Bone marrow cells contribute to regeneration of damaged glomerular endothelial cells.

abstract：:The purpose of this study was to explore risk factors affecting the incidence of chronic kidney disease (CKD) in general population. We conducted a 10-year follow-up study with 123 764 (male: 41 012, female: 82 752) adults aged 40 years and over who received community-based annual examinations. The primary outcome for...

journal_title：Kidney international

authors： Yamagata K,Ishida K,Sairenchi T,Takahashi H,Ohba S,Shiigai T,Narita M,Koyama A

更新日期：2007-01-01 00:00:00

abstract：:Changes in tissue oxygen levels trigger molecular signaling pathways that regulate cellular proliferation and differentiation in multiple cell types. The functional role of oxygen signaling in the immune system is not well understood. Rama and colleagues demonstrate that hypoxia induces dendritic-cell maturation; thus...

journal_title：Kidney international

authors： Maltzman JS,Haase VH

更新日期：2008-04-01 00:00:00

abstract：:The present study examined the effect of elevated glucose on glomerular cell membrane lipid peroxidation. Glomeruli were isolated from male Sprague-Dawley rat kidneys utilizing a standard sieving method and incubated in medium containing different concentrations of glucose at 37 degrees C for one and 48 hours. The lev...

journal_title：Kidney international

authors： Ha H,Yoon SJ,Kim KH

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Previous reports have shown the presence of erythrogenic toxin type B (ETB), apoptosis, proliferation, and leukocyte infiltration in biopsies from patients with acute poststreptococcal glomerulonephritis (APSGN). METHODS:Attempting to correlate the apoptotic and proliferative events with the interaction of ...

journal_title：Kidney international

authors： Viera NT,Romero MJ,Montero MK,Rincon J,Mosquera JA

更新日期：2001-03-01 00:00:00

abstract：:We examined the potential of in vivo linkage of plasminogen activator inhibitor-1 (PAI-1) and angiotensin II (Ang II) in the setting of endothelial injury and sclerosis following radiation injury in the rat. PAI-1 is a major physiological inhibitor of the plasminogen activator (PA)/plasmin system, a key regulator of f...

journal_title：Kidney international

authors： Oikawa T,Freeman M,Lo W,Vaughan DE,Fogo A

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Approximately 8% of autosomal-dominant polycystic kidney disease (ADPKD) patients have intracranial aneurysms. The risk of growth and rupture of those discovered by presymptomatic screening is key to the feasibility and success of a screening program. This study was initiated to ascertain this risk. METHODS...

journal_title：Kidney international

authors： Gibbs GF,Huston J 3rd,Qian Q,Kubly V,Harris PC,Brown RD Jr,Torres VE

更新日期：2004-05-01 00:00:00

abstract：:To test the hypothesis that systemic administration of immunoglobulin might reduce glomerular injury in membranous nephropathy through mechanisms involving inhibition of complement activation, we studied the passive Heymann nephritis (PHN) model of membranous nephropathy in rats. The daily administration of immunoglob...

journal_title：Kidney international

authors： Nangaku M,Pippin J,Richardson CA,Schulze M,Young BA,Alpers CE,Gordon KL,Johnson RJ,Couser WG

更新日期：1996-12-01 00:00:00

abstract：:Interstitial monocytic infiltration of the kidney occurs within hours of acute kidney injury and is an important determinant of functional decline and fibrosis. Li et al. used several surface markers to distinguish between dendritic cells and inflammatory monocytes following acute kidney injury and to identify two che...

journal_title：Kidney international

authors： Swaminathan S,Griffin MD

更新日期：2008-12-01 00:00:00

abstract：:Diabetes is a major cause of chronic kidney disease, and oral antidiabetic drugs are the mainstay of therapy for most patients with Type 2 diabetes. Here we evaluated their role on renal outcomes by using a national Veterans Administration database to assemble a retrospective cohort of 93,577 diabetic patients who fil...

journal_title：Kidney international

authors： Hung AM,Roumie CL,Greevy RA,Liu X,Grijalva CG,Murff HJ,Ikizler TA,Griffin MR

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:The underlying mechanisms of renal transplant dysfunction are poorly understood. There is little information on tubular function in kidney grafts. The cDNAs encoding kidney-specific cell surface proteins required for renal reabsorption of sodium (sodium cotransporter in thick ascending limb of Henle, rBSC1) ...

journal_title：Kidney international

authors： Michimata M,Wang W,Fujita S,Mizutani H,Fujimori K,Satomi S,Ohta M,Ito S,Kimura T,Araki T,Imai Y,Matsubara M

更新日期：2001-08-01 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is a renal hereditary disorder associated with increased cardiovascular mortality, due to mutations in polycystin-1 and polycystin-2 genes. Endothelial polycystin-deficient cells have an altered mechanosensitivity to fluid shear stress and subsequent deficit in calc...

