The paracellular permeability of opossum kidney cells, a proximal tubule cell line.

abstract：BACKGROUND:Inhibition of angiotensin action, pharmacologically or genetically, during the neonatal period leads to renal anomalies involving hypoplastic papilla and dilated calyx. Recently, we documented that angiotensinogen (Agt -/-) or angiotensin type 1 receptor nullizygotes (Agtr1 -/-) do not develop renal pelvis n...

journal_title：Kidney international

authors： Miyazaki Y,Tsuchida S,Fogo A,Ichikawa I

更新日期：1999-05-01 00:00:00

abstract：:Isolated perfused rat kidneys were passively sensitized by addition of either mouse ascitic fluid containing monoclonal IgE against dinitrophenol (DNP) or DNP-specific purified IgE. After washing the organ, defined doses of DNP-bovine serum albumin were given as bolus injection via the kidney artery. Antigen challenge...

journal_title：Kidney international

authors： Pirotzky E,Pintos-Morell G,Burtin C,Boudet J,Bidault J,Benveniste J

更新日期：1987-08-01 00:00:00

abstract：:The binding of albumin to the glomerular capillary wall was studied using albumin-gold in perfused kidneys, the interaction of [3H]albumin with isolated glomeruli at 37 degrees C and 4 degrees C and the interaction at [3H]albumin with purified basement membrane. The albumin-gold was found to bind predominantly to the ...

journal_title：Kidney international

authors： Adal Y,Smit MF,Osicka TM,Comper WD

更新日期：1995-04-01 00:00:00

abstract：:Acute kidney injury (AKI) following cardiac surgery is closely interrelated with hemodynamic instability and sympathetic activity, and adversely influences prognosis. Here, we investigated in a randomized placebo-controlled trial whether dexmedetomidine, an α2 adrenoreceptor agonist, could prevent AKI after valvular h...

journal_title：Kidney international

authors： Cho JS,Shim JK,Soh S,Kim MK,Kwak YL

更新日期：2016-03-01 00:00:00

abstract：:In a double-blind, randomized, placebo-controlled cross-over study, we investigated in seven patients with chronic renal failure the effect of conjugated estrogens (0.6 mg/kg/day for 5 days) on template bleeding time and on thromboxane A2 (TxA2), beta-thromboglobulin (beta-TG) and prostacyclin (PGI2) concentrations in...

journal_title：Kidney international

authors： Heistinger M,Stockenhuber F,Schneider B,Pabinger I,Brenner B,Wagner B,Balcke P,Lechner K,Kyrle PA

更新日期：1990-12-01 00:00:00

abstract：:Hyperinsulinemia can contribute to hypertension through effects on sodium transport. To test whether the stimulatory effect of insulin on renal proximal tubule sodium transport is preserved in insulin resistance, we compared the effects of insulin on abdominal adipocytes and proximal tubules in rats and humans. Insuli...

journal_title：Kidney international

authors： Nakamura M,Yamazaki O,Shirai A,Horita S,Satoh N,Suzuki M,Hamasaki Y,Noiri E,Kume H,Enomoto Y,Homma Y,Seki G

更新日期：2015-03-01 00:00:00

abstract：:Mice chronically infected with the virus of lymphocytic choriomeningitis (LCM) develop immune complex glomerulonephritis. Others have shown that adoptive immunization of these mice by the i.p. injection of syngeneic immune spleen cells terminates the chronic viral carrier state. The present studies were designed to de...

journal_title：Kidney international

authors： Hoffsten PE,Villalobos R,Hill C,Klahr S

更新日期：1977-05-01 00:00:00

abstract：:Chronic kidney disease is characterized as impaired renal function along with the imbalance and dysregulation of mineral metabolism; recognized as chronic kidney disease-mineral and bone disorder. Hyperphosphatemia, characterized by altered phosphate homeostasis along with elevated fibroblast growth factor-23 and inta...

journal_title：Kidney international

authors： Tsuboi Y,Ohtomo S,Ichida Y,Hagita H,Ozawa K,Iida M,Nagao S,Ikegami H,Takahashi T,Horiba N

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Renal anemia is an important determinant for left ventricular hypertrophy in dialysis patients and an independent prognosis parameter for the cardiovascular survival in dialysis patients. In addition, an autonomic dysfunction is associated with the uremic state and influences the cardiovascular risk in patie...

journal_title：Kidney international

authors： Frank H,Heusser K,Höffken B,Huber P,Schmieder RE,Schobel HP

更新日期：2004-08-01 00:00:00

abstract：:Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a recently described member of the epidermal growth factor (EGF) family. It binds to heparan sulfate proteoglycans via a cationic domain and is a potent mitogen for epithelial cells, fibroblasts and vascular smooth muscle cells. In the present stud...

