Immunoreactive and bioactive luteinizing hormone in pubertal patients with chronic renal failure. Cooperative Study Group on Pubertal Development in Chronic Renal Failure.

abstract：BACKGROUND:Non-(1-84) parathyroid hormone (PTH) fragments are large circulating carboxyl-terminal (C) fragments with a partially preserved amino-terminal (N) structure. hPTH (7-84), a synthetic surrogate, has been demonstrated to exert biologic effects in vivo and in vitro which are opposite to those of hPTH (1-34) on ...

journal_title：Kidney international

authors： D'Amour P,Brossard JH,Rousseau L,Nguyen-Yamamoto L,Nassif E,Lazure C,Gauthier D,Lavigne JR,Zahradnik RJ

更新日期：2005-09-01 00:00:00

abstract：:Defects in the primary cilium/basal body complex of renal tubular cells cause polycystic kidney disease (PKD). To uncover pathways associated with disease progression, we determined the kidney transcriptome of 10-day-old severely and mildly affected cpk mice, a model of recessive PKD. In the severe phenotype, the most...

journal_title：Kidney international

authors： Mrug M,Zhou J,Woo Y,Cui X,Szalai AJ,Novak J,Churchill GA,Guay-Woodford LM

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The relationship between low hematocrit and contrast-induced nephropathy has not been investigated. METHODS:Of 6,773 consecutive patients treated with percutaneous coronary intervention, contrast-induced nephropathy (an increase of >/=25% or >/=0.5 mg/dL in preprocedure serum creatinine, at 48 hours postpro...

journal_title：Kidney international

authors： Nikolsky E,Mehran R,Lasic Z,Mintz GS,Lansky AJ,Na Y,Pocock S,Negoita M,Moussa I,Stone GW,Moses JW,Leon MB,Dangas G

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Hypercholesterolemia may affect both endothelial function and arterial distensibility (DC). Renal transplant recipients (NTX) exhibit advanced structural and functional alterations of arterial vessel walls. The aim of this double-blind, randomized trial was to evaluate the effects of fluvastatin (FLU) on bra...

journal_title：Kidney international

authors： Hausberg M,Kosch M,Stam F,Heidenreich S,Kisters K,Rahn KH,Barenbrock M

更新日期：2001-04-01 00:00:00

abstract：:Residual kidney function (RKF) may confer a variety of benefits to patients on maintenance dialysis. RKF provides continuous clearance of middle molecules and protein-bound solutes. Whereas the definition of RKF varies across studies, interdialytic urine volume may emerge as a pragmatic alternative to more cumbersome ...

journal_title：Kidney international

authors： Mathew AT,Fishbane S,Obi Y,Kalantar-Zadeh K

更新日期：2016-08-01 00:00:00

abstract：:Previously, uremic toxins were sometimes regarded as a large, mysterious, but also anonymous group of factors potentially contributing to morbidity and mortality in end-stage renal disease. By identifying the protein-bound solute p-cresol as a risk factor for mortality in dialysis patients, Bammens and colleagues for ...

journal_title：Kidney international

authors： Ketteler M

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Low birth weight is an important risk factor for hypertension and unfavorable prognoses of a number of renal diseases. It is also associated with reduced kidney size and nephron number. A differentiation between the effects of low birth weight versus being born premature or small for gestational age has, how...

journal_title：Kidney international

authors： Schmidt IM,Chellakooty M,Boisen KA,Damgaard IN,Mau Kai C,Olgaard K,Main KM

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:The hypothesis that angiotensin-converting enzyme (ACE) inhibitors interfere with the treatment of anemia with recombinant human erythropoietin (rHuEPO) remains controversial. To test this hypothesis, a retrospective analysis was conducted in a large group of hemodialysis patients with renal anemia. METHODS...

journal_title：Kidney international

authors： Hayashi K,Hasegawa K,Kobayashi S

更新日期：2001-11-01 00:00:00

abstract：:Staphylococcal neutral phosphatase (NPtase) is a highly cationic bacterial surface bound protein. It has significant affinity for human and rat immunoglobulins in vitro and an electrostatic interaction may be involved. Radioisotopic studies showed that NPtase had a high affinity for the polyanionic structures of the r...

journal_title：Kidney international

authors： Yousif Y,Okada K,Batsford S,Vogt A

更新日期：1996-07-01 00:00:00

abstract：:Vascular calcification (VC) is an important reason for the high burden of vascular disease among chronic dialysis patients. Chronic kidney disease (CKD) is associated with increased promoters and decreased inhibitors of VC. The circulating levels of fetuin-A, a well-described inhibitor of calcification, regulate the c...

journal_title：Kidney international

authors： Mehrotra R

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Knowledge of the long-term renal prognosis of diarrhea associated hemolytic uremic syndrome (HUS) is important for patient counseling and follow-up. However, estimates of long-term risk are highly variable, with previous studies not using a healthy control group. METHODS:A municipal water system in the smal...

journal_title：Kidney international

authors： Garg AX,Clark WF,Salvadori M,Macnab J,Suri RS,Haynes RB,Matsell D,Walkerton Health Study Investigators.

