当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Health-related quality of life predicts outcomes but is not affected by peritoneal clearance: The ADEMEX trial.

Health-related quality of life predicts outcomes but is not affected by peritoneal clearance: The ADEMEX trial.

Abstract：

BACKGROUND:We hypothesized that increasing small solute clearance in peritoneal dialysis (PD) would lead to improvements in patient health-related quality of life (HRQOL). METHODS:Patients were randomized to a control group [standard 4 x 2 L continuous ambulatory peritoneal dialysis (CAPD)] and an intervention group (CAPD with a target creatinine clearance >/=60 L/week/1.73 m(2)). The Kidney Disease Quality of Life Short Form was obtained at baseline and at 6, 12, and 24 months. Physical (PCS), mental (MCS), and kidney disease component summary (KDCS) scores were computed. RESULTS:The two groups were comparable at baseline with respect to HRQOL. Baseline variables highly predictive of better QOL included absence of diabetes, younger age, higher starting GFR, and serum albumin. Baseline values of QOL were highly predictive of survival and hospitalizations. An unadjusted comparison revealed that patients in the intervention group had significantly higher PCS and KDCS scores at six months. However, there were no significant differences between the intervention and control patients at 12 or 24 months. When similar analyses were carried out adjusting for different patterns of patient dropout, there were no significant differences between the two groups at any time point in terms of PCS, MCS, and KDCS scores. CONCLUSION:We found no evidence of a long-term benefit in HRQOL of CAPD patients by increasing peritoneal small-solute clearances when HRQOL parameters were adjusted for patient dropout. Measures of HRQOL have a significant predictive value for patient survival and hospitalizations.

journal_name

Kidney Int

journal_title

Kidney international

authors

Paniagua R,Amato D,Vonesh E,Guo A,Mujais S,Mexican Nephrology Collaborative Study Group.

doi

10.1111/j.1523-1755.2005.00175.x

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

1093-104

issue

3

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)50556-5

journal_volume

67

pub_type

临床试验,杂志文章,随机对照试验

相关文献

KIDNEY INTERNATIONAL文献大全
  • Elevated cysteinyl leukotriene excretion in experimental glomerulonephritis.

    abstract：:The involvement of cysteinyl leukotrienes (LT) in the etiology of glomerulonephritis (GN) was investigated in a rat model of nephrotoxic serum nephritis in which renal function, morphology, LTC4 synthase activity and urinary cysteinyl LT excretion were monitored over seven days. Significant alterations in renal functi...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1994.401

    authors： Petric R,Ford-Hutchinson AW

    更新日期：1994-11-01 00:00:00

  • Oxidation of low density lipoprotein by mesangial cells may promote glomerular injury.

    abstract：:Low density lipoprotein (LDL) deposition and local oxidation play a key role in the pathogenesis of atherosclerosis and may likewise contribute to glomerular injury. These studies were designed to determine whether cultured human mesangial cells oxidize homologous LDL and to compare the effects of unmodified and oxidi...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1994.214

    authors： Wheeler DC,Chana RS,Topley N,Petersen MM,Davies M,Williams JD

    更新日期：1994-06-01 00:00:00

  • Visualization of renal autoregulation in the split hydronephrotic kidney of rats.

    abstract：:The autoregulatory ability of the renal vascular system in the split hydronephrotic kidney was quantitated with intravital microscopy. The luminal diameters of the arcuate and interlobular arteries as well as the afferent and efferent arterioles were measured. Glomerular blood flow was determined by the dual slit tech...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1989.104

    authors： Steinhausen M,Blum M,Fleming JT,Holz FG,Parekh N,Wiegman DL

    更新日期：1989-05-01 00:00:00

  • Calcium channel blockers protect transplant patients from cyclosporine-induced daily renal hypoperfusion.