journal_title：Kidney international

authors： Paizis K,Kirkland G,Polihronis M,Katerelos M,Kanellis J,Power DA

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Little information is available regarding cardiac morbidity and mortality in children with end-stage renal disease. We sought to determine the incidence of cardiac morbidity and mortality in pediatric chronic dialysis patients. METHODS:Medicare incident pediatric (0 to 19 years) dialysis patients from 1991 ...

journal_title：Kidney international

authors： Chavers BM,Li S,Collins AJ,Herzog CA

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:It is not known whether angiotensin-converting-enzyme (ACE) inhibitors slow the progression of polycystic kidney disease (PKD). We performed a patient-level meta-analysis to compare the effect of antihypertensive regimens, including ACE inhibitors, to those without ACE inhibitors (controls) on kidney disease...

journal_title：Kidney international

authors： Jafar TH,Stark PC,Schmid CH,Strandgaard S,Kamper AL,Maschio G,Becker G,Perrone RD,Levey AS,ACE Inhibition in Progressive Renal Disease (AIPRD) Study Group.

更新日期：2005-01-01 00:00:00

abstract：:In this retrospective study, we analyzed clinical laboratory, and pathologic variables to determine their value in predicting survival and survival free of renal failure for 170 consecutive patients with idiopathic renal vasculitis and glomerulonephritis evaluated during a 15 year period. Of the 170 patients, 108 had ...

journal_title：Kidney international

authors： Wilkowski MJ,Velosa JA,Holley KE,Offord KP,Chu CP,Torres VE,McCarthy JT,Donadio JV Jr,Wagoner RD

更新日期：1989-12-01 00:00:00

abstract：:The clinical value of biocompatible peritoneal dialysis solutions is uncertain because of inconsistent findings in randomized controlled trials. A systematic review by Cho et al. examining 20 such trials suggests a beneficial effect on residual renal function. However, the finding is not robust and may relate to decre...

journal_title：Kidney international

authors： Blake PG,Jain AK,Yohanna S

更新日期：2013-11-01 00:00:00

abstract：:Obesity has been suggested to have a detrimental impact on kidney structure and function, leading to focal glomerulosclerosis and hypertension. It is also associated with hyperleptinemia and elevated renal sympathetic nerve activity. Prenatal undernutrition promotes postnatal obesity, hypertension, and an altered rena...

journal_title：Kidney international

authors： Williams PJ,Kurlak LO,Perkins AC,Budge H,Stephenson T,Keisler D,Symonds ME,Gardner DS

更新日期：2007-08-01 00:00:00

abstract：:The renal effects of a single intravenous dose of two different E. coli lipopolysaccharides (LPS 0111:B4 and LPS 0127:B8), at the same dose of 100 micrograms/kg, were evaluated in euvolemic Munich-Wistar (MW) rats by whole kidney clearance techniques and micropuncture studies. Following LPS infusion, a significant dec...

journal_title：Kidney international

authors： Lugon JR,Boim MA,Ramos OL,Ajzen H,Schor N

更新日期：1989-10-01 00:00:00

abstract：:Kidney-targeted gene therapy could be an ideal treatment for renal diseases since the therapeutic molecule is limited in the kidney and the systemic effect may be minimized. The technical development of the gene delivery to kidney and the identification of the responsive gene for a particular disease encourage the cha...

journal_title：Kidney international

authors： Imai E,Takabatake Y,Mizui M,Isaka Y

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Optimal nutrient intake is important in the maintenance of a positive nitrogen balance in hemodialysis (HD) patients. The objectives of this study were (1) to assess the influence of two levels of protein intakes on nitrogen balance in stable adult HD patients, and (2) to identify a minimum level of protein ...

journal_title：Kidney international

authors： Rao M,Sharma M,Juneja R,Jacob S,Jacob CK

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:In addition to nitric oxide (NO) and prostacyclin (PGI2), the vascular endothelium can influence local vascular tone by a mechanism involving the hyperpolarization of vascular smooth muscle cells. This response is attributed to the release of an endothelium-derived hyperpolarizing factor (EDHF). The present ...

journal_title：Kidney international

authors： Büssemaker E,Popp R,Binder J,Busse R,Fleming I

更新日期：2003-05-01 00:00:00

abstract：:Alterations in myocardial wall texture stand out among ADPKD cardiovascular manifestations in hypertensive and normotensive patients. To elucidate their pathogenesis, we analyzed the cardiac phenotype in Pkd1(cond/cond)Nestin(cre) (CYG+) cystic mice exposed to increased blood pressure, at 5 to 6 and 20 to 24 weeks of ...