journal_title：Kidney international

authors： Lorthioir A,Joannidès R,Rémy-Jouet I,Fréguin-Bouilland C,Iacob M,Roche C,Monteil C,Lucas D,Renet S,Audrézet MP,Godin M,Richard V,Thuillez C,Guerrot D,Bellien J

更新日期：2015-02-01 00:00:00

abstract：:High glucose evokes a variety of signals in mesangial cells that alter cellular functions responsible for the development of diabetic glomerulopathy. The hypoxia-inducible factor-1alpha (HIF-1alpha) regulates cellular homeostasis under hypoxic conditions, but it also has pleiotropic effects in response to cellular str...

journal_title：Kidney international

authors： Isoe T,Makino Y,Mizumoto K,Sakagami H,Fujita Y,Honjo J,Takiyama Y,Itoh H,Haneda M

更新日期：2010-07-01 00:00:00

abstract：:Complement factor 5a (C5a) interaction with its receptor (C5aR1) contributes to the pathogenesis of inflammatory diseases, including acute kidney injury. However, its role in chronic inflammation, particularly in pathogen-associated disorders, is largely unknown. Here we tested whether the development of chronic infla...

journal_title：Kidney international

authors： Choudhry N,Li K,Zhang T,Wu KY,Song Y,Farrar CA,Wang N,Liu CF,Peng Q,Wu W,Sacks SH,Zhou W

更新日期：2016-09-01 00:00:00

abstract：:Genetic variation at the MYH9 locus is linked to the high incidence of focal segmental glomerulosclerosis (FSGS) and non-diabetic end-stage renal disease among African Americans. To further define risk alleles with FSGS we performed a genome-wide association analysis using more than one million single-nucleotide polym...

journal_title：Kidney international

authors： Genovese G,Tonna SJ,Knob AU,Appel GB,Katz A,Bernhardy AJ,Needham AW,Lazarus R,Pollak MR

更新日期：2010-10-01 00:00:00

abstract：:Hypocalcemia, hyperphosphatemia, and resistance to the action of PTH are well characterized features in the setting of advanced chronic renal failure (CRF). Although the underlying mechanisms are ill-understood, clinical and experimental evidence points to both PTH receptor down-regulation and post-receptor abnormalit...

journal_title：Kidney international

authors： Ureña P,Kubrusly M,Mannstadt M,Hruby M,Trinh MM,Silve C,Lacour B,Abou-Samra AB,Segre GV,Drüeke T

更新日期：1994-02-01 00:00:00

abstract：:Chronic kidney disease (CKD) promotes development of cardiac abnormalities and is highly prevalent in patients with heart failure, particularly in those with preserved ejection fraction. CKD is associated with endothelial dysfunction, however, whether CKD can induce impairment of endothelium-to-cardiomyocyte crosstalk...

journal_title：Kidney international

authors： Juni RP,Al-Shama R,Kuster DWD,van der Velden J,Hamer HM,Vervloet MG,Eringa EC,Koolwijk P,van Hinsbergh VWM

更新日期：2020-12-22 00:00:00

abstract：BACKGROUND:Prolonged antihypertensive therapy might be less effective in reversing the left ventricular hypertrophy (LVH) in uremics bearing the deleted (DD) allele of the angiotensin converting enzyme (ACE) gene than in patients with the inserted (II) allele or in those heterozygous (ID) for the gene. METHODS:Thirtee...

journal_title：Kidney international

authors： Cannella G,Paoletti E,Barocci S,Massarino F,Delfino R,Ravera G,Di Maio G,Nocera A,Patrone P,Rolla D

更新日期：1998-08-01 00:00:00

abstract：:Ravulizumab is a long-acting C5 inhibitor engineered from eculizumab with increased elimination half-life, allowing an extended dosing interval from two to eight weeks. Here we evaluate the efficacy and safety of ravulizumab in adults with atypical hemolytic uremic syndrome presenting with thrombotic microangiopathy. ...

journal_title：Kidney international

authors： Rondeau E,Scully M,Ariceta G,Barbour T,Cataland S,Heyne N,Miyakawa Y,Ortiz S,Swenson E,Vallee M,Yoon SS,Kavanagh D,Haller H,311 Study Group.

