当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Endothelial nitric oxide synthase gene polymorphisms and the renal hemodynamic response to L-arginine.

Endothelial nitric oxide synthase gene polymorphisms and the renal hemodynamic response to L-arginine.

Abstract：

:Nitric oxide is generated from L-arginine by nitric oxide synthase (NOS), an enzyme that exists in several isoforms. Some studies found that a polymorphism (G894T) in the endothelial NOS gene was associated with decreased nitric oxide bioactivity and vascular complications. However, it is not known whether the enzyme had a reduced activity. Here we measured the effect of an infusion of L-arginine on renal hemodynamic function in subjects segregated by the presence or absence of the T allele. If this polymorphism represented a functional variant, subjects with the GT/TT form should exhibit a blunted renal hemodynamic response to L-arginine compared to those with a GG allele. All subjects were given a diet controlled for sodium and protein intake. GG subjects had lower mean arterial pressure and an augmented glomerular filtration rate at baseline. In response to a graded L-arginine infusion, this group had significant changes in effective renal plasma flow, glomerular filtration rate, filtration fraction, renal vascular resistance, and renal blood flow. The renal response to L-arginine in GT/TT subjects was blunted. Circulating cGMP levels and endothelial NOS mRNA expression, measured in skin biopsies by real-time PCR, did not differ between the groups. Our study shows that the G894T allele of endothelial NOS is associated with a blunted response to L-arginine, suggesting this polymorphism may be a functional variant in humans.

journal_name

Kidney Int

journal_title

Kidney international

authors

Cherney DZ,Scholey JW,Zhou J,Zimpelmann J,Kennedy C,Burns KD,Lai V,Miller JA

doi

10.1038/ki.2008.574

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

327-32

issue

3

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)53682-X

journal_volume

75

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • Interactions between gender and the angiotensin type 1 receptor gene polymorphism.

    abstract：BACKGROUND:The cardiovascular effects of angiotensin II are mediated by the angiotensin II type 1 receptor (AGT1R); one polymorphism of the AGT1R gene, A1166-->C, has been associated with hypertension. The hemodynamic response to angiotensin II is blunted in women compared to men, but interactions between gender, blood...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1523-1755.2003.00867.x

    authors： Reich H,Duncan JA,Weinstein J,Cattran DC,Scholey JW,Miller JA

    更新日期：2003-04-01 00:00:00

  • Indigenous people in Australia, Canada, New Zealand and the United States are less likely to receive renal transplantation.

    abstract：:In Australia, Canada, New Zealand, and the United States indigenous people have high rates of chronic kidney disease but poor access to effective therapies. To more fully define these issues, we compared the demographics of renal transplantation of indigenous patients in these 4 countries. Data encompassing 312,507 in...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2009.236

    authors： Yeates KE,Cass A,Sequist TD,McDonald SP,Jardine MJ,Trpeski L,Ayanian JZ

    更新日期：2009-09-01 00:00:00

  • Angiotensin II does not acutely reverse the reduction of proteinuria by long-term ACE inhibition.

    abstract：:Angiotensin converting enzyme (ACE) inhibitors are known to lower urinary protein excretion in human renal disease. This proteinuria lowering effect of ACE inhibition has been hypothesized to be a result of renal hemodynamic changes due to the inhibition of angiotensin II (Ang II) production. To test this hypothesis w...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章

    doi：10.1038/ki.1991.268

    authors： Heeg JE,de Jong PE,van der Hem GK,de Zeeuw D

    更新日期：1991-10-01 00:00:00

  • Molecular cloning of KS, a novel rat gene expressed exclusively in the kidney.

    abstract：BACKGROUND:We aimed to identify genes with kidney specific, developmentally regulated expression. Here we report the cDNA sequence and expression pattern of KS, a novel kidney-specific rat gene. METHODS:A partial cDNA was identified by differential display polymerase chain reaction (PCR) of a renal cell fraction enric...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00143.x

    authors： Hilgers KF,Nagaraj SK,Karginova EA,Kazakova IG,Chevalier RL,Carey RM,Pentz ES,Gomez RA

    更新日期：1998-11-01 00:00:00

  • Adenosine induces mesangial cell contraction by an A1-type receptor.

    abstract：:Adenosine is known to decrease renal blood flow and glomerular filtration rate. We have tested the hypothesis that adenosine exerts contractile effects on mesangial cells. Furthermore, we have studied, using selective agonists and antagonists for adenosine, which kind of adenosine receptor, A1 or A2, is mainly implica...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1989.126

    authors： Olivera A,Lamas S,Rodriguez-Puyol D,López-Novoa JM

    更新日期：1989-06-01 00:00:00

  • A non-nucleotide-bridged DNA decoy inhibits renal epithelial nitric oxide synthase expression.

