The role of Oxalobacter formigenes colonization in calcium oxalate stone disease.

abstract：:Multiphoton excitation fluorescence microscopy is a state-of-the-art confocal imaging technique ideal for deep optical sectioning of living tissues. It is capable of performing ultrasensitive, quantitative imaging of organ functions in health and disease with high spatial and temporal resolution which other imaging mo...

journal_title：Kidney international

authors： Sipos A,Toma I,Kang JJ,Rosivall L,Peti-Peterdi J

更新日期：2007-11-01 00:00:00

abstract：:Rare autosomal dominant tubulointerstitial kidney disease is caused by mutations in the genes encoding uromodulin (UMOD), hepatocyte nuclear factor-1β (HNF1B), renin (REN), and mucin-1 (MUC1). Multiple names have been proposed for these disorders, including 'Medullary Cystic Kidney Disease (MCKD) type 2', 'Familial Ju...

journal_title：Kidney international

authors： Eckardt KU,Alper SL,Antignac C,Bleyer AJ,Chauveau D,Dahan K,Deltas C,Hosking A,Kmoch S,Rampoldi L,Wiesener M,Wolf MT,Devuyst O,Kidney Disease: Improving Global Outcomes.

更新日期：2015-10-01 00:00:00

abstract：:Micropuncture studies were carried out in surface nephrons of rats with nephrotoxic-serum (NTS)-induced nephrotic syndrome during a period of active sodium and water retention. It was found that hydrostatic pressure and tubular diameter were increased in the proximal tubules (13.4 +/- 0.2 vs. 10.4 +/- 0.2 mm Hg; 31.3 ...

journal_title：Kidney international

authors： Kuroda S,Aynedjian HS,Bank N

更新日期：1979-11-01 00:00:00

abstract：BACKGROUND:The obstructed kidney in unilateral ureteral obstruction (UUO) is characterized by renal atrophy and tissue loss, which is mediated by renal tubular apoptosis. We sought to determine whether NO is involved in renal tubular apoptosis in vitro and in vivo. METHODS:Rat renal tubular epithelial cells (NRK-52E) ...

journal_title：Kidney international

authors： Miyajima A,Chen J,Poppas DP,Vaughan ED Jr,Felsen D

更新日期：2001-04-01 00:00:00

abstract：:The profibrotic adhesion molecule, osteopontin (OPN), is upregulated in kidneys of humans and mice with diabetes. The thiazolidinedione (TZD) insulin sensitizers decrease albuminuria in diabetic nephropathy (DN) and reduce OPN expression in vascular and cardiac tissue. To examine whether OPN is a critical mediator of ...

journal_title：Kidney international

authors： Nicholas SB,Liu J,Kim J,Ren Y,Collins AR,Nguyen L,Hsueh WA

更新日期：2010-04-01 00:00:00

abstract：:In chronic serum sickness, glomerular immune complexes form, yet C57BL/6 mice do not develop glomerulonephritis unless complement factor H (CfH) is absent, indicating the relevance of complement regulation. Complement receptor 3 (CD11b) and Fcγ receptors on leukocytes, and CfH on platelets, can bind immune complexes. ...

journal_title：Kidney international

authors： Alexander JJ,Chaves LD,Chang A,Jacob A,Ritchie M,Quigg RJ

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Our preliminary studies indicate that chronic caffeine consumption has adverse renal effects in nephropathy associated with high blood pressure and insulin resistance. The purpose of this study was to investigate the effects of early (beginning at 8 weeks of age) and long-term (30 weeks) caffeine treatment (...

journal_title：Kidney international

authors： Tofovic SP,Kost CK Jr,Jackson EK,Bastacky SI

更新日期：2002-04-01 00:00:00

abstract：:Genetic variation at the MYH9 locus is linked to the high incidence of focal segmental glomerulosclerosis (FSGS) and non-diabetic end-stage renal disease among African Americans. To further define risk alleles with FSGS we performed a genome-wide association analysis using more than one million single-nucleotide polym...

journal_title：Kidney international

authors： Genovese G,Tonna SJ,Knob AU,Appel GB,Katz A,Bernhardy AJ,Needham AW,Lazarus R,Pollak MR

更新日期：2010-10-01 00:00:00

abstract：:The loss of interstitial capillaries is a feature of several experimental models of renal disease and this contributes to secondary kidney injury. Angiopoietin-1 is a secreted growth factor which binds to Tie-2 present on endothelia to enhance cell survival thereby stabilizing capillary architecture in-vitro. Previous...

journal_title：Kidney international

authors： Long DA,Price KL,Ioffe E,Gannon CM,Gnudi L,White KE,Yancopoulos GD,Rudge JS,Woolf AS

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:There is growing evidence pointing to an involvement of cytokines and growth factors in renal osteodystrophy. In this study, the expression of interleukin-l beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-beta (TGF-beta), and basic fibroblast growth factor (bFGF) in bone...

