Preserved Na/HCO3 cotransporter sensitivity to insulin may promote hypertension in metabolic syndrome.

abstract：:Bovine serum albumin (BSA, pI 4.9) was maleylated to yield highly anionic MBSA (pI 3.0). Maleylation of BSA lead to an expansion of molecular size of native BSA from an effective molecular radius (EMR) of 37 A to 57 A for MBSA as assessed by gel filtration chromatography. MBSA, but not BSA, bound to the peripheral cap...

journal_title：Kidney international

authors： Barnes JL,Reznicek MJ,Radnik RA,Venkatachalam MA

更新日期：1988-08-01 00:00:00

abstract：UNLABELLED:Hereditary systemic amyloidosis associated with a new apolipoprotein AII stop codon mutation Stop78Arg. BACKGROUND:Mutations in the gene for apolipoprotein AII (apoAII) have recently been found to cause hereditary renal amyloidosis. In each case amyloid deposition has been associated with a peptide extensio...

journal_title：Kidney international

authors： Yazaki M,Liepnieks JJ,Barats MS,Cohen AH,Benson MD

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Osteogenic protein-1/bone morphogenetic protein-7 (OP-1/BMP-7), a member of the transforming growth factor-beta superfamily, has been shown to prevent kidney damage from ischemia/reperfusion injury in rats. The molecular events involved in OP-1 action on kidney are not yet understood. METHODS:In this study,...

journal_title：Kidney international

authors： Bosukonda D,Shih MS,Sampath KT,Vukicevic S

更新日期：2000-11-01 00:00:00

abstract：:Freeze-fracture and thin-section electron microscopy and morphometry were used to characterize further the response of the rat medullary collecting duct to potassium depletion. In freeze-fracture replicas, principal cells and intercalated cells were identified based on the assumption that intercalated cells possess a ...

journal_title：Kidney international

authors： Stetson DL,Wade JB,Giebisch G

更新日期：1980-01-01 00:00:00

abstract：:Excess fatty acids accompanied by triglyceride accumulation in parenchymal cells of multiple tissues including skeletal and cardiac myocytes, hepatocytes, and pancreatic beta cells results in chronic cellular dysfunction and injury. The process, now termed lipotoxicity, can account for many manifestations of the 'meta...

journal_title：Kidney international

authors： Weinberg JM

更新日期：2006-11-01 00:00:00

abstract：:A second generation hepatitis C virus recombinant immunoblot assay (RIBA) was used to screen stored perioperative serum from 641 renal allograft recipients. One hundred and nine (17%) were anti-HCV positive at the time of transplant. RIBA positivity was found to be an independent predictor of post-transplant liver dis...

journal_title：Kidney international

authors： Roth D,Zucker K,Cirocco R,DeMattos A,Burke GW,Nery J,Esquenazi V,Babischkin S,Miller J

更新日期：1994-01-01 00:00:00

abstract：:The metabolism of phenylalanine and tyrosine was evaluated in six normal men, five chronically uremic men, and three men undergoing maintenance hemodialysis. Phenylalanine, tyrosine, and 13 acidic metabolites of those amino acids were measured in plasma postabsorptively and in plasma and urine after a phenylalanine lo...

journal_title：Kidney international

authors： Jones MR,Kopple JD,Swendseid ME

更新日期：1978-08-01 00:00:00

abstract：BACKGROUND:Ischemic acute renal failure (iARF) is associated with increased nitric oxide (NO) production during the reperfusion period, as endothelial nitric oxide synthase (eNOS) is maximally activated, and renal tubular inducible NOS (iNOS) is stimulated. Increased NO production leads to augmented tubular injury, pro...

journal_title：Kidney international

authors： Schwartz IF,Schwartz D,Traskonov M,Chernichovsky T,Wollman Y,Gnessin E,Topilsky I,Levo Y,Iaina A

更新日期：2002-11-01 00:00:00

abstract：:Mineralocorticoid hormones stimulate Na+ absorption and K+ secretion by the cortical collecting tubule. There is good evidence that this stimulation involves increasing luminal membrane Na+ permeability and the turnover rate (or number) of the Na+-K+ pumps. These experiments were designed to examine whether mineraloco...

journal_title：Kidney international

authors： Stokes JB

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:Atherogenic lipoproteins cause injury to the vascular wall in the early phase of atherogenesis. We assessed the effects of native (nLDL) and oxidized (oxLDL) low-density lipoprotein (LDL) and lipoprotein (a) [Lp(a)] on O2- formation and cell death in cultured human umbilical vein endothelial cells (HUVECs) a...

