Oxygen-dependent regulation of erythropoietin gene expression in rat hepatocytes.

abstract：:Long-term treatment (8 and 13 weeks) of rats with FGF-2 led to albuminuria and to increase in serum creatinine indicating the development of chronic renal failure. Histologically, the classic picture of focal segmental glomerulosclerosis (FSGS) was found; males were more severely affected than females. Among the early...

journal_title：Kidney international

authors： Kriz W,Hähnel B,Rösener S,Elger M

更新日期：1995-11-01 00:00:00

abstract：:Metabolic acidosis is common in patients with chronic kidney disease, which is known to affect bone metabolism. We examined the effect of metabolic acidosis on the development of vascular and other soft-tissue calcifications in uremic rats treated with calcitriol. Extraskeletal calcification was measured in vivo, in c...

journal_title：Kidney international

authors： Mendoza FJ,Lopez I,Montes de Oca A,Perez J,Rodriguez M,Aguilera-Tejero E

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:In cultured renal epithelial cells, exposure to oxalate, a constituent of many kidney stones, elicits a cascade of responses that often leads to cell death. Oxalate toxicity is mediated via generation of reactive oxygen species (ROS) in a process that depends at least in part upon lipid signaling molecules t...

journal_title：Kidney international

authors： Cao LC,Honeyman TW,Cooney R,Kennington L,Scheid CR,Jonassen JA

更新日期：2004-11-01 00:00:00

abstract：:The profibrotic adhesion molecule, osteopontin (OPN), is upregulated in kidneys of humans and mice with diabetes. The thiazolidinedione (TZD) insulin sensitizers decrease albuminuria in diabetic nephropathy (DN) and reduce OPN expression in vascular and cardiac tissue. To examine whether OPN is a critical mediator of ...

journal_title：Kidney international

authors： Nicholas SB,Liu J,Kim J,Ren Y,Collins AR,Nguyen L,Hsueh WA

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF-A) is expressed constitutively in the adult glomerular podocytes at high levels; however, the regulation of its production is unclear. Recent data from podocyte-specific knockout mice suggest that VPF/VEGF-A is critical for the proper ...

journal_title：Kidney international

authors： Datta K,Li J,Karumanchi SA,Wang E,Rondeau E,Mukhopadhyay D

更新日期：2004-10-01 00:00:00

abstract：:To determine whether the induction of immune-mediated glomerular injury influences the formation of cyclooxygenase products by glomerular cells, we determined prostaglandin E2 (PGE2) and thromboxane B2 (TXB2) (as the stable metabolite of TXA2) formation in isolated glomeruli of rats with passive Heymann nephritis (PHN...

journal_title：Kidney international

authors： Stahl RA,Adler S,Baker PJ,Chen YP,Pritzl PM,Couser WG

更新日期：1987-05-01 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is associated with a urine-concentrating defect attributed to renal cystic changes. As PKD genes are expressed in the brain, altered central release of arginine vasopressin could also play a role. In order to help determine this we measured central and nephrogenic c...

journal_title：Kidney international

authors： Ho TA,Godefroid N,Gruzon D,Haymann JP,Maréchal C,Wang X,Serra A,Pirson Y,Devuyst O

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:High-dose folinic acid is used to accelerate methotrexate elimination to avoid renal toxicity of the drug. The present study was carried out to examine the role of the renal organic anion transporters OAT-K1 and OAT-K2 in the urinary excretion of methotrexate, especially in the methotrexate-folinic acid resc...

journal_title：Kidney international

authors： Takeuchi A,Masuda S,Saito H,Doi T,Inui K

更新日期：2001-09-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia emerged in Wuhan, China in December 2019. Unfortunately, there is a lack of evidence about the optimal management of novel coronavirus disease 2019 (COVID-19), and even less is available in patients on maintenance hemodialysis therapy than in the g...

journal_title：Kidney international

authors： Goicoechea M,Sánchez Cámara LA,Macías N,Muñoz de Morales A,Rojas ÁG,Bascuñana A,Arroyo D,Vega A,Abad S,Verde E,García Prieto AM,Verdalles Ú,Barbieri D,Delgado AF,Carbayo J,Mijaylova A,Acosta A,Melero R,Tejedor A,Ben

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Heparins are currently the anticoagulants of choice in long-term hemodialysis (HD). Because of their shortcomings, including the increasing incidence of heparin-induced thrombocytopenia (HIT II), alternative anticoagulation is necessary. The study objectives were to provide safe and effective HD by investiga...

