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Role of hyperpolarization-activated cation channels in pyeloureteric peristalsis.

Abstract：

:Although it has been recognized for more than 140 years that the pacemaker driving pyeloureteric peristalsis resides within the kidney, the cellular mechanisms underlying this autorhythmicity have been little investigated. The demonstration by Hurtado et al. of a role of hyperpolarization-activated cation channels in the maintenance of coordinated propagating contractions in the mouse renal pelvis raises a number of intriguing possibilities in addition to the provided correlation with 'pacemaker' function as in the heart and neurons.

journal_name

Kidney Int

journal_title

Kidney international

authors

Lang RJ

doi

10.1038/ki.2009.485

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

483-5

issue

6

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)54292-0

journal_volume

77

pub_type

评论,杂志文章

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