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:We aimed to identify genes with kidney specific, developmentally regulated expression. Here we report the cDNA sequence and expression pattern of KS, a novel kidney-specific rat gene. METHODS:A partial cDNA was identified by differential display polymerase chain reaction (PCR) of a renal cell fraction enric...

journal_title：Kidney international

authors： Hilgers KF,Nagaraj SK,Karginova EA,Kazakova IG,Chevalier RL,Carey RM,Pentz ES,Gomez RA

更新日期：1998-11-01 00:00:00

abstract：:Freeze-fracture and thin-section electron microscopy and morphometry were used to characterize further the response of the rat medullary collecting duct to potassium depletion. In freeze-fracture replicas, principal cells and intercalated cells were identified based on the assumption that intercalated cells possess a ...

journal_title：Kidney international

authors： Stetson DL,Wade JB,Giebisch G

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND:Wegener's granulomatosis (WG) is a rare systemic autoimmune disease characterized by small-vessel vasculitis leading to organ damage and the presence of antineutrophil cytoplasmic autoantibodies (ANCAs). ANCAs were shown to be involved in the pathogenesis of the disease by increasing adhesion of polymorphonu...

journal_title：Kidney international

authors： Gencik M,Meller S,Borgmann S,Fricke H

更新日期：2000-12-01 00:00:00

abstract：:Podocytes are highly differentiated cells that play an important role in maintaining glomerular filtration barrier integrity; a function regulated by small GTPase proteins of the Rho family. To investigate the role of Rho A in podocyte biology, we created transgenic mice expressing doxycycline-inducible constitutively...

journal_title：Kidney international

authors： Wang L,Ellis MJ,Gomez JA,Eisner W,Fennell W,Howell DN,Ruiz P,Fields TA,Spurney RF

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Ischemic acute renal failure (iARF) is associated with increased nitric oxide (NO) production during the reperfusion period, as endothelial nitric oxide synthase (eNOS) is maximally activated, and renal tubular inducible NOS (iNOS) is stimulated. Increased NO production leads to augmented tubular injury, pro...

journal_title：Kidney international

authors： Schwartz IF,Schwartz D,Traskonov M,Chernichovsky T,Wollman Y,Gnessin E,Topilsky I,Levo Y,Iaina A

更新日期：2002-11-01 00:00:00

abstract：:Medial arterial calcification involves chondrogenic/osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs). Zhao et al. report that phosphate activates the mammalian target of rapamycin (mTOR) cascade in VSMCs, leading to downregulation of Klotho. Furthermore, rapamycin was shown to halt medial calcif...

journal_title：Kidney international

authors： Hamano T

更新日期：2015-10-01 00:00:00

abstract：:NO, a simple molecule synthesized from L-arginine by NO synthases, has been identified to play an important role in cell communication, cell defense and cell injury. The half life of NO is very short because NO either reacts with superoxide anion (O2-), and/or binds to heme molecules or Fe-S groups present in proteins...

journal_title：Kidney international

authors： Raij L,Baylis C

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Chronic oversecretion of parathyroid hormone (PTH) is associated with parathyroid hyperplasia, reflecting a disturbed balance between cell proliferation and apoptosis. This study addressed the unsolved issue of apoptosis in hyperparathyroidism. METHODS:Parathyroid glands from 19 patients with primary (1 deg...

journal_title：Kidney international

authors： Zhang P,Duchambon P,Gogusev J,Nabarra B,Sarfati E,Bourdeau A,Drüeke TB

更新日期：2000-02-01 00:00:00

abstract：:It is unknown whether mild chronic kidney disease (CKD) is associated with adverse cardiovascular (CV) prognosis after accounting for coronary artery disease (CAD). Here we evaluated the interplay between CKD and CAD in predicting CV death or myocardial infarction (MI) and all-cause death. We included 1541 consecutive...

journal_title：Kidney international

authors： Bittencourt MS,Hulten EA,Ghoshhajra B,Abbara S,Murthy VL,Divakaran S,Nasir K,Gowdak LH,Riella LV,Chiumiento M,Hoffmann U,Di Carli MF,Blankstein R