    abstract：:Renal toxicity, possibly due to vasoconstriction and vascular injury, is the most relevant side-effect of chronic cyclosporine (CsA) therapy given to prevent graft rejection. In kidney transplant recipients each oral dose of CsA is invariably followed by a transient reduction in renal plasma flow (RPF) and glomerular ...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章

    doi：10.1038/ki.1993.101

    authors： Ruggenenti P,Perico N,Mosconi L,Gaspari F,Benigni A,Amuchastegui CS,Bruzzi I,Remuzzi G

    更新日期：1993-03-01 00:00:00

  • Dysregulation of cytokine expression in tubulointerstitial nephritis associated with murine malaria.

    abstract：:We examined the circulating levels of the proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 alpha, IL-6, granulocyte macrophage-colony stimulating factor (GM-CSF), and the anti-inflammatory cytokine IL-10, and their expression in kidneys acutely infected with murine malaria parasite...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.1998.00848.x

    authors： Rui-Mei L,Kara AU,Sinniah R

    更新日期：1998-04-01 00:00:00

  • Erythropoiesis-stimulating agent treatment with full anemia correction: a new perspective.

    abstract：:Erythropoiesis stimulating agent (ESA) treatment has been a major advance in the care of patients with kidney disease, resulting in reduced symptoms and blood transfusions, and improved quality of life. Recent studies, however, have indicated that attempts to treat to near normal Hgb targets may result in increased ri...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/ki.2008.467

    authors： Fishbane S

    更新日期：2009-02-01 00:00:00

  • Regulated necrosis in kidney ischemia-reperfusion injury.

    abstract：:Ischemia-reperfusion injury (IRI) is the outcome of an inflammatory process that is triggered when an organ undergoes a transient reduction or cessation of blood flow, followed by re-establishment of perfusion. In the clinical setting, IRI contributes to significant acute kidney injury, patient morbidity and mortality...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1016/j.kint.2019.02.009

    authors： Pefanis A,Ierino FL,Murphy JM,Cowan PJ

    更新日期：2019-08-01 00:00:00

  • Endothelial bound lipoprotein lipase (LpL) depletion in hypoalbuminemia results from decreased endothelial binding, not decreased secretion.

    abstract：:Hypertriglyceridemia in nephrotic (NS) and Nagase analbuminemic rats (Analb) results from reduced triglyceride clearance. NS and Analb have reduced or absent albumin, reduced plasma oncotic pressure (pi), but Analb lack proteinuria. The heparin releasable lipoprotein lipase (LpL) pool in both models is greatly reduced...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5000318

    authors： Shearer GC,Kaysen GA

    更新日期：2006-08-01 00:00:00

  • Protection from toxicant-mediated renal injury in the rat with anti-CD54 antibody.

    abstract：BACKGROUND:The benefit of the potent chemotherapeutic agent cisplatin in treating neoplasms is limited by nephrotoxicity. We tested the hypothesis that CD54 [intercellular adhesion molecule-1 (ICAM-1)] is an important mediator in cisplatin-mediated renal failure. METHODS:The effect of a monoclonal anti-CD54 antibody w...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00629.x

    authors： Kelly KJ,Meehan SM,Colvin RB,Williams WW,Bonventre JV

    更新日期：1999-09-01 00:00:00

  • Renal anaphylaxis. I. Antigen-initiated responses from isolated perfused rat kidney.

    abstract：:Isolated perfused rat kidneys were passively sensitized by addition of either mouse ascitic fluid containing monoclonal IgE against dinitrophenol (DNP) or DNP-specific purified IgE. After washing the organ, defined doses of DNP-bovine serum albumin were given as bolus injection via the kidney artery. Antigen challenge...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1987.197

    authors： Pirotzky E,Pintos-Morell G,Burtin C,Boudet J,Bidault J,Benveniste J

    更新日期：1987-08-01 00:00:00

  • Differential expression of transforming growth factor-beta isoforms and receptors in experimental membranous nephropathy.

