A non-nucleotide-bridged DNA decoy inhibits renal epithelial nitric oxide synthase expression.

abstract：:A morphometric technique is used to estimate the absolute and relative surface areas of the brush border microvilli and cell walls bordering lateral intercellular spaces. In isolated, perfused proximal tubule from rabbit, the luminal and lateral surfaces are equal in area. For proximal convoluted tubules (PCT) each su...

journal_title：Kidney international

authors： Welling LW,Welling DJ

更新日期：1975-12-01 00:00:00

abstract：:The kidney is influenced by circadian rhythms and is entrained to the sleep-wake cycle allowing anticipation of the metabolic and physiological demands of the kidney throughout a 24-hour cycle. Although sleep disruption has been studied extensively in cardiovascular and metabolic disease, its association with chronic ...

journal_title：Kidney international

authors： McMullan CJ,Curhan GC,Forman JP

更新日期：2016-06-01 00:00:00

abstract：:The role of immunoglobulin (Ig) Fc-macrophage cell surface receptor affinity (macrophage Fc-affinity) in determining the mediation systems responsible for immune glomerular injury has been studied. Glomerular injury was initiated in rabbits by the passive administration of immunoglobulin preparations directed against ...

journal_title：Kidney international

authors： Boyce NW,Holdsworth SR

更新日期：1989-10-01 00:00:00

abstract：:The Standardized Outcomes in Nephrology (SONG) initiative is designed to improve research productivity by building consensus. Stakeholders involved with peritoneal dialysis (PD) have put life participation on top of their list, along with treatment-related infection, cardiovascular complications, and patient and techn...

journal_title：Kidney international

authors： Davies SJ

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:In interstitial fibrosis, monocytes and myofibroblasts have been directly implicated in scarring, apoptosis, and tissue necrosis. While much has been done to explore the role of these cell types individually in fibrosis, the interactive dependency of monocytes and myofibroblasts has been only marginally expl...

journal_title：Kidney international

authors： Rodgers KD,Rao V,Meehan DT,Fager N,Gotwals P,Ryan ST,Koteliansky V,Nemori R,Cosgrove D

更新日期：2003-04-01 00:00:00

abstract：:Erythropoiesis stimulating agent (ESA) treatment has been a major advance in the care of patients with kidney disease, resulting in reduced symptoms and blood transfusions, and improved quality of life. Recent studies, however, have indicated that attempts to treat to near normal Hgb targets may result in increased ri...

journal_title：Kidney international

authors： Fishbane S

更新日期：2009-02-01 00:00:00

abstract：:We have previously shown that ultrasonography can detect hyperechogenic crystal deposits in the kidney medulla of patients with gout. In this cross-sectional study we investigated the frequency and clinical correlates of hyperechogenic kidney medulla in 502 consecutive primary consultants for gout (ACR/EULAR criteria)...

journal_title：Kidney international

authors： Bardin T,Nguyen QD,Tran KM,Le NH,Do MD,Richette P,Letavernier E,Correas JM,Resche-Rigon M

更新日期：2021-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1) are key mediators of adverse peritoneal membrane remodeling in peritoneal dialysis eventually leading to ultrafiltration failure. Both are pleiotropic growth factors with cell type-dependent regulation of expression and biological eff...

journal_title：Kidney international

authors： Catar R,Witowski J,Wagner P,Annett Schramm I,Kawka E,Philippe A,Dragun D,Jörres A

更新日期：2013-12-01 00:00:00

abstract：:The ankyrin repeat and sterile α motif (SAM) domain-containing six gene (Anks6) is a candidate for polycystic kidney disease (PKD). Originally identified in the PKD/Mhm(cy/+) rat model of PKD, the disease is caused by a mutation (R823W) in the SAM domain of the encoded protein. Recent studies support the etiological r...

journal_title：Kidney international

authors： Bakey Z,Bihoreau MT,Piedagnel R,Delestré L,Arnould C,de Villiers Ad,Devuyst O,Hoffmann S,Ronco P,Gauguier D,Lelongt B

更新日期：2015-08-01 00:00:00

abstract：:The renal effects of a single intravenous dose of two different E. coli lipopolysaccharides (LPS 0111:B4 and LPS 0127:B8), at the same dose of 100 micrograms/kg, were evaluated in euvolemic Munich-Wistar (MW) rats by whole kidney clearance techniques and micropuncture studies. Following LPS infusion, a significant dec...

journal_title：Kidney international

authors： Lugon JR,Boim MA,Ramos OL,Ajzen H,Schor N

更新日期：1989-10-01 00:00:00

abstract：:Direct-acting antivirals have revolutionized the treatment of hepatitis C virus (HCV) infection in patients with chronic kidney disease, with implications for the timing of antiviral treatment among kidney transplant candidates and for the use of HCV viremic donors. A recent consensus conference reviewed the available...