    abstract：UNLABELLED:A non-nucleotide-bridged DNA decoy inhibits renal epithelial nitric oxide synthase expression. BACKGROUND:The expression of inducible nitric oxide synthase (iNOS) is subject to strict tissue-specific transcriptional control. In mouse renal epithelium, an interferon-gamma (IFN-gamma)-induced signaling protei...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00809.x

    authors： Amoah-Apraku B,Fang MZ,Guzman NJ

    更新日期：2000-01-01 00:00:00

  • Transcription factor HNF1beta and novel partners affect nephrogenesis.

    abstract：:Heterozygous mutations of the tissue-specific transcription factor hepatocyte nuclear factor (HNF)1beta, cause maturity onset diabetes of the young (MODY5) and kidney anomalies including agenesis, hypoplasia, dysplasia and cysts. Because of these renal anomalies, HNF1beta is classified as a CAKUT (congenital anomalies...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2008.149

    authors： Dudziak K,Mottalebi N,Senkel S,Edghill EL,Rosengarten S,Roose M,Bingham C,Ellard S,Ryffel GU

    更新日期：2008-07-01 00:00:00

  • Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery.

    abstract：:Urinary exosomes containing apical membrane and intracellular fluid are normally secreted into the urine from all nephron segments, and may carry protein markers of renal dysfunction and structural injury. We studied methods for collection, storage, and preservation of urinary exosomal proteins. We collected urine fro...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5000273

    authors： Zhou H,Yuen PS,Pisitkun T,Gonzales PA,Yasuda H,Dear JW,Gross P,Knepper MA,Star RA

    更新日期：2006-04-01 00:00:00

  • The complement factor 5a receptor 1 has a pathogenic role in chronic inflammation and renal fibrosis in a murine model of chronic pyelonephritis.

    abstract：:Complement factor 5a (C5a) interaction with its receptor (C5aR1) contributes to the pathogenesis of inflammatory diseases, including acute kidney injury. However, its role in chronic inflammation, particularly in pathogen-associated disorders, is largely unknown. Here we tested whether the development of chronic infla...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2016.04.023

    authors： Choudhry N,Li K,Zhang T,Wu KY,Song Y,Farrar CA,Wang N,Liu CF,Peng Q,Wu W,Sacks SH,Zhou W

    更新日期：2016-09-01 00:00:00

  • IgM in the kidney: a multiple personality disorder.

    abstract：:IgM in the blood of normal individuals consists mainly of 'natural' polyreactive antibodies. Natural IgM is thought to provide an initial defense against infection and to promote the healing of wounded cells. Yet, as Panzer and colleagues show, these benefits can be eclipsed when the IgM binds to damaged cells of the ...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2015.153

    authors： Platt JL,Cascalho M

    更新日期：2015-09-01 00:00:00

  • Association of short sleep duration and rapid decline in renal function.

    abstract：:The kidney is influenced by circadian rhythms and is entrained to the sleep-wake cycle allowing anticipation of the metabolic and physiological demands of the kidney throughout a 24-hour cycle. Although sleep disruption has been studied extensively in cardiovascular and metabolic disease, its association with chronic ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2015.12.048

    authors： McMullan CJ,Curhan GC,Forman JP

    更新日期：2016-06-01 00:00:00

  • Renal injury in the extremely obese patients with normal renal function.

    abstract：:We studied the glomerular architecture in renal biopsies of 95 patients undergoing bariatric surgery for extreme obesity but whose renal function was normal. The comparison group was 40 control patients having protocol biopsies. These latter patients had normal weight and renal function, were non-diabetic, non-hyperte...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5002796

    authors： Serra A,Romero R,Lopez D,Navarro M,Esteve A,Perez N,Alastrue A,Ariza A

    更新日期：2008-04-01 00:00:00

  • A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.

    abstract：:Urinary exosomes have received considerable attention as a potential biomarker source for the diagnosis of renal diseases. Notwithstanding, their use in protein biomarker research is hampered by the lack of efficient methods for vesicle isolation, lysis, and protein quantification. Here we report an improved ultracent...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2012.25

    authors： Raj DA,Fiume I,Capasso G,Pocsfalvi G

    更新日期：2012-06-01 00:00:00

  • Pleiotropic effects of dihydrotestosterone in immortalized mouse proximal tubule cells. Technical note.

    abstract：:Dihydrotestosterone (DHT) binding studies and the effects of DHT on the expression of beta-glucuronidase (Gus) and kidney androgen-regulated protein (KAP) genes and cell growth were investigated in immortalized early PKSV-PCT and late PKSV-PR proximal tubule cells, derived from transgenic mice carrying the L-pyruvate ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00721.x

    authors： Ouar Z,Solé E,Bens M,Rafestin-Oblin ME,Meseguer A,Vandewalle A

    更新日期：1998-01-01 00:00:00

  • Lipid peroxidation in human proteinuric disease.