更新日期：2020-06-01 00:00:00

abstract：:This study offers morphological evidence of the involvement of lipid abnormalities in human glomerular injury. Renal biopsy tissues from patients with several types of glomerular diseases were immunocytochemically examined using antibodies to apolipoproteins (apo) A-I, B-100, and E, and antibodies to low density lipop...

journal_title：Kidney international

authors： Takemura T,Yoshioka K,Aya N,Murakami K,Matumoto A,Itakura H,Kodama T,Suzuki H,Maki S

更新日期：1993-04-01 00:00:00

abstract：:To determine whether acute renal failure (ARF) increases the long-term risk of progressive chronic kidney disease (CKD), we studied the outcome of patients whose initial kidney function was normal or near normal but who had an episode of dialysis-requiring ARF and did not develop end-stage renal disease within 30 days...

journal_title：Kidney international

authors： Lo LJ,Go AS,Chertow GM,McCulloch CE,Fan D,Ordoñez JD,Hsu CY

更新日期：2009-10-01 00:00:00

abstract：:The importance of the relationship between the alteration of podocytic processes (PP) and proteinuria has been controversial for almost 30 years. In spite of several morphometric studies the range of PP alterations in different proteinuric conditions has gone unnoticed. Thus, we studied the distribution of abnormally ...

journal_title：Kidney international

authors： Fries JW,Rumpelt HJ,Thoenes W

更新日期：1987-11-01 00:00:00

abstract：:Our findings indicate that hypoaldosteronism occurs commonly (23/31 patients) in hyperkalemic patients with chronic renal insufficiency and that the deficiency of aldosterone contributes to the pathogenesis of the hyperkalemia. In most patients (83%), hypoaldosteronism could be accounted for by deficient renal secreti...

journal_title：Kidney international

authors： Schambelan M,Sebastian A,Biglieri EG

更新日期：1980-01-01 00:00:00

abstract：:An open, randomized trial study on the therapeutic effect of recombinant alpha-interferon (IFN alpha) in 40 patients with hepatitis B virus membranous nephropathy (HBVMN) was conducted. All were pathologically proven to have HBVMN which showed no response to corticosteroid treatment represented by persistent heavy pro...

journal_title：Kidney international

authors： Lin CY

更新日期：1995-01-01 00:00:00

abstract：:Fibrates, the PPAR alpha ligand-like compounds increase the expression of proximal tubule liver fatty acid binding protein (L-FABP) and significantly decrease cisplatin-induced acute kidney injury. To study whether the bezafibrate-mediated upregulation of renal L-FABP was involved in this cytoprotective effect we trea...

journal_title：Kidney international

authors： Negishi K,Noiri E,Maeda R,Portilla D,Sugaya T,Fujita T

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:The relationship between blood pressure (BP) and mortality in hemodialysis patients has remained controversial. Some studies suggested that a lower pre- or postdialysis BP was associated with excess mortality, while others showed poorer outcome in patients with uncontrolled hypertension. We conducted a multi...

journal_title：Kidney international

authors： Shoji T,Tsubakihara Y,Fujii M,Imai E

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Hemodialysis access thrombosis is a significant cause of morbidity for hemodialysis patients and results from decreased access flow caused by venous outflow tract stenosis. Ultrasound dilution (UD) is a practical, noninvasive, and reliable indicator of access flow and is effective in predicting venous stenos...

journal_title：Kidney international

authors： Goldstein SL,Allsteadt A

更新日期：2001-06-01 00:00:00

abstract：:Familial aggregation of non-diabetic end-stage renal disease (ESRD) is found in African Americans and variants in the apolipoprotein L1 gene (APOL1) contribute to this risk. To detect genetic associations with milder forms of nephropathy in the high-risk families, analyses were performed using generalized estimating e...

journal_title：Kidney international

authors： Freedman BI,Langefeld CD,Turner J,Núñez M,High KP,Spainhour M,Hicks PJ,Bowden DW,Reeves-Daniel AM,Murea M,Rocco MV,Divers J

更新日期：2012-10-01 00:00:00

abstract：:Multiple microRNAs (miRs) are implicated in muscle cell differentiation and muscle mass regulation. Pharmacological agents targeting miR-486 and other miRs, involved in muscle mass regulation, could potentially be developed into therapeutic agents for muscle wasting. Muscle wasting is prevalent among patients with chr...

journal_title：Kidney international

authors： Mak RH,Cheung WW

更新日期：2012-08-01 00:00:00

abstract：:Insulin resistance has been associated with kidney disease even in the absence of diabetes; however, pathways linking insulin resistance to kidney disease are unclear. The purpose of this study was to determine if transforming growth factor (TGF)-beta1, a key cytokine associated with kidney disease, responds to circul...

journal_title：Kidney international

authors： Huan Y,DeLoach S,Daskalakis C,Dunn SR,Sharma K,Falkner B

更新日期：2010-08-01 00:00:00

abstract：:Unilateral ureteral obstruction in rabbits leads to an influx of macrophages into the kidney, a proliferation of interstitial cells, and an increase in arachidonic acid metabolism. The role of the macrophage in the metabolic changes of hydronephrosis was investigated by using endotoxin and nitrogen mustard. The in viv...

journal_title：Kidney international

authors： Lefkowith JB,Okegawa T,DeSchryver-Kecskemeti K,Needleman P

更新日期：1984-07-01 00:00:00