Risk factors for chronic kidney disease in a community-based population: a 10-year follow-up study.

abstract：:Prevention of nephrolithiasis (NL) is now medically feasible and widely recommended. However, diagnosis and treatment of remediable causes of stones requires testing and drugs that impose a cost; this cost is balanced by the presumed reductions in stone related events and medical encounters. In order to assess the bal...

journal_title：Kidney international

authors： Parks JH,Coe FL

更新日期：1996-11-01 00:00:00

abstract：:Antibody responses to antigens are impaired in humans and animals with chronic renal failure (CRF), and parathyroid hormone (PTH) inhibits Staphylococcus aureus Cowan I (SAC) or pokeweed mitogen (PWM)-induced antibody production by B cells from normal subjects. Since CRF is associated with secondary hyperparathyroidis...

journal_title：Kidney international

authors： Gaciong Z,Alexiewicz JM,Massry SG

更新日期：1991-11-01 00:00:00

abstract：:To analyze the role of clusterin in renal diseases involving a regenerative process, we have used a novel rodent model to compare temporal and spatial expression of clusterin mRNA. Thus, renal artery stenosis was used to induce unilateral non-infarctive renal atrophy. After several weeks, when cellular pathology of at...

journal_title：Kidney international

authors： Gobé GC,Buttyan R,Wyburn KR,Etheridge MR,Smith PJ

更新日期：1995-02-01 00:00:00

abstract：:IgM in the blood of normal individuals consists mainly of 'natural' polyreactive antibodies. Natural IgM is thought to provide an initial defense against infection and to promote the healing of wounded cells. Yet, as Panzer and colleagues show, these benefits can be eclipsed when the IgM binds to damaged cells of the ...

journal_title：Kidney international

authors： Platt JL,Cascalho M

更新日期：2015-09-01 00:00:00

abstract：:Circulating parathyroid hormone (PTH) shows a complex relationship with hard outcomes in subjects with chronic kidney disease (CKD). Moreover, intervention studies directly targeting PTH failed to yield unequivocal results. Disturbed PTH metabolism, posttranslational modifications of PTH, and end-organ hyporesponsiven...

journal_title：Kidney international

authors： Evenepoel P,Bover J,Ureña Torres P

更新日期：2016-12-01 00:00:00

abstract：:Primary distal renal tubular acidosis is a rare genetic disease. Mutations in SLC4A1, ATP6V0A4, and ATP6V1B1 genes have been described as the cause of the disease, transmitted as either an autosomal dominant or recessive trait. Particular clinical features, such as sensorineural hearing loss, have been mainly describe...

journal_title：Kidney international

authors： Palazzo V,Provenzano A,Becherucci F,Sansavini G,Mazzinghi B,Orlandini V,Giunti L,Roperto RM,Pantaleo M,Artuso R,Andreucci E,Bargiacchi S,Traficante G,Stagi S,Murer L,Benetti E,Emma F,Giordano M,Rivieri F,Colussi G,

更新日期：2017-05-01 00:00:00

abstract：:The sympathetic nervous system modulates renal function through its receptors namely beta1 (cardiac output and renin release), alpha1 (systemic and renovascular constriction), and beta2 renovascular dilation. Sympathetic overactivity is commonly seen in chronic kidney disease (CKD) and is an important contributor to i...

journal_title：Kidney international

authors： Bakris GL,Hart P,Ritz E

更新日期：2006-12-01 00:00:00

abstract：:Recent reports indicate a decreased mortality risk for patients on chronic peritoneal dialysis in the United States. We sought to determine whether a higher use of automated versus continuous ambulatory peritoneal dialysis was associated with this improvement. Analyses were carried out using data from the United State...

journal_title：Kidney international

authors： Mehrotra R,Chiu YW,Kalantar-Zadeh K,Vonesh E

更新日期：2009-07-01 00:00:00

abstract：:Transgenic rats [TGR; strain name TGR(mRen2)27] harboring the mouse Ren-2 renin gene have been recently generated as a model for the study of primary hypertension that offers the advantage of a clearly-defined genetic alteration. Expression of the mouse Ren-2 gene causes severe hypertension (200 to 260 mm Hg) which is...

journal_title：Kidney international

authors： Bachmann S,Peters J,Engler E,Ganten D,Mullins J

更新日期：1992-01-01 00:00:00

abstract：:Tubular atrophy and interstitial fibrosis, important in progression of renal diseases, including diabetic (D) and cyclosporine-induced (CSA) nephropathy, have been considered irreversible. Normoglycemia for 10 years following pancreas transplantation alone (PTA) reversed D glomerulopathy lesions. This study quantified...

