Short-term vitamin D receptor activation increases serum creatinine due to increased production with no effect on the glomerular filtration rate.

Abstract:

:Vitamin D receptor activation has been associated with increased serum creatinine and reduced estimated glomerular filtration rates, raising concerns that its use may be detrimental to kidney function. Here we studied the effect of vitamin D receptor activation on serum creatinine, creatinine generation, and its clearance. We measured baseline serum creatinine and 24-h urine creatinine in 16 patients with chronic kidney disease. The measurements were repeated every day for 7 days, during which time the patients received 2 μg paricalcitol, an orally active vitamin D receptor activator, every morning. At 4 days after stopping the vitamin analog, measurements were continued for 3 days. Geometric mean parathyroid hormone levels decreased from 77 pg/ml at baseline to 43 pg/ml at the end of treatment and significantly rebounded to 87 pg/ml following paricalcitol withdrawal, thereby supporting the biological efficacy of the analog dose used. With this therapy, the serum creatinine significantly increased at a rate of 0.010 mg/dl/day and urine creatinine at a rate of 17.6 mg/day. Creatinine and iothalamate clearances did not change, whereas urine albumin decreased insignificantly. Thus, short-term vitamin D receptor activation increases creatinine generation and serum creatinine, but it does not influence the glomerular filtration rate.

journal_name

Kidney Int

journal_title

Kidney international

authors

Agarwal R,Hynson JE,Hecht TJ,Light RP,Sinha AD

doi

10.1038/ki.2011.207

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

1073-9

issue

10

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)54946-6

journal_volume

80

pub_type

临床试验,杂志文章
  • Formaldehyde kinetics and bacteriology in dialyzers.

    abstract::The kinetics of formaldehyde washout in new and reused dialyzers with 2% (w/v) and 4% formaldehyde solution was studied. Using a standard method of rinsing, the concentration of formaldehyde decreases exponentially, but the rate of decrease and the steady-state level depends on the type of dialyzer. The residual quant...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1985.221

    authors: Hakim RM,Friedrich RA,Lowrie EG

    更新日期:1985-12-01 00:00:00

  • Renoprotection with vitamin D: specific for diabetic nephropathy?

    abstract::Zhang and co-workers report on the renoprotective role of the vitamin D receptor (VDR) in diabetic nephropathy using the method of streptozotocin-induced hyperglycemia in wild-type and VDR(-/-) mice. Also, experiments with cultured mesangial cells and podocytes confirm the effect of the active vitamin D metabolite 1,2...

    journal_title:Kidney international

    pub_type: 评论,杂志文章

    doi:10.1038/sj.ki.5002693

    authors: Klaus G

    更新日期:2008-01-01 00:00:00

  • Single-cell RNA-sequence analysis of mouse glomerular mesangial cells uncovers mesangial cell essential genes.

    abstract::Mesangial cells are essential for the structure and function of glomeruli, but the mechanisms underlying these roles are not well understood. Here, we performed a single-cell RNA-sequence (RNA-seq) analysis of mouse mesangial cells using the Fluidigm C1 platform. We found that gene expression in individual mesangial c...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1016/j.kint.2017.01.016

    authors: Lu Y,Ye Y,Yang Q,Shi S

    更新日期:2017-08-01 00:00:00

  • Presence of an anti-viral factor in peritoneal dialysis effluent.

    abstract::Viral peritonitis is an exceptionally rare occurrence in peritoneal dialysis. In fact, up to now, only one case report has been documented in the literature. In a prospective study, peritoneal dialysis effluent (PDE) was specifically cultured for the following viruses: the herpes group of viruses, including herpes sim...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1989.191

    authors: Pomeranz A,Korzets Z,Smetana O,Yuhas Y,Elan I,Bernheim J

    更新日期:1989-08-01 00:00:00

  • 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose reduces renal crystallization and oxidative stress in a hyperoxaluric rat model.

    abstract::Adhesion of calcium oxalate (CaOx) crystals to kidney cells may be a key event in the pathogenesis of kidney stones associated with marked hyperoxaluria. Previously, we found that 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG), isolated from a traditional medicinal herb, reduced CaOx crystal adhesion to renal epithelial ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.2010.458

    authors: Lee HJ,Jeong SJ,Lee HJ,Lee EO,Bae H,Lieske JC,Kim SH

    更新日期:2011-03-01 00:00:00

  • The intensity of acidosis differentially alters the pathways of ammoniagenesis in LLC-PK1 cells.

