Regression of glomerular injury by losartan in experimental diabetic nephropathy.

abstract：BACKGROUND:Since the cloning of the gene for autosomal dominant polycystic kidney disease type 2 (PKD2), approximately 40 different mutations of that gene have been reported to be associated with the disease. The relationship between the PKD2 genotype and phenotype, however, remains unclear. METHODS:Detailed clinical ...

journal_title：Kidney international

authors： Hateboer N,Veldhuisen B,Peters D,Breuning MH,San-Millán JL,Bogdanova N,Coto E,van Dijk MA,Afzal AR,Jeffery S,Saggar-Malik AK,Torra R,Dimitrakov D,Martinez I,de Castro SS,Krawczak M,Ravine D

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Clinical studies have shown that the angiotensin-converting enzyme (ACE) inhibitors or angiotensin II (Ang II) receptor antagonists decrease proteinuria and slow the progression of nephropathy in diabetes, indicating that Ang II plays an important role in the development of nephropathy. We have previously re...

journal_title：Kidney international

authors： Zhang SL,Filep JG,Hohman TC,Tang SS,Ingelfinger JR,Chan JS

更新日期：1999-02-01 00:00:00

abstract：:Sodium thiosulfate, a reversible oxidation product of hydrogen sulfide, has vasodilating and anti-oxidative properties, making it an attractive agent to alleviate damaging effects of hypertension. In experimental settings, inhibition of nitric oxide synthase causes hypertension, renal dysfunction and damage. We hypoth...

journal_title：Kidney international

authors： Nguyen ITN,Klooster A,Minnion M,Feelisch M,Verhaar MC,van Goor H,Joles JA

更新日期：2020-08-01 00:00:00

abstract：:Orskov and colleagues demonstrate the impact of birth weight on the mean age of end-stage renal disease (ESRD) in a large Danish ADPKD cohort. Each kilogram of birth weight extended the mean age of ESRD onset by 1.7 years. Placental insufficiency, activation of the renin-angiotensin-aldosterone system, increased fetal...

journal_title：Kidney international

authors： Chapman AB

更新日期：2012-05-01 00:00:00

abstract：:Toward an etiological classification of developmental disorders of the kidney and upper urinary tract. There are a large number of developmental disorders and syndromes that affect the kidney and upper urinary tract. These have generally been classified according to morphological criteria established decades ago. Alth...

journal_title：Kidney international

authors： Pohl M,Bhatnagar V,Mendoza SA,Nigam SK

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:We hypothesized that increasing small solute clearance in peritoneal dialysis (PD) would lead to improvements in patient health-related quality of life (HRQOL). METHODS:Patients were randomized to a control group [standard 4 x 2 L continuous ambulatory peritoneal dialysis (CAPD)] and an intervention group (...

journal_title：Kidney international

authors： Paniagua R,Amato D,Vonesh E,Guo A,Mujais S,Mexican Nephrology Collaborative Study Group.

更新日期：2005-03-01 00:00:00

abstract：:Acute kidney injury (AKI) increases the risk for chronic kidney disease (CKD). However, there are few tools to detect microstructural changes after AKI. Here, cationic ferritin-enhanced magnetic resonance imaging (CFE-MRI) was applied to examine the heterogeneity of kidney pathology in the transition from AKI to CKD. ...

journal_title：Kidney international

authors： Charlton JR,Xu Y,Wu T,deRonde KA,Hughes JL,Dutta S,Oxley GT,Cwiek A,Cathro HP,Charlton NP,Conaway MR,Baldelomar EJ,Parvin N,Bennett KM

更新日期：2021-01-01 00:00:00

abstract：:About 75% of urinary stones contain oxalate. As Oxalobacter formigenes is a Gram-negative anaerobic bacterium that degrades oxalate in the intestinal tract, we assessed the role of O. formigenes in oxalate metabolism by evaluating its intestinal absorption, plasma concentration, and urinary excretion. Of 37 calcium ox...

journal_title：Kidney international

authors： Siener R,Bangen U,Sidhu H,Hönow R,von Unruh G,Hesse A

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:We have recently demonstrated an increase in apoptosis in Han:SPRD rat kidneys with autosomal-dominant polycystic kidney disease (ADPKD). Caspase-3 and caspase-7 are major mediators of apoptosis. There are two pathways of caspase-3 and caspase-7-mediated apoptosis: (1) the "extrinsic" pathway involving the d...

journal_title：Kidney international

authors： Tao Y,Kim J,Stanley M,He Z,Faubel S,Schrier RW,Edelstein CL

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Normalization of proteinuria and even regression of glomerulosclerosis seem to occur in progressive renal disease upon blockade of the renin-angiotensin system. Here we quantified the effect of a combination of an angiotensin converting enzyme (ACE) inhibitor and an angiotensin II (Ang II) receptor antagonis...

