Real-time monitoring of mesangial cell-macrophage cross-talk using SEAP in vitro and ex vivo.

abstract：:Recent studies including the current article by Sawinski et al. demonstrate that hepatitis C virus (HCV) infection is associated with worse outcomes in kidney transplant recipients with and without HIV infection. We comment on the significance of these findings in the context of newer options for the treatment of HCV ...

journal_title：Kidney international

authors： Del Bello D,Ross MJ,Huprikar SS

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:The detailed mechanisms of glucocorticoid action in idiopathic nephrotic syndrome and progressive glomerulonephritides have not been clearly elucidated. The pharmacological actions of glucocorticoids are mediated by their binding to an intracellular protein, the glucocorticoid receptor (GR). The determinatio...

journal_title：Kidney international

authors： Yan K,Kudo A,Hirano H,Watanabe T,Tasaka T,Kataoka S,Nakajima N,Nishibori Y,Shibata T,Kohsaka T,Higashihara E,Tanaka H,Watanabe H,Nagasawa T,Awa S

更新日期：1999-07-01 00:00:00

abstract：:The mechanism of the binding of IgA to the mesangium in IgA nephropathy (IgAN) is unknown. Interactions between IgA and components of the mesangial matrix may contribute. We measured by enzyme-linked immunosorbent assay the binding of serum IgA, IgG, and IgM from patients with IgAN, human immunodeficiency virus type I...

journal_title：Kidney international

authors： van den Wall Bake AW,Kirk KA,Gay RE,Switalski LM,Julian BA,Jackson S,Gay S,Mestecky J

更新日期：1992-08-01 00:00:00

abstract：:We used the perfused hemicorpus preparation to measure individual rates of protein synthesis and degradation. Using fed animals, perfused either with or without insulin, muscle protein synthesis and hemicorpus protein degradation rates were similar, but myofibrillar protein degradation was clearly increased in the ure...

journal_title：Kidney international

authors： Li JB,Wassner SJ

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND:In uremic patients with secondary hyperparathyroidism (2HPT), nodular hyperplasia of parathyroid gland shows a monoclonal pattern of cell proliferation, in which a decreased density of vitamin D receptor (VDR) also is demonstrated. The present study aimed at elucidating the mechanism of parathyroid cell prol...

journal_title：Kidney international

authors： Tokumoto M,Tsuruya K,Fukuda K,Kanai H,Kuroki S,Hirakata H

更新日期：2002-10-01 00:00:00

abstract：:Many xenobiotics including the pharmacoenhancer cobicistat increase serum creatinine by inhibiting its renal active tubular secretion without affecting the glomerular filtration rate. This study aimed to define the transporters involved in creatinine secretion, applying that knowledge to establish the mechanism for xe...

journal_title：Kidney international

authors： Lepist EI,Zhang X,Hao J,Huang J,Kosaka A,Birkus G,Murray BP,Bannister R,Cihlar T,Huang Y,Ray AS

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Angiotensin II (Ang II) can up-regulate nicotinamide adenine dinucleotide phosphate [NAD(P)H] oxidase, whose product superoxide anion (O2-) can interact with nitric oxide (NO) to form peroxynitrite (ONOO-). We tested the hypothesis that Ang II subtype 1 (AT1) receptor activation enhances oxidative stress and...

journal_title：Kidney international

authors： Onozato ML,Tojo A,Goto A,Fujita T,Wilcox CS

更新日期：2002-01-01 00:00:00

abstract：:Autologous and allogeneic bone marrow grafting both require cytoreductive therapy but only the allogeneic procedure requires immunosuppressive agents. Allogeneic bone marrow transplantation has been reported to be associated with a high incidence of both renal failure and veno-occlusive disease (VOD) of the liver, the...

journal_title：Kidney international

authors： Merouani A,Shpall EJ,Jones RB,Archer PG,Schrier RW

更新日期：1996-09-01 00:00:00

abstract：:Urinary microvesicles, such as 40-100 nm exosomes and 100-1000 nm microparticles, contain many proteins that may serve as biomarkers of renal disease. Microvesicles have been isolated by ultracentrifugation or nanomembrane ultrafiltration from normal urine; however, little is known about the efficiency of these method...

journal_title：Kidney international

authors： Rood IM,Deegens JK,Merchant ML,Tamboer WP,Wilkey DW,Wetzels JF,Klein JB

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:We evaluated the effects of different concentrations of iron dextran administered through the intraperitoneal route, in iron-deficient rats, on hematocrit (Hct in percentage), serum iron (mg/dL), total iron binding capacity (TIBC in mg/dL), and the function and histology of the peritoneal membrane. METHODS:...