    abstract::Utilizing [5-15N] and [2-15N]-labeled glutamine and gas chromatography mass spectrometry methodology, we examined the pathways of ammoniagenesis under basal and acute acidotic conditions of pH 7.0 and pH 6.8, respectively. LLC-PK1 cultures were incubated for one hour with gentle rocking in a bicarbonate buffer of pH 7...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1994.137

    authors: Nissim I,Sahai A,Sandler RS,Tannen RL

    更新日期:1994-04-01 00:00:00

  • Increased Na/H antiport activity and abundance in uremic red blood cells.

    abstract::Alterations in red blood cell sodium (Na) transport have been described in chronic renal failure. This study examines the possible impact of uremia on two ouabain-insensitive pathways, the Na/H antiporter and the Cl-/NaCO3- anion exchanger. The Vmax of Na/H antiporter measured as Na influx driven by outward H gradient...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1993.283

    authors: Corry DB,Tuck ML,Nicholas S,Weinman EJ

    更新日期:1993-09-01 00:00:00

  • Oxalate ions and calcium oxalate crystals stimulate MCP-1 expression by renal epithelial cells.

    abstract:BACKGROUND:Crystals of calcium oxalate monohydrate (COM) and excess oxalate ions (OX) stimulate an array of responses inducing localized injury and inflammation in the kidneys. These inflammatory responses are key regulators of development of nephrolithiasis. We propose that monocyte chemoattractant protein-1 (MCP-1), ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.2002.00106.x

    authors: Umekawa T,Chegini N,Khan SR

    更新日期:2002-01-01 00:00:00

  • Renal vascular sclerosis is associated with inherited thrombophilias.

    abstract::Vascular sclerosis is often seen in renal biopsies. It is usually associated with diabetes mellitus, hypertension, smoking, etc. However, whether inherited thrombophilic states such as factor V gene mutation, prothrombin gene mutation, and methylenetetrahydrofolate reductase (MTHFR) gene mutation are associated with t...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/sj.ki.5001551

    authors: Goforth RL,Rennke H,Sethi S

    更新日期:2006-08-01 00:00:00

  • Impaired monocyte CD11b expression in interstitial inflammation in hemodialysis patients.

    abstract:BACKGROUND:It is not known to what extent intravascular phenotypic alterations in adhesion molecule expression induced by hemodialysis influence the recruitment of monocytes and their ability to up-regulate CD11b at the local site of inflammation in the interstitium. Using a skin suction chamber technique, we addressed...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.2000.00060.x

    authors: Thylén P,Lundahl J,Fernvik E,Grönneberg R,Halldén G,Jacobson SH

    更新日期:2000-05-01 00:00:00

  • Thrombin regulates components of the fibrinolytic system in human mesangial cells.

    abstract::Besides its procoagulant activity, thrombin has been shown to stimulate cell proliferation and to regulate the fibrinolytic pathway. We report here the effect of purified human alpha thrombin on the synthesis of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1) by cultured human me...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1990.297

    authors: Villamediana LM,Rondeau E,He CJ,Medcalf RL,Peraldi MN,Lacave R,Delarue F,Sraer JD

    更新日期:1990-11-01 00:00:00

  • KIM-1 expression in kidney allograft biopsies: Improving the gold standard.

    abstract::Long-term outcomes of kidney allografts have shown only marginal improvement over the last three decades, despite the remarkable improvement in acute rejection and one-year graft survival. Novel biomarkers of tubular injury may prevent irreversible damage to the tubulointerstitial compartment and improve allograft sur...

    journal_title:Kidney international

    pub_type: 评论,杂志文章

    doi:10.1038/sj.ki.5002772

    authors: Abulezz S

    更新日期:2008-03-01 00:00:00

  • Meprin, a brush-border enzyme, plays an important role in hypoxic/ischemic acute renal tubular injury in rats.

    abstract:BACKGROUND:It has been shown that non-congenic mice strains with lower levels of renal meprin develop less renal injury following renal ischemia and reperfusion. We have demonstrated that following ischemia-reperfusion renal injury, there is a rapid shift of meprin localization and intensity from the brush border to th...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.2002.00209.x

    authors: Carmago S,Shah SV,Walker PD

    更新日期:2002-03-01 00:00:00

  • Evaluation of renal Kt/V as a marker of renal function in predialysis patients.

    abstract:BACKGROUND:The use of renal Kt/V (r-Kt/V) as an indicator for the need of dialysis initiation has been recommended in the NKF-DOQI guidelines. In analogy to clinical practice in peritoneal dialysis, a fall of r-Kt/V below a threshold of 2.0 per week may indicate inadequate renal toxin elimination. However, there are no...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.2001.00957.x

    authors: Kuhlmann MK,Heckmann M,Riegel W,Köhler H

    更新日期:2001-10-01 00:00:00

  • Demonstration of plasma proteinase inhibitors in beta 2-microglobulin amyloid deposits.

