Dopamine induces ERK activation in renal epithelial cells through H2O2 produced by monoamine oxidase.

Abstract:

BACKGROUND:The rat renal proximal tubule cells contain a large amount of monoamine oxidase, which catalyzes the oxidative deamination of catecholamines such as dopamine (DA). The aim of this study is to investigate the potential role of hydrogen peroxide (H2O2) produced by monoamine oxidase (MAO) isoform on regulation of cell signaling and function. METHODS:Primary rat proximal tubular cells, which contain almost exclusively MAO-A, and human embryonic kidney 293 (HEK 293) cells stably transfected with human MAO-B cDNA were treated with DA or tyramine in the presence or the absence of some inhibitors. Then, Shc protein tyrosine phosphorylation and extracellular-regulated kinase (ERK) activation were evaluated by immunoprecipitation/immunoblot analysis and cell proliferation by [3H]thymidine incorporation or cell counting. RESULTS:In rat proximal tubule cells, DA induced tyrosine phosphorylation of Shc, ERK activation, and a significant increase in DNA synthesis. The involvement of MAO-dependent H2O2 generation induced by DA (5 micromol/L) was supported by the demonstration that the DA effects were (1) fully prevented by cell pretreatment with the MAO inhibitor pargyline, the antioxydant N-acetylcysteine (NAC), and the DA uptake inhibitor GBR 12909; (2) not abrogated by the D1 and D2 receptor antagonists; (3) observed in HEK 293 MAO-B cells but not in HEK 293 wild-type cells, which do not express MAO; and (4) similar to those induced by another MAO substrate, tyramine. CONCLUSIONS:Taken together, these results show that in addition to the effects related to receptor stimulation, DA, and probably the other catecholamines, may induce some of its effects through the MAO-dependent H2O2 production.

journal_name

Kidney Int

journal_title

Kidney international

authors

Vindis C,Séguélas MH,Lanier S,Parini A,Cambon C

doi

10.1046/j.1523-1755.2001.00468.x

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

76-86

issue

1

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)47442-3

journal_volume

59

pub_type

杂志文章
  • Immunological quantification of advanced glycosylation end-products in the serum of patients on hemodialysis or CAPD.

    abstract::We have developed an immunological procedure for measuring advanced glycosylation end-products (AGEs) in serum. Using this method, we measured AGEs in healthy volunteers, patients with diabetes, renal failure without treatment and in patients with renal failure, treated with hemodialysis (HD) or continuous ambulatory ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1994.262

    authors: Papanastasiou P,Grass L,Rodela H,Patrikarea A,Oreopoulos D,Diamandis EP

    更新日期:1994-07-01 00:00:00

  • Induction of glomerulonephritis in rats with staphylococcal phosphatase: new aspects in post-infectious ICGN.

    abstract::Staphylococcal neutral phosphatase (NPtase) is a highly cationic bacterial surface bound protein. It has significant affinity for human and rat immunoglobulins in vitro and an electrostatic interaction may be involved. Radioisotopic studies showed that NPtase had a high affinity for the polyanionic structures of the r...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1996.314

    authors: Yousif Y,Okada K,Batsford S,Vogt A

    更新日期:1996-07-01 00:00:00

  • Does the downregulation of the FGF23 signaling pathway in hyperplastic parathyroid glands contribute to refractory secondary hyperparathyroidism in CKD patients?

    abstract::Compared to normal tissue, hyperplastic parathyroid glands of patients with chronic kidney disease on dialysis express lower levels of FGFR1 and Klotho proteins. Similar findings are reported in uremic rats with advanced chronic kidney disease. Moreover, in these animals, FGF23 administration fails to reduce PTH serum...

    journal_title:Kidney international

    pub_type: 评论,杂志文章

    doi:10.1038/ki.2009.512

    authors: Lafage-Proust MH

    更新日期:2010-03-01 00:00:00

  • Proteasome inhibitor-based therapy for antibody-mediated rejection.

    abstract::The development of donor-specific anti-human leukocyte antigen antibodies (DSAs) following renal transplantation significantly reduces long-term renal graft function and survival. The traditional therapies for antibody-mediated rejection (AMR) have provided inconsistent results and transient effects that may be due to...

