Phenylalanine metabolism in uremic and normal man.

abstract：:The essential role of the glycoprotein hormone erythropoietin (Epo) in the control of red blood cell production is well established. Synthesis of Epo is induced in response to low oxygen (hypoxia). In response to stimulation, increases in serum Epo levels are paralleled by changes in the abundance of Epo mRNA. These c...

journal_title：Kidney international

authors： Göpfert T,Eckardt KU,Geb B,Kurtz A

更新日期：1997-02-01 00:00:00

abstract：:In organ donation, the donor, recipient, and transplant team must all accept potential health risks to the donor and any uncertainties. To gauge these risks, we surveyed general altruism and risk-taking behaviors in 112 potential donors, 111 potential recipients, and 51 transplant professionals. Next, participants ind...

journal_title：Kidney international

authors： Young A,Karpinski M,Treleaven D,Waterman A,Parikh CR,Thiessen-Philbrook H,Yang RC,Garg AX

更新日期：2008-05-01 00:00:00

abstract：:Changes in tissue oxygen levels trigger molecular signaling pathways that regulate cellular proliferation and differentiation in multiple cell types. The functional role of oxygen signaling in the immune system is not well understood. Rama and colleagues demonstrate that hypoxia induces dendritic-cell maturation; thus...

journal_title：Kidney international

authors： Maltzman JS,Haase VH

更新日期：2008-04-01 00:00:00

abstract：:We studied the adaptation to early (72 hr) and late (20 days) K loading (400 mmol/day, 4 equal meals every 6 hour) in six healthy humans. Throughout the study, each single K meal was followed by an acute transient rise in plasma K, aldosterone and kaliuresis. "K balance" (urinary K excretion approximately 80% of intak...

journal_title：Kidney international

authors： Rabelink TJ,Koomans HA,Hené RJ,Dorhout Mees EJ

更新日期：1990-11-01 00:00:00

abstract：:Continuous antigen stimulation during chronic infection or malignancy can promote functional T cell silencing, a phenomenon called T cell exhaustion. The prevalence and impact of T cell exhaustion following organ transplantation, another immune stimulus with persistently high antigen load, are unknown. Here, we charac...

journal_title：Kidney international

authors： Fribourg M,Anderson L,Fischman C,Cantarelli C,Perin L,La Manna G,Rahman A,Burrell BE,Heeger PS,Cravedi P

更新日期：2019-08-01 00:00:00

abstract：:Utilizing [5-15N] and [2-15N]-labeled glutamine and gas chromatography mass spectrometry methodology, we examined the pathways of ammoniagenesis under basal and acute acidotic conditions of pH 7.0 and pH 6.8, respectively. LLC-PK1 cultures were incubated for one hour with gentle rocking in a bicarbonate buffer of pH 7...

journal_title：Kidney international

authors： Nissim I,Sahai A,Sandler RS,Tannen RL

更新日期：1994-04-01 00:00:00

abstract：:The ability to pursue gene therapy has been limited by the availability of an effective and safe system for gene delivery, especially to the kidney. Electroporation is an efficient method to transfer physiologically the gene to the cells without complicated preparation. Given that the systemic delivery of the function...

journal_title：Kidney international

authors： Imai E,Isaka Y

更新日期：2002-01-01 00:00:00

abstract：:Nephrons possess a segmental organization where each segment is specialized for the secretion and reabsorption of particular solutes. The developmental control of nephron segment patterning remains one of the enigmas within the field of renal biology. Achieving an understanding of the mechanisms that direct nephron se...

journal_title：Kidney international

authors： Wingert RA,Davidson AJ

更新日期：2008-05-01 00:00:00

abstract：:We examined the process of receptor-mediated endocytosis in A-9 lung fibroblast and chinese hamster ovary (CHO) cells transfected with the recently cloned vasopressin V1a receptor (51). We used a fluorescent labeled vasopressin analog (rhodamine-mercaptopropionic acid lysine vasopressin) and radiolabeled vasopressin t...

journal_title：Kidney international

authors： Lutz W,Sanders M,Salisbury J,Lolait S,O'Carroll AM,Kumar R

更新日期：1993-04-01 00:00:00

abstract：:Intrauterine growth retardation (IUGR) aggravates the course of acute mesangioproliferative glomerulonephritis (GN) in the rat. Observational studies in children suggest that IUGR may be associated with a severe course of kidney diseases such as IgA nephropathy. We tested the hypothesis that IUGR leads to aggravation ...

journal_title：Kidney international

authors： Plank C,Ostreicher I,Hartner A,Marek I,Struwe FG,Amann K,Hilgers KF,Rascher W,Dötsch J

