Abstract：
:Vascular calcification is prevalent in dialysis patients and is associated with a high burden of cardiovascular disease. Fetuin-A is a potent inhibitor of vascular calcification, but the precise mechanism by which it mediates vascular calcification in uremia is unclear. Matsui and colleagues demonstrate that circulating fetuin-A forms fetuin-mineral complex in the serum of uremic rats and thereby inhibits vascular calcification. This suggests that fetuin-mineral complex may reflect extraosseous calcification stress, opening new perspectives on vascular calcification in uremia.
journal_name
Kidney Intjournal_title
Kidney internationalauthors
Komaba H,Fukagawa Mdoi
10.1038/ki.2009.52subject
Has Abstractpub_date
2009-05-01 00:00:00pages
874-6issue
9eissn
0085-2538issn
1523-1755pii
S0085-2538(15)53822-2journal_volume
75pub_type
评论,杂志文章abstract：:Long-term treatment (8 and 13 weeks) of rats with FGF-2 led to albuminuria and to increase in serum creatinine indicating the development of chronic renal failure. Histologically, the classic picture of focal segmental glomerulosclerosis (FSGS) was found; males were more severely affected than females. Among the early...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1995.433
更新日期：1995-11-01 00:00:00
abstract：BACKGROUND:It is currently impossible to reliably predict which diabetic patients will develop nephropathy and progress to kidney failure. Microalbuminuria, often regarded as a predictor of overt diabetic renal disease is, in fact, an indicator of established glomerular damage. We have shown that glomerular expression ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2003.00130.x
更新日期：2003-08-01 00:00:00
abstract：BACKGROUND:Diabetic nephropathy is commonly associated with renal salt and water retention and hypertension. The molecular mechanisms involved and how the kidney responds to this volume expansion, in terms of renal transporter regulation, are not understood. METHODS:Targeted proteomics employing semiquantitative immun...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2002.00353.x
更新日期：2002-06-01 00:00:00
abstract：:Polycystic kidney disease progresses more rapidly in men than in women. To investigate the basis for this sexual dimorphism, we exposed Madin-Darby canine kidney (MDCK) cells grown on collagen-coated cell culture inserts to control media, or to estradiol or testosterone (1 nM-1 microM). Compared to control and estradi...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1997.211
更新日期：1997-05-01 00:00:00
abstract：:Compelling evidence indicates that vascular endothelial growth factor (VEGF) is a fundamental regulator of normal and abnormal angiogenesis. The loss of a single VEGF allele results in defective vascularization and early embryonic lethality. VEGF plays also a critical role in kidney development, and its inactivation d...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1046/j.1523-1755.1999.00610.x
更新日期：1999-09-01 00:00:00
abstract：:The cardiorenal safety database from the Celecoxib Long-term Arthritis Safety Study (CLASS) was analyzed to examine whether supratherapeutic doses of celecoxib are associated with decreased renal function and blood pressure (BP) effects compared with standard doses of diclofenac and ibuprofen in osteoarthritis (OA) an...