    journal_title:Kidney international

    pub_type: 杂志文章,评审

    doi:10.1038/ki.2011.502

    authors: Walsh RC,Alloway RR,Girnita AL,Woodle ES

    更新日期:2012-06-01 00:00:00

  • MicroRNA-214 promotes chronic kidney disease by disrupting mitochondrial oxidative phosphorylation.

    abstract::Mitochondria are critical in determining a cell's energy homeostasis and fate, and mitochondrial dysfunction has been implicated in the pathogenesis of chronic kidney disease (CKD). We sought to identify causative mitochondrial microRNAs. A microarray screen of kidney tissue from healthy mice identified 97 microRNAs t...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1016/j.kint.2018.12.028

    authors: Bai M,Chen H,Ding D,Song R,Lin J,Zhang Y,Guo Y,Chen S,Ding G,Zhang Y,Jia Z,Huang S,He JC,Yang L,Zhang A

    更新日期:2019-06-01 00:00:00

  • Predominant role of FcgammaRIII in the induction of accelerated nephrotoxic glomerulonephritis.

    abstract:BACKGROUND:Nephrotoxic glomerulonephritis is induced by the administration of antibody against the glomerular basement membrane (GBM). We demonstrated previously that Fc receptors for immunoglobulin G (IgG) (FcgammaR) play crucial roles in the induction of accelerated nephrotoxic glomerulonephritis by using FcRgamma-de...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.2003.00203.x

    authors: Fujii T,Hamano Y,Ueda S,Akikusa B,Yamasaki S,Ogawa M,Saisho H,Verbeek JS,Taki S,Saito T

    更新日期:2003-10-01 00:00:00

  • Renal hemodynamics during separate and combined infusion of amino acids and dopamine.

    abstract::Healthy volunteers (N = 9) and patients with varying degrees of renal insufficiency (N = 36) were given a low dose of dopamine and/or amino acids intravenously during a simultaneous measurement of the glomerular filtration rate and the effective renal plasma flow. Dopamine infusion led to a rise in the glomerular filt...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1986.79

    authors: ter Wee PM,Rosman JB,van der Geest S,Sluiter WJ,Donker AJ

    更新日期:1986-04-01 00:00:00

  • Body mass index, dialysis modality, and survival: analysis of the United States Renal Data System Dialysis Morbidity and Mortality Wave II Study.

    abstract:BACKGROUND:The impact of obesity on survival in end-stage renal disease (ESRD) patients as related to dialysis modality (i.e., a direct comparison of hemodialysis with peritoneal dialysis) has not been assessed adjusting for differences in medication use, follow-up > or =2 years, or accounting for changes in dialysis m...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1111/j.1523-1755.2004.00385.x

    authors: Abbott KC,Glanton CW,Trespalacios FC,Oliver DK,Ortiz MI,Agodoa LY,Cruess DF,Kimmel PL

    更新日期:2004-02-01 00:00:00

  • Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat.

    abstract::Many xenobiotics including the pharmacoenhancer cobicistat increase serum creatinine by inhibiting its renal active tubular secretion without affecting the glomerular filtration rate. This study aimed to define the transporters involved in creatinine secretion, applying that knowledge to establish the mechanism for xe...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.2014.66

    authors: Lepist EI,Zhang X,Hao J,Huang J,Kosaka A,Birkus G,Murray BP,Bannister R,Cihlar T,Huang Y,Ray AS

    更新日期:2014-08-01 00:00:00

  • Lipotoxicity.

    abstract::Excess fatty acids accompanied by triglyceride accumulation in parenchymal cells of multiple tissues including skeletal and cardiac myocytes, hepatocytes, and pancreatic beta cells results in chronic cellular dysfunction and injury. The process, now termed lipotoxicity, can account for many manifestations of the 'meta...

    journal_title:Kidney international

    pub_type: 杂志文章,评审

    doi:10.1038/sj.ki.5001834

    authors: Weinberg JM

    更新日期:2006-11-01 00:00:00

  • Gender-specific association of adiponectin as a predictor of progression of chronic kidney disease: the Mild to Moderate Kidney Disease Study.

    abstract::Progressive renal vascular sclerosis is a key feature of chronic kidney disease (CKD). Adiponectin, an adipokine with potent anti-inflammatory and antiatherosclerotic properties, is associated with insulin resistance, type II diabetes and cardiovascular disease. In this study, we evaluated the predictive value of adip...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/sj.ki.5002191

    authors: Kollerits B,Fliser D,Heid IM,Ritz E,Kronenberg F,MMKD Study Group.

