Targeting PIs to improve PTs:a new approach to treating genetic diseases of the proximal tubule.

Abstract:

:Defective recycling of megalin consequent to impaired phosphatidylinositol metabolism has been implicated as a mechanism causing tubular proteinuria in patients with Lowe syndrome. In this issue, Berquez et al. describe an innovative approach using a clinically approved drug to "rebalance" phosphatidylinositols and restore megalin traffic in mouse and cell models of the disease.

journal_name

Kidney Int

journal_title

Kidney international

authors

Weisz OA

doi

10.1016/j.kint.2020.06.018

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

824-826

issue

4

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(20)30717-1

journal_volume

98

pub_type

杂志文章
  • Autosomal-dominant medullary cystic kidney disease type 1: clinical and molecular findings in six large Cypriot families.

    abstract:BACKGROUND:Autosomal-dominant medullary cystic kidney disease (ADMCKD), a hereditary chronic interstitial nephropathy, recently attracted attention because of the cloning or mapping of certain gene loci, namely NPHP1, NPHP2 and NPHP3 for familial juvenile nephronophthisis (NPH) and MCKD1 and MCKD2 for the adult form of...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1111/j.1523-1755.2002.kid581.x

    authors: Stavrou C,Koptides M,Tombazos C,Psara E,Patsias C,Zouvani I,Kyriacou K,Hildebrandt F,Christofides T,Pierides A,Deltas CC

    更新日期:2002-10-01 00:00:00

  • IF-LCM: laser capture microdissection of immunofluorescently defined cells for mRNA analysis rapid communication.

    abstract:BACKGROUND:The next phase of the molecular revolution will bring functional genomics down to the level of individual cells in a tissue. Laser capture microdissection (LCM) coupled with reverse transcription-polymerase chain reaction (RT-PCR) can measure gene expression in normal, cancerous, injured, or fibrotic tissue....

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.2000.00295.x

    authors: Murakami H,Liotta L,Star RA

    更新日期:2000-09-01 00:00:00

  • Hypertension, glomerular number, and birth weight in African Americans and white subjects in the southeastern United States.

    abstract::Low nephron number has been related to low birth weight and hypertension. In the southeastern United States, the estimated prevalence of chronic kidney disease due to hypertension is five times greater for African Americans than white subjects. This study investigates the relationships between total glomerular number ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/sj.ki.5000041

    authors: Hughson MD,Douglas-Denton R,Bertram JF,Hoy WE

    更新日期:2006-02-01 00:00:00

  • Effect of acute potassium load on reabsorption in Henle's loop in chronic renal failure in the rat.

    abstract::To determine the effect of an acute load of potassium on potassium reabsorption by the loop of Henle in chronic renal failure, the right kidney was removed and branches of the left renal artery were ligated in 17 rats. One week later and after 2 days of a potassium-free diet, rats were studied before (period 1) and af...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1985.100

    authors: Milanes CL,Jamison RL

    更新日期:1985-06-01 00:00:00

  • Higher body mass index is associated with incident diabetes and chronic kidney disease independent of genetic confounding.

    abstract::It is unknown whether the association between body mass index (BMI) and chronic kidney disease (CKD) is mediated by genetic confounding or obesity-associated diabetes. We investigated the association between BMI and incident CKD in 29,136 Swedish twins with no history of CKD or diabetes, first using traditional Cox re...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1016/j.kint.2018.12.019

    authors: Xu H,Kuja-Halkola R,Chen X,Magnusson PKE,Svensson P,Carrero JJ

    更新日期:2019-05-01 00:00:00

  • 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose reduces renal crystallization and oxidative stress in a hyperoxaluric rat model.

    abstract::Adhesion of calcium oxalate (CaOx) crystals to kidney cells may be a key event in the pathogenesis of kidney stones associated with marked hyperoxaluria. Previously, we found that 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG), isolated from a traditional medicinal herb, reduced CaOx crystal adhesion to renal epithelial ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.2010.458

    authors: Lee HJ,Jeong SJ,Lee HJ,Lee EO,Bae H,Lieske JC,Kim SH

    更新日期:2011-03-01 00:00:00

  • High-dose erythropoietin has no effect on short- or long-term graft function following deceased donor kidney transplantation.

    abstract::We evaluated short- and long-term effects of high-dose recombinant human erythropoietin (rHuEPO) in kidney transplantation in a prospective double-blind, placebo-controlled study. Patients with chronic kidney disease following receipt of a deceased donor kidney allograft were randomized to 3 doses of 40,000 units rHuE...

