Starting dialysis is dangerous: how do we balance the risk?

abstract：:Whole-genome microarrays identify large numbers of gene expression changes that appear specifically related to disease states such as antineutrophil cytoplasmic autoantibody (ANCA) and systemic lupus erythematosus. Although understanding this enormous volume of esoteric data is difficult, a few basic concepts regardin...

journal_title：Kidney international

authors： Stegall MD,Park W

更新日期：2007-10-01 00:00:00

abstract：:The X-linked Hyp and Gy mutations are murine homologues of X-linked hypophosphatemia (XLH), a dominant disorder of phosphate (Pi) homeostasis characterized by growth retardation, rickets, hypophosphatemia and decreased renal tubular maximum for Pi reabsorption relative to glomerular filtration rate (Tmp/GFR). In Hyp a...

journal_title：Kidney international

authors： Tenenhouse HS,Beck L

更新日期：1996-04-01 00:00:00

abstract：INTRODUCTION:Transforming growth factor-beta (TGF-beta) is known to play a pivotal role in the regulation of extracellular matrix (ECM) accumulation. Since diabetic nephropathy (DMN) is characterized by basement membrane thickening and mesangial expansion, control of ECM deposition is believed to be important in the pa...

journal_title：Kidney international

authors： Wong TY,Poon P,Chow KM,Szeto CC,Cheung MK,Li PK

更新日期：2003-05-01 00:00:00

abstract：:Polycystin-1 (PC1) and -2 (PC2), products of the PKD1 and PKD2 genes, are mutated in autosomal dominant polycystic kidney disease (ADPKD). They localize to the primary cilia; however, their ciliary function is in dispute. Loss of either the primary cilia or PC1 or PC2 causes cyst formation. However, loss of both cilia...

journal_title：Kidney international

authors： Shao L,El-Jouni W,Kong F,Ramesh J,Kumar RS,Shen X,Ren J,Devendra S,Dorschel A,Wu M,Barrera I,Tabari A,Hu K,Haque N,Yambayev I,Li S,Kumar A,Behera TR,McDonough G,Furuichi M,Xifaras M,Lu T,Alhayaza RM,Miyabaya

更新日期：2020-11-01 00:00:00

abstract：:The circumstances under which furosemide increases renal blood flow was examined in mongrel dogs as it may relate to a tubuloglomerular feedback mechanism. Two maneuvers, desoxycorticosterone (DOCA) plus salt treatment and inhibition of tubular fluid flow, were used in the dogs to evaluate the renal vascular effects o...

journal_title：Kidney international

authors： Gerber JG,Nies AS

更新日期：1980-10-01 00:00:00

abstract：BACKGROUND:Guidelines for treating anemia in dialysis patients accept, as high-end range of serum ferritin useful to optimize erythropoietin therapy, values high as 500 to 900 microg/L, on the hypothesis that ferritin might be not representative of iron overload. METHODS:A superconducting quantum interference device (...

journal_title：Kidney international

authors： Canavese C,Bergamo D,Ciccone G,Longo F,Fop F,Thea A,Martina G,Piga A

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Our purpose was to compare the function and complications of two high-flow polyurethane hemodialysis catheters. METHODS:This prospective, randomized trial compared the Ash-Split (MedComp) and Opti-Flow (Bard Access Systems) catheters. All patients referred for tunneled hemodialysis catheter placement were o...

journal_title：Kidney international

authors： Trerotola SO,Kraus M,Shah H,Namyslowski J,Johnson MS,Stecker MS,Ahmad I,McLennan G,Patel NH,O'Brien E,Lane KA,Ambrosius WT

更新日期：2002-07-01 00:00:00

abstract：UNLABELLED:Inhibition of pressure natriuresis in mice lacking the AT2 receptor. BACKGROUND:Angiotensin II type 2 (AT2) receptor knockout mice have higher blood pressures than wild-type mice; however, the hypertension is imperfectly defined. We tested the hypothesis that renal mechanisms could be contributory. METHODS...

journal_title：Kidney international

authors： Gross V,Schunck WH,Honeck H,Milia AF,Kärgel E,Walther T,Bader M,Inagami T,Schneider W,Luft FC

更新日期：2000-01-01 00:00:00

abstract：:The purpose of these studies was to quantitatively assess the role of endogenous angiotensin II activity in controlling transport in the proximal convoluted tubule (PCT) and whole nephron. We used the nonpeptide angiotensin II receptor antagonist DuP 753, which lacks the agonist and kinin/prostaglandin-inducing proper...

journal_title：Kidney international

authors： Xie MH,Liu FY,Wong PC,Timmermans PB,Cogan MG

更新日期：1990-09-01 00:00:00

abstract：:Freeze-fracture and thin-section electron microscopy and morphometry were used to characterize further the response of the rat medullary collecting duct to potassium depletion. In freeze-fracture replicas, principal cells and intercalated cells were identified based on the assumption that intercalated cells possess a ...