journal_title：Kidney international

authors： Balbo BE,Amaral AG,Fonseca JM,de Castro I,Salemi VM,Souza LE,Dos Santos F,Irigoyen MC,Qian F,Chammas R,Onuchic LF

更新日期：2016-09-01 00:00:00

abstract：:Nephronophthisis is an autosomal recessive chronic tubulointerstitial disease that progresses to end-stage renal disease (ESRD) in about 10% of cases during infancy. Mutations in the INVS (NPHP2) gene were found in a few patients with infantile nephronophthisis. Mutations of NPHP3, known to be associated with adolesce...

journal_title：Kidney international

authors： Tory K,Rousset-Rouvière C,Gubler MC,Morinière V,Pawtowski A,Becker C,Guyot C,Gié S,Frishberg Y,Nivet H,Deschênes G,Cochat P,Gagnadoux MF,Saunier S,Antignac C,Salomon R

更新日期：2009-04-01 00:00:00

abstract：:Staphylococcal neutral phosphatase (NPtase) is a highly cationic bacterial surface bound protein. It has significant affinity for human and rat immunoglobulins in vitro and an electrostatic interaction may be involved. Radioisotopic studies showed that NPtase had a high affinity for the polyanionic structures of the r...

journal_title：Kidney international

authors： Yousif Y,Okada K,Batsford S,Vogt A

更新日期：1996-07-01 00:00:00

abstract：:Monoclonal antibodies (mAb) reactive against complement components involved in the classical activation pathway were applied in an indirect immunoperoxidase technique for the histological study of normal and diseased human renal tissues. Prominent staining with antibodies against the C4d fragment was seen in all glome...

journal_title：Kidney international

authors： Zwirner J,Felber E,Herzog V,Riethmüller G,Feucht HE

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:Only few noninvasive methods have the potential to quantitate renal blood flow (RBF) in humans. Positron emission tomography (PET) is a clinical imaging method that can be used to measure the tissue blood flow noninvasively. The purpose of this study was to validate PET measurement of RBF using 15O-labeled w...

journal_title：Kidney international

authors： Juillard L,Janier MF,Fouque D,Lionnet M,Le Bars D,Cinotti L,Barthez P,Gharib C,Laville M

更新日期：2000-06-01 00:00:00

abstract：:The members of the matrix metalloproteinase gene family play critical roles in numerous physiologic events, including cellular migration, tissue remodeling in wound healing and development, as well as in the evolution of the inflammatory process. The 72 kDa gelatinase A (formerly denoted 72 kDa Type IV collagenase) is...

journal_title：Kidney international

authors： Turck J,Pollock AS,Lovett DH

更新日期：1997-05-01 00:00:00

abstract：:A newly described glomerulotubular feedback loop may explain the relationship between glomerular damage, epitope spreading, tubulointerstitial nephritis, proteinuria as a progression factor, and the importance of the local milieu in kidney damage. It also opens the horizons for exciting innovative approaches to therap...

journal_title：Kidney international

authors： Sung SS,Bolton WK

更新日期：2010-03-01 00:00:00

abstract：:Diabetes mellitus is associated with natriuresis, whereas estrogen has been shown to be renoprotective in diabetic nephropathy and may independently regulate renal sodium reabsorption. The aim of this study was to determine the effects of 17-beta estradiol (E(2)) replacement to diabetic, ovariectomized (OVX) female ra...

journal_title：Kidney international

authors： Riazi S,Maric C,Ecelbarger CA

更新日期：2006-02-01 00:00:00

abstract：:Recipients of kidney transplants have elevated cancer risk compared with the general population. Improvements over time in transplant care and cancer treatment may have affected incidence and outcomes of cancer among recipients of kidney transplant. To evaluate this, we used linked United States transplant and cancer ...

journal_title：Kidney international

authors： Blosser CD,Haber G,Engels EA

更新日期：2020-11-04 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1) are key mediators of adverse peritoneal membrane remodeling in peritoneal dialysis eventually leading to ultrafiltration failure. Both are pleiotropic growth factors with cell type-dependent regulation of expression and biological eff...

journal_title：Kidney international

authors： Catar R,Witowski J,Wagner P,Annett Schramm I,Kawka E,Philippe A,Dragun D,Jörres A

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:It has been shown that non-congenic mice strains with lower levels of renal meprin develop less renal injury following renal ischemia and reperfusion. We have demonstrated that following ischemia-reperfusion renal injury, there is a rapid shift of meprin localization and intensity from the brush border to th...

journal_title：Kidney international

authors： Carmago S,Shah SV,Walker PD

更新日期：2002-03-01 00:00:00