    journal_title:Kidney international

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/ki.2011.349

    authors: Hafer C,Becker T,Kielstein JT,Bahlmann E,Schwarz A,Grinzoff N,Drzymala D,Bonnard I,Richter N,Lehner F,Klempnauer J,Haller H,Traeder J,Fliser D

    更新日期:2012-02-01 00:00:00

  • Early hospital readmission among hemodialysis patients in the United States is associated with subsequent mortality.

    abstract::Dialysis providers in the United States may soon be held accountable for their patients' 30-day hospital readmissions. However, few studies have evaluated the timing of readmissions, which determines the window in which dialysis providers could act to prevent readmission. We therefore examined the timing of readmissio...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1016/j.kint.2017.03.025

    authors: Plantinga LC,King L,Patzer RE,Lea JP,Burkart JM,Hockenberry JM,Jaar BG

    更新日期:2017-10-01 00:00:00

  • Expression of the polycystin-1 C-terminal cytoplasmic tail increases Cl channel activity in Xenopus oocytes.

    abstract::Expression of the polycystin-1 C-terminal cytoplasmic tail increases Cl(-) channel activity in Xenopus oocytes. Background. Cyst expansion in autosomal-dominant polycystic kidney disease (ADPKD) is characterized by active Cl(-) secretion in excess of solute reabsorption. However, the connections between elevated epith...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1111/j.1523-1755.2005.00441.x

    authors: Chernova MN,Vandorpe DH,Clark JS,Alper SL

    更新日期:2005-08-01 00:00:00

  • Serum adiponectin predicts all-cause mortality and end stage renal disease in patients with type I diabetes and diabetic nephropathy.

    abstract::Adiponectin levels are increased in patients with type I diabetes especially in the presence of microangiopathy. Here we determined the predictive value of serum adiponectin levels and 8 adiponectin gene polymorphisms for mortality, cardiovascular events and end-stage renal disease in type I diabetic patients. This pr...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.2008.201

    authors: Jorsal A,Tarnow L,Frystyk J,Lajer M,Flyvbjerg A,Parving HH,Vionnet N,Rossing P

    更新日期:2008-09-01 00:00:00

  • Glycosaminoglycan and proteoglycan inhibit the depolymerization of beta2-microglobulin amyloid fibrils in vitro.

    abstract:BACKGROUND:Although several kinds of evidence suggest that glycosaminoglycans (GAGs) and proteoglycans (PGs) may contribute to the development of beta2-microglobulin-related (Abeta2m) amyloidosis, the precise roles of these molecules for the development of Abeta2m amyloidosis are poorly understood. METHODS:We investig...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.2003.00167.x

    authors: Yamaguchi I,Suda H,Tsuzuike N,Seto K,Seki M,Yamaguchi Y,Hasegawa K,Takahashi N,Yamamoto S,Gejyo F,Naiki H

    更新日期:2003-09-01 00:00:00

  • Aboriginal patients on the road to kidney transplantation: is residence location a barrier?

    abstract::Aboriginal dialysis patients have reduced access to kidney transplantation. The reasons for this disparity are unknown. Tonelli et al. show that in Canada, residence location does not significantly impact on an Aboriginal dialysis patient's likelihood of receiving kidney transplantation. This Commentary explores the i...

    journal_title:Kidney international

    pub_type: 评论,杂志文章

    doi:10.1038/sj.ki.5001762

    authors: Yeates KE

    更新日期:2006-09-01 00:00:00

  • Distribution of pyruvate carboxylase along the rat nephron: an immunological and enzymatic study.

    abstract::Antibodies against purified rat-kidney-cortex pyruvate carboxylase were raised in rabbits. These polyspecific antibodies recognize pyruvate carboxylase enzymes alone without cross reactivity with other carboxylases as detected by immunoblotting. The abundance of pyruvate carboxylase in the various renal fractions was ...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1991.147

    authors: Salto R,Oliver J,del Mar Sola M,Vargas AM

    更新日期:1991-06-01 00:00:00

  • Differences in tolerance for health risk to the living donor among potential donors, recipients, and transplant professionals.

    abstract::In organ donation, the donor, recipient, and transplant team must all accept potential health risks to the donor and any uncertainties. To gauge these risks, we surveyed general altruism and risk-taking behaviors in 112 potential donors, 111 potential recipients, and 51 transplant professionals. Next, participants ind...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.2008.65

    authors: Young A,Karpinski M,Treleaven D,Waterman A,Parikh CR,Thiessen-Philbrook H,Yang RC,Garg AX

    更新日期:2008-05-01 00:00:00

  • Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney.

