Non-muscle myosin IIA is required for the development of the zebrafish glomerulus.

abstract：:The effects of acidosis on renal function and morphology were examined in the isolated perfused rat kidney (IPK). Kidneys were perfused with oxygenated Krebs-Henseleit-albumin medium for 60 minutes at pH 7.4 or pH 7.0. At the lower pH, GFR was reduced by 25%, TRNa by 32% and oxygen consumption by 41% as compared to pe...

journal_title：Kidney international

authors： Shanley PF,Shapiro JI,Chan L,Burke TJ,Johnson GC

更新日期：1988-12-01 00:00:00

abstract：:While hemodialysis therapy in its present form is capable of sustaining life, dialysis patients are not metabolically normal and we are unable to say what technical factors contribute adequate therapy. Recent efforts to resolve these problems have led to the assumption that substances in the molecular weight range of ...

journal_title：Kidney international

authors： Lowrie EG,Steinberg SM,Galen MA,Gagneux SA,Lazarus JM,Gottlieb MN,Merrill JP

更新日期：1976-11-01 00:00:00

abstract：BACKGROUND:The feasibility of simultaneously infusing glucose and amino acid (AA)-based peritoneal dialysis solutions was tested to determine whether peritoneal dialysis patients could achieve an adequate nonprotein calorie/nitrogen ratio while preventing a marked increase in blood urea nitrogen (BUN), which is usually...

journal_title：Kidney international

authors： Canepa A,Carrea A,Menoni S,Verrina E,Trivelli A,Gusmano R,Perfumo F

更新日期：2001-05-01 00:00:00

abstract：:Fibroblast growth factor 23 (FGF23) is a phosphate-regulating hormone that acts primarily on the kidney and parathyroid. With declining kidney function there is an increase in circulating FGF23 levels, which is associated with vascular calcification and mortality in chronic kidney disease. Whether FGF23 exerts direct ...

journal_title：Kidney international

authors： Jimbo R,Kawakami-Mori F,Mu S,Hirohama D,Majtan B,Shimizu Y,Yatomi Y,Fukumoto S,Fujita T,Shimosawa T

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:The podocyte is the focus of much research into the mechanisms of renal disease progression, and the number of podocytes per glomerulus has thus become a parameter of much interest. When counting podocytes, the actual particle counted is the cell nucleus. The majority of published studies estimating podocyte...

journal_title：Kidney international

authors： White KE,Bilous RW

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Fractalkine is a newly identified T-cell and monocyte/macrophage (Mphi) chemokine with a transmembrane domain and is a cell-surface protein on activated endothelium. It can mediate adhesion of cells expressing the fractalkine receptor CX3CR1. These unique features make fractalkine well suited for leukocyte r...

journal_title：Kidney international

authors： Feng L,Chen S,Garcia GE,Xia Y,Siani MA,Botti P,Wilson CB,Harrison JK,Bacon KB

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Regular access monitoring is recommended to detect and treat access stenosis in order to prevent access thrombosis and failure. METHODS:In 1999, we instituted monthly access blood flow monitoring using the ultrasound dilution technique (UDT). In a sequential observational trial, 222 patients were studied fo...

journal_title：Kidney international

authors： Shahin H,Reddy G,Sharafuddin M,Katz D,Franzwa BS,Dixon BS

更新日期：2005-11-01 00:00:00

abstract：:Increasing evidence points to the importance of aberrant O-glycosylated immunoglobulin A1 (IgA1) in the pathogenesis of IgA nephropathy (IgAN), a disease widely considered to be a polygenic disorder. We earlier found that haplotypes in two key glycosyltransferase genes, C1GALT1 and ST6GALNAC2, were associated with sus...

journal_title：Kidney international

authors： Zhu L,Tang W,Li G,Lv J,Ding J,Yu L,Zhao M,Li Y,Zhang X,Shen Y,Zhang H,Wang H

更新日期：2009-07-01 00:00:00

abstract：:Sustained oliguria during fluid resuscitation represents a perplexing problem in patients undergoing therapy for septic acute kidney injury. Here, we tested whether lipopolysaccharide induces filtrate leakage from the proximal tubular lumen into the interstitium, thus disturbing the recovery of urine output during the...

journal_title：Kidney international

authors： Nakano D,Kitada K,Wan N,Zhang Y,Wiig H,Wararat K,Yanagita M,Lee S,Jia L,Titze JM,Nishiyama A

更新日期：2020-05-01 00:00:00

abstract：:To test the hypothesis that systemic administration of immunoglobulin might reduce glomerular injury in membranous nephropathy through mechanisms involving inhibition of complement activation, we studied the passive Heymann nephritis (PHN) model of membranous nephropathy in rats. The daily administration of immunoglob...