更新日期：2006-12-01 00:00:00

abstract：:The inner medullary collecting duct (IMCD) is a major target site of atrial natriuretic peptide (ANP) for diuresis and natriuresis, and it is in a hypertonic condition made by the renal countercurrent multiplication system. We investigated the effects of hyperosmolality on ANP-stimulated cGMP generation in IMCD and gl...

journal_title：Kidney international

authors： Shinohara M,Nonoguchi H,Ujiie K,Terada Y,Owada A,Tomita K,Marumo F

更新日期：1994-05-01 00:00:00

abstract：:Copy number variations associate with different developmental phenotypes and represent a major cause of congenital anomalies of the kidney and urinary tract (CAKUT). Because rare pathogenic copy number variations are often large and contain multiple genes, identification of the underlying genetic drivers has proven to...

journal_title：Kidney international

authors： Westland R,Verbitsky M,Vukojevic K,Perry BJ,Fasel DA,Zwijnenburg PJ,Bökenkamp A,Gille JJ,Saraga-Babic M,Ghiggeri GM,D'Agati VD,Schreuder MF,Gharavi AG,van Wijk JA,Sanna-Cherchi S

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:It is known that chronic renal insufficiency (CRI) patients with gout may have subtle lead poisoning. In addition, gout episodes frequently aggravate progressive renal insufficiency because of the use of nephrotoxic drugs and urate deposition. Our study was arranged to evaluate the causal effect of environme...

journal_title：Kidney international

authors： Lin JL,Yu CC,Lin-Tan DT,Ho HH

更新日期：2001-07-01 00:00:00

abstract：:The effects of chronic respiratory alkalosis on divalent ion homeostasis have not been reported in any species. We studied four normal male subjects during a four-day control period (residence at 500 m), during six days of chronic respiratory alkalosis induced by hypobaric hypoxia (residence at 3450 m), followed by a ...

journal_title：Kidney international

authors： Krapf R,Jaeger P,Hulter HN

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Tacrolimus has a narrow therapeutic window, and bioavailability is known to vary considerably between renal transplant recipients. Most centers still rely on measurement of trough levels, but there are conflicting reports on the correlation between tacrolimus trough levels and systemic exposure, as measured ...

journal_title：Kidney international

authors： Scholten EM,Cremers SC,Schoemaker RC,Rowshani AT,van Kan EJ,den Hartigh J,Paul LC,de Fijter JW

更新日期：2005-06-01 00:00:00

abstract：:Inflammation is the immune system's response to infectious or noninfectious sources of danger. Danger recognition is facilitated by various innate immune receptor families including the Toll-like receptors (TLRs), which detect danger signals in extracellular and intracellular compartments. It is an evolving concept th...

journal_title：Kidney international

authors： Anders HJ,Schlondorff DO

更新日期：2010-07-01 00:00:00

abstract：:The kinetics of formaldehyde washout in new and reused dialyzers with 2% (w/v) and 4% formaldehyde solution was studied. Using a standard method of rinsing, the concentration of formaldehyde decreases exponentially, but the rate of decrease and the steady-state level depends on the type of dialyzer. The residual quant...

journal_title：Kidney international

authors： Hakim RM,Friedrich RA,Lowrie EG

更新日期：1985-12-01 00:00:00

abstract：:The role of glutathione (GSH) in the preservation of renal function and the pathogenesis of renal injury has been investigated using the isolated perfused rat kidney as a model. In kidneys perfused for 80 min with 5 mM glucose as the only exogenous substrate, tissue GSH becomes depleted, renal function deteriorates, a...

journal_title：Kidney international

authors： Brezis M,Rosen S,Silva P,Epstein FH

更新日期：1983-08-01 00:00:00

abstract：:Recent studies suggest the presence of local angiotensin generating system in the kidney. By using in situ hybridization technique, mRNA for angiotensinogen has been shown to be present in the proximal tubule. In the present study, we have attempted to examine the production of angiotensinogen and renin-like activity ...

journal_title：Kidney international

authors： Yanagawa N,Capparelli AW,Jo OD,Friedal A,Barrett JD,Eggena P

更新日期：1991-05-01 00:00:00

abstract：:To test the contribution of bicarbonate (Bi) to hemodynamic stability during hemodialysis (HD), we compared the effects of ultrafiltration dialysis with bicarbonate and with acetate under conditions of high-sodium (141 mEq/liter) and low-sodium (130 mEq/liter) dialysate concentrations in 12 stable HD patients. Group 1...

journal_title：Kidney international

authors： Velez RL,Woodard TD,Henrich WL

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND:Children with chronic renal failure (CRF) exhibit growth retardation and a disturbed growth hormone/insulin-like growth factor-I (GH/IGF-I) axis. Treatment of children with CRF with GH or GH/IGF-I can partially restore linear growth. The molecular basis for decreased longitudinal growth is not known but may ...