journal_title：Kidney international

authors： Remuzzi A,Gagliardini E,Donadoni C,Fassi A,Sangalli F,Lepre MS,Remuzzi G,Benigni A

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:An Experimental model of proliferative glomerulonephritis induced by an antibody against Thy-1 antigen has been established. However, the pathophysiologic role and the critical epitope of Thy-1 molecule for induction of mesangial cell dysfunction remain unknown. We have reported that monoclonal antibody 1-22...

journal_title：Kidney international

authors： Morioka T,Yao J,Suzuki Y,Oite T

更新日期：2004-12-01 00:00:00

abstract：:This study examined the consequences of nephrectomy in United States Army personnel who lost a kidney due to trauma during World War II (WWII). Records of 62 servicemen who underwent nephrectomy at an average age of 25 years were obtained. Mortality was compared with that of WWII servicemen of the same age. Medical re...

journal_title：Kidney international

authors： Narkun-Burgess DM,Nolan CR,Norman JE,Page WF,Miller PL,Meyer TW

更新日期：1993-05-01 00:00:00

abstract：:The nature of the light chains in mesangial IgA deposits and serum IgA was studied in patients with IgA nephropathy. Immunofluorescence (IF) studies using murine monoclonal antibodies, rabbit and goat anti-human monospecific antisera were performed in kidney sections from 15 IgA nephritic patients with only IgA isotyp...

journal_title：Kidney international

authors： Lai KN,Chui SH,Lai FM,Lam CW

更新日期：1988-02-01 00:00:00

abstract：:IgA1 proteins from sera of patients with IgA nephropathy (IgAN) are galactosylated to a lesser degree than those from healthy controls. The increased reactivity of intact or de-sialylated serum IgA1 with N-acetylgalactosamine (GalNAc)-specific lectins, Helix aspersa (HAA) and Caragana arborescens (CAA) and de-sialylat...

journal_title：Kidney international

authors： Tomana M,Matousovic K,Julian BA,Radl J,Konecny K,Mestecky J

更新日期：1997-08-01 00:00:00

abstract：:Although the goal glomerular filtration rate (GFR) for chronic dialysis initiation is currently above 5 ml/min per 1.73 m(2), there is no convincing evidence that patients will benefit from this approach. With close follow-up of advanced chronic kidney disease patients, aiming to start dialysis at an estimated GFR (eG...

journal_title：Kidney international

authors： Rosansky SJ,Durkin MW

更新日期：2014-10-01 00:00:00

abstract：:The parathyroid hormone response to hypocalcemia was investigated in hemodialysis patients with osteomalacia and compared to those with osteitis fibrosa. Hypocalcemia was induced during hemodialysis by employing a dialysate devoid of calcium. Patients with osteomalacia had a blunted maximum amino terminal parathyroid ...

journal_title：Kidney international

authors： Andress D,Felsenfeld AJ,Voigts A,Llach F

更新日期：1983-09-01 00:00:00

abstract：:The highly amiloride-sensitive epithelial sodium channel (ENaC) is an apical membrane constituent of cells of many salt-absorbing epithelia. In the kidney, the functional relevance of ENaC expression has been well established. ENaC mediates the aldosterone-dependent sodium reabsorption in the distal nephron and is inv...

journal_title：Kidney international

authors： Bonny O,Hummler E

更新日期：2000-04-01 00:00:00

abstract：:Disturbed pulsatile LH secretion has been suggested to play a role in the etiology of delayed puberty and disturbed reproductive function in chronic renal failure (CRF), but interpretation of gonadotropin secretion from plasma concentration measurements is confounded by alterations in hormone metabolic clearance. To s...

journal_title：Kidney international

authors： Schaefer F,Veldhuis JD,Robertson WR,Dunger D,Schärer K

更新日期：1994-05-01 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive enlargement of kidney cysts leading to chronic kidney disease (CKD) and end-stage renal disease (ESRD). Identification of an early biomarker that can predict progression of CKD is urgently needed. In an earlier Consortium for Radiolog...

journal_title：Kidney international

authors： Yu ASL,Shen C,Landsittel DP,Harris PC,Torres VE,Mrug M,Bae KT,Grantham JJ,Rahbari-Oskoui FF,Flessner MF,Bennett WM,Chapman AB,Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP).

