Evidence for Rho protein regulation of renal tubular epithelial cell function.

abstract：:Systemic AA type amyloidosis with renal involvement is the major cause of morbidity and mortality in patients with familial Mediterranean fever (FMF). A histopathological examination is essential to achieve a definite diagnosis in systemic amyloidosis. The diagnostic yield of the procedure varies according to the biop...

journal_title：Kidney international

authors： Sungur C,Sungur A,Ruacan S,Arik N,Yasavul U,Turgan C,Caglar S

更新日期：1993-10-01 00:00:00

abstract：:Using in situ hybridization and immunocytochemistry we describe the renal localization of the PDGF alpha-receptor. PDGF alpha-receptor mRNA was uniformly present in human metanephric kidney in interstitial cells and vascular arcades that course through the blastema. PDGF alpha-receptor mRNA was present in some mesangi...

journal_title：Kidney international

authors： Floege J,Hudkins KL,Seifert RA,Francki A,Bowen-Pope DF,Alpers CE

更新日期：1997-04-01 00:00:00

abstract：:We examined the effect of daily cyclosporin A administration on the development and extent of tubulointerstitial nephritis produced in rats immunized with tubular basement membranes in adjuvant. Six mg/kg/day of cyclosporin A, given from the time of immunization, completely blocked the development of interstitial lesi...

journal_title：Kidney international

authors： Shih W,Hines WH,Neilson EG

更新日期：1988-06-01 00:00:00

abstract：INTRODUCTION:Monocyte chemoattractant protein-1 (MCP-1) promotes renal inflammation, thereby contributing to acute and chronic nephropathies. Its production is stimulated by oxidative stress. Thus, this study tested whether pro-oxidant iron/carbohydrate complexes, used to treat iron deficiency, induce MCP-1 in renal/ex...

journal_title：Kidney international

authors： Zager RA

更新日期：2005-10-01 00:00:00

abstract：:This NIH-funded multicenter randomized study of focal segmental glomerulosclerosis (FSGS) treatment compared the efficacy of a 12-month course of cyclosporine to a combination of oral pulse dexamethasone and mycophenolate mofetil in children and adults with steroid-resistant primary FSGS. Of the 192 patients enrolled,...

journal_title：Kidney international

authors： Gipson DS,Trachtman H,Kaskel FJ,Greene TH,Radeva MK,Gassman JJ,Moxey-Mims MM,Hogg RJ,Watkins SL,Fine RN,Hogan SL,Middleton JP,Vehaskari VM,Flynn PA,Powell LM,Vento SM,McMahan JL,Siegel N,D'Agati VD,Friedman AL

更新日期：2011-10-01 00:00:00

abstract：:Insulin and growth factors activate the phosphatidylinositide-3-kinase pathway, leading to stimulation of several kinases including serum- and glucocorticoid-inducible kinase isoform SGK3, a transport regulating kinase. Here, we explored the contribution of SGK3 to the regulation of renal tubular phosphate transport. ...

journal_title：Kidney international

authors： Bhandaru M,Kempe DS,Rotte A,Capuano P,Pathare G,Sopjani M,Alesutan I,Tyan L,Huang DY,Siraskar B,Judenhofer MS,Stange G,Pichler BJ,Biber J,Quintanilla-Martinez L,Wagner CA,Pearce D,Föller M,Lang F

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Left ventricular enlargement is very common at the inception of dialysis therapy, and highly predictive of future cardiac morbidity and mortality. It is not known whether cardiac size increases further while on dialysis therapy and whether potentially reversible risk factors for later progression can be iden...

journal_title：Kidney international

authors： Foley RN,Parfrey PS,Kent GM,Harnett JD,Murray DC,Barre PE

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:The ontogeny of the renal mineralocorticoid (MR) and glucocorticoid (GR) receptors in the ovine fetus, and the effects of early exposure to synthetic or natural glucocorticoids on the expression of these genes in late gestation were examined. METHODS:A partial cDNA sequence for the ovine MR was cloned and u...

journal_title：Kidney international

authors： Hantzis V,Albiston A,Matsacos D,Wintour EM,Peers A,Koukoulas I,Myles K,Moritz K,Dodic M

更新日期：2002-02-01 00:00:00

abstract：:Changes in macula densa intracellular pH (pHi) were used to monitor the direction of flux mediated by the apical Na:2Cl:K cotransporter. At the macula densa, a decrease in luminal [Cl] ([Cl]1) from 60 to 1 mM produced cellular alkalinization secondary to a cascade of events involving a decrease in apical Na:2Cl:K cotr...

journal_title：Kidney international

authors： Lapointe JY,Laamarti A,Hurst AM,Fowler BC,Bell PD

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:Dialysis efficiency has a great influence on the outcome of patients. Few data are available on the removal of solutes with molecular weights higher than urea and creatinine. The aim of our study was to assess the transport and the removal of substances with molecular weights up to 15 kD and to evaluate the ...

journal_title：Kidney international

authors： Montini G,Amici G,Milan S,Mussap M,Naturale M,Rätsch IM,Ammenti A,Sorino P,Verrina E,Andreetta B,Zacchello G,Italian Registry of Pediatric Peritoneal Dialysis.