    abstract：:In membranous nephropathy (MN) overproduction of matrix by glomerular epithelial cells (GEC) is believed to be responsible for glomerular basement membrane thickening and spikes. We studied experimental MN in rats (passive Heymann nephritis, PHN) at 5, 10 and 30 days. PHN rats exhibited a marked increase in GEC immuno...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1996.294

    authors： Shankland SJ,Pippin J,Pichler RH,Gordon KL,Friedman S,Gold LI,Johnson RJ,Couser WG

    更新日期：1996-07-01 00:00:00

  • Interaction between variants of two glycosyltransferase genes in IgA nephropathy.

    abstract：:Increasing evidence points to the importance of aberrant O-glycosylated immunoglobulin A1 (IgA1) in the pathogenesis of IgA nephropathy (IgAN), a disease widely considered to be a polygenic disorder. We earlier found that haplotypes in two key glycosyltransferase genes, C1GALT1 and ST6GALNAC2, were associated with sus...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2009.99

    authors： Zhu L,Tang W,Li G,Lv J,Ding J,Yu L,Zhao M,Li Y,Zhang X,Shen Y,Zhang H,Wang H

    更新日期：2009-07-01 00:00:00

  • Thrombin regulates components of the fibrinolytic system in human mesangial cells.

    abstract：:Besides its procoagulant activity, thrombin has been shown to stimulate cell proliferation and to regulate the fibrinolytic pathway. We report here the effect of purified human alpha thrombin on the synthesis of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1) by cultured human me...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1990.297

    authors： Villamediana LM,Rondeau E,He CJ,Medcalf RL,Peraldi MN,Lacave R,Delarue F,Sraer JD

    更新日期：1990-11-01 00:00:00

  • Evidence for the presence of a K-dependent acidifying adenosine triphosphatase in the rabbit renal medulla.

    abstract：:To date direct evidence for the presence of a H-K-ATPase in the medulla comes from proton and potassium transport studies performed on K-restricted animals and K dependent ATP hydrolysis and Rb uptake in both normal and K-depleted animals. The present work examines K-dependent acidification in the medulla of rabbits o...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1992.392

    authors： Curran KA,Hebert MJ,Cain BD,Wingo CS

    更新日期：1992-11-01 00:00:00

  • Potentiation of [Ca2+]i response to angiotensin III by cAMP in cortical thick ascending limb.

    abstract：BACKGROUND:In the rat cortical thick ascending limb (CTAL), intracellular Ca2+ ([Ca2+]i) responses to angiotensin II (Ang II) and angiotensin III (Ang III) were mediated by the Ang II subtype 1A receptor (AT1A-R), whereas the arginine vasopressin (AVP)-dependent cAMP accumulation involved the vasopressin receptor type ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2002.00366.x

    authors： Hus-Citharel A,Marchetti J,Corvol P,Llorens-Cortes C

    更新日期：2002-06-01 00:00:00

  • Alpha-adrenoceptors and angiotensinogen gene expression in opossum kidney cells.

    abstract：:To investigate whether alpha (alpha)-adrenoceptor agonists have a stimulatory effect on the expression of the angiotensinogen (Ang) gene in opossum kidney (OK) cells, we used OK 27 cells with a fusion gene containing the 5'-flanking regulatory sequence of the rat angiotensinogen gene fused with a human growth hormone ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.277

    authors： Wang TT,Lachance S,Delalandre A,Carrière S,Chan JS

    更新日期：1995-07-01 00:00:00

  • Expression of heat shock proteins 47 and 70 in the peritoneum of patients on continuous ambulatory peritoneal dialysis.

    abstract：BACKGROUND:Peritoneal sclerosis, characterized by collagen accumulation, is a serious complication in continuous ambulatory peritoneal dialysis (CAPD) therapy. Heat shock protein 47 (HSP47) is a collagen-specific molecular chaperon and is closely associated with collagen synthesis. METHODS:We determined the expression...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00883.x

    authors： Shioshita K,Miyazaki M,Ozono Y,Abe K,Taura K,Harada T,Koji T,Taguchi T,Kohno S