journal_title：Kidney international

authors： Stetson DL,Wade JB,Giebisch G

更新日期：1980-01-01 00:00:00

abstract：:The adjuvanted hepatitis B vaccine, HB-AS04, elicits more rapid and persistent protective antibody concentrations than double doses of conventional recombinant vaccines in patients with renal insufficiency. We compared the immunogenicity, reactogenicity, and safety of the AS02(V)-adjuvanted hepatitis B vaccine HB-AS02...

journal_title：Kidney international

authors： Surquin M,Tielemans CL,Kulcsár I,Ryba M,Vörös P,Mat O,Treille S,Dhaene M,Stolear JC,Kuriyakose SO,Leyssen MX,Houard SA

更新日期：2010-02-01 00:00:00

abstract：:Urinary exosomes containing apical membrane and intracellular fluid are normally secreted into the urine from all nephron segments, and may carry protein markers of renal dysfunction and structural injury. We studied methods for collection, storage, and preservation of urinary exosomal proteins. We collected urine fro...

journal_title：Kidney international

authors： Zhou H,Yuen PS,Pisitkun T,Gonzales PA,Yasuda H,Dear JW,Gross P,Knepper MA,Star RA

更新日期：2006-04-01 00:00:00

abstract：:Many transgenic and knockout mice with increased urine flow have structural abnormalities of the renal pelvis and inner medulla. Here, we used high resolution contrast enhanced T1-weighted magnetic resonance imaging of mice whose urea transporters UT-A1 and UT-A3 were deleted (UT-A1/3(-/-) mice) as a model for the in ...

journal_title：Kidney international

authors： Jacob VA,Harbaugh CM,Dietz JR,Fenton RA,Kim SM,Castrop H,Schnermann J,Knepper MA,Chou CL,Anderson SA

更新日期：2008-11-01 00:00:00

abstract：:Valproate is an antiepileptic drug known to induce hyperammonemia in humans. This hyperammonemia might result from a reduced detoxification of ammonium in the liver and/or from an accelerated renal ammoniagenesis. Six dogs with normal acid-base equilibrium and eight dogs with chronic metabolic acidosis were infused wi...

journal_title：Kidney international

authors： Rengel-Aranda M,Gougoux A,Vinay P,Lopez-Novoa JM

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:The development of strategies to enhance the survival of transplanted organs and to potentially lower or even discontinue immunosuppressive therapy would represent a significant advancement in post-transplant patient care. METHODS:We studied the effect of pretransplant infusion of donor leukocytes alone or ...

journal_title：Kidney international

authors： Noris M,Azzollini N,Mister M,Pezzotta A,Piccinini G,Casiraghi F,Cugini D,Perico N,Orisio S,Remuzzi G

更新日期：1999-09-01 00:00:00

abstract：:Many features of chronic kidney disease may be reversed, but it is unclear whether advanced lesions, such as adhesions of sclerotic glomerular tufts to Bowman's capsule (synechiae), can resolve during treatment. We previously showed, using a renal ablation model, that the renoprotective effect of the AT-1 receptor blo...

journal_title：Kidney international

authors： Teles F,Machado FG,Ventura BH,Malheiros DM,Fujihara CK,Silva LF,Zatz R

更新日期：2009-01-01 00:00:00

abstract：:IgA nephropathy (IgAN) often shows lesions morphologically identical with those of focal segmental glomerulosclerosis (FSGS). In order to determine the possible role of FSGS in IgAN lesions, we measured glomerular capsular adhesions, often the first step toward FSGS, in biopsies from 127 patients with IgAN, 100 with l...

journal_title：Kidney international

authors： Hill GS,Karoui KE,Karras A,Mandet C,Van Huyen JD,Nochy D,Bruneval P

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Although several kinds of evidence suggest that glycosaminoglycans (GAGs) and proteoglycans (PGs) may contribute to the development of beta2-microglobulin-related (Abeta2m) amyloidosis, the precise roles of these molecules for the development of Abeta2m amyloidosis are poorly understood. METHODS:We investig...

journal_title：Kidney international

authors： Yamaguchi I,Suda H,Tsuzuike N,Seto K,Seki M,Yamaguchi Y,Hasegawa K,Takahashi N,Yamamoto S,Gejyo F,Naiki H

更新日期：2003-09-01 00:00:00

abstract：:Nephronophthisis is an autosomal recessive chronic tubulointerstitial disease that progresses to end-stage renal disease (ESRD) in about 10% of cases during infancy. Mutations in the INVS (NPHP2) gene were found in a few patients with infantile nephronophthisis. Mutations of NPHP3, known to be associated with adolesce...

journal_title：Kidney international

authors： Tory K,Rousset-Rouvière C,Gubler MC,Morinière V,Pawtowski A,Becker C,Guyot C,Gié S,Frishberg Y,Nivet H,Deschênes G,Cochat P,Gagnadoux MF,Saunier S,Antignac C,Salomon R

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Tacrolimus has a narrow therapeutic window, and bioavailability is known to vary considerably between renal transplant recipients. Most centers still rely on measurement of trough levels, but there are conflicting reports on the correlation between tacrolimus trough levels and systemic exposure, as measured ...