    abstract::beta 2-microglobulin-related amyloidosis (A beta 2M) represents a frequent complication in long-term dialysis patients. Although the pathogenetic mechanism has yet to be fully understood, it is known that amyloid fibrils usually consist of intact molecules of beta 2-microglobulin (beta 2m). Plasma proteinase inhibitor...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1992.368

    authors: Campistol JM,Shirahama T,Abraham CR,Rodgers OG,Solé M,Cohen AS,Skinner M

    更新日期:1992-10-01 00:00:00

  • Inhibition of active sodium transport by radiographic contrast media.

    abstract::We demonstrate that salts of diatrizoate and iothalamate, radiographic contrast agents, depress the active transport of sodium in the urinary bladder of the Columbian toad, Bufo marinus. Isolated toad bladders were incubated in isotonic Ringer's solutions with isosmolar displacement of sodium chloride by contrast medi...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1975.11

    authors: Ziegler TW,Ludens JH,Fanestil DD,Talner LB

    更新日期:1975-02-01 00:00:00

  • Direct involvement of the receptor-mediated apoptotic pathways in cisplatin-induced renal tubular cell death.

    abstract:BACKGROUND:Tumor necrosis factor (TNF) receptor family members, such as Fas and TNF receptor 1 (TNFR1), are thought to induce apoptosis in a variety of cells and organs. Although a number of potential scenarios have been postulated for the involvement of these receptors in the pathogenesis of acute renal failure (ARF),...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.2003.00709.x

    authors: Tsuruya K,Ninomiya T,Tokumoto M,Hirakawa M,Masutani K,Taniguchi M,Fukuda K,Kanai H,Kishihara K,Hirakata H,Iida M

    更新日期:2003-01-01 00:00:00

  • Renal involvement in von Hippel-Lindau disease.

    abstract::Renal involvement in von Hippel-Lindau (VHL) disease has emerged as the most prevalent cause of death in this hereditary disorder. In a group of 43 VHL patients (23 unrelated families) with renal lesions we examined whether severity of renal disease is affected by parental inheritance and VHL subtype (1, without pheoc...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1996.395

    authors: Chauveau D,Duvic C,Chrétien Y,Paraf F,Droz D,Melki P,Hélénon O,Richard S,Grünfeld JP

    更新日期:1996-09-01 00:00:00

  • Quartan malarial nephrotic syndrome in children.

    abstract::Quartan malarial infection causes an immune complex nephritis in some individuals, which, once established, is sustained by mechanisms not yet fully explained, but which probably involve autoimmune processes. The presenting clinical and biochemical findings of the quartan malarial nephrotic syndrome are similar to tho...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1979.103

    authors: Hendrickse RG,Adeniyi A

    更新日期:1979-07-01 00:00:00

  • Alloreactive T cells and 'the persistence of memory'.

    abstract::Circulating donor-reactive effector memory T cells have been associated with allograft injury in humans. The next step to translate this observation into clinical practice is the design of clinical trials aimed at individualization of T cell-targeted therapy. The administration of immunosuppressive therapy based on th...

    journal_title:Kidney international

    pub_type: 评论,杂志文章

    doi:10.1038/ki.2013.295

    authors: Poggio ED,Augustine JJ

    更新日期:2013-12-01 00:00:00

  • Pathophysiological aspects of edema formation in diabetic nephropathy.

    abstract::The present study was undertaken to evaluate some pathophysiological mechanisms of edema formation in diabetic nephropathy. Sixty-three subjects were investigated: 9 normal subjects (I), 9 normoalbuminuric Type 1 (insulin-dependent) diabetic patients (II), 15 microalbuminuric Type 1 diabetic patients (III), 16 Type 1 ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1990.332

    authors: Hommel E,Mathiesen ER,Aukland K,Parving HH

    更新日期:1990-12-01 00:00:00

  • Modulation of growth factors by growth hormone in children with chronic renal failure. The Southwest Pediatric Nephrology Study Group.

    abstract::Anthropometric measurements and circulating growth factors were studied serially in 44 prepubertal children with growth failure and chronic renal failure (GFR = 10 to 40 ml/min/1.73 m2) who were randomized to receive either recombinant human growth hormone (rhGH; N = 30) or no treatment (N = 14). RhGH was given as Nut...

    journal_title:Kidney international

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1038/ki.1997.268

    authors: Powell DR,Liu F,Baker BK,Hintz RL,Lee PD,Durham SK,Brewer ED,Frane JW,Watkins SL,Hogg RJ

    更新日期:1997-06-01 00:00:00

  • Biocompatible peritoneal dialysis solutions: many questions but few answers.

