Regulated necrosis in kidney ischemia-reperfusion injury.

abstract：:Despite the high cardiovascular risk associated with chronic kidney disease, a recent systematic review confirmed that patients with kidney disease remain underrepresented in cardiovascular trials. Two ongoing trials are assessing the risk:benefit of aggressive evaluation and intervention for ischemic heart disease in...

journal_title：Kidney international

authors： Wyatt CM,Shineski M,Chertow GM,Bangalore S

更新日期：2016-06-01 00:00:00

abstract：:We have previously suggested that albumin in tubule fluid at concentrations found in the nephrotic syndrome (NS) binds furosemide, thereby diminishing diuretic effect. This mechanism may contribute to diuretic resistance in NS. If this hypothesis is correct, displacement of albumin from furosemide should restore diure...

journal_title：Kidney international

authors： Kirchner KA,Voelker JR,Brater DC

更新日期：1991-09-01 00:00:00

abstract：:Dopamine plays an important role in regulation of renal sodium transport. Proximal tubule cells produce dopamine after decarboxylation of L-DOPA via the enzyme aromatic L-amino acid decarboxylase (AADC). The presence and cellular localization of AADC-like immunoreactivity (-LI) and AADC mRNA were examined during pre- ...

journal_title：Kidney international

authors： Meister B,Fried G,Holgert H,Aperia A,Hökfelt T

更新日期：1992-09-01 00:00:00

abstract：:Acid (H+) retention appears to contribute to progressive decline in glomerular filtration rate (GFR) in patients with chronic kidney disease (CKD), including some patients without metabolic acidosis. Identification of patients with H+ retention but without metabolic acidosis could facilitate targeted alkali therapy; h...

journal_title：Kidney international

authors： Goraya N,Simoni J,Sager LN,Madias NE,Wesson DE

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:We have previously reported that the serum concentration of 2-(alpha-mannopyranosyl)-L-tryptophan (MPT), tryptophan glycoconjugate, is a more accurate measure of renal function than that of serum creatinine concentration. The aim of the present study was to compare the diagnostic value of serum concentration...

journal_title：Kidney international

authors： Yonemura K,Takahira R,Yonekawa O,Wada N,Hishida A

更新日期：2004-04-01 00:00:00

abstract：:The effects of chronic respiratory alkalosis on divalent ion homeostasis have not been reported in any species. We studied four normal male subjects during a four-day control period (residence at 500 m), during six days of chronic respiratory alkalosis induced by hypobaric hypoxia (residence at 3450 m), followed by a ...

journal_title：Kidney international

authors： Krapf R,Jaeger P,Hulter HN

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Phenylalanine is converted to para- and ortho-tyrosine by hydroxyl free radical, or to para-tyrosine by the phenylalanine hydroxylase enzyme. The aim of this study was to measure para- and ortho-tyrosine in the urine and plasma of patients with chronic renal disease and/or diabetes, to obtain information on ...

journal_title：Kidney international

authors： Molnár GA,Wagner Z,Markó L,Kó Szegi T,Mohás M,Kocsis B,Matus Z,Wagner L,Tamaskó M,Mazák I,Laczy B,Nagy J,Wittmann I

更新日期：2005-11-01 00:00:00

abstract：:The possibility that hypercalciuria could cause calcium stone formation through a mechanism other than by increasing urinary saturation of stone-forming calcium salts was explored. The effect of increasing calcium concentration on the inhibitor activity against the spontaneous precipitation of calcium oxalate was exam...

journal_title：Kidney international

authors： Zerwekh JE,Hwang TI,Poindexter J,Hill K,Wendell G,Pak CY

更新日期：1988-05-01 00:00:00

abstract：:We demonstrate that salts of diatrizoate and iothalamate, radiographic contrast agents, depress the active transport of sodium in the urinary bladder of the Columbian toad, Bufo marinus. Isolated toad bladders were incubated in isotonic Ringer's solutions with isosmolar displacement of sodium chloride by contrast medi...

journal_title：Kidney international

authors： Ziegler TW,Ludens JH,Fanestil DD,Talner LB

更新日期：1975-02-01 00:00:00

abstract：:Although it has been recognized for more than 140 years that the pacemaker driving pyeloureteric peristalsis resides within the kidney, the cellular mechanisms underlying this autorhythmicity have been little investigated. The demonstration by Hurtado et al. of a role of hyperpolarization-activated cation channels in ...

journal_title：Kidney international

authors： Lang RJ

更新日期：2010-03-01 00:00:00

abstract：:Zhang and co-workers report on the renoprotective role of the vitamin D receptor (VDR) in diabetic nephropathy using the method of streptozotocin-induced hyperglycemia in wild-type and VDR(-/-) mice. Also, experiments with cultured mesangial cells and podocytes confirm the effect of the active vitamin D metabolite 1,2...

journal_title：Kidney international

authors： Klaus G

更新日期：2008-01-01 00:00:00

abstract：:Hypertriglyceridemia is the most prevalent lipid alteration in end-stage renal disease, and we studied the relationship between serum triglycerides and all-cause and cardiovascular death in these patients. Since abdominal fat modifies the effect of lipids on atherosclerosis, we analyzed the interaction between serum l...

journal_title：Kidney international

authors： Postorino M,Marino C,Tripepi G,Zoccali C,CREDIT Working Group.