journal_title：Kidney international

authors： Pöschel KA,Bucha E,Esslinger HU,Ulbricht K,Nörtersheuser P,Stein G,Nowak G

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Variant forms of lysozyme, a ubiquitous bacteriolytic enzyme, are known to lead to hereditary non-neuropathic renal amyloidosis and, so far, three different mutations of the lysozyme gene have been reported. In this study, we report a novel lysozyme variant, Phe57Ile, associated with renal amyloidosis in thr...

journal_title：Kidney international

authors： Yazaki M,Farrell SA,Benson MD

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:The biologic responses to transforming growth factor-beta (TGF-beta) suggest many potential therapeutic applications; however, in the only clinical trial to examine the effect of the systemic administration of a TGF-beta isoform, patients experienced significant but reversible declines in renal function. We ...

journal_title：Kidney international

authors： Ledbetter S,Kurtzberg L,Doyle S,Pratt BM

更新日期：2000-12-01 00:00:00

abstract：:Suramin is a polysulfonated naphthylurea originally designed as a treatment for trypanosomiasis; but that has also been used to treat rodent models of fulminant hepatic failure and focal brain ischemia. In this study, we determined the effects of suramin on renal ischemia/reperfusion-induced acute kidney injury in mic...

journal_title：Kidney international

authors： Zhuang S,Lu B,Daubert RA,Chavin KD,Wang L,Schnellmann RG

更新日期：2009-02-01 00:00:00

abstract：:The involvement of sodium/potassium-ATPase in regulating parathyroid hormone (PTH) secretion is inferred from in vitro studies. Recently, the α-klotho-dependent rapid recruitment of this ATPase to the parathyroid cell plasma membrane in response to low extracellular calcium ion was suggested to be linked to increased ...

journal_title：Kidney international

authors： Martuseviciene G,Hofman-Bang J,Clausen T,Olgaard K,Lewin E

更新日期：2011-04-01 00:00:00

abstract：:How much dialysis is required for optimal well-being and long-term survival? The Frequent Hemodialysis Network completed two prospective trials examining the effect of more frequent, short hours and, now, of nocturnal hemodialysis compared with standard thrice-weekly treatments. Whereas the short-hours trial reported ...

journal_title：Kidney international

authors： Davenport A

更新日期：2011-11-01 00:00:00

abstract：:There are two fundamentally different growth responses for cells comprising the nephron: hyperplasia or hypertrophy. Cells that progress through the normal cell cycle double their DNA content and eventually divide during mitosis. Those cells that hypertrophy stop the growth process in the G1-phase of the cell cycle; w...

journal_title：Kidney international

authors： Wolf G

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:There is accumulating evidence that adult bone marrow (BM) cells show unexpected plasticity, and can differentiate into a wide range of specialized cells. In the case of intrinsic renal glomerular cells, BM-derived cells have been reported to differentiate into both mesangial cells and podocytes. However, th...

journal_title：Kidney international

authors： Ikarashi K,Li B,Suwa M,Kawamura K,Morioka T,Yao J,Khan F,Uchiyama M,Oite T

更新日期：2005-05-01 00:00:00

abstract：:To investigate whether the administration of cimetidine can improve the reliability of creatinine as a marker of GFR, we compared the creatinine clearance (CCr) to the clearance of the true filtration markers 51Cr-EDTA (CEDTA) and inulin (CIn), after oral ingestion of cimetidine in 10 healthy men and 29 patients with ...

journal_title：Kidney international

authors： Hilbrands LB,Artz MA,Wetzels JF,Koene RA

更新日期：1991-12-01 00:00:00

abstract：:Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis involves innate and adaptive immune cells in the induction of autoimmunity and in autoimmune effector responses. Most Fcγ receptors (FcγRs) activate immune cells, but FcγRIIB, found in humans and mice on B cells and innate cells, is an inhibitor...

journal_title：Kidney international

authors： Ooi JD,Gan PY,Chen T,Eggenhuizen PJ,Chang J,Alikhan MA,Odobasic D,Holdsworth SR,Kitching AR

更新日期：2014-12-01 00:00:00

abstract：:The pathologic and clinical features of 16 patients with dense intramembranous deposit disease are described. By light microscopy nine patients had membranoproliferative glomerulonephritis, five had focal segmental necrotizing glomerulonephritis with segmental epithelial crescents, four of whom also had a prominent tu...