journal_title：Kidney international

authors： Edmondson SR,Baker NL,Oh J,Kovacs G,Werther GA,Mehls O

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Systematic studies on safety and efficacy of enteral nutrition in patients with acute renal failure (ARF) are lacking. METHODS:We studied enteral nutrition-related complications and adequacy of nutrient administration during 2525 days of artificial nutrition in 247 consecutive patients fed exclusively by th...

journal_title：Kidney international

authors： Fiaccadori E,Maggiore U,Giacosa R,Rotelli C,Picetti E,Sagripanti S,Melfa L,Meschi T,Borghi L,Cabassi A

更新日期：2004-03-01 00:00:00

abstract：:The nature of the light chains in mesangial IgA deposits and serum IgA was studied in patients with IgA nephropathy. Immunofluorescence (IF) studies using murine monoclonal antibodies, rabbit and goat anti-human monospecific antisera were performed in kidney sections from 15 IgA nephritic patients with only IgA isotyp...

journal_title：Kidney international

authors： Lai KN,Chui SH,Lai FM,Lam CW

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND:Hyperuricemia has been linked to cardiovascular and renal diseases, possibly through the generation of reactive oxygen species (ROS) and subsequent endothelial dysfunction. The enzymatic effect of xanthine oxidase is the production of ROS and uric acid. Studies have shown that inhibiting xanthine oxidase wit...

journal_title：Kidney international

authors： Khosla UM,Zharikov S,Finch JL,Nakagawa T,Roncal C,Mu W,Krotova K,Block ER,Prabhakar S,Johnson RJ

更新日期：2005-05-01 00:00:00

abstract：:Ischemia-reperfusion injury is an important cause of graft failure. Because carnitine regulates substrate flux and energy balance across membranes which may be deranged in ischemia we determined whether its use was effective in preventing kidney injury in an allogeneic transplant model. Brown Norway rats received a Le...

journal_title：Kidney international

authors： Azzollini N,Cugini D,Cassis P,Pezzotta A,Gagliardini E,Abbate M,Arduini A,Peschechera A,Remuzzi G,Noris M

更新日期：2008-12-01 00:00:00

abstract：:Mitochondrial diseases represent a significant clinical challenge. Substantial efforts have been devoted to identifying therapeutic strategies for mitochondrial disorders, but effective interventions have remained elusive. Recently, we reported attenuation of disease in a mouse model of the human mitochondrial disease...

journal_title：Kidney international

authors： Johnson SC,Martinez F,Bitto A,Gonzalez B,Tazaerslan C,Cohen C,Delaval L,Timsit J,Knebelmann B,Terzi F,Mahal T,Zhu Y,Morgan PG,Sedensky MM,Kaeberlein M,Legendre C,Suh Y,Canaud G

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:The plasma concentrations of total homocysteine (tHcy) and total cysteine (tCys) are determined by intracellular metabolism and by renal plasma clearance, and we hypothesized that glomerular filtration is a major determinant of plasma tHcy and tCys. We studied the relationships between the glomerular filtrat...

journal_title：Kidney international

authors： Wollesen F,Brattström L,Refsum H,Ueland PM,Berglund L,Berne C

更新日期：1999-03-01 00:00:00

abstract：:X-ray crystal interferometer-based X-ray phase-contrast microtomography (phase-contrast microtomography) is able to image microstructures within soft tissue without the use of a contrast agent. Here we determined the feasibility of using this technique in the non-destructive inspection of formalin-fixed kidney tissue ...

journal_title：Kidney international

authors： Wu J,Takeda T,Lwin TT,Momose A,Sunaguchi N,Fukami T,Yuasa T,Akatsuka T

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:In X-linked Alport syndrome, mutations in the COL4A5 gene encoding the alpha 5 chain of type IV collagen result in progressive renal failure. This nephropathy appears to relate to the arrest of a switch from an alpha 1/alpha 2 to an alpha 3/alpha 4/alpha 5 network of type IV collagen in the developing glomer...

journal_title：Kidney international

authors： Harvey SJ,Zheng K,Sado Y,Naito I,Ninomiya Y,Jacobs RM,Hudson BG,Thorner PS

更新日期：1998-12-01 00:00:00

abstract：:Circulating immune complexes (CIC), measured by the solid-phase Clq method, were found to be in abnormal concentration in about half of 39 patients with membranoproliferative glomerulonephritis (MPGN). In contrast, they were present, usually in higher concentration, in nearly all patients with active lupus nephritis. ...

journal_title：Kidney international

authors： Davis CA,Marder H,West CD

更新日期：1981-12-01 00:00:00