    abstract::The clinical value of biocompatible peritoneal dialysis solutions is uncertain because of inconsistent findings in randomized controlled trials. A systematic review by Cho et al. examining 20 such trials suggests a beneficial effect on residual renal function. However, the finding is not robust and may relate to decre...

    journal_title:Kidney international

    pub_type: 评论,杂志文章

    doi:10.1038/ki.2013.303

    authors: Blake PG,Jain AK,Yohanna S

    更新日期:2013-11-01 00:00:00

  • EOS789, a novel pan-phosphate transporter inhibitor, is effective for the treatment of chronic kidney disease-mineral bone disorder.

    abstract::Chronic kidney disease is characterized as impaired renal function along with the imbalance and dysregulation of mineral metabolism; recognized as chronic kidney disease-mineral and bone disorder. Hyperphosphatemia, characterized by altered phosphate homeostasis along with elevated fibroblast growth factor-23 and inta...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1016/j.kint.2020.02.040

    authors: Tsuboi Y,Ohtomo S,Ichida Y,Hagita H,Ozawa K,Iida M,Nagao S,Ikegami H,Takahashi T,Horiba N

    更新日期:2020-08-01 00:00:00

  • "Biomarking" the transition from genetic risk to kidney disease.

    abstract::Only some individuals carrying the high-risk APOL1 genotype go on to develop kidney disease phenotypes. In this issue of Kidney International, Nadkarni and colleagues report the associations of several biomarkers with renal outcomes in individuals with high-risk APOL1 genotypes. In the era of precision medicine, these...

    journal_title:Kidney international

    pub_type: 评论,杂志文章

    doi:10.1016/j.kint.2018.03.005

    authors: Kruzel-Davila E,Skorecki K

    更新日期:2018-06-01 00:00:00

  • TGF-beta 1 dissociates human proximal tubule cell growth and Na(+)-H+ exchange activity.

    abstract::Stimulation of proximal tubule cell (PTC) growth in a variety of physiological and pathological renal conditions is preceded by increased renal production of transforming growth factor-beta 1 (TGF-beta 1) and by augmented tubular sodium transport via activated sodium hydrogen exchange (NHE). Since TGF-beta 1 has been ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.1998.00916.x

    authors: Johnson DW,Saunders HJ,Brew BK,Poronnik P,Cook DI,Field MJ,Pollock CA

    更新日期:1998-06-01 00:00:00

  • Blockade of Angiotensin II type-1 receptor reduces oxidative stress in adipose tissue and ameliorates adipocytokine dysregulation.

    abstract::Dysregulated production of adipocytokines may be involved in the development of atherosclerotic cardiovascular disease in metabolic syndrome and chronic kidney disease (CKD) associated with metabolic syndrome. The aim of this study was to determine the effects of treatment with angiotensin II (Ang II) type-1 receptor ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/sj.ki.5001810

    authors: Kurata A,Nishizawa H,Kihara S,Maeda N,Sonoda M,Okada T,Ohashi K,Hibuse T,Fujita K,Yasui A,Hiuge A,Kumada M,Kuriyama H,Shimomura I,Funahashi T

    更新日期:2006-11-01 00:00:00

  • Apoptosis and necrosis: mechanisms of cell death induced by cyclosporine A in a renal proximal tubular cell line.

    abstract:BACKGROUND:The mechanisms of cyclosporine (CsA)-induced nephrotoxicity are not fully understood. While hemodynamic changes may be involved in vivo, there is also some evidence for tubular involvement. We previously showed direct toxicity of CsA in the LLC-PK1 renal tubular cell line. In the current study we examined me...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.1998.00202.x

    authors: Healy E,Dempsey M,Lally C,Ryan MP

    更新日期:1998-12-01 00:00:00

  • Circulating immune complexes in membranoproliferative glomerulonephritis.

    abstract::Circulating immune complexes (CIC), measured by the solid-phase Clq method, were found to be in abnormal concentration in about half of 39 patients with membranoproliferative glomerulonephritis (MPGN). In contrast, they were present, usually in higher concentration, in nearly all patients with active lupus nephritis. ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1981.203

    authors: Davis CA,Marder H,West CD

    更新日期:1981-12-01 00:00:00

  • Effects of C-peptide on glomerular and renal size and renal function in diabetic rats.

    abstract:BACKGROUND:Strict glycemic control and antihypertensive treatment may decrease but not eliminate the risk of progressive nephropathy in diabetic patients. C-peptide has been shown to exert beneficial effects on complications, including incipient nephropathy, in type 1 diabetes. METHODS:Renal effects of 14 days of intr...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.2001.00964.x

    authors: Samnegård B,Jacobson SH,Jaremko G,Johansson BL,Sjöquist M

    更新日期:2001-10-01 00:00:00