journal_title：Kidney international

authors： Fioretto P,Sutherland DE,Najafian B,Mauer M

更新日期：2006-03-01 00:00:00

abstract：:Osteocytes within the mineralized bone matrix control bone remodeling by regulating osteoblast and osteoclast activity. Osteocytes express the aging suppressor Klotho, but the functional role of this protein in skeletal homeostasis is unknown. Here we identify Klotho expression in osteocytes as a potent regulator of b...

journal_title：Kidney international

authors： Komaba H,Kaludjerovic J,Hu DZ,Nagano K,Amano K,Ide N,Sato T,Densmore MJ,Hanai JI,Olauson H,Bellido T,Larsson TE,Baron R,Lanske B

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:The Banff working formulation of renal transplant pathology is intended to have international application. There remains a need to develop methods to harmonize the application of such grading systems between laboratories. Banff grades do not always permit precise management decisions to be made. Alternative ...

journal_title：Kidney international

authors： Furness PN,Taub N,Convergence of European Renal Transplant Pathology Assessment Procedures (CERTPAP) Project.

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Neointimal hyperplasia occurs commonly at the anastomoses of arteriovenous grafts for chronic hemodialysis, causing stenosis and occlusion. Antiproliferative drugs may be effective in inhibiting hyperplasia, but local drug delivery would be required to minimize systemic side effects. We examined the feasibil...

journal_title：Kidney international

authors： Masaki T,Rathi R,Zentner G,Leypoldt JK,Mohammad SF,Burns GL,Li L,Zhuplatov S,Chirananthavat T,Kim SJ,Kern S,Holman J,Kim SW,Cheung AK

更新日期：2004-11-01 00:00:00

abstract：:Progressive glomerulonephritis and attendant end-stage renal disease (ESRD) result from antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. The optimum time of kidney transplantation in patients with ESRD due to ANCA-associated vasculitis (AAV) and the risk of renal or nonrenal recurrence of vasculitis a...

journal_title：Kidney international

authors： Gera M,Griffin MD,Specks U,Leung N,Stegall MD,Fervenza FC

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:The ontogeny of the renal mineralocorticoid (MR) and glucocorticoid (GR) receptors in the ovine fetus, and the effects of early exposure to synthetic or natural glucocorticoids on the expression of these genes in late gestation were examined. METHODS:A partial cDNA sequence for the ovine MR was cloned and u...

journal_title：Kidney international

authors： Hantzis V,Albiston A,Matsacos D,Wintour EM,Peers A,Koukoulas I,Myles K,Moritz K,Dodic M

更新日期：2002-02-01 00:00:00

abstract：:Pathological classifications in current use for the assessment of glomerular disease have been typically opinion-based and built on the expert assumptions of renal pathologists about lesions historically thought to be relevant to prognosis. Here we develop a unique approach for the pathological classification of a glo...

journal_title：Kidney international

authors： Working Group of the International IgA Nephropathy Network and the Renal Pathology Society.,Roberts IS,Cook HT,Troyanov S,Alpers CE,Amore A,Barratt J,Berthoux F,Bonsib S,Bruijn JA,Cattran DC,Coppo R,D'Agati V,D'Amico G,Emanci

更新日期：2009-09-01 00:00:00

abstract：:Calcitonin secretion is stimulated by acute hypercalcemia. Furthermore, in the rat, the calcemic response to parathyroid hormone (PTH) is decreased by calcitonin stimulation. However, in renal failure, it is not known if an increase in the serum calcium concentration within the physiologic range of serum calcium stimu...

journal_title：Kidney international

authors： Torres A,Rodriguez M,Felsenfeld A,Martin-Malo A,Llach F

更新日期：1991-10-01 00:00:00

abstract：:31P NMR as a descriptive technique is of interest to nephrologists. Particular contributions of 31P NMR to our understanding of renal function may be enumerated.: "Free" metabolite levels are different from those classically accepted; in particular, ADP and Pi are low with implications for the control of renal metabol...

journal_title：Kidney international

authors： Ross B,Freeman D,Chan L

更新日期：1986-01-01 00:00:00

abstract：:[Arg(8)]-vasopressin (AVP) has several functions via its three distinct receptors, V1a, V1b, and V2. The V1a vasopressin receptor (V1aR) is expressed in blood vessels and involved in vascular contraction. Recently, we generated V1a receptor-deficient (V1aR(-/-)) mice and found that they were hypotensive. In addition, ...

journal_title：Kidney international

authors： Aoyagi T,Koshimizu TA,Tanoue A

更新日期：2009-11-01 00:00:00

abstract：:Intravenous conjugated estrogens reduce the prolonged bleeding time in uremic patients and in a rat model of uremia. However, estrogens have major side effects related to their hormonal activity. We investigated whether a beta-resorcylic acid lactone, zeranol (a compound with close spatial similarity to estrogens but ...