    更新日期:2007-06-01 00:00:00

  • Endothelial nitric oxide synthase gene polymorphisms and the renal hemodynamic response to L-arginine.

    abstract::Nitric oxide is generated from L-arginine by nitric oxide synthase (NOS), an enzyme that exists in several isoforms. Some studies found that a polymorphism (G894T) in the endothelial NOS gene was associated with decreased nitric oxide bioactivity and vascular complications. However, it is not known whether the enzyme ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.2008.574

    authors: Cherney DZ,Scholey JW,Zhou J,Zimpelmann J,Kennedy C,Burns KD,Lai V,Miller JA

    更新日期:2009-02-01 00:00:00

  • Inhibition of pressure natriuresis in mice lacking the AT2 receptor.

    abstract:UNLABELLED:Inhibition of pressure natriuresis in mice lacking the AT2 receptor. BACKGROUND:Angiotensin II type 2 (AT2) receptor knockout mice have higher blood pressures than wild-type mice; however, the hypertension is imperfectly defined. We tested the hypothesis that renal mechanisms could be contributory. METHODS...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.2000.00820.x

    authors: Gross V,Schunck WH,Honeck H,Milia AF,Kärgel E,Walther T,Bader M,Inagami T,Schneider W,Luft FC

    更新日期:2000-01-01 00:00:00

  • Risk factors for chronic allograft nephropathy after renal transplantation: a protocol biopsy study.

    abstract:BACKGROUND:Chronic allograft nephropathy (CAN) leads to chronic allograft dysfunction and loss. Regular renal transplant biopsies may be useful to find risk factors for CAN. METHODS:We carried out 688 protocol biopsies in 258 patients at 6, 12, and 26 weeks after renal transplantation. Patients with signs of CAN in th...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1111/j.1523-1755.2005.00087.x

    authors: Schwarz A,Mengel M,Gwinner W,Radermacher J,Hiss M,Kreipe H,Haller H

    更新日期:2005-01-01 00:00:00

  • Modulation by calcium of the inhibitor activity of naturally occurring urinary inhibitors.

    abstract::The possibility that hypercalciuria could cause calcium stone formation through a mechanism other than by increasing urinary saturation of stone-forming calcium salts was explored. The effect of increasing calcium concentration on the inhibitor activity against the spontaneous precipitation of calcium oxalate was exam...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1988.100

    authors: Zerwekh JE,Hwang TI,Poindexter J,Hill K,Wendell G,Pak CY

    更新日期:1988-05-01 00:00:00

  • Magnetic resonance imaging accurately tracks kidney pathology and heterogeneity in the transition from acute kidney injury to chronic kidney disease.

    abstract::Acute kidney injury (AKI) increases the risk for chronic kidney disease (CKD). However, there are few tools to detect microstructural changes after AKI. Here, cationic ferritin-enhanced magnetic resonance imaging (CFE-MRI) was applied to examine the heterogeneity of kidney pathology in the transition from AKI to CKD. ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1016/j.kint.2020.08.021

    authors: Charlton JR,Xu Y,Wu T,deRonde KA,Hughes JL,Dutta S,Oxley GT,Cwiek A,Cathro HP,Charlton NP,Conaway MR,Baldelomar EJ,Parvin N,Bennett KM

    更新日期:2021-01-01 00:00:00

  • The cell cycle and acute kidney injury.

    abstract::Acute kidney injury (AKI) activates pathways of cell death and cell proliferation. Although seemingly discrete and unrelated mechanisms, these pathways can now be shown to be connected and even to be controlled by similar pathways. The dependence of the severity of renal-cell injury on cell cycle pathways can be used ...

    journal_title:Kidney international

    pub_type: 杂志文章,评审

    doi:10.1038/ki.2009.224

    authors: Price PM,Safirstein RL,Megyesi J

    更新日期:2009-09-01 00:00:00

  • Therapeutic effects of oral nutritional supplementation during hemodialysis.