journal_title：Kidney international

authors： Galle J,Schneider R,Heinloth A,Wanner C,Galle PR,Conzelmann E,Dimmeler S,Heermeier K

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:Podocytes play an important role in the development of proteinuria and focal glomerulosclerosis. Previously we have demonstrated that a combination of two monoclonal antibodies (mAb) against aminopeptidase A (APA), an enzyme present on podocytes, induces a massive acute albuminuria in mice. The present study...

journal_title：Kidney international

authors： Assmann KJ,van Son JP,Dïjkman HB,Mentzel S,Wetzels JF

更新日期：2002-07-01 00:00:00

abstract：:Leukocytes play a major role in the development and progression of autoimmune diseases. We measured gene expression differences in leukocytes from patients that were antineutrophil cytoplasmic autoantibody (ANCA) positive, patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA), and healthy donor...

journal_title：Kidney international

authors： Alcorta DA,Barnes DA,Dooley MA,Sullivan P,Jonas B,Liu Y,Lionaki S,Reddy CB,Chin H,Dempsey AA,Jennette JC,Falk RJ

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:The T allele of the G protein beta3 subunit (GNB3) C825T polymorphism has been associated with increased signal transduction, increased activity of the kidney Na+/H+ exchanger, and also with late-onset essential hypertension. Hypertension is a strong independent risk factor for progression in IgA nephropathy...

journal_title：Kidney international

authors： Thibaudin L,Berthoux P,Thibaudin D,Mariat C,Berthoux F

更新日期：2004-07-01 00:00:00

abstract：:The purpose of this investigation is to analyze changes in plasma 1,25-(OH)2D and 24,25-(OH)2D after successful renal transplantation in 20 children and young adults. Studies were performed on 8 subjects between the 1st and 10th month and on 12 others between the 20th and 30th to 36th month. Samples were assayed for p...

journal_title：Kidney international

authors： Garabedian M,Silve C,Levy-Bentolila D,Bourdeau A,Ulmann A,Nguyen TM,Lieberherr M,Broyer M,Balsan S

更新日期：1981-09-01 00:00:00

abstract：:Problems with vascular access are an important cause of morbidity and mortality in hemodialysis patients. We established a rodent model of arteriovenous fistula by anastomosing the end of a lateral vein to the side of the ventral artery of the rat tail. All operations were technically successful and in all animals the...

journal_title：Kidney international

authors： Lin T,Horsfield C,Robson MG

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Renal anemia is an important determinant for left ventricular hypertrophy in dialysis patients and an independent prognosis parameter for the cardiovascular survival in dialysis patients. In addition, an autonomic dysfunction is associated with the uremic state and influences the cardiovascular risk in patie...

journal_title：Kidney international

authors： Frank H,Heusser K,Höffken B,Huber P,Schmieder RE,Schobel HP

更新日期：2004-08-01 00:00:00

abstract：:Prevention of nephrolithiasis (NL) is now medically feasible and widely recommended. However, diagnosis and treatment of remediable causes of stones requires testing and drugs that impose a cost; this cost is balanced by the presumed reductions in stone related events and medical encounters. In order to assess the bal...

journal_title：Kidney international

authors： Parks JH,Coe FL

更新日期：1996-11-01 00:00:00

abstract：:The mechanism of the binding of IgA to the mesangium in IgA nephropathy (IgAN) is unknown. Interactions between IgA and components of the mesangial matrix may contribute. We measured by enzyme-linked immunosorbent assay the binding of serum IgA, IgG, and IgM from patients with IgAN, human immunodeficiency virus type I...

journal_title：Kidney international

authors： van den Wall Bake AW,Kirk KA,Gay RE,Switalski LM,Julian BA,Jackson S,Gay S,Mestecky J

更新日期：1992-08-01 00:00:00

abstract：:Disasters result in a substantial number of renal challenges, either by the creation of crush injury in victims trapped in collapsed buildings or by the destruction of existing dialysis facilities, leaving chronic dialysis patients without access to their dialysis units, medications, or medical care. Over the past two...

journal_title：Kidney international

authors： Gibney RT,Sever MS,Vanholder RC

更新日期：2014-05-01 00:00:00

abstract：:Many xenobiotics including the pharmacoenhancer cobicistat increase serum creatinine by inhibiting its renal active tubular secretion without affecting the glomerular filtration rate. This study aimed to define the transporters involved in creatinine secretion, applying that knowledge to establish the mechanism for xe...

journal_title：Kidney international

authors： Lepist EI,Zhang X,Hao J,Huang J,Kosaka A,Birkus G,Murray BP,Bannister R,Cihlar T,Huang Y,Ray AS