更新日期：2011-04-01 00:00:00

abstract：:Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor, fibroblast growth factor-inducible 14 (TWEAK-Fn14), are widely expressed and are involved in both injury and repair. Hotta et al. now demonstrate an important role for Fn14 in the common clamp ischemia model of acute kidney injury. Their da...

journal_title：Kidney international

authors： Weinberg JM

更新日期：2011-01-01 00:00:00

abstract：:Intravascular hemolysis is relatively rare but can lead to acute kidney injury (AKI), from increased destruction of erythrocytes and release of free hemoglobin. Since hemolysis and hemoglobinuria are known causes of acute kidney injury we sought to define clinicopathologic findings and outcomes of patients with hemoly...

journal_title：Kidney international

authors： Dvanajscak Z,Walker PD,Cossey LN,Messias NC,Boils CL,Kuperman MB,Larsen CP

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Mice overexpressing thymic stromal lymphopoietin (TSLP) develop mixed cryoglobulinemia with renal disease closely resembling human cryoglobulin-associated membranoproliferative glomerulonephritis (MPGN), including glomerular deposits of immunoglobulins and complement. We assessed the effect of complement inh...

journal_title：Kidney international

authors： Mühlfeld AS,Segerer S,Hudkins K,Farr AG,Bao L,Kraus D,Holers VM,Quigg RJ,Alpers CE

更新日期：2004-04-01 00:00:00

abstract：:IgA nephropathy (IgAN) often shows lesions morphologically identical with those of focal segmental glomerulosclerosis (FSGS). In order to determine the possible role of FSGS in IgAN lesions, we measured glomerular capsular adhesions, often the first step toward FSGS, in biopsies from 127 patients with IgAN, 100 with l...

journal_title：Kidney international

authors： Hill GS,Karoui KE,Karras A,Mandet C,Van Huyen JD,Nochy D,Bruneval P

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Controversy exists regarding the possible associations between a single nucleotide polymorphism of the transcobalamin II encoding gene (TCN2 776C>G) and plasma levels of vitamin B(12), folate, or total homocysteine. METHODS:In a cross-sectional study of 732 kidney allograft recipients, patients were categor...

journal_title：Kidney international

authors： Winkelmayer WC,Skoupy S,Eberle C,Födinger M,Sunder-Plassmann G

更新日期：2004-05-01 00:00:00

abstract：:To analyze the role of clusterin in renal diseases involving a regenerative process, we have used a novel rodent model to compare temporal and spatial expression of clusterin mRNA. Thus, renal artery stenosis was used to induce unilateral non-infarctive renal atrophy. After several weeks, when cellular pathology of at...

journal_title：Kidney international

authors： Gobé GC,Buttyan R,Wyburn KR,Etheridge MR,Smith PJ

更新日期：1995-02-01 00:00:00

abstract：UNLABELLED:Expression of apoptosis regulatory genes in chronic cyclosporine nephrotoxicity favors apoptosis. BACKGROUND:Chronic cyclosporine (CsA) nephrotoxicity is characterized by interstitial fibrosis, tubular dropout, and loss of cellularity in areas of fibrosis. Apoptosis was found to play a role in CsA-induced f...

journal_title：Kidney international

authors： Shihab FS,Andoh TF,Tanner AM,Yi H,Bennett WM

更新日期：1999-12-01 00:00:00

abstract：:Screening for chronic kidney disease is recommended in people at high risk, but data on the independent and combined associations of estimated glomerular filtration rate (eGFR) and albuminuria with all-cause and cardiovascular mortality are limited. To clarify this, we performed a collaborative meta-analysis of 10 coh...

journal_title：Kidney international

authors： van der Velde M,Matsushita K,Coresh J,Astor BC,Woodward M,Levey A,de Jong P,Gansevoort RT,Chronic Kidney Disease Prognosis Consortium.,van der Velde M,Matsushita K,Coresh J,Astor BC,Woodward M,Levey AS,de Jong PE,Gansevoo