journal_title：Kidney international

authors： Sibley RK,Kim Y

更新日期：1984-04-01 00:00:00

abstract：:Clinical trials and experimental studies have highlighted the importance of epigenetic processes in the development of diabetic complications. One of the earliest features of diabetic nephropathy is renal enlargement. The epidermal growth factor (EGF) has a pivotal role in the development of diabetic nephromegaly and ...

journal_title：Kidney international

authors： Gilbert RE,Huang Q,Thai K,Advani SL,Lee K,Yuen DA,Connelly KA,Advani A

更新日期：2011-06-01 00:00:00

abstract：:Defective recycling of megalin consequent to impaired phosphatidylinositol metabolism has been implicated as a mechanism causing tubular proteinuria in patients with Lowe syndrome. In this issue, Berquez et al. describe an innovative approach using a clinically approved drug to "rebalance" phosphatidylinositols and re...

journal_title：Kidney international

authors： Weisz OA

更新日期：2020-10-01 00:00:00

abstract：:Experiments in rodents have demonstrated an important role for selectins in kidney ischemia-reperfusion injury (IRI). However, the relevance of this in larger mammals, as well as the impact on long-term structure and function is unknown. We tested the hypothesis that small molecule selectin ligand inhibition attenuate...

journal_title：Kidney international

authors： Jayle C,Milinkevitch S,Favreau F,Doucet C,Richer JP,Deretz S,Mauco G,Rabb H,Hauet T

更新日期：2006-05-01 00:00:00

abstract：:Metabolic changes due to chronic renal failure (CRF) were studied in isolated liver cells. In 14 CRF and 14 sham-operated rats, liver cells were isolated by the Berry and Friend method and incubated with various substrates in order to study gluconeogenesis, ureagenesis, ketogenesis, oxygen consumption as well as cytos...

journal_title：Kidney international

authors： Cano N,Catelloni F,Fontaine E,Novaretti R,di Costanzo-Dufetel J,Reynier JP,Leverve XM

更新日期：1995-06-01 00:00:00

abstract：:Erythropoietin (EPO) therapy in hemodialysis patients may be associated with an enhanced risk of vascular access and extracorporeal thrombosis. Assessment of blood coagulation and fibrinolysis was performed monthly on a group of 21 hemodialysis patients treated with EPO, and on four iron-deficient hemodialysis patient...

journal_title：Kidney international

authors： Taylor JE,Belch JJ,McLaren M,Henderson IS,Stewart WK

更新日期：1993-07-01 00:00:00

abstract：:The role of peritoneal dialysis (PD) in renal replacement therapy (RRT) remains unclear. There are no controlled trials to provide hard evidence of its efficacy. Comparative studies with haemodialysis from different centres and countries have given conflicting results even when allowing for case mix. Data from the Uni...

journal_title：Kidney international

authors： Coles GA,Williams JD

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:Renal inflammation is regulated by a network of local and systemic mediators. Of them, transforming growth factor-beta1 (TGF-beta 1) and glucocorticoids play an important role in deactivating monocytes/macrophages. We examined the hypothesis that TGF-beta 1 effects may be partially achieved through modulatio...

journal_title：Kidney international

authors： Peltier J,Perez J,Bellocq A,Escoubet B,Fouqueray B,Baud L

更新日期：2003-06-01 00:00:00

abstract：:The structure of the duodenal mucosa was evaluated in duodenal biopsy samples obtained from patients with moderate renal failure (MRF) and in dialysis patients (HD) in an effort to examine the possibility that changes in duodenal mucosa may contribute to the impaired calcium absorption in renal failure (RF). The effec...

journal_title：Kidney international

authors： Goldstein DA,Horowitz RE,Petit S,Haldimann B,Massry SG

更新日期：1981-02-01 00:00:00

abstract：BACKGROUND:Tissue kallikrein regulates blood circulation. Low urinary kallikrein excretion was associated with hypertension and renal disease in blacks. The polymorphic KLK1 promoter includes -130 GN coupled with multiple single base substitutions. The -130 G12 allele in the KLK1 promoter was associated with lower tran...

journal_title：Kidney international

authors： Lee-Chen GJ,Liu KP,Lai YC,Juang HS,Huang SY,Lin CY

更新日期：2004-04-01 00:00:00

abstract：:Starting from observations in intact cells and extending to studies in native membranes and solubilized membrane proteins, a significant body of evidence has been accumulated to indicate that some of the short-term regulatory influences on the Na+-H+ exchanger in the apical membrane of the proximal convoluted tubule a...

journal_title：Kidney international

authors： Weinman EJ,Dubinsky W,Shenolikar S

更新日期：1989-10-01 00:00:00