更新日期：2014-08-01 00:00:00

abstract：:Clinical trials and experimental studies have highlighted the importance of epigenetic processes in the development of diabetic complications. One of the earliest features of diabetic nephropathy is renal enlargement. The epidermal growth factor (EGF) has a pivotal role in the development of diabetic nephromegaly and ...

journal_title：Kidney international

authors： Gilbert RE,Huang Q,Thai K,Advani SL,Lee K,Yuen DA,Connelly KA,Advani A

更新日期：2011-06-01 00:00:00

abstract：:In summary, the three major segments of the collecting duct subserve three different functions in the urinary concentrating mechanism. The main function of the cortical collecting tubule is to raise the fractional solute contribution and absolute concentration of urea in fluid that it delivers to the outer medullary c...

journal_title：Kidney international

authors： Kokko JP

更新日期：1987-02-01 00:00:00

abstract：:Heme oxygenase (HO) is the rate-limiting enzyme in the degradation of heme, converting heme to biliverdin, during which iron is released and carbon monoxide (CO) is emitted; biliverdin is subsequently converted to bilirubin by biliverdin reductase. At least two isozymes possess HO activity: HO-1 represents the isozyme...

journal_title：Kidney international

authors： Nath KA

更新日期：2006-08-01 00:00:00

abstract：:Cyanate is a uremic toxin responsible for the carbamylation of proteins, which has been implicated as playing a key role in accelerating the progression of atherosclerosis in patients with chronic kidney disease. El-Gamal et al. report that while cyanate promotes protein carbamylation in vivo, the resulting endothelia...

journal_title：Kidney international

authors： Hawkins CL

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Tumor necrosis factor (TNF)-alpha rapidly primes neutrophils (PMN) for an anti-neutrophil cytoplasmic antibody (ANCA)-induced respiratory burst and is thus proinflammatory. TNF-alpha also progressively accelerates apoptosis. We investigated the effect of TNF-alpha-mediated apoptosis on ANCA antigen expressio...

journal_title：Kidney international

authors： Kettritz R,Scheumann J,Xu Y,Luft FC,Haller H

更新日期：2002-02-01 00:00:00

abstract：:Vascular permeability factor (VPF), also known as vascular endothelial growth factor (VEGF), is a potent microvascular permeability-enhancing mediator as well as a selective mitogen for vascular endothelium. In this study, in situ hybridization and immunohistochemistry co-localized VPF mRNA and protein to glomerular v...

journal_title：Kidney international

authors： Brown LF,Berse B,Tognazzi K,Manseau EJ,Van de Water L,Senger DR,Dvorak HF,Rosen S

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:The beneficial effect of blood transfusions before cadaveric renal transplantation on allograft survival, although previously well documented, has become controversial in light of their adverse effects. Recently, it has been suggested that their clinical benefits are due to HLA-DR sharing between the blood d...

journal_title：Kidney international

authors： Hiesse C,Busson M,Buisson C,Farahmand H,Bierling P,Benbunan M,Bedrossian J,Aubert P,Glotz D,Loirat C,Rondeau E,Viron B,Bleux H,Lang P

更新日期：2001-07-01 00:00:00

abstract：:Incompatible donor/recipient pairs with broadly sensitized recipients have difficulty finding a crossmatch-compatible match, despite a large kidney paired donation pool. One approach to this problem is to combine kidney paired donation with lower-risk crossmatch-incompatible transplantation with intravenous immunoglob...

journal_title：Kidney international

authors： Blumberg JM,Gritsch HA,Reed EF,Cecka JM,Lipshutz GS,Danovitch GM,McGuire S,Gjertson DW,Veale JL

更新日期：2013-11-01 00:00:00

abstract：:Zhang et al. found that plasma concentrations of the thiamine antimetabolite oxythiamine are significantly increased in patients with end-stage renal disease. These investigators discuss the potential sources of oxythiamine and the consequences of its plasma elevation. This commentary addresses the significance of the...

journal_title：Kidney international

authors： Moradi H,Said HM

更新日期：2016-08-01 00:00:00

abstract：:Mechanisms responsible for renal hemodynamic alterations were studied in jaundiced (by bile-duct ligation) rabbits (BDL) 10 days after ligation of the biliary tract, in comparison with sham-operated rabbits (SO). Arterial hematocrit, plasma volume, blood pressure, abdominal inferior vena cava pressure, and heart rate ...

journal_title：Kidney international

authors： Hishida A,Honda N,Sudo M,Nagase M

更新日期：1980-02-01 00:00:00