journal_title：Kidney international

authors： Reddy DK,Moore HL,Lee JH,Saran R,Nolph KD,Khanna R,Twardowski ZJ

更新日期：2001-02-01 00:00:00

abstract：:This study was undertaken to test the hypothesis that, given equal arterial pressure reductions, the combination of an angiotensin converting enzyme (ACE) inhibitor and calcium antagonist slows declines in renal function and yields greater reductions in albuminuria over either agent alone. This hypothesis was evaluate...

journal_title：Kidney international

authors： Bakris GL,Barnhill BW,Sadler R

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:We hypothesized that increasing small solute clearance in peritoneal dialysis (PD) would lead to improvements in patient health-related quality of life (HRQOL). METHODS:Patients were randomized to a control group [standard 4 x 2 L continuous ambulatory peritoneal dialysis (CAPD)] and an intervention group (...

journal_title：Kidney international

authors： Paniagua R,Amato D,Vonesh E,Guo A,Mujais S,Mexican Nephrology Collaborative Study Group.

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Recent advances in the understanding of the molecular biology of rodent renal development have lead to the ability to culture the components of the developing rat kidney-the ureteric bud (UB) and the metanephric mesenchyme (MM)-in isolation from one another. Here we here describe a method for subculturing an...

journal_title：Kidney international

authors： Steer DL,Bush KT,Meyer TN,Schwesinger C,Nigam SK

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Regular monitoring of dialysis grafts is recommended, but the value of dialysis graft blood flow monitoring and venous pressures in predicting subsequent outcomes are controversial. METHODS:Over a period of one month, we performed simultaneous flow and venous pressure monitoring in 71 dialysis patients with...

journal_title：Kidney international

authors： McDougal G,Agarwal R

更新日期：2001-08-01 00:00:00

abstract：:Serum calcitriol and the free calcitriol index together with factors considered to regulate calcitriol production were measured in eleven patients with moderate chronic renal failure (MCRF) and eleven age- and sex-matched normal subjects. Although the serum dialysable calcium levels were similar in the two groups, the...

journal_title：Kidney international

authors： Prince RL,Hutchison BG,Kent JC,Kent GN,Retallack RW

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:Although the existence of multiple isoforms of plasma membrane calcium ATPase (PMCA) is now well documented, their biological functions are not yet known. In this study, we set out to investigate the potential role of PMCA isoforms, previously identified in renal cortical tissue, in tubular reabsorption of c...

journal_title：Kidney international

authors： Caride AJ,Chini EN,Penniston JT,Dousa TP

更新日期：1999-11-01 00:00:00

abstract：:Anecdotal reports of complement component deficiencies in patients with immune complex disease led to a systematic study of the levels of seven complement components in serum specimens from 178 patients with glomerulonephritis and 163 normal subjects. Deficiencies were found with significantly higher frequency (22.7%)...

journal_title：Kidney international

authors： Coleman TH,Forristal J,Kosaka T,West CD

更新日期：1983-11-01 00:00:00

abstract：:X-ray films of the hand skeleton (mammography technique), serum chemistry, and quantitative bone histology (micromorphometry of undecalcified sections, iliac crest spongiosa) were compared in 25 patients on maintenance hemodialysis. The X-ray findings correlated better with serum PTH levels than with bone histology. O...

journal_title：Kidney international

authors： Ritz E,Prager P,Krempien B,Bommer J,Malluche HH,Schmidt-Gayk H

更新日期：1978-04-01 00:00:00

abstract：:Disturbed pulsatile LH secretion has been suggested to play a role in the etiology of delayed puberty and disturbed reproductive function in chronic renal failure (CRF), but interpretation of gonadotropin secretion from plasma concentration measurements is confounded by alterations in hormone metabolic clearance. To s...

journal_title：Kidney international

authors： Schaefer F,Veldhuis JD,Robertson WR,Dunger D,Schärer K

更新日期：1994-05-01 00:00:00

abstract：:A cyclical corticosteroid-cyclophosphamide regimen is recommended for patients with primary membranous nephropathy at high risk of progression. We hypothesized that sequential therapy with tacrolimus and rituximab is superior to cyclical alternating treatment with corticosteroids and cyclophosphamide in inducing persi...

journal_title：Kidney international

authors： Fernández-Juárez G,Rojas-Rivera J,Logt AV,Justino J,Sevillano A,Caravaca-Fontán F,Ávila A,Rabasco C,Cabello V,Varela A,Díez M,Martín-Reyes G,Diezhandino MG,Quintana LF,Agraz I,Gómez-Martino JR,Cao M,Rodríguez-Moreno A,

更新日期：2020-11-07 00:00:00

abstract：:Crim1 is a cell-surface, transmembrane protein that binds to a variety of cystine knot-containing growth factors, including vascular endothelial growth factor A. In the developing renal glomerulus, Crim1 acts to tether vascular endothelial growth factor A to the podocyte cell surface, thus regulating its release to gl...