journal_title：Kidney international

authors： Santos FR,Moysés RM,Montenegro FL,Jorgetti V,Noronha IL

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Adrenomedullin (ADM) exerts antiproliferative effects on rat mesangial cells in vitro and, therefore is a possible renoprotective agent. In contrast, nitric oxide (NO) is capable of exerting both cytoprotective and cytotoxic actions. It was the objective of the present study to examine whether NO stimulates ...

journal_title：Kidney international

authors： Dötsch J,Schoof E,Schöcklmann HO,Brüne B,Knerr I,Repp R,Rascher W

更新日期：2002-05-01 00:00:00

abstract：:Substrate oxidation was assessed by measuring 14CO2 production from 14C-labeled substrates in proximal convoluted tubules (PCT), medullary (MTAL), and cortical (CTAL) thick ascending limb of Henle, nephron segments rich in mitochondria and characterized by active solute transport. PCT, MTAL, and CTAL were dissected fr...

journal_title：Kidney international

authors： Klein KL,Wang MS,Torikai S,Davidson WD,Kurokawa K

更新日期：1981-07-01 00:00:00

abstract：BACKGROUND:Endotoxin is an important factor in the development of acute renal failure related to infection and in acceleration of chronic nephritis. Lipopolysaccharide (LPS; the major component of endotoxin) is one of the most potent triggers for renal cells to produce monocyte chemoattractant protein-1 (MCP-1), a key ...

journal_title：Kidney international

authors： Wang Y,Rangan GK,Goodwin B,Tay YC,Harris DC

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:The rat renal proximal tubule cells contain a large amount of monoamine oxidase, which catalyzes the oxidative deamination of catecholamines such as dopamine (DA). The aim of this study is to investigate the potential role of hydrogen peroxide (H2O2) produced by monoamine oxidase (MAO) isoform on regulation ...

journal_title：Kidney international

authors： Vindis C,Séguélas MH,Lanier S,Parini A,Cambon C

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:It is still unclear whether age per se is associated with preservation of renal functional reserve, that is, of the increase in glomerular filtration rate (GFR) induced by appropriate vasodilating stimulus. METHODS:To gain insights into this issue, we evaluated the renal response to a maximal vasodilating s...

journal_title：Kidney international

authors： Fuiano G,Sund S,Mazza G,Rosa M,Caglioti A,Gallo G,Natale G,Andreucci M,Memoli B,De Nicola L,Conte G

更新日期：2001-03-01 00:00:00

abstract：:A major factor contributing to failure of arteriovenous fistulas (AVFs) is migration of smooth muscle cells into the forming neointima. To identify the source of smooth muscle cells in neointima, we created end-to-end AVFs by anastomosing the common carotid artery to the jugular vein and studied neural crest-derived s...

journal_title：Kidney international

authors： Liang M,Wang Y,Liang A,Mitch WE,Roy-Chaudhury P,Han G,Cheng J

更新日期：2015-09-01 00:00:00

abstract：:In recent times, therapy for renal anemia has changed dramatically in that iron administration has increased and doses of erythropoiesis-stimulating agents (ESAs) have decreased. Here we used a prospective, observational, multicenter design and measured the serum ferritin and hemoglobin levels every 3 months for 2 yea...

journal_title：Kidney international

authors： Kuragano T,Matsumura O,Matsuda A,Hara T,Kiyomoto H,Murata T,Kitamura K,Fujimoto S,Hase H,Joki N,Fukatsu A,Inoue T,Itakura I,Nakanishi T

更新日期：2014-10-01 00:00:00

abstract：:In a rat model of glomerular immune injury induced by administration of anti-glomerular basement membrane antibody and resembling human rapidly progressive glomerulonephritis, we explored whether activation of inducible nitric oxide synthase (iNOS) regulates synthesis of eicosanoids originating from cyclooxygenation o...

journal_title：Kidney international

authors： Lianos EA,Guglielmi K,Sharma M

更新日期：1998-03-01 00:00:00

abstract：:Gene expression differs substantially among individual cells of the same type. We speculate that genes that are expressed in all but a portion of cells of a given cell type would be likely essential and required for either the cell survival (housekeeping) or for the cell type's unique structure and function, enabling ...

journal_title：Kidney international

authors： Lu Y,Ye Y,Bao W,Yang Q,Wang J,Liu Z,Shi S

更新日期：2017-11-01 00:00:00

abstract：:One of the challenges of treating patients with glomerulonephritis is to accurately assess disease activity. As renal biopsies are routinely stained for deposits of C3 activation fragments and glomerular C3 deposits are found in most forms of glomerulonephritis, we sought to determine whether a relatively noninvasive ...

journal_title：Kidney international

authors： Sargsyan SA,Serkova NJ,Renner B,Hasebroock KM,Larsen B,Stoldt C,McFann K,Pickering MC,Thurman JM