    更新日期：2000-02-01 00:00:00

  • Furosemide-induced vasodilation: importance of the state of hydration and filtration.

    abstract：:The circumstances under which furosemide increases renal blood flow was examined in mongrel dogs as it may relate to a tubuloglomerular feedback mechanism. Two maneuvers, desoxycorticosterone (DOCA) plus salt treatment and inhibition of tubular fluid flow, were used in the dogs to evaluate the renal vascular effects o...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1980.158

    authors： Gerber JG,Nies AS

    更新日期：1980-10-01 00:00:00

  • Electrophysiological indices of CNS function in hemodialysis and CAPD.

    abstract：:Fourteen Center hemodialysis (CHD) patients, 13 continuous ambulatory peritoneal dialysis (CAPD) patients, and 10 normals matched by group for age and sex were compared using a battery of evoked (EP) and event-related (ERP) brain potential measures to determine the effects on central nervous system (CNS) functioning o...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1986.279

    authors： Marsh JT,Brown WS,Wolcott D,Landsverk J,Nissenson AR

    更新日期：1986-12-01 00:00:00

  • Effect of spironolactone and captopril on nitric oxide and S-nitrosothiol formation in kidney of L-NAME-treated rats.

    abstract：:Although angiotensin-converting enzyme (ACE) inhibitors are well-established drugs in the treatment of hypertension, they are not supposed to be sufficient in the inhibition of aldosterone formation. The present study analyzes the effect of aldosterone receptor antagonist, spironolactone and ACE inhibitor, captopril o...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5001513

    authors： Pechanova O,Matuskova J,Capikova D,Jendekova L,Paulis L,Simko F

    更新日期：2006-07-01 00:00:00

  • Overexpression of complement inhibitor Crry does not prevent cryoglobulin-associated membranoproliferative glomerulonephritis.

    abstract：BACKGROUND:Mice overexpressing thymic stromal lymphopoietin (TSLP) develop mixed cryoglobulinemia with renal disease closely resembling human cryoglobulin-associated membranoproliferative glomerulonephritis (MPGN), including glomerular deposits of immunoglobulins and complement. We assessed the effect of complement inh...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00495.x

    authors： Mühlfeld AS,Segerer S,Hudkins K,Farr AG,Bao L,Kraus D,Holers VM,Quigg RJ,Alpers CE

    更新日期：2004-04-01 00:00:00

  • The online measurement of hemodialysis dose (Kt): clinical outcome as a function of body surface area.

    abstract：BACKGROUND:Recent advances enable the direct measurement of small molecule clearance, Kecn, during each dialysis. Average Kecn and treatment length, t, are multiplied giving total clearance, Kt. The body surface area (BSA) is a fixed transformation of height and weight and is a well recognized measure of body size. Thi...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00533.x

    authors： Lowrie EG,Li Z,Ofsthun N,Lazarus JM

    更新日期：2005-09-01 00:00:00

  • Clinical and genetic predictors of atypical hemolytic uremic syndrome phenotype and outcome.

    abstract：:Atypical hemolytic uremic syndrome (aHUS) is a rare, genetic, life-threatening disease. The Global aHUS Registry collects real-world data on the natural history of the disease. Here we characterize end-stage renal disease (ESRD)-free survival, the rate of thrombotic microangiopathy, organ involvement and the genetic b...

    journal_title：Kidney international

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.kint.2018.02.029

    authors： Schaefer F,Ardissino G,Ariceta G,Fakhouri F,Scully M,Isbel N,Lommelé Å,Kupelian V,Gasteyger C,Greenbaum LA,Johnson S,Ogawa M,Licht C,Vande Walle J,Frémeaux-Bacchi V,Global aHUS Registry.