journal_title：Kidney international

authors： Sawinski D,Wyatt CM,Locke JE

更新日期：2017-11-01 00:00:00

abstract：:Nitric oxide is generated from L-arginine by nitric oxide synthase (NOS), an enzyme that exists in several isoforms. Some studies found that a polymorphism (G894T) in the endothelial NOS gene was associated with decreased nitric oxide bioactivity and vascular complications. However, it is not known whether the enzyme ...

journal_title：Kidney international

authors： Cherney DZ,Scholey JW,Zhou J,Zimpelmann J,Kennedy C,Burns KD,Lai V,Miller JA

更新日期：2009-02-01 00:00:00

abstract：:Healthy volunteers (N = 9) and patients with varying degrees of renal insufficiency (N = 36) were given a low dose of dopamine and/or amino acids intravenously during a simultaneous measurement of the glomerular filtration rate and the effective renal plasma flow. Dopamine infusion led to a rise in the glomerular filt...

journal_title：Kidney international

authors： ter Wee PM,Rosman JB,van der Geest S,Sluiter WJ,Donker AJ

更新日期：1986-04-01 00:00:00

abstract：:Focal and segmental glomerulosclerosis (FSGS) is a major cause of end-stage kidney disease. Recent advances in molecular genetics show that defects in the podocyte play a major role in its pathogenesis and mutations in inverted formin 2 (INF2) cause autosomal dominant FSGS. In order to delineate the role of INF2 mutat...

journal_title：Kidney international

authors： Gbadegesin RA,Lavin PJ,Hall G,Bartkowiak B,Homstad A,Jiang R,Wu G,Byrd A,Lynn K,Wolfish N,Ottati C,Stevens P,Howell D,Conlon P,Winn MP

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Hemodialysis access thrombosis is a significant cause of morbidity for hemodialysis patients and results from decreased access flow caused by venous outflow tract stenosis. Ultrasound dilution (UD) is a practical, noninvasive, and reliable indicator of access flow and is effective in predicting venous stenos...

journal_title：Kidney international

authors： Goldstein SL,Allsteadt A

更新日期：2001-06-01 00:00:00

abstract：:The influence of transforming growth factor beta 1 (TGF-beta 1) and of dexamethasone on fibronectin (FN) synthesis of human renal tubular epithelial cells in culture (TEC) was studied. Cocultivation with TGF-beta 1 increased the steady state level of FN RNA within 24 to 48 hours. By PCR and Northern blotting it was fo...

journal_title：Kidney international

authors： Viedt C,Bürger A,Hänsch GM

更新日期：1995-12-01 00:00:00

abstract：:Apoptosis mediated by verotoxins (VTs) has been identified in a renal carcinoma cell line, ACHN cells, which are an in vitro model of renal tubular epithelial cells. ACHN cells express the renal tubular marker CD24 as well as globotriaosyl ceramide/CD77, the receptor for VTs. VT binding to the ACHN cell surface was co...

journal_title：Kidney international

authors： Taguchi T,Uchida H,Kiyokawa N,Mori T,Sato N,Horie H,Takeda T,Fujimoto J

更新日期：1998-06-01 00:00:00

abstract：:Hypertension is associated with an accelerated rate of decline in renal function in patients with chronic renal disease. To identify factors that might alter the rate of decline in renal function, we reviewed records of 200 patients from the Nephrology Clinic of the Durham VA Medical Center who had chronic progressive...

journal_title：Kidney international

authors： Brazy PC,Fitzwilliam JF

更新日期：1990-04-01 00:00:00

abstract：:Urinary microvesicles, such as 40-100 nm exosomes and 100-1000 nm microparticles, contain many proteins that may serve as biomarkers of renal disease. Microvesicles have been isolated by ultracentrifugation or nanomembrane ultrafiltration from normal urine; however, little is known about the efficiency of these method...

journal_title：Kidney international

authors： Rood IM,Deegens JK,Merchant ML,Tamboer WP,Wilkey DW,Wetzels JF,Klein JB

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Fractalkine is a newly identified T-cell and monocyte/macrophage (Mphi) chemokine with a transmembrane domain and is a cell-surface protein on activated endothelium. It can mediate adhesion of cells expressing the fractalkine receptor CX3CR1. These unique features make fractalkine well suited for leukocyte r...

journal_title：Kidney international

authors： Feng L,Chen S,Garcia GE,Xia Y,Siani MA,Botti P,Wilson CB,Harrison JK,Bacon KB