    abstract：BACKGROUND:While metabolically generated oxidants are produced locally in experimental glomerular diseases, little is still known of their significance and the respective scavenger systems in human glomerular diseases. METHODS:Here we studied kidneys from patients with congenital nephrotic syndrome of the Finnish type...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.059002481.x

    authors： Solin ML,Ahola H,Haltia A,Ursini F,Montine T,Roveri A,Kerjaschki D,Holthöfer H

    更新日期：2001-02-01 00:00:00

  • RenaGel, a nonabsorbed calcium- and aluminum-free phosphate binder, lowers serum phosphorus and parathyroid hormone. The RenaGel Study Group.

    abstract：BACKGROUND:This multicenter, open-label, dose-titration study assessed the safety and efficacy of RenaGel(R), a nonabsorbed calcium- and aluminum-free phosphate binder, in lowering serum phosphorus. Secondary outcomes were its effects on serum intact parathyroid hormone (iPTH) and serum lipids. METHODS:Phosphate binde...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1046/j.1523-1755.1999.00240.x

    authors： Slatopolsky EA,Burke SK,Dillon MA

    更新日期：1999-01-01 00:00:00

  • The role of PDGF-D in healthy and fibrotic kidneys.

    abstract：:Platelet-derived growth factor (PDGF)-D, a specific PDGF receptor β (PDGFR-β) ligand, mediates mesangial proliferation in vitro and in vivo. However, its role in renal development, physiology, and fibrosis is relatively unknown. In healthy murine kidneys, PDGF-D was found to be expressed on renal mesenchymal cells (me...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2015.12.037

    authors： Buhl EM,Djudjaj S,Babickova J,Klinkhammer BM,Folestad E,Borkham-Kamphorst E,Weiskirchen R,Hudkins K,Alpers CE,Eriksson U,Floege J,Boor P

    更新日期：2016-04-01 00:00:00

  • Inhibition of pressure natriuresis in mice lacking the AT2 receptor.

    abstract：UNLABELLED:Inhibition of pressure natriuresis in mice lacking the AT2 receptor. BACKGROUND:Angiotensin II type 2 (AT2) receptor knockout mice have higher blood pressures than wild-type mice; however, the hypertension is imperfectly defined. We tested the hypothesis that renal mechanisms could be contributory. METHODS...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00820.x

    authors： Gross V,Schunck WH,Honeck H,Milia AF,Kärgel E,Walther T,Bader M,Inagami T,Schneider W,Luft FC

    更新日期：2000-01-01 00:00:00

  • Acetate and bicarbonate hemodialysis in patients with and without autonomic dysfunction.

    abstract：:To test the contribution of bicarbonate (Bi) to hemodynamic stability during hemodialysis (HD), we compared the effects of ultrafiltration dialysis with bicarbonate and with acetate under conditions of high-sodium (141 mEq/liter) and low-sodium (130 mEq/liter) dialysate concentrations in 12 stable HD patients. Group 1...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章

    doi：10.1038/ki.1984.134

    authors： Velez RL,Woodard TD,Henrich WL

    更新日期：1984-07-01 00:00:00

  • The role of hyperparathyroidism, erythropoietin therapy, and CMV infection in the failure of arteriovenous fistula in hemodialysis.

    abstract：BACKGROUND:Vascular access failure is the main cause of morbidity in hemodialysis. Venous stenosis and subsequent thrombosis, as the result of intimal hyperplasia, is the major cause of vascular access failure. Intimal hyperplasia of the arteriovenous fistula (AVF) closely resembles the main histopathologic feature of ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00120.x

    authors： Grandaliano G,Teutonico A,Allegretti A,Losappio R,Mancini A,Gesualdo L,Schena FP,Pertosa G

    更新日期：2003-08-01 00:00:00

  • Enhanced posttransplant management of patients with diabetes improves patient outcomes.

    abstract：:The survival of patients with diabetes mellitus in the general population has improved in recent years. Here we assessed whether similar trends have occurred in 1688 kidney recipients, including 413 with diabetes prior to transplant between 1996 and 2007. Compared to patients without diabetes, the 5-year mortality was...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2014.70

    authors： Keddis MT,El Ters M,Rodrigo E,Dean P,Wohlfahrtova M,Kudva YC,Lorenz EC,Cosio FG

    更新日期：2014-09-01 00:00:00

  • Androgen exposure potentiates formation of intratubular communities and renal abscesses by Escherichia coli.

    abstract：:Females across their lifespan and certain male populations are susceptible to urinary tract infections (UTI). The influence of female vs. male sex on UTI is incompletely understood, in part because preclinical modeling has been performed almost exclusively in female mice. Here, we employed established and new mouse mo...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2018.04.023

    authors： Olson PD,McLellan LK,Hreha TN,Liu A,Briden KE,Hruska KA,Hunstad DA

    更新日期：2018-09-01 00:00:00

  • Potential mechanisms of marked hyperoxaluria not due to primary hyperoxaluria I or II.