journal_title：Kidney international

authors： Wilkinson L,Gilbert T,Sipos A,Toma I,Pennisi DJ,Peti-Peterdi J,Little MH

更新日期：2009-12-01 00:00:00

abstract：:Heterozygous mutations of the tissue-specific transcription factor hepatocyte nuclear factor (HNF)1beta, cause maturity onset diabetes of the young (MODY5) and kidney anomalies including agenesis, hypoplasia, dysplasia and cysts. Because of these renal anomalies, HNF1beta is classified as a CAKUT (congenital anomalies...

journal_title：Kidney international

authors： Dudziak K,Mottalebi N,Senkel S,Edghill EL,Rosengarten S,Roose M,Bingham C,Ellard S,Ryffel GU

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Cardiovascular death continues to be a major problem in renal failure. Structural abnormalities of the heart and the vasculature contribute to the increased cardiovascular risk. They are ameliorated by angiotensin-converting enzyme (ACE) inhibitors, but because of the nonspecifity of ACE inhibition, it is un...

journal_title：Kidney international

authors： Amann K,Gassmann P,Buzello M,Orth SR,Törnig J,Gross ML,Magener A,Mall G,Ritz E

更新日期：2000-07-01 00:00:00

abstract：:Nephropathic cystinosis is a multisystem autosomal recessive disease caused by cystine accumulation, which is usually treated by oral cysteamine. In order to determine long-term effects of this therapy, we enrolled 86 adult patients (mean age 26.7 years) diagnosed with nephropathic cystinosis, 75 of whom received cyst...

journal_title：Kidney international

authors： Brodin-Sartorius A,Tête MJ,Niaudet P,Antignac C,Guest G,Ottolenghi C,Charbit M,Moyse D,Legendre C,Lesavre P,Cochat P,Servais A

更新日期：2012-01-01 00:00:00

abstract：:Levels of components of the classical and alternative complement pathways and the activity of the C3 nephritic factor (C3NeF) were measured in serum specimens from patients with type I (subendothelial deposits) and type II (intramembranous dense deposits) membranoproliferative glomerulonephritis (MPGN) and the results...

journal_title：Kidney international

authors： Ooi YM,Vallota EH,West CD

更新日期：1976-01-01 00:00:00

abstract：:Pain was surveyed via structured interview and the McGill Pain Questionnaire in 53 dialysis and 27 transplant patients. Increased patient control over the dialysis procedure was not associated with a reduction in pain though perceived control may have been. Compliance with the dialysis regimen did not predict pain and...

journal_title：Kidney international

authors： Binik YM,Baker AG,Kalogeropoulos D,Devins GM,Guttmann RD,Hollomby DJ,Barré PE,Hutchison T,Prud'Homme M,McMullen L

更新日期：1982-06-01 00:00:00

abstract：:In uremic patients resistance to the action of insulin has been documented, but it is not known at what stage of renal disease it appears. We therefore examined 29 patients with IgA glomerulonephritis (IgAGN) and 21 patients with adult polycystic kidney disease (ADPKD) in different stages of renal failure, and in addi...

journal_title：Kidney international

authors： Fliser D,Pacini G,Engelleiter R,Kautzky-Willer A,Prager R,Franek E,Ritz E

更新日期：1998-05-01 00:00:00

abstract：:Human mesangial cells (MC) in culture, when stimulated by interleukin 1 alpha(IL-1 alpha) or tumour necrosis factor (TNF alpha), but not with lipopolysaccharide (LPS), express interleukin 8 (IL-8) mRNA, and both cell associated and extracellular IL-8. Dexamethasone treatment of mesangial cells induced partial inhibiti...

journal_title：Kidney international

authors： Brown Z,Strieter RM,Chensue SW,Ceska M,Lindley I,Neild GH,Kunkel SL,Westwick J

更新日期：1991-07-01 00:00:00

abstract：:The renal handling of gentamicin in the rat was examined by clearance, microinjection, and renal cortical-slice techniques. The steady-state renal clearance of 14C-gentamicin, when corrected for the 7.5% binding to plasma protein, was not significantly different from that of 3H-inulin. At the end of the renal clearanc...

journal_title：Kidney international

authors： Pastoriza-Munoz E,Bowman RL,Kaloyanides GJ

更新日期：1979-10-01 00:00:00

abstract：:The Dietary Approaches to Stop Hypertension (DASH) diet lowers blood pressure, an important risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD). However, it is unclear whether adherence to a DASH diet confers protection against future ESRD, especially among those with pre-existing CKD and h...

journal_title：Kidney international

authors： Banerjee T,Crews DC,Tuot DS,Pavkov ME,Burrows NR,Stack AG,Saran R,Bragg-Gresham J,Powe NR,Centers for Disease Control and Prevention Chronic Kidney Disease Surveillance Team.

更新日期：2019-06-01 00:00:00