journal_title：Kidney international

authors： Nangaku M,Pippin J,Richardson CA,Schulze M,Young BA,Alpers CE,Gordon KL,Johnson RJ,Couser WG

更新日期：1996-12-01 00:00:00

abstract：:Cytomegalovirus (CMV) seropositivity is associated with increased risk for atherosclerotic disease in patients with end-stage renal disease. This association is due to a unique peripheral blood CD4(+) T cell population which lack CD28 (CD4(+)CD28(-) T cells). Here we found that this patient population has a significan...

journal_title：Kidney international

authors： Betjes MG,Huisman M,Weimar W,Litjens NH

更新日期：2008-09-01 00:00:00

abstract：:Compared to normal tissue, hyperplastic parathyroid glands of patients with chronic kidney disease on dialysis express lower levels of FGFR1 and Klotho proteins. Similar findings are reported in uremic rats with advanced chronic kidney disease. Moreover, in these animals, FGF23 administration fails to reduce PTH serum...

journal_title：Kidney international

authors： Lafage-Proust MH

更新日期：2010-03-01 00:00:00

abstract：:Obesity has been suggested to have a detrimental impact on kidney structure and function, leading to focal glomerulosclerosis and hypertension. It is also associated with hyperleptinemia and elevated renal sympathetic nerve activity. Prenatal undernutrition promotes postnatal obesity, hypertension, and an altered rena...

journal_title：Kidney international

authors： Williams PJ,Kurlak LO,Perkins AC,Budge H,Stephenson T,Keisler D,Symonds ME,Gardner DS

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Regular monitoring of dialysis grafts is recommended, but the value of dialysis graft blood flow monitoring and venous pressures in predicting subsequent outcomes are controversial. METHODS:Over a period of one month, we performed simultaneous flow and venous pressure monitoring in 71 dialysis patients with...

journal_title：Kidney international

authors： McDougal G,Agarwal R

更新日期：2001-08-01 00:00:00

abstract：:Tubulointerstitial nephritis (TIN) is a disease pattern with heterogeneous causes. Recently a specific subtype of autoimmune TIN, IgG4-related TIN, has been identified that is part of systemic IgG4-related disease/ autoimmune pancreatitis. On biopsy, this TIN shows an IgG4+ plasma cell-rich infiltrate, akin to the pan...

journal_title：Kidney international

authors： Cornell LD

更新日期：2010-11-01 00:00:00

abstract：:A dose escalation study of adipose-derived human mesenchymal stem cell (MSC) therapy was studied in 21 subjects. This dose escalation study confirmed no significant cellular toxicity, but it showed improvement in renal oxygenation and glomerular filtration rate. No significant renal toxicity from cell therapy was show...

journal_title：Kidney international

authors： Sivanathan KN,Coates PT

更新日期：2020-04-01 00:00:00

abstract：:Acute kidney injury (AKI) is associated with progression to advanced chronic kidney disease (CKD). We tested whether patients who survive AKI and are at higher risk for CKD progression can be identified during their hospital admission, thus providing opportunities to intervene. This was assessed in patients in the Dep...

journal_title：Kidney international

authors： Chawla LS,Amdur RL,Amodeo S,Kimmel PL,Palant CE

更新日期：2011-06-01 00:00:00

abstract：:Absorption of amino acids by the necturus proximal tubules was measured under free-flow conditions The coexistence of proximal tubular amino acid influx was determined by infusing saline into tubular lumens by the stopped-flow microperfusion technique. Under free-flow conditions, fractional absorption of individual am...

journal_title：Kidney international

authors： Oken DE,Weise M

更新日期：1978-06-01 00:00:00

abstract：:Adynamic bone disease (ABD) is increasingly recognized, especially in dialysis patients treated with oral calcium carbonate, vitamin D supplements, or supraphysiological dialysate calcium. We undertook this study to assess the effect of lowering dialysate calcium on episodes of hypercalcemia, serum parathyroid hormone...

journal_title：Kidney international

authors： Haris A,Sherrard DJ,Hercz G

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:While the most common glomerular lesion associated with human immunodeficiency virus (HIV) infection is collapsing focal segmental glomerulosclerosis (FSGS) [HIV-associated nephropathy (HIVAN)], immune complex-mediated forms of glomerulonephritis have been increasingly reported. One form of glomerulonephriti...

journal_title：Kidney international

authors： Haas M,Kaul S,Eustace JA

更新日期：2005-04-01 00:00:00

abstract：:In chronic serum sickness, glomerular immune complexes form, yet C57BL/6 mice do not develop glomerulonephritis unless complement factor H (CfH) is absent, indicating the relevance of complement regulation. Complement receptor 3 (CD11b) and Fcγ receptors on leukocytes, and CfH on platelets, can bind immune complexes. ...