    更新日期：2018-08-01 00:00:00

  • Rebound kinetics of beta2-microglobulin after hemodialysis.

    abstract：BACKGROUND:Evaluation of beta2-microglobulin (beta2m) removal during hemodialysis using predialysis and immediate postdialysis plasma concentrations is only valid in the absence of postdialysis rebound. Postdialysis rebound of beta2m has not been studied extensively, and its importance in the determination of beta2m cl...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1523-1755.1999.00669.x

    authors： Leypoldt JK,Cheung AK,Deeter RB

    更新日期：1999-10-01 00:00:00

  • Renal adaptation to altered dietary sulfur amino acid intake occurs at luminal brushborder membrane.

    abstract：:The beta-amino acid transport capabilities of rat renal epithelium were assessed using brushborder membrane vesicles (BBMV). Taurine, a metabolically inert sulfur-containing amino acid, was studied with emphasis on the renal adaptation to dietary sulfur amino acid alteration. Three isoproteinic diets were given to Spr...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1983.198

    authors： Chesney RW,Gusowski N,Friedman AL

    更新日期：1983-11-01 00:00:00

  • A clinical study of anti-NDP in the sera of patients in a large repetitive hemodialysis program.

    abstract：:Anti-NDP has been detected in the sera of 38 of 430 patients on regular hemodialysis at the Regional Kidney Disease Program in Minneapolis. It developed in these patients from 7 to 58 months after commencement of dialysis. Bacterial infection appeared temporally related to the development of anti-NDP in 12 patients. H...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1976.133

    authors： Crosson JT,Moulds J,Comty CM,Polesky HF

    更新日期：1976-12-01 00:00:00

  • Increased Na/H antiport activity and abundance in uremic red blood cells.

    abstract：:Alterations in red blood cell sodium (Na) transport have been described in chronic renal failure. This study examines the possible impact of uremia on two ouabain-insensitive pathways, the Na/H antiporter and the Cl-/NaCO3- anion exchanger. The Vmax of Na/H antiporter measured as Na influx driven by outward H gradient...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1993.283

    authors： Corry DB,Tuck ML,Nicholas S,Weinman EJ

    更新日期：1993-09-01 00:00:00

  • Isolation of genes identified in mouse renal proximal tubule by comparing different gene expression profiles.

    abstract：:An expression profile is a list based on a large scale sequencing of 1000 cDNA clones, showing the expressed genes and the abundance of their transcripts in a given cell or tissue (Okubo K et al: Nature Genet 2:173, 1992). We constructed an expression profile of mouse renal proximal tubules (PT) carefully isolated by ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00808.x

    authors： Takenaka M,Imai E,Kaneko T,Ito T,Moriyama T,Yamauchi A,Hori M,Kawamoto S,Okubo K

    更新日期：1998-03-01 00:00:00

  • Proinflammatory gene expression and macrophage recruitment in the rat remnant kidney.

    abstract：BACKGROUND:Macrophage (Mphi) infiltration may contribute to chronic renal injury. We therefore sought to examine the expression of genes associated with Mphi recruitment in the rat remnant kidney model. METHODS:Male Munich Wistar rats underwent 5/6 nephrectomy or sham operation (SHM, N = 18) and received no treatment ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2000.00327.x

    authors： Taal MW,Zandi-Nejad K,Weening B,Shahsafaei A,Kato S,Lee KW,Ziai F,Jiang T,Brenner BM,MacKenzie HS

    更新日期：2000-10-01 00:00:00

  • B-lymphocytes support and regulate indirect T-cell alloreactivity in individual patients with chronic antibody-mediated rejection.

    abstract：:We explored how B-lymphocytes influence in vitro T-cell alloresponses in patients with antibody-mediated rejection (AMR), testing whether B-cells would be preferentially involved in this group of patients. Peripheral blood mononuclear cells were collected from 65 patients having biopsy: 14 patients with AMR and 5 with...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2015.100

    authors： Shiu KY,McLaughlin L,Rebollo-Mesa I,Zhao J,Semik V,Cook HT,Roufosse C,Brookes P,Bowers RW,Galliford J,Taube D,Lechler RI,Hernandez-Fuentes MP,Dorling A

    更新日期：2015-09-01 00:00:00