journal_title：Kidney international
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ki.5001766
更新日期：2006-10-01 00:00:00
abstract：:We studied the specific binding of radiolabeled bradykinin ([3H]BK) and vasopressin ([3H]AVP) to membrane preparations of bovine and porcine kidney medulla. [3H]BK reversibly labeled a single site (Kd = 1.06 nM) in bovine kidney medulla independently of [Mg2+]. The number of BK receptors in bovine kidney medulla, Bmax...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1996.353
更新日期：1996-08-01 00:00:00
abstract：:Protein misfolding in the endoplasmic reticulum (ER) leads to ER stress. The unfolded protein response and ER-associated degradation (ERAD) interact in a coordinated manner with the ubiquitin-proteasome system and autophagy to alleviate protein misfolding or its consequences. The intersecting actions of these processe...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/ki.2012.390
更新日期：2013-07-01 00:00:00
abstract：:Clinical studies have demonstrated a poor correlation between localization tests, which are designed to determine the site of urinary tract infection, and symptoms of upper urinary tract infection. One explanation is that microorganisms may be present in the kidney but not initiate an inflammatory response with associ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1992.200
更新日期：1992-05-01 00:00:00
abstract：:The renal handling of gentamicin in the rat was examined by clearance, microinjection, and renal cortical-slice techniques. The steady-state renal clearance of 14C-gentamicin, when corrected for the 7.5% binding to plasma protein, was not significantly different from that of 3H-inulin. At the end of the renal clearanc...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1979.149
更新日期：1979-10-01 00:00:00
abstract：BACKGROUND:Small, uncontrolled studies of dialysis-dependent chronic kidney disease (CKD) patients have demonstrated abnormalities of cardiovascular autonomic control and vascular compliance, which may contribute to adverse cardiovascular morbidity in this population. However, there is little information utilizing newe...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2005.00165.x
更新日期：2005-03-01 00:00:00
abstract：:Unilateral ureteral obstruction in rabbits leads to an influx of macrophages into the kidney, a proliferation of interstitial cells, and an increase in arachidonic acid metabolism. The role of the macrophage in the metabolic changes of hydronephrosis was investigated by using endotoxin and nitrogen mustard. The in viv...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1984.127
更新日期：1984-07-01 00:00:00
abstract：:Few studies have examined tubular function after subtotal nephrectomy (Nx) and conservative treatments. The effects of 70% and 80% Nx (associated with dietary phosphate restriction in the latter case) on the apical brush border membrane (BBM) enzymes 5'-nucleotidase, gamma glutamyl-transferase and alkaline-phosphatase...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1997.485
更新日期：1997-12-01 00:00:00
abstract：BACKGROUND:The renin-angiotensin system has been known to regulate blood pressure and body fluid homeostasis. Several lines of evidence have shown that renin gene expression and release are up-regulated by beta-adrenergic stimulation, sodium depletion, and angiotensin converting enzyme inhibition, but down-regulated by...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.1998.00209.x
更新日期：1998-12-01 00:00:00
abstract：BACKGROUND:Rho proteins are small guanine 5'-triphosphate (GTP)-binding proteins felt to be important regulators of several aspects of cell function, including the organization of the actin cytoskeleton. The effects of Rho proteins on the regulation of renal tubular epithelial cell function are not known. METHODS:Sele...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2000.00372.x
更新日期：2000-11-01 00:00:00
abstract：:Interstitial monocytic infiltration of the kidney occurs within hours of acute kidney injury and is an important determinant of functional decline and fibrosis. Li et al. used several surface markers to distinguish between dendritic cells and inflammatory monocytes following acute kidney injury and to identify two che...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/ki.2008.555
更新日期：2008-12-01 00:00:00
abstract：:Exosomes are small membrane vesicles that are secreted from a variety of cell types into various body fluids including the blood and urine. These vesicles are thought to play a role in cell-cell interactions. CD24 is a small but extensively glycosylated protein linked to the cell surface by means of a glycosyl-phospha...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5002486
更新日期：2007-11-01 00:00:00
abstract：BACKGROUND:Proteinase 3 is the major autoantigen in Wegener's granulomatosis (WG). Membrane PR3 expression is bimodal; low expressing cells (mPR3(low)) can be distinguished from cells with high expression (mPR3(high)) within a given individual. High mPR3 expression is a WG risk factor and is associated with relapse. Ho...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2004.00640.x
更新日期：2004-06-01 00:00:00
abstract：:Renal sodium reabsorption is a key determinant of final urine concentration. Our aim was to determine whether differences existed between aged and young rats in their response to water restriction with regard to the regulation of abundance of any of the major distal renal sodium transporter proteins. Male Fisher 344 x...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5000076
更新日期：2006-01-01 00:00:00
abstract：:This study examined the utility of interleukin-10 (IL-10), a cytokine with potent anti-macrophage and anti-Th1 activity, in the treatment of experimental anti-glomerular basement membrane (GBM) nephritis in the rat. Accelerated anti-GBM disease was induced in Sprague-Dawley rats by immunization with rabbit IgG, follow...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1997.248
更新日期：1997-06-01 00:00:00
abstract：:Tubulointerstitial nephritis antigen (TIN-ag) is an extracellular matrix (ECM) glycoprotein that has been recently isolated and cloned from the rabbit kidney. It is an integral component of the basal lamina, and unlike other basement membrane proteins it is exclusively expressed in the tubular basement membranes (TBMs...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1997.375
更新日期：1997-09-01 00:00:00
abstract：BACKGROUND:A need exists for a therapy that lowers parathyroid hormone (PTH) without increasing calcium x phosphorus in patients with secondary hyperparathyroidism. The calcimimetic AMG 073 increases the sensitivity of the parathyroid calcium-sensing receptor to extracellular calcium, thereby reducing PTH secretion. Co...