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Recent studies have demonstrated that a high concentration of phosphate directly stimulates parathyroid hormone (PTH) secretion. High serum levels of phosphate are usually observed in patients with end-stage renal disease. The aim of the present study was to evaluate whether serum phosphate concentration had...

journal_title：Kidney international

authors： de Francisco AL,Cobo MA,Setien MA,Rodrigo E,Fresnedo GF,Unzueta MT,Amado JA,Ruiz JC,Arias M,Rodriguez M

更新日期：1998-12-01 00:00:00

abstract：:The clinical value of biocompatible peritoneal dialysis solutions is uncertain because of inconsistent findings in randomized controlled trials. A systematic review by Cho et al. examining 20 such trials suggests a beneficial effect on residual renal function. However, the finding is not robust and may relate to decre...

journal_title：Kidney international

authors： Blake PG,Jain AK,Yohanna S

更新日期：2013-11-01 00:00:00

abstract：:We studied the effect of three antihypertensive drugs on the growth of glomeruli in four- to five-week-old Munich-Wistar rats (N = 24), which were undergoing rapid maturation processes. Young rats were given an angiotensin converting enzyme inhibitor (ACEI, enalapril, 50 mg/liter drinking water), verapamil (50 mg/lite...

journal_title：Kidney international

authors： Fogo A,Yoshida Y,Yared A,Ichikawa I

更新日期：1990-12-01 00:00:00

abstract：:Since 1992 and the discovery of an MIP (major intrinsic protein of lens fiber cell) homologue protein that selectively permeates water, aquaporin (AQP), there has been an explosion of research in this field. Early research speculated that aquaporins played indispensible physiological roles in bacteria and plants, as w...

journal_title：Kidney international

authors： Yamamoto T,Sasaki S

更新日期：1998-10-01 00:00:00

abstract：:Diabetes mellitus is associated with natriuresis, whereas estrogen has been shown to be renoprotective in diabetic nephropathy and may independently regulate renal sodium reabsorption. The aim of this study was to determine the effects of 17-beta estradiol (E(2)) replacement to diabetic, ovariectomized (OVX) female ra...

journal_title：Kidney international

authors： Riazi S,Maric C,Ecelbarger CA

更新日期：2006-02-01 00:00:00

abstract：:A controlled trial of cyclosporine in patients diagnosed with progressive membranous nephropathy (MGN) was carried out to determine whether cyclosporine (D) would be more effective than placebo (P) in reducing the rate of deterioration in renal function. Patients (N = 64) with MGN were placed on a restricted protein d...

journal_title：Kidney international

authors： Cattran DC,Greenwood C,Ritchie S,Bernstein K,Churchill DN,Clark WF,Morrin PA,Lavoie S

更新日期：1995-04-01 00:00:00

abstract：:Primary hyperoxaluria is characterized by severe urolithiasis, nephrocalcinosis, and early renal failure. As treatment options are scarce, we aimed for a new therapeutic tool using colonic degradation of endogenous oxalate by Oxalobactor formigenes. Oxalobacter was orally administered for 4 weeks as frozen paste (IxOC...

journal_title：Kidney international

authors： Hoppe B,Beck B,Gatter N,von Unruh G,Tischer A,Hesse A,Laube N,Kaul P,Sidhu H

更新日期：2006-10-01 00:00:00

abstract：:Insulin resistance from chronic kidney disease (CKD) stimulates muscle protein wasting but mechanisms causing this resistance are controversial. To help resolve this, we used microarray analyses to identify initiators of insulin resistance in the muscles of mice with CKD, glucose intolerance, and insulin resistance. C...

journal_title：Kidney international

authors： Thomas SS,Dong Y,Zhang L,Mitch WE

更新日期：2013-08-01 00:00:00

abstract：:Proliferation of mesangial cells is frequently found in glomerulonephritis, such as IgA glomerulonephritis. Recent reports suggest that a brain/embryo-type myosin isoform (MIIB2) is involved in cell proliferation. We have studied the expression of MIIB2 in renal biopsy samples from patients with various renal diseases...

journal_title：Kidney international

authors： Kishino M,Kimura A,Yamaguchi K,Ohtani H,Yamada Y,Takahashi T,Mune M,Mimura K,Maeda T,Matsumura S,Tsuji T,Yukawa S

更新日期：1996-05-01 00:00:00

abstract：:Propofol has been shown to provide protection against renal ischemia/reperfusion injury experimentally, but clinical evidence is lacking. Here we studied the effect of propofol anesthesia on the occurrence of acute kidney injury following heart surgery with cardiopulmonary bypass. One hundred and twelve patients who u...

journal_title：Kidney international

authors： Yoo YC,Shim JK,Song Y,Yang SY,Kwak YL

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:In renal cells, hyperosmolarity has been shown to induce the accumulation of myo-inositol, via the Na+/myo-inositol cotransporter (SMIT). Previously we showed that SMIT mRNA in the kidney is localized in the medullary thick ascending limb of Henle (TALH). Here we used renal cells derived from the rabbit oute...

journal_title：Kidney international

authors： Yorek MA,Dunlap JA,Lowe WL Jr

更新日期：1999-01-01 00:00:00