更新日期：2015-07-01 00:00:00

abstract：:Urinary proteomics is a promising tool for biomarker investigation, particularly in complex kidney diseases. Fabris and colleagues report that urinary laminin subunit alpha-2 is a potential diagnostic marker of medullary sponge kidney (MSK) disease by using a label-free quantitative proteomics platform and a clinicall...

journal_title：Kidney international

authors： Chutipongtanate S

更新日期：2017-02-01 00:00:00

abstract：:Vascular calcification is prevalent in dialysis patients and is associated with a high burden of cardiovascular disease. Fetuin-A is a potent inhibitor of vascular calcification, but the precise mechanism by which it mediates vascular calcification in uremia is unclear. Matsui and colleagues demonstrate that circulati...

journal_title：Kidney international

authors： Komaba H,Fukagawa M

更新日期：2009-05-01 00:00:00

abstract：:Antibodies to human leukocyte antigens (HLAs) are a risk factor for acute renal allograft rejection and loss. The role of non-HLAs and their significance to allograft rejection have gained recent attention. Here, we applied protein microarray technology, with the capacity to simultaneously identify 5056 potential anti...

journal_title：Kidney international

authors： Sutherland SM,Li L,Sigdel TK,Wadia PP,Miklos DB,Butte AJ,Sarwal MM

更新日期：2009-12-01 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive enlargement of kidney cysts leading to chronic kidney disease (CKD) and end-stage renal disease (ESRD). Identification of an early biomarker that can predict progression of CKD is urgently needed. In an earlier Consortium for Radiolog...

journal_title：Kidney international

authors： Yu ASL,Shen C,Landsittel DP,Harris PC,Torres VE,Mrug M,Bae KT,Grantham JJ,Rahbari-Oskoui FF,Flessner MF,Bennett WM,Chapman AB,Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP).

更新日期：2018-03-01 00:00:00

abstract：:Swelling activated anion channels have recently been recognized to play an important role in not only volume regulatory electrolyte movement, but also in organic osmolyte transport. A swelling-activated, outwardly rectifying anion channel termed VSOAC (volume-sensitive organic osmolyte/anion channel) is a major pathwa...

journal_title：Kidney international

authors： Jackson PS,Strange K

更新日期：1996-06-01 00:00:00

abstract：:Metabolic changes due to chronic renal failure (CRF) were studied in isolated liver cells. In 14 CRF and 14 sham-operated rats, liver cells were isolated by the Berry and Friend method and incubated with various substrates in order to study gluconeogenesis, ureagenesis, ketogenesis, oxygen consumption as well as cytos...

journal_title：Kidney international

authors： Cano N,Catelloni F,Fontaine E,Novaretti R,di Costanzo-Dufetel J,Reynier JP,Leverve XM

更新日期：1995-06-01 00:00:00

abstract：:Regardless of the source of injury, an imbalance in the control of mesangial cell proliferation appears to play a direct role in the degree of progressive renal injury and glomerulosclerosis. Some of the regulatory mechanisms include specific soluble or non-soluble extracellular factors and a complex array of receptor...

journal_title：Kidney international

authors： Schöcklmann HO,Lang S,Sterzel RB

更新日期：1999-10-01 00:00:00

abstract：:To examine whether hypoxia-inducible factor (HIF)-1α mediates the profibrotic effects of angiotensin II, we treated cultured renal medullary interstitial cells with angiotensin II and found that it increased HIF-1α levels. This was accompanied by a significant upregulation of collagen I/III, the tissue inhibitor of me...

journal_title：Kidney international

authors： Wang Z,Tang L,Zhu Q,Yi F,Zhang F,Li PL,Li N

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Microarray technology is a powerful tool that can probe the molecular pathogenesis of renal injury. In this present study microarray analysis was used to monitor serial changes in the renal transcriptome of a rat model of mesangial proliferative glomerulonephritis. Administration of anti-Thy1 antibody result...

journal_title：Kidney international

authors： Sadlier DM,Ouyang X,McMahon B,Mu W,Ohashi R,Rodgers K,Murray D,Nakagawa T,Godson C,Doran P,Brady HR,Johnson RJ

更新日期：2005-12-01 00:00:00

abstract：:Tubulointerstitial nephritis (TIN) is a disease pattern with heterogeneous causes. Recently a specific subtype of autoimmune TIN, IgG4-related TIN, has been identified that is part of systemic IgG4-related disease/ autoimmune pancreatitis. On biopsy, this TIN shows an IgG4+ plasma cell-rich infiltrate, akin to the pan...

journal_title：Kidney international

authors： Cornell LD

更新日期：2010-11-01 00:00:00