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Macrophage (Mphi) infiltration may contribute to chronic renal injury. We therefore sought to examine the expression of genes associated with Mphi recruitment in the rat remnant kidney model. METHODS:Male Munich Wistar rats underwent 5/6 nephrectomy or sham operation (SHM, N = 18) and received no treatment ...

journal_title：Kidney international

authors： Taal MW,Zandi-Nejad K,Weening B,Shahsafaei A,Kato S,Lee KW,Ziai F,Jiang T,Brenner BM,MacKenzie HS

更新日期：2000-10-01 00:00:00

abstract：:Indomethacin antagonizes the natriuretic and chloruretic response to hydrochlorothiazide in most studies. Neither the mechanism nor nephron site of this antagonism has been determined. To identify sites and potential mechanisms, cortical micropuncture was performed during hydrochlorothiazide treatment in control and i...

journal_title：Kidney international

authors： Kirchner KA,Brandon S,Mueller RA,Smith MJ,Bower JD

更新日期：1987-05-01 00:00:00

abstract：:The survival of patients with diabetes mellitus in the general population has improved in recent years. Here we assessed whether similar trends have occurred in 1688 kidney recipients, including 413 with diabetes prior to transplant between 1996 and 2007. Compared to patients without diabetes, the 5-year mortality was...

journal_title：Kidney international

authors： Keddis MT,El Ters M,Rodrigo E,Dean P,Wohlfahrtova M,Kudva YC,Lorenz EC,Cosio FG

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Renal disease is commonly associated with hyperlipidemia and correlates with glomerular accumulation of atherogenic lipoproteins, for example, lipoprotein(a) [Lp(a)], and mesangial hypercellularity. Specific binding of Lp(a) to mesangial cells and induction of c-myc and c-fos expression has been demonstrated...

journal_title：Kidney international

authors： Mondorf UF,Piiper A,Herrero M,Olbrich HG,Bender M,Gross W,Scheuermann E,Geiger H

更新日期：1999-04-01 00:00:00

abstract：:The recent identification of RPGRIP1L as a Joubert syndrome gene brings the total of known genes to five. Three of these are also associated with the lethal Meckel syndrome, and two with Senior-Løken syndrome; both of these disorders share Joubert syndrome phenotypes, illustrating the genetic complexity of this. ...

journal_title：Kidney international

authors： Harris PC

更新日期：2007-12-01 00:00:00

abstract：:In the present study we assessed the prevalence of thin glomerular basement membrane (TGBM) in a large group of native kidney biopsies done for evaluation of renal disease. TGBM was present in 54 of 1078 biopsies (5%). In 12 of 54 biopsies (24%), TGBM was the only abnormality present. In the remaining biopsies TGBM wa...

journal_title：Kidney international

authors： Cosio FG,Falkenhain ME,Sedmak DD

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:Controversy exists regarding the possible associations between a single nucleotide polymorphism of the transcobalamin II encoding gene (TCN2 776C>G) and plasma levels of vitamin B(12), folate, or total homocysteine. METHODS:In a cross-sectional study of 732 kidney allograft recipients, patients were categor...

journal_title：Kidney international

authors： Winkelmayer WC,Skoupy S,Eberle C,Födinger M,Sunder-Plassmann G

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Hyperlipidemia is a risk factor for long-term renal transplant dysfunction, but no prospective clinical trials have investigated the effects of statin treatment on graft function in renal transplant recipients. The aim of the present study was to evaluate the effect of fluvastatin on long-term renal transpla...

journal_title：Kidney international

authors： Fellström B,Holdaas H,Jardine AG,Holme I,Nyberg G,Fauchald P,Grönhagen-Riska C,Madsen S,Neumayer HH,Cole E,Maes B,Ambühl P,Olsson AG,Hartmann A,Logan JO,Pedersen TR,Assessment of Lescol in Renal Transplantation Study Inve

更新日期：2004-10-01 00:00:00

abstract：:Sodium depletion has a protective effect on target-organ damage in hypertension independent of blood pressure. Here we tested whether chronic dietary sodium restriction may prevent the development of renal alterations associated with insulin resistance by reducing the inflammatory and oxidant state. Rats were fed norm...

journal_title：Kidney international

authors： Oudot C,Lajoix AD,Jover B,Rugale C

更新日期：2013-04-01 00:00:00

abstract：:Myeloproliferative neoplasms are clonal hematopoietic stem cell disorders that can produce an undefined glomerulopathy. To better characterize the glomerular disease associated with myeloproliferative neoplasms, we evaluated features of 11 patients with myeloproliferative neoplasm-related glomerulopathy that included ...

journal_title：Kidney international

authors： Said SM,Leung N,Sethi S,Cornell LD,Fidler ME,Grande JP,Herrmann S,Tefferi A,D'Agati VD,Nasr SH

更新日期：2011-10-01 00:00:00