journal_title：Kidney international
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1046/j.1523-1755.2003.00720.x
更新日期：2003-01-01 00:00:00
abstract：:Tuberous sclerosis complex is a genetic disorder characterized by hamartomatous lesions in multiple organs, frequently involving the kidney. We conducted a retrospective review of the clinical and radiographic records of 167 patients with tuberous sclerosis to determine the frequency of renal disease, the likelihood o...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5001853
更新日期：2006-11-01 00:00:00
abstract：:Endostatin (EST), an antiangiogenic factor, is enriched in aging kidneys. EST is also an interactive partner of transglutaminase 2 (TG2), an enzyme that cross-links extracellular matrix proteins. Here we tested whether EST and TG2 play a role in the fibrosis of aging. In wild-type mice, aging kidneys exhibited a 2- to...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2016.01.030
更新日期：2016-06-01 00:00:00
abstract：UNLABELLED:A non-nucleotide-bridged DNA decoy inhibits renal epithelial nitric oxide synthase expression. BACKGROUND:The expression of inducible nitric oxide synthase (iNOS) is subject to strict tissue-specific transcriptional control. In mouse renal epithelium, an interferon-gamma (IFN-gamma)-induced signaling protei...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2000.00809.x
更新日期：2000-01-01 00:00:00
abstract：:Podocytes are highly differentiated cells that play an important role in maintaining glomerular filtration barrier integrity; a function regulated by small GTPase proteins of the Rho family. To investigate the role of Rho A in podocyte biology, we created transgenic mice expressing doxycycline-inducible constitutively...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2011.472
更新日期：2012-06-01 00:00:00
abstract：:The involvement of sodium/potassium-ATPase in regulating parathyroid hormone (PTH) secretion is inferred from in vitro studies. Recently, the α-klotho-dependent rapid recruitment of this ATPase to the parathyroid cell plasma membrane in response to low extracellular calcium ion was suggested to be linked to increased ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2010.501
更新日期：2011-04-01 00:00:00
abstract：:The association between dietary sodium and potassium intake with the development of kidney disease remains unclear, particularly among younger individuals. Here, we determined whether dietary sodium and potassium intake are associated with incident chronic kidney disease (CKD) using data from 1,030 adults (age 23-35 i...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2020.02.037
更新日期：2020-07-01 00:00:00
abstract：:Mineralocorticoid hormones stimulate Na+ absorption and K+ secretion by the cortical collecting tubule. There is good evidence that this stimulation involves increasing luminal membrane Na+ permeability and the turnover rate (or number) of the Na+-K+ pumps. These experiments were designed to examine whether mineraloco...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1985.177
更新日期：1985-10-01 00:00:00
abstract：:Experiments were performed using a variety of methods to assess the functional status of different nephron populations following 45 min of renal ischemia in the rat. Micropuncture techniques revealed that SNGFR and reabsorption in the surface nephrons are only modestly reduced after ischemia, whereas kidney GFR and re...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1983.122
更新日期：1983-07-01 00:00:00