更新日期：2011-06-01 00:00:00

abstract：:To investigate whether the administration of cimetidine can improve the reliability of creatinine as a marker of GFR, we compared the creatinine clearance (CCr) to the clearance of the true filtration markers 51Cr-EDTA (CEDTA) and inulin (CIn), after oral ingestion of cimetidine in 10 healthy men and 29 patients with ...

journal_title：Kidney international

authors： Hilbrands LB,Artz MA,Wetzels JF,Koene RA

更新日期：1991-12-01 00:00:00

abstract：:Albuminuria and a reduced glomerular filtration rate are conventional predictors of a future decline in kidney function in patients with type 2 diabetes mellitus. Using a nested case-control study we assessed whether circulating transforming growth factor-β1 (TGF-β1) and bone morphogenetic protein-7 (BMP-7) levels mor...

journal_title：Kidney international

authors： Wong MG,Perkovic V,Woodward M,Chalmers J,Li Q,Hillis GS,Yaghobian Azari D,Jun M,Poulter N,Hamet P,Williams B,Neal B,Mancia G,Cooper M,Pollock CA

更新日期：2013-02-01 00:00:00

abstract：:Long-term (5 years) treatment of 20 growth-retarded pre-pubertal children with chronic renal insufficiency (CRI) led to a significant (P < 0.00005) improvement in standardized height from -2.6 at baseline to -0.7 at five years. Eight patients were paused after reaching target height (50th centile midparental height) a...

journal_title：Kidney international

authors： Fine RN,Kohaut E,Brown D,Kuntze J,Attie KM

更新日期：1996-03-01 00:00:00

abstract：:Innate lymphoid cells are a recently recognized group of immune cells with critical roles in tissue homeostasis and inflammation. Regulatory innate lymphoid cells are a newly identified subset of innate lymphoid cells, which play a suppressive role in the innate immune response, favoring the resolution of intestinal i...

journal_title：Kidney international

authors： Cao Q,Wang R,Wang Y,Niu Z,Chen T,Wang C,Jin L,Huang Q,Li Q,Wang XM,Azmi F,Lee VWS,Wang YM,Zheng G,Alexander SI,Harris DCH

更新日期：2020-01-01 00:00:00

abstract：:Intravital multiphoton microscopy is a powerful tool to study kidney physiology in living animals. However, certain technical issues have curbed its usage to date, including limited depth of tissue penetration and high background emission of endogenous signals. Most previous studies have used the excitation range 700–...

journal_title：Kidney international

authors： Schuh CD,Haenni D,Craigie E,Ziegler U,Weber B,Devuyst O,Hall AM

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Guidelines for treating anemia in dialysis patients accept, as high-end range of serum ferritin useful to optimize erythropoietin therapy, values high as 500 to 900 microg/L, on the hypothesis that ferritin might be not representative of iron overload. METHODS:A superconducting quantum interference device (...

journal_title：Kidney international

authors： Canavese C,Bergamo D,Ciccone G,Longo F,Fop F,Thea A,Martina G,Piga A

更新日期：2004-03-01 00:00:00

abstract：:Ischemia-reperfusion injury is an important cause of graft failure. Because carnitine regulates substrate flux and energy balance across membranes which may be deranged in ischemia we determined whether its use was effective in preventing kidney injury in an allogeneic transplant model. Brown Norway rats received a Le...

journal_title：Kidney international

authors： Azzollini N,Cugini D,Cassis P,Pezzotta A,Gagliardini E,Abbate M,Arduini A,Peschechera A,Remuzzi G,Noris M

更新日期：2008-12-01 00:00:00

abstract：:Circulating donor-reactive effector memory T cells have been associated with allograft injury in humans. The next step to translate this observation into clinical practice is the design of clinical trials aimed at individualization of T cell-targeted therapy. The administration of immunosuppressive therapy based on th...

journal_title：Kidney international

authors： Poggio ED,Augustine JJ

更新日期：2013-12-01 00:00:00

abstract：:Eight patients with chronic renal failure (GFR 18.8 +/- 2.7 ml/min) were randomized to a crossover comparison of a very low protein diet (VLPD) containing 0.28 g protein and 35 kcal per kg per day, plus an isosmolar mixture of either ketoacids (KA) or essential amino acids (EAA). Subjects initiated the diets 14 days b...

journal_title：Kidney international

authors： Masud T,Young VR,Chapman T,Maroni BJ

更新日期：1994-04-01 00:00:00

abstract：:In landmark clinical trials, pharmacological inhibition of the renin-angiotensin system (RAS) with angiotensin-converting enzyme inhibitors (ACEIs) attenuated the decline in renal function associated with chronic renal disease (CRD). Hemodynamic and nonhemodynamic effects of angiotensin II (Ang II) attest to its centr...

journal_title：Kidney international

authors： Taal MW,Brenner BM

更新日期：2000-05-01 00:00:00