    abstract:BACKGROUND:Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) is a potent scavenger of free radicals and has the antioxidant ability to inhibit lipid peroxidation. Its protective effect on brain ischemia has been shown. This study aimed to elucidate its possible therapeutic effects on renal oxidative stress in a rat ische...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1111/j.1523-1755.2004.00567.x

    authors: Doi K,Suzuki Y,Nakao A,Fujita T,Noiri E

    更新日期:2004-05-01 00:00:00

  • Leukocyte and serum S100A8/S100A9 expression reflects disease activity in ANCA-associated vasculitis and glomerulonephritis.

    abstract::Antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) commonly results in glomerulonephritis, in which neutrophils and monocytes have important roles. The heterodimer calprotectin (S100A8/S100A9, mrp8/14) is a Toll-like receptor-4 ligand found in neutrophils and monocytes and is elevated in inflammatory...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.2013.2

    authors: Pepper RJ,Hamour S,Chavele KM,Todd SK,Rasmussen N,Flint S,Lyons PA,Smith KG,Pusey CD,Cook HT,Salama AD

    更新日期:2013-06-01 00:00:00

  • Increased expression of a brain/embryo-type myosin heavy chain isoform (MIIB2) in mesangial proliferative glomerulonephritis.

    abstract::Proliferation of mesangial cells is frequently found in glomerulonephritis, such as IgA glomerulonephritis. Recent reports suggest that a brain/embryo-type myosin isoform (MIIB2) is involved in cell proliferation. We have studied the expression of MIIB2 in renal biopsy samples from patients with various renal diseases...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1996.191

    authors: Kishino M,Kimura A,Yamaguchi K,Ohtani H,Yamada Y,Takahashi T,Mune M,Mimura K,Maeda T,Matsumura S,Tsuji T,Yukawa S

    更新日期:1996-05-01 00:00:00

  • The acid-activated signaling pathway: starting with Pyk2 and ending with increased NHE3 activity.

    abstract::On a typical Western diet, the body is faced with the generation of a metabolically derived acid load that must be excreted to maintain systemic acid-base balance. The kidney is responsible for this task and matches daily acid excretion with daily acid production. Multiple nephron segments are involved in the process,...

    journal_title:Kidney international

    pub_type: 杂志文章,评审

    doi:10.1038/sj.ki.5002543

    authors: Preisig PA

    更新日期:2007-12-01 00:00:00

  • Metabolic support of collecting duct transport.

    abstract::The present studies address the metabolic processes that support the reabsorption of sodium and the secretion of bicarbonate in the interspersed but distinct principal and intercalated cells of the cortical collecting duct (CCD). In microperfused rabbit CCD, sodium reabsorption was measured by lumen-to-bath 22Na flux,...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.1998.00754.x

    authors: Hering-Smith KS,Hamm LL

    更新日期:1998-02-01 00:00:00

  • Polycystin deficiency induces dopamine-reversible alterations in flow-mediated dilatation and vascular nitric oxide release in humans.

    abstract::Autosomal dominant polycystic kidney disease (ADPKD) is a renal hereditary disorder associated with increased cardiovascular mortality, due to mutations in polycystin-1 and polycystin-2 genes. Endothelial polycystin-deficient cells have an altered mechanosensitivity to fluid shear stress and subsequent deficit in calc...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.2014.241

    authors: Lorthioir A,Joannidès R,Rémy-Jouet I,Fréguin-Bouilland C,Iacob M,Roche C,Monteil C,Lucas D,Renet S,Audrézet MP,Godin M,Richard V,Thuillez C,Guerrot D,Bellien J

    更新日期:2015-02-01 00:00:00

  • Renoprotective effects of vitamin D analogs.

    abstract::Recent decades have witnessed the revelation of expanding roles of the vitamin D endocrine system beyond calcium and phosphorus metabolism. Along with these non-calcemic or non-classic actions of vitamin D are newly discovered therapeutic actions of vitamin D analogs in a number of pathological conditions, including k...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.2009.175

    authors: Li YC

    更新日期:2010-07-01 00:00:00

  • The renal action of atrial natriuretic peptide during control of glomerular filtration.

    abstract::Studies were performed in anesthetized dogs (N = 7) to determine the effects of synthetic atrial natriuretic peptide (ANP) on sodium excretion in the presence and absence of control of glomerular filtration rate produced by suprarenal aortic clamping. Intrarenal infusion of synthetic atrial natriuretic peptide (0.3 mi...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1986.144

    authors: Burnett JC Jr,Opgenorth TJ,Granger JP

    更新日期:1986-07-01 00:00:00

  • Binding inhibitors restore furosemide potency in tubule fluid containing albumin.