journal_title：Kidney international

authors： Scholten EM,Cremers SC,Schoemaker RC,Rowshani AT,van Kan EJ,den Hartigh J,Paul LC,de Fijter JW

更新日期：2005-06-01 00:00:00

abstract：:Diabetic nephropathy is a growing health concern with characteristic sterile inflammation. As the underlying mechanisms of this inflammation remain poorly defined, specific therapies targeting sterile inflammation in diabetic nephropathy are lacking. Intriguingly, an association of diabetic nephropathy with inflammaso...

journal_title：Kidney international

authors： Shahzad K,Bock F,Dong W,Wang H,Kopf S,Kohli S,Al-Dabet MM,Ranjan S,Wolter J,Wacker C,Biemann R,Stoyanov S,Reymann K,Söderkvist P,Groß O,Schwenger V,Pahernik S,Nawroth PP,Gröne HJ,Madhusudhan T,Isermann B

更新日期：2015-01-01 00:00:00

abstract：:Transport and metabolism of adenosine were studied in the S1, S2, and S3 segments of the rabbit proximal renal tubule. Isolated segments were perfused in vitro with uniformly labelled 14C-adenosine to measure the lumen-to-bath flux of adenosine. This flux rate was measured by the disappearance of 14C from the luminal ...

journal_title：Kidney international

authors： Barfuss DW,McCann WP,Katholi RE

更新日期：1992-05-01 00:00:00

abstract：:Cystinosis as a clinical entity is a progressive dysfunction of multiple organs caused by the accumulation of cystine in the tissues, leading, for example, to end-stage renal failure, diabetes, hypothyroidism, myopathy, and central nervous system deterioration. Brodin-Sartorius and colleagues present a long-term study...

journal_title：Kidney international

authors： Cherqui S

更新日期：2012-01-01 00:00:00

abstract：:During vasculitis, activation of the kinin system induces inflammation, whereby the kinin B1-receptor is expressed and activated after ligand binding. Additionally, activated blood cells release microvesicles into the circulation. Here we determined whether leukocyte-derived microvesicles bear B1-kinin receptors durin...

journal_title：Kidney international

authors： Kahn R,Mossberg M,Ståhl AL,Johansson K,Lopatko Lindman I,Heijl C,Segelmark M,Mörgelin M,Leeb-Lundberg LM,Karpman D

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:We hypothesized that increasing small solute clearance in peritoneal dialysis (PD) would lead to improvements in patient health-related quality of life (HRQOL). METHODS:Patients were randomized to a control group [standard 4 x 2 L continuous ambulatory peritoneal dialysis (CAPD)] and an intervention group (...

journal_title：Kidney international

authors： Paniagua R,Amato D,Vonesh E,Guo A,Mujais S,Mexican Nephrology Collaborative Study Group.

更新日期：2005-03-01 00:00:00

abstract：:Antibodies against purified rat-kidney-cortex pyruvate carboxylase were raised in rabbits. These polyspecific antibodies recognize pyruvate carboxylase enzymes alone without cross reactivity with other carboxylases as detected by immunoblotting. The abundance of pyruvate carboxylase in the various renal fractions was ...

journal_title：Kidney international

authors： Salto R,Oliver J,del Mar Sola M,Vargas AM

更新日期：1991-06-01 00:00:00

abstract：:In organ donation, the donor, recipient, and transplant team must all accept potential health risks to the donor and any uncertainties. To gauge these risks, we surveyed general altruism and risk-taking behaviors in 112 potential donors, 111 potential recipients, and 51 transplant professionals. Next, participants ind...

journal_title：Kidney international

authors： Young A,Karpinski M,Treleaven D,Waterman A,Parikh CR,Thiessen-Philbrook H,Yang RC,Garg AX

更新日期：2008-05-01 00:00:00

abstract：:Impaired olfactory function is a marker of neurologic dysfunction in the uremic state. Retained uremic toxins not adequately cleared with dialysis may undermine the integrity of the olfactory epithelium and olfactory bulb and malign central olfactory processing. The evidence suggests that only renal transplantation, w...

journal_title：Kidney international

authors： Bomback AS,Raff AC

更新日期：2011-10-01 00:00:00

abstract：:Renal fibrosis is a common pathway leading to the progression of chronic kidney disease, and bone marrow-derived fibroblasts contribute significantly to the development of renal fibrosis. However, the signaling mechanisms underlying the activation of these fibroblasts are not completely understood. Here, we examined t...

journal_title：Kidney international

authors： Liang H,Zhang Z,Yan J,Wang Y,Hu Z,Mitch WE,Wang Y

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Podocytes are highly differentiated glomerular epithelial cells with limited potential to divide. They are responsible for maintaining and supporting the glomerular basement membrane so as to facilitate efficient filtration. The hypothesis tested was whether the development of glomerulosclerosis in the purom...

journal_title：Kidney international

authors： Kim YH,Goyal M,Kurnit D,Wharram B,Wiggins J,Holzman L,Kershaw D,Wiggins R

更新日期：2001-09-01 00:00:00