journal_title：Kidney international

authors： Zoja C,Viganò G,Corna D,Salmona M,Remuzzi G,Garattini S

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:The p21 protein is found in the nucleus of most cells where it modulates cell cycle activity. At low levels, p21 stabilizes interactions between D cyclins and their cyclin-dependent kinases (cdks), but at high levels after induction by several different stress pathways, it causes cell cycle arrest. The p21 m...

journal_title：Kidney international

authors： Megyesi J,Andrade L,Vieira JM Jr,Safirstein RL,Price PM

更新日期：2001-12-01 00:00:00

abstract：:In this issue, McMahon et al. report that, by combining phenotypic, metabolomic, and genetic data, they could better detect chronic kidney disease at the early stages and provide insight into its pathobiology. The most significant findings of the study are that several urinary metabolites (e.g., glycine and histidine)...

journal_title：Kidney international

authors： Zhang G,Saito R,Sharma K

更新日期：2017-06-01 00:00:00

abstract：:Hemodialysis has a profound effect on fluid balance. Since fluid is initially withdrawn from the intravascular compartment, blood volume will decrease rapidly. A fluid shift (refill) from the overhydrated interstitium towards the intravascular compartment counteracts hypovolemia. Underestimation of postdialytic dry we...

journal_title：Kidney international

authors： de Vries JP,Kouw PM,van der Meer NJ,Olthof CG,Oe LP,Donker AJ,de Vries PM

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:Previous reports have shown the presence of erythrogenic toxin type B (ETB), apoptosis, proliferation, and leukocyte infiltration in biopsies from patients with acute poststreptococcal glomerulonephritis (APSGN). METHODS:Attempting to correlate the apoptotic and proliferative events with the interaction of ...

journal_title：Kidney international

authors： Viera NT,Romero MJ,Montero MK,Rincon J,Mosquera JA

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Cisplatin (CP) induced polyuria in rats is associated with a reduction in medullary hypertonicity, normally generated by the thick ascending limb (TAL) salt transporters, and the collecting duct urea transporters (UT). To investigate the molecular basis of this abnormality, we determined the protein abundanc...

journal_title：Kidney international

authors： Ecelbarger CA,Sands JM,Doran JJ,Cacini W,Kishore BK

更新日期：2001-12-01 00:00:00

abstract：:The present study examined the effect of elevated glucose on glomerular cell membrane lipid peroxidation. Glomeruli were isolated from male Sprague-Dawley rat kidneys utilizing a standard sieving method and incubated in medium containing different concentrations of glucose at 37 degrees C for one and 48 hours. The lev...

journal_title：Kidney international

authors： Ha H,Yoon SJ,Kim KH

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Rho proteins are small guanine 5'-triphosphate (GTP)-binding proteins felt to be important regulators of several aspects of cell function, including the organization of the actin cytoskeleton. The effects of Rho proteins on the regulation of renal tubular epithelial cell function are not known. METHODS:Sele...

journal_title：Kidney international

authors： Anderson RJ,Ray CJ,Popoff MR

更新日期：2000-11-01 00:00:00

abstract：:The monitoring of the levels of alloantibodies following transplantation might facilitate early diagnosis of chronic rejection (CR), the leading cause of renal allograft failure. Here, we used serial alloantibody surveillance to monitor patients with preoperative positive flow cytometric crossmatch (FCXM). Sixty-nine ...

journal_title：Kidney international

authors： Kimball PM,Baker MA,Wagner MB,King A

更新日期：2011-05-01 00:00:00

abstract：:The incidence of acute kidney injury (AKI) is high in elderly people, and is difficult to prevent and treat. One of its major causes is renal ischemia-reperfusion injury (IRI). A young systemic environment may prevent the senescence of old organs. However, it is unknown whether a young milieu may reduce renal IRI in t...

journal_title：Kidney international

authors： Liu D,Lun L,Huang Q,Ning Y,Zhang Y,Wang L,Yin Z,Zhang Y,Xia L,Yin Z,Fu B,Cai G,Sun X,Chen X

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:The aim of this study was to define cut-off values for serum creatinine as an indicator of several levels of renal impairment. METHODS:To identify the suitable values, receiver operating characteristic curves were constructed based on the data of 984 laboratory assessments of renal function. The glomerular ...

journal_title：Kidney international

authors： Couchoud C,Pozet N,Labeeuw M,Pouteil-Noble C

更新日期：1999-05-01 00:00:00