更新日期：2002-03-01 00:00:00

abstract：:The contractile properties of recombinant human erythropoietin (rHuEPO) on isolated resistance vessels of renal and mesenteric vascular beds were studied in an in vitro model using a small vessel myograph. Under isometric conditions, rHuEPO caused a contraction of this vasculature in a concentration range between 10 U...

journal_title：Kidney international

authors： Heidenreich S,Rahn KH,Zidek W

更新日期：1991-02-01 00:00:00

abstract：:The terminally differentiated podocyte, also called glomerular visceral epithelial cell, are highly specialized cells. They function as a critical size and charge barrier to prevent proteinuria. Podocytes are injured in diabetic and non-diabetic renal diseases. The clinical signature of podocyte injury is proteinuria,...

journal_title：Kidney international

authors： Shankland SJ

更新日期：2006-06-01 00:00:00

abstract：:The erythropoietin analogs have been an important advance for the treatment of the anemia of kidney disease, resulting in reduced need for blood transfusion and improved quality of life. Recent studies, however, have indicated risks associated with targeting higher levels of hemoglobin (Hb). As a result, in March 2007...

journal_title：Kidney international

authors： Fishbane S,Nissenson AR

更新日期：2007-10-01 00:00:00

abstract：:Atypical hemolytic uremic syndrome (aHUS) is a form of thrombotic microangiopathy (TMA) caused by dysregulated complement activation. Clinically, aHUS is effectively treated by an anti-C5 monoclonal antibody (mAb) but whether the disease is mediated by the C5a receptor (C5aR) or C5b-9 pathway, or both, is unknown. Her...

journal_title：Kidney international

authors： Ueda Y,Miwa T,Ito D,Kim H,Sato S,Gullipalli D,Zhou L,Golla M,Song D,Dunaief JL,Palmer MB,Song WC

更新日期：2019-07-01 00:00:00

abstract：:In the present study we assessed the prevalence of thin glomerular basement membrane (TGBM) in a large group of native kidney biopsies done for evaluation of renal disease. TGBM was present in 54 of 1078 biopsies (5%). In 12 of 54 biopsies (24%), TGBM was the only abnormality present. In the remaining biopsies TGBM wa...

journal_title：Kidney international

authors： Cosio FG,Falkenhain ME,Sedmak DD

更新日期：1994-08-01 00:00:00

abstract：:[Arg(8)]-vasopressin (AVP) has several functions via its three distinct receptors, V1a, V1b, and V2. The V1a vasopressin receptor (V1aR) is expressed in blood vessels and involved in vascular contraction. Recently, we generated V1a receptor-deficient (V1aR(-/-)) mice and found that they were hypotensive. In addition, ...

journal_title：Kidney international

authors： Aoyagi T,Koshimizu TA,Tanoue A

更新日期：2009-11-01 00:00:00

abstract：:The prevalence of raised Na+/Li+ countertransport (CT) activity (greater than 0.41 mmol/liter RBC/hr) was assessed in 185 consecutive insulin-dependent diabetic patients attending an outpatient diabetic clinic. Normoalbuminuria was defined as an overnight albumin excretion rate (AER) of less than 20 micrograms/min (N ...

journal_title：Kidney international

authors： Lopes de Faria JB,Friedman R,Tariq T,Viberti G

更新日期：1992-04-01 00:00:00

abstract：:As new components of the renin-angiotensin system (RAS) are elucidated, our understanding of the complexities of their interactions also advances. Previous studies have determined that podocytes possess a local RAS that can generate angiotensin II. Podocytes have also been shown to express angiotensin-converting enzym...

journal_title：Kidney international

authors： Harris RC

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Controversy exists regarding the possible associations between a single nucleotide polymorphism of the transcobalamin II encoding gene (TCN2 776C>G) and plasma levels of vitamin B(12), folate, or total homocysteine. METHODS:In a cross-sectional study of 732 kidney allograft recipients, patients were categor...

journal_title：Kidney international

authors： Winkelmayer WC,Skoupy S,Eberle C,Födinger M,Sunder-Plassmann G

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Lipoprotein glomerulopathy (LPG) is characterized by intraglomerular lipoprotein thrombosis and high plasma concentrations of apolipoprotein (apo) E. An apo E variant, apo E2 (Arg145Pro) Sendai, was recently identified in three patients with LPG. We detected a novel point mutation in the apo E gene in a pati...

journal_title：Kidney international

authors： Matsunaga A,Sasaki J,Komatsu T,Kanatsu K,Tsuji E,Moriyama K,Koga T,Arakawa K,Oikawa S,Saito T,Kita T,Doi T

更新日期：1999-08-01 00:00:00

abstract：:The antiphospholipid syndrome is a common autoimmune disease caused by pathogenic antiphospholipid antibodies, leading to recurrent thrombosis and/or obstetrical complications. Importantly for nephrologists, antiphospholipid antibodies are associated with various renal manifestations including large renal vessel throm...

journal_title：Kidney international

authors： Bienaimé F,Legendre C,Terzi F,Canaud G

更新日期：2017-01-01 00:00:00

abstract：:To determine the effect of an acute load of potassium on potassium reabsorption by the loop of Henle in chronic renal failure, the right kidney was removed and branches of the left renal artery were ligated in 17 rats. One week later and after 2 days of a potassium-free diet, rats were studied before (period 1) and af...

journal_title：Kidney international

authors： Milanes CL,Jamison RL

更新日期：1985-06-01 00:00:00

abstract：:Fibroblast growth factor 23 (FGF23) is a phosphate-regulating hormone that acts primarily on the kidney and parathyroid. With declining kidney function there is an increase in circulating FGF23 levels, which is associated with vascular calcification and mortality in chronic kidney disease. Whether FGF23 exerts direct ...

journal_title：Kidney international

authors： Jimbo R,Kawakami-Mori F,Mu S,Hirohama D,Majtan B,Shimizu Y,Yatomi Y,Fukumoto S,Fujita T,Shimosawa T

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:The "intact" parathyroid hormone (PTH) assay recognizes PTH-(1-84) as well as amino terminally truncated PTH fragments, that is, large carboxyterminal PTH fragments (C-PTH fragments). The present study investigated whether the use of the plasma PTH-(1-84)/C-PTH fragment ratio enhances the noninvasive assessm...

journal_title：