    abstract:BACKGROUND:Protein-calorie malnutrition is common in chronic hemodialysis (CHD) patients and correlates with morbidity and mortality in these patients. There are limited trials evaluating the efficacy of oral nutritional supplementation in malnourished CHD patients. METHODS:Eighty-five CHD patients with evidence of ma...

    journal_title:Kidney international

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1523-1755.2002.00530.x

    authors: Caglar K,Fedje L,Dimmitt R,Hakim RM,Shyr Y,Ikizler TA

    更新日期:2002-09-01 00:00:00

  • Inhibition of active sodium transport by radiographic contrast media.

    abstract::We demonstrate that salts of diatrizoate and iothalamate, radiographic contrast agents, depress the active transport of sodium in the urinary bladder of the Columbian toad, Bufo marinus. Isolated toad bladders were incubated in isotonic Ringer's solutions with isosmolar displacement of sodium chloride by contrast medi...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1975.11

    authors: Ziegler TW,Ludens JH,Fanestil DD,Talner LB

    更新日期:1975-02-01 00:00:00

  • Autosomal dominant tubulointerstitial kidney disease: diagnosis, classification, and management--A KDIGO consensus report.

    abstract::Rare autosomal dominant tubulointerstitial kidney disease is caused by mutations in the genes encoding uromodulin (UMOD), hepatocyte nuclear factor-1β (HNF1B), renin (REN), and mucin-1 (MUC1). Multiple names have been proposed for these disorders, including 'Medullary Cystic Kidney Disease (MCKD) type 2', 'Familial Ju...

    journal_title:Kidney international

    pub_type: 共识发展会议,杂志文章,实务指引

    doi:10.1038/ki.2015.28

    authors: Eckardt KU,Alper SL,Antignac C,Bleyer AJ,Chauveau D,Dahan K,Deltas C,Hosking A,Kmoch S,Rampoldi L,Wiesener M,Wolf MT,Devuyst O,Kidney Disease: Improving Global Outcomes.

    更新日期:2015-10-01 00:00:00

  • Effects of oxygen breathing and erythropoietin on hypoxic vasodilation in uremic anemia.

    abstract::Loss of hypoxic vasodilation has been proposed as a causative factor in the development of hypertension in dialysis patients treated with recombinant human erythropoietin (rHuEPO). Venous occlusion plethysmography was therefore performed on 22 dialysis patients (aged 23 to 71 years, dialysis duration 6 to 260 months, ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1992.376

    authors: Roger SD,Grasty MS,Baker LR,Raine AE

    更新日期:1992-10-01 00:00:00

  • The STARMEN trial indicates that alternating treatment with corticosteroids and cyclophosphamide is superior to sequential treatment with tacrolimus and rituximab in primary membranous nephropathy.

    abstract::A cyclical corticosteroid-cyclophosphamide regimen is recommended for patients with primary membranous nephropathy at high risk of progression. We hypothesized that sequential therapy with tacrolimus and rituximab is superior to cyclical alternating treatment with corticosteroids and cyclophosphamide in inducing persi...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1016/j.kint.2020.10.014

    authors: Fernández-Juárez G,Rojas-Rivera J,Logt AV,Justino J,Sevillano A,Caravaca-Fontán F,Ávila A,Rabasco C,Cabello V,Varela A,Díez M,Martín-Reyes G,Diezhandino MG,Quintana LF,Agraz I,Gómez-Martino JR,Cao M,Rodríguez-Moreno A,

    更新日期:2020-11-07 00:00:00

  • Mutations in the COL4A4 gene in thin basement membrane disease.

    abstract:BACKGROUND:Patients with thin basement membrane disease (TBMD) are often from families where hematuria segregates with the COL4A3 and COL4A4 genes. These genes also are affected in autosomal recessive Alport syndrome. The aim of this study was to demonstrate COL4A4 mutations in TBMD. METHODS:Forty-eight unrelated indi...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.2003.00780.x

    authors: Buzza M,Dagher H,Wang YY,Wilson D,Babon JJ,Cotton RG,Savige J

    更新日期:2003-02-01 00:00:00

  • Neuropilin1 regulates glomerular function and basement membrane composition through pericytes in the mouse kidney.