更新日期：2012-01-01 00:00:00

abstract：:The safety of dietary protein and phosphorous restriction was evaluated in the Modification of Diet in Renal Disease (MDRD) Study. In Study A, 585 patients with a glomerular filtration rate (GFR) of 25 to 55 ml/min/1.73 m2 were randomly assigned to a usual-protein diet (1.3 g/kg/day) or a low-protein diet (0.58 g/kg/d...

journal_title：Kidney international

authors： Kopple JD,Levey AS,Greene T,Chumlea WC,Gassman JJ,Hollinger DL,Maroni BJ,Merrill D,Scherch LK,Schulman G,Wang SR,Zimmer GS

更新日期：1997-09-01 00:00:00

abstract：:The use of the immuno-suppressant cyclosporine A (CsA) after transplantation has been associated with less favorable plasma lipid profiles, which may contribute to the high incidence of cardiovascular morbidity and mortality in transplant recipients. Recent studies have suggested that oxidative modification of LDL pla...

journal_title：Kidney international

authors： van den Dorpel MA,Ghanem H,Rischen-Vos J,Man in't Veld AJ,Jansen H,Weimar W

更新日期：1997-05-01 00:00:00

abstract：:Autophagy is a conserved multistep pathway that degrades and recycles damaged organelles and macromolecules to maintain intracellular homeostasis. The autophagy pathway is upregulated under stress conditions including cell starvation, hypoxia, nutrient and growth-factor deprivation, endoplasmic reticulum stress, and o...

journal_title：Kidney international

authors： Kaushal GP,Shah SV

更新日期：2016-04-01 00:00:00

abstract：:Primary hyperoxaluria is characterized by severe urolithiasis, nephrocalcinosis, and early renal failure. As treatment options are scarce, we aimed for a new therapeutic tool using colonic degradation of endogenous oxalate by Oxalobactor formigenes. Oxalobacter was orally administered for 4 weeks as frozen paste (IxOC...

journal_title：Kidney international

authors： Hoppe B,Beck B,Gatter N,von Unruh G,Tischer A,Hesse A,Laube N,Kaul P,Sidhu H

更新日期：2006-10-01 00:00:00

abstract：:Here we studied a possible association between low parathyroid hormone (PTH) status and mortality in incident patients undergoing hemodialysis . A total of 1983 patients were included at baseline and prospectively followed for 24 months. Patients were classified according to their Kidney Disease: Improving Global Outc...

journal_title：Kidney international

authors： Merle E,Roth H,London GM,Jean G,Hannedouche T,Bouchet JL,Drüeke T,Fouque D,Daugas E,French Calcium and Phosphate Observatory.

更新日期：2016-03-01 00:00:00

abstract：:Propofol has been shown to provide protection against renal ischemia/reperfusion injury experimentally, but clinical evidence is lacking. Here we studied the effect of propofol anesthesia on the occurrence of acute kidney injury following heart surgery with cardiopulmonary bypass. One hundred and twelve patients who u...

journal_title：Kidney international

authors： Yoo YC,Shim JK,Song Y,Yang SY,Kwak YL

更新日期：2014-08-01 00:00:00

abstract：:Determination of serum oxalate concentration is important for the diagnosis and monitoring of hyperoxalurias, and extends to patients with all types of renal disease. Approximately 5 to 10 ml of blood is required for each test by conventional methods, and the test is not adapted for use in children. We developed a hig...

journal_title：Kidney international

authors： Gaulier JM,Cochat P,Lardet G,Vallon JJ

更新日期：1997-12-01 00:00:00

abstract：:[Arg(8)]-vasopressin (AVP) has several functions via its three distinct receptors, V1a, V1b, and V2. The V1a vasopressin receptor (V1aR) is expressed in blood vessels and involved in vascular contraction. Recently, we generated V1a receptor-deficient (V1aR(-/-)) mice and found that they were hypotensive. In addition, ...

journal_title：Kidney international

authors： Aoyagi T,Koshimizu TA,Tanoue A

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:An imbalance between protein load and folding capacity is referred to as endoplasmic reticulum (ER) stress. As a defense mechanism, cells express ER stress inducible chaperons, such as oxygen-regulated proteins 150 (ORP150) and glucose-regulated proteins (GRPs). While ER stress is important in various diseas...

journal_title：Kidney international

authors： Inagi R,Nangaku M,Onogi H,Ueyama H,Kitao Y,Nakazato K,Ogawa S,Kurokawa K,Couser WG,Miyata T

更新日期：2005-12-01 00:00:00

abstract：:Carefully age-matched, purebred male beagle dogs that underwent uninephrectomy one month after they were made diabetic with alloxan were used to establish a model of rapidly developing diabetic nephropathy in a large animal. The diabetic animals, all requiring insulin, were divided into two groups: one group with cont...

journal_title：Kidney international

authors： Steffes MW,Buchwald H,Wigness BD,Groppoli TJ,Rupp WM,Rohde TD,Blackshear PJ,Mauer SM

更新日期：1982-05-01 00:00:00