journal_title：Kidney international

authors： Alexander JJ,Chaves LD,Chang A,Jacob A,Ritchie M,Quigg RJ

更新日期：2015-05-01 00:00:00

abstract：:Diabetes mellitus is associated with natriuresis, whereas estrogen has been shown to be renoprotective in diabetic nephropathy and may independently regulate renal sodium reabsorption. The aim of this study was to determine the effects of 17-beta estradiol (E(2)) replacement to diabetic, ovariectomized (OVX) female ra...

journal_title：Kidney international

authors： Riazi S,Maric C,Ecelbarger CA

更新日期：2006-02-01 00:00:00

abstract：:Urinary microvesicles, such as 40-100 nm exosomes and 100-1000 nm microparticles, contain many proteins that may serve as biomarkers of renal disease. Microvesicles have been isolated by ultracentrifugation or nanomembrane ultrafiltration from normal urine; however, little is known about the efficiency of these method...

journal_title：Kidney international

authors： Rood IM,Deegens JK,Merchant ML,Tamboer WP,Wilkey DW,Wetzels JF,Klein JB

更新日期：2010-10-01 00:00:00

abstract：:Reliable estimates of the long-term outcomes of acute kidney injury (AKI) are needed to inform clinical practice and guide allocation of health care resources. This systematic review and meta-analysis aimed to quantify the association between AKI and chronic kidney disease (CKD), end-stage kidney disease (ESKD), and d...

journal_title：Kidney international

authors： See EJ,Jayasinghe K,Glassford N,Bailey M,Johnson DW,Polkinghorne KR,Toussaint ND,Bellomo R

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Long-term graft function is the result of multiple parameters, including both immune and non-immune components, which have a beneficial or detrimental potential. Among these, despite its frequency and theoretical interest (expression of "danger signals" in the graft itself), the effects of acute graft pyelon...

journal_title：Kidney international

authors： Giral M,Pascuariello G,Karam G,Hourmant M,Cantarovich D,Dantal J,Blancho G,Coupel S,Josien R,Daguin P,Méchineau S,Soulillou JP

更新日期：2002-05-01 00:00:00

abstract：:Endostatin (EST), an antiangiogenic factor, is enriched in aging kidneys. EST is also an interactive partner of transglutaminase 2 (TG2), an enzyme that cross-links extracellular matrix proteins. Here we tested whether EST and TG2 play a role in the fibrosis of aging. In wild-type mice, aging kidneys exhibited a 2- to...

journal_title：Kidney international

authors： Lin CH,Chen J,Zhang Z,Johnson GV,Cooper AJ,Feola J,Bank A,Shein J,Ruotsalainen HJ,Pihlajaniemi TA,Goligorsky MS

更新日期：2016-06-01 00:00:00

abstract：:Although much emphasis has been placed on screening for albuminuria in type II diabetic patients, less attention has been focused on the role of glomerular filtration rate (GFR) in the assessment of risk. Herein, we examined the association between GFR and vascular complications in a consecutive cohort of 5174 type II...

journal_title：Kidney international

authors： Kong AP,So WY,Szeto CC,Chan NN,Luk A,Ma RC,Ozaki R,Ng VW,Ho CS,Lam CW,Chow CC,Cockram CS,Chan JC,Tong PC

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Gene expression profiling of nephropathies may facilitate development of diagnostic strategies for complex renal diseases as well as provide insight into the molecular pathogenesis of kidney diseases. To test molecular based renal disease categorization, differential gene expression profiles were compared be...

journal_title：Kidney international

authors： Henger A,Kretzler M,Doran P,Bonrouhi M,Schmid H,Kiss E,Cohen CD,Madden S,Porubsky S,Gröne EF,Schlöndorff D,Nelson PJ,Gröne HJ

更新日期：2004-03-01 00:00:00

abstract：:Levels of components of the classical and alternative complement pathways and the activity of the C3 nephritic factor (C3NeF) were measured in serum specimens from patients with type I (subendothelial deposits) and type II (intramembranous dense deposits) membranoproliferative glomerulonephritis (MPGN) and the results...

journal_title：Kidney international

authors： Ooi YM,Vallota EH,West CD

更新日期：1976-01-01 00:00:00

abstract：:Fifty-one adults with HIV infection, including 20 chronic hemodialysis patients with superimposed HIV infection and 31 patients with HIV-associated nephropathy requiring chronic maintenance hemodialysis were followed to evaluate survival on outpatient dialysis in relation to the clinical stage of the HIV infection. Re...

journal_title：Kidney international

authors： Ortiz C,Meneses R,Jaffe D,Fernandez JA,Perez G,Bourgoignie JJ

更新日期：1988-08-01 00:00:00