    abstract::Neuropilin1 (Nrp1) is a co-receptor best known to regulate the development of endothelial cells and is a target of anticancer therapies. However, its role in other vascular cells including pericytes is emergent. The kidney is an organ with high pericyte density and cancer patients develop severe proteinuria following ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1016/j.kint.2016.10.010

    authors: Wnuk M,Anderegg MA,Graber WA,Buergy R,Fuster DG,Djonov V

    更新日期:2017-04-01 00:00:00

  • Familial, hemodynamic and metabolic factors in the predisposition to diabetic kidney disease.

    abstract::Proteinuric diabetic patients have an increased risk of cardiovascular disease and almost always have hypertension. In the early stages of diabetic renal disease (microalbuminuria) when renal function is well preserved, systemic arterial blood pressure is already elevated compared to insulin-dependent diabetic patient...

    journal_title:Kidney international

    pub_type: 杂志文章,评审

    doi:10.1038/ki.1994.56

    authors: Earle K,Viberti GC

    更新日期:1994-02-01 00:00:00

  • Renoprotective benefits of RAS inhibition: from ACEI to angiotensin II antagonists.

    abstract::In landmark clinical trials, pharmacological inhibition of the renin-angiotensin system (RAS) with angiotensin-converting enzyme inhibitors (ACEIs) attenuated the decline in renal function associated with chronic renal disease (CRD). Hemodynamic and nonhemodynamic effects of angiotensin II (Ang II) attest to its centr...

    journal_title:Kidney international

    pub_type: 杂志文章,评审

    doi:10.1046/j.1523-1755.2000.00031.x

    authors: Taal MW,Brenner BM

    更新日期:2000-05-01 00:00:00

  • The renal PTH/PTHrP receptor is down-regulated in rats with chronic renal failure.

    abstract::Hypocalcemia, hyperphosphatemia, and resistance to the action of PTH are well characterized features in the setting of advanced chronic renal failure (CRF). Although the underlying mechanisms are ill-understood, clinical and experimental evidence points to both PTH receptor down-regulation and post-receptor abnormalit...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1994.79

    authors: Ureña P,Kubrusly M,Mannstadt M,Hruby M,Trinh MM,Silve C,Lacour B,Abou-Samra AB,Segre GV,Drüeke T

    更新日期:1994-02-01 00:00:00

  • Acute effects of simultaneous intraperitoneal infusion of glucose and amino acids.

    abstract:BACKGROUND:The feasibility of simultaneously infusing glucose and amino acid (AA)-based peritoneal dialysis solutions was tested to determine whether peritoneal dialysis patients could achieve an adequate nonprotein calorie/nitrogen ratio while preventing a marked increase in blood urea nitrogen (BUN), which is usually...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.2001.0590051967.x

    authors: Canepa A,Carrea A,Menoni S,Verrina E,Trivelli A,Gusmano R,Perfumo F

    更新日期:2001-05-01 00:00:00

  • Calcitriol and doxercalciferol are equivalent in controlling bone turnover, suppressing parathyroid hormone, and increasing fibroblast growth factor-23 in secondary hyperparathyroidism.

    abstract::We compared the effects of calcitriol and doxercalciferol, in combination with either calcium carbonate or sevelamer, on bone, mineral, and fibroblast growth factor-23 (FGF-23) metabolism in patients with secondary hyperparathyroidism. A total of 60 pediatric patients treated with peritoneal dialysis were randomized t...

    journal_title:Kidney international

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/ki.2010.352

    authors: Wesseling-Perry K,Pereira RC,Sahney S,Gales B,Wang HJ,Elashoff R,Jüppner H,Salusky IB

    更新日期:2011-01-01 00:00:00

  • Predictors and consequences of altered mineral metabolism: the Dialysis Outcomes and Practice Patterns Study.

    abstract:BACKGROUND:Altered mineral metabolism contributes to bone disease, cardiovascular disease, and other clinical problems in patients with end-stage renal disease. METHODS:This study describes the recent status, significant predictors, and potential consequences of abnormal mineral metabolism in representative groups of ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1111/j.1523-1755.2005.00185.x

    authors: Young EW,Albert JM,Satayathum S,Goodkin DA,Pisoni RL,Akiba T,Akizawa T,Kurokawa K,Bommer J,Piera L,Port FK

    更新日期:2005-03-01 00:00:00