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Hypertension and impaired renal function accompany juvenile obesity: the effect of prenatal diet.

Abstract：

:Obesity has been suggested to have a detrimental impact on kidney structure and function, leading to focal glomerulosclerosis and hypertension. It is also associated with hyperleptinemia and elevated renal sympathetic nerve activity. Prenatal undernutrition promotes postnatal obesity, hypertension, and an altered renal structure and function. In this study, we examined the effects of prenatal nutrient restriction and juvenile obesity in sheep. We found that juvenile obesity led to chronic hyperleptinemia and reduced renal function as assessed by nuclear scintigraphy. Additional factors include hypertension, glomerulosclerosis, and increased kidney apoptosis. Prenatal undernutrition, synchronous with early kidney development, coupled postnatally with juvenile obesity had no effect on systemic pathophysiological sequalae associated with obesity per se. Hypertension, hyperleptinemia, and poor renal function were all observed in this group. All indices of renal pathology such as increased expression of proinflammatory cytokines, angiotensin II, glucocorticoid receptors, and increased apoptosis and glomerulosclerosis were entirely absent in obese prenatally undernourished offspring. Our data indicate that juvenile obesity per se leads to systemic hypertension and renal structural and functional pathology. Prenatal undernutrition effectively abolishes any renal histopathology associated with juvenile obesity.

journal_name

Kidney Int

journal_title

Kidney international

authors

Williams PJ,Kurlak LO,Perkins AC,Budge H,Stephenson T,Keisler D,Symonds ME,Gardner DS

doi

10.1038/sj.ki.5002276

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

279-89

issue

3

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)52633-1

journal_volume

72

pub_type

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