    abstract：BACKGROUND:Hyperoxaluria may be idiopathic, secondary, or due to primary hyperoxaluria (PH). Hepatic alanine:glyoxylate aminotransferase (AGT) or glyoxylate/hydroxypyruvate reductase (GR/HPR) deficiency causes PHI or PHII, respectively. Hepatic glycolate oxidase (GO) is a candidate enzyme for a third form of inherited ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2002.00468.x

    authors： Monico CG,Persson M,Ford GC,Rumsby G,Milliner DS

    更新日期：2002-08-01 00:00:00

  • Expression of decay accelerating factor mRNA and complement C3 mRNA in human diseased kidney.

    abstract：BACKGROUND:Decay accelerating factor (DAF), a product of mesangial cells in vitro, is expressed on the surface of cells and is a candidate for the focal suppression of complement activation. It is not clear at present whether the levels of expression of DAF and intrarenal C3 synthesis correlate with the level of tissue...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00961.x

    authors： Abe K,Miyazaki M,Koji T,Furusu A,Ozono Y,Harada T,Sakai H,Nakane PK,Kohno S

    更新日期：1998-07-01 00:00:00

  • Non-muscle myosin IIA is required for the development of the zebrafish glomerulus.

    abstract：:Mutations in the MYH9 gene, coding for the non-muscle myosin heavy chain IIA (NMHC-IIA), are responsible for syndromes characterized by macrothrombocytopenia associated with deafness, cataracts, and severe glomerular disease. Electron microscopy of renal biopsies from these patients found glomerular abnormalities char...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2011.256

    authors： Müller T,Rumpel E,Hradetzky S,Bollig F,Wegner H,Blumenthal A,Greinacher A,Endlich K,Endlich N

    更新日期：2011-11-01 00:00:00

  • Reaching consensus on the important outcomes for peritoneal dialysis patients.

    abstract：:The Standardized Outcomes in Nephrology (SONG) initiative is designed to improve research productivity by building consensus. Stakeholders involved with peritoneal dialysis (PD) have put life participation on top of their list, along with treatment-related infection, cardiovascular complications, and patient and techn...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2019.05.002

    authors： Davies SJ

    更新日期：2019-09-01 00:00:00

  • Erythropoietin, but not the correction of anemia alone, protects from chronic kidney allograft injury.

    abstract：:Anemia can contribute to chronic allograft injury by limiting oxygen delivery to tissues, particularly in the tubulointerstitium. To determine mechanisms by which erythropoietin (EPO) prevents chronic allograft injury we utilized a rat model of full MHC-mismatched kidney transplantation (Wistar Furth donor and Lewis r...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2011.473

    authors： Cassis P,Gallon L,Benigni A,Mister M,Pezzotta A,Solini S,Gagliardini E,Cugini D,Abbate M,Aiello S,Rocchetta F,Scudeletti P,Perico N,Noris M,Remuzzi G

    更新日期：2012-05-01 00:00:00

  • Impaired monocyte CD11b expression in interstitial inflammation in hemodialysis patients.

    abstract：BACKGROUND:It is not known to what extent intravascular phenotypic alterations in adhesion molecule expression induced by hemodialysis influence the recruitment of monocytes and their ability to up-regulate CD11b at the local site of inflammation in the interstitium. Using a skin suction chamber technique, we addressed...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00060.x

    authors： Thylén P,Lundahl J,Fernvik E,Grönneberg R,Halldén G,Jacobson SH

    更新日期：2000-05-01 00:00:00

  • Mitochondrial DNA deletion: a cause of chronic tubulointerstitial nephropathy.

    abstract：:We report the first case of a mitochondrial DNA (mtDNA) deletion diagnosed by renal biopsy. An eight-year-old girl with megaloblastic anemia and severe growth retardation developed progressive renal insufficiency accompanied by partial Fanconi syndrome. Histologic examination of the renal biopsy disclosed nonspecific ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1994.181

    authors： Szabolcs MJ,Seigle R,Shanske S,Bonilla E,DiMauro S,D'Agati V

    更新日期：1994-05-01 00:00:00

  • Foxp3+ regulatory T cells participate in repair of ischemic acute kidney injury.

    abstract：:T lymphocytes modulate early ischemia-reperfusion injury in the kidney; however, their role during repair is unknown. We studied the role of TCRbeta(+)CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs), known to blunt immune responses, in repair after ischemia-reperfusion injury to the kidney. Using a murine model of is...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2009.259

    authors： Gandolfo MT,Jang HR,Bagnasco SM,Ko GJ,Agreda P,Satpute SR,Crow MT,King LS,Rabb H

    更新日期：2009-10-01 00:00:00