    abstract::We have previously suggested that albumin in tubule fluid at concentrations found in the nephrotic syndrome (NS) binds furosemide, thereby diminishing diuretic effect. This mechanism may contribute to diuretic resistance in NS. If this hypothesis is correct, displacement of albumin from furosemide should restore diure...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1991.228

    authors: Kirchner KA,Voelker JR,Brater DC

    更新日期:1991-09-01 00:00:00

  • Pain management in polycystic kidney disease.

    abstract::Pain is a common complaint in patients with autosomal-dominant polycystic kidney disease, and a systematic approach is needed to differentiate the etiology of the pain and define an approach to management. A thorough history is the best clue to the multifactorial causes of the pain, superimposed upon an understanding ...

    journal_title:Kidney international

    pub_type: 杂志文章,评审

    doi:10.1046/j.1523-1755.2001.00985.x

    authors: Bajwa ZH,Gupta S,Warfield CA,Steinman TI

    更新日期:2001-11-01 00:00:00

  • Results of the CARDIA study suggest that higher dietary potassium may be kidney protective.

    abstract::The association between dietary sodium and potassium intake with the development of kidney disease remains unclear, particularly among younger individuals. Here, we determined whether dietary sodium and potassium intake are associated with incident chronic kidney disease (CKD) using data from 1,030 adults (age 23-35 i...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1016/j.kint.2020.02.037

    authors: Elfassy T,Zhang L,Raij L,Bibbins-Domingo K,Lewis CE,Allen NB,Liu KJ,Peralta CA,Odden MC,Zeki Al Hazzouri A

    更新日期:2020-07-01 00:00:00

  • Chronic peritoneal dialysis in iron-deficient rats with solutions containing iron dextran.

    abstract:BACKGROUND:We evaluated the effects of different concentrations of iron dextran administered through the intraperitoneal route, in iron-deficient rats, on hematocrit (Hct in percentage), serum iron (mg/dL), total iron binding capacity (TIBC in mg/dL), and the function and histology of the peritoneal membrane. METHODS:...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.2001.059002764.x

    authors: Reddy DK,Moore HL,Lee JH,Saran R,Nolph KD,Khanna R,Twardowski ZJ

    更新日期:2001-02-01 00:00:00

  • Simultaneous occlusion of Na+ and phosphate by the intestinal brush border membrane Na+/phosphate cotransporter.

    abstract::The molecular mechanism of Na+ and phosphate transport by the intestinal brush border membrane Na+/phosphate cotransporter was examined using anion and cation exchange columns interfaced to a light-activated microsecond timer. The nature of ion:cotransporter interaction was examined for sensitivity to itself versus no...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1038/ki.1996.141

    authors: Peerce BE

    更新日期:1996-04-01 00:00:00

  • Cyclooxygenase-2 (COX-2) inhibition limits abnormal COX-2 expression and progressive injury in the remnant kidney.

    abstract:BACKGROUND:The pathogenesis of progressive nephropathies involves hemodynamic and inflammatory factors. In the 5/6 nephrectomy model, a selective increase of cyclooxygenase-2 (COX-2) expression was shown, whereas treatment with a nonsteroidal anti-inflammatory or a specific COX-2 inhibitor was renoprotective. We invest...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1046/j.1523-1755.2003.00319.x

    authors: Fujihara CK,Antunes GR,Mattar AL,Andreoli N,Malheiros DM,Noronha IL,Zatz R

    更新日期:2003-12-01 00:00:00

  • Adiponectin in renal disease: relationship to phenotype and genetic variation in the gene encoding adiponectin.

    abstract:BACKGROUND:The prevalence of cardiovascular disease (CVD) and inflammation is high in patients with end-stage renal disease (ESRD). Adiponectin is an adipocytokine that may have significant anti-inflammatory and anti-atherosclerotic effects. Low adiponectin levels have previously been found in patients with high risk f...

    journal_title:Kidney international

    pub_type: 杂志文章

    doi:10.1111/j.1523-1755.2004.00370.x

    authors: Stenvinkel P,Marchlewska A,Pecoits-Filho R,Heimbürger O,Zhang Z,Hoff C,Holmes C,Axelsson J,Arvidsson S,Schalling M,Barany P,Lindholm B,Nordfors L

    更新日期:2004-01-01 00:00:00

  • Is hemodiafiltration the technical solution to chronic inflammation affecting hemodialysis patients?

    abstract::Chronic inflammation is a complication of conventional hemodialysis that induces progressive cardiovascular damage. An apparently straightforward manipulation to treat this-removal of a large amount of uremic toxins by convection-has proven that the relationships between inflammation and convective techniques such as ...

    journal_title:Kidney international

    pub_type: 评论,杂志文章

    doi:10.1038/ki.2014.81

    authors: Santoro A,Mancini E

    更新日期:2014-08-01 00:00:00