereas kidney GFR and re...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1983.122
更新日期：1983-07-01 00:00:00
abstract：:Recent studies of timing of dialysis initiation have challenged the recent trend to earlier initiation of therapy. The observed outcomes though are a consequence of the balance between the risks of advanced uremia versus the inherent dangers relating to dialysis therapy itself. Many of these risks are inherent in how ...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/ki.2012.133
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:While tubular cell death is a characteristic of acute renal failure (ARF), the molecular mechanisms that modulate this cell death are unclear. Cell fate in acute renal failure hinges on a balance of survival and mortality factors in a changing environment. We further explored this issue by studying selected ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2000.00925.x
更新日期：2000-03-01 00:00:00
abstract：:Absorption of amino acids by the necturus proximal tubules was measured under free-flow conditions The coexistence of proximal tubular amino acid influx was determined by infusing saline into tubular lumens by the stopped-flow microperfusion technique. Under free-flow conditions, fractional absorption of individual am...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1978.67
更新日期：1978-06-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to examine the lipid abnormalities associated with urinary albumin excretion rate (UAER) in type 2 diabetic patients. METHODS:A total of 275 (122 men and 153 women; aged 60.6 +/- 11.1 years) patients were selected with stringent criteria to prevent confounders. Normoalbuminuria...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2005.00235.x
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND:Bioimpedance, a noninvasive technique to analyze body composition, has attracted interest in determining body hydration in hemodialysis patients. However, the so-called whole-body (wrist-to-ankle) bioimpedance analysis (WBIA) is sensitive to changes in regional fluid distribution and tends to underestimate f...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.1999.00588.x
更新日期：1999-08-01 00:00:00
abstract：:Tremendous progress has been made over recent years in the understanding of the mechanisms regulating calcium, phosphorus, vitamin D, and parathyroid hormone homeostasis in the normal human body and in patients with different degrees of renal failure. In addition, some of these findings have been translated into clini...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2008.692
更新日期：2009-05-01 00:00:00
abstract：BACKGROUND:Glucocorticoids (GC) represent the mainstay of treatment of idiopathic nephrotic syndrome (INS) and might be involved in the pathogenesis of the disease. We evaluated basal secretion of cortisol, number and affinity of glucocorticoid receptors, dexamethasone (Dex)-mediated inhibition of concanavalin-A (Con-A...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2004.00392.x
更新日期：2004-02-01 00:00:00
abstract：BACKGROUND:Dialysis efficiency has a great influence on the outcome of patients. Few data are available on the removal of solutes with molecular weights higher than urea and creatinine. The aim of our study was to assess the transport and the removal of substances with molecular weights up to 15 kD and to evaluate the ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2002.00216.x
更新日期：2002-03-01 00:00:00
abstract：:Tenascin-C is an extracellular matrix glycoprotein that plays a critical role in kidney fibrosis by orchestrating a fibrogenic niche. Here, we demonstrate that tenascin-C is a biomarker and a mediator of kidney fibrogenesis by impairing tubular integrity. Tenascin-C was found to be increased in kidney biopsies from pa...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2020.01.026
更新日期：2020-05-01 00:00:00
abstract：:The release of cytokines and prostaglandins (PG) by peritoneal macrophages (PM luminal diameter of) may influence the cytokine network controlling peritoneal inflammation and in the long-term the function of the peritoneum as a dialysis membrane. In the present study, an evaluation of the long-term effects of peritone...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1996.75
更新日期：1996-02-01 00:00:00
abstract：:In this issue, McMahon et al. report that, by combining phenotypic, metabolomic, and genetic data, they could better detect chronic kidney disease at the early stages and provide insight into its pathobiology. The most significant findings of the study are that several urinary metabolites (e.g., glycine and histidine)...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1016/j.kint.2017.03.022
更新日期：2017-06-01 00:00:00
abstract：:Development of physiologically relevant cellular models with strong translatability to human pathophysiology is critical for identification and validation of novel therapeutic targets. Herein we describe a detailed protocol for generation of an advanced 3-dimensional kidney cellular model using induced pluripotent ste...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2018.05.003
更新日期：2018-12-01 00:00:00
abstract：:In recent years, a substantial body of experimental and clinical work has been devoted to C3 glomerulopathy and Ig-mediated membranoproliferative glomerulonephritis. Despite the rapid accumulation of data, several uncertainties about these 2 rare forms of nephropathies persist. They concern their pathophysiology, clas...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1016/j.kint.2020.05.053
更新日期：2020-11-01 00:00:00
abstract：:A morphometric technique is used to estimate the absolute and relative surface areas of the brush border microvilli and cell walls bordering lateral intercellular spaces. In isolated, perfused proximal tubule from rabbit, the luminal and lateral surfaces are equal in area. For proximal convoluted tubules (PCT) each su...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1975.125
更新日期：1975-12-01 00:00:00
abstract：:Many renal diseases are associated with fibrin deposition in the glomeruli, a situation that reflects an abnormality in the balance between the coagulation and fibrinolytic systems. We recently demonstrated that normal mouse kidney contains very low levels of type 1 plasminogen activator inhibitor (PAI-1), a potent an...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1995.17
更新日期：1995-01-01 00:00:00
abstract：:We examined the effect of daily cyclosporin A administration on the development and extent of tubulointerstitial nephritis produced in rats immunized with tubular basement membranes in adjuvant. Six mg/kg/day of cyclosporin A, given from the time of immunization, completely blocked the development of interstitial lesi...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1988.119
更新日期：1988-06-01 00:00:00
abstract：:Urinary peptidomics focuses on endogenous urinary peptide content. Many studies now show the usefulness of this approach for the discovery and validation of biomarkers in kidney diseases that are as varied as chronic kidney disease, acute kidney injury, congenital anomalies of the kidney and the urinary tract, and pol...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1016/j.kint.2015.10.010
更新日期：2016-03-01 00:00:00
abstract：:Toward an etiological classification of developmental disorders of the kidney and upper urinary tract. There are a large number of developmental disorders and syndromes that affect the kidney and upper urinary tract. These have generally been classified according to morphological criteria established decades ago. Alth...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1046/j.1523-1755.2002.00086.x
更新日期：2002-01-01 00:00:00
abstract：:Vitamin D receptor agonists (VDRAs) inhibit the renin-angiotensin system (RAS) and reduce podocyte loss and fibrosis over and above RAS blockade. Several studies in humans show that VDRAs are antiproteinuric and have the potential to delay the progression of renal disease. Whether VDRAs will accomplish this goal among...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/ki.2010.77
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:The "intact" parathyroid hormone (PTH) assay recognizes PTH-(1-84) as well as amino terminally truncated PTH fragments, that is, large carboxyterminal PTH fragments (C-PTH fragments). The present study investigated whether the use of the plasma PTH-(1-84)/C-PTH fragment ratio enhances the noninvasive assessm...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2001.00949.x
更新日期：2001-10-01 00:00:00
abstract：:Because of high risk of cardiovascular disease, patients with chronic kidney disease may benefit from cholesterol-lowering therapy beyond statins. A cost-effectiveness analysis of adding ezetimibe to high-dose statins for primary cardiovascular disease prevention in patients with non-dialysis-dependent chronic kidney ...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1016/j.kint.2019.02.029
更新日期：2019-07-01 00:00:00
abstract：:Acute kidney injury (AKI) occurs in about half of patients in septic shock and the mortality of AKI with sepsis is extremely high. An effective therapeutic intervention is urgently required. Statins are 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors that also have pleiotropic actions. They have been report...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5000300
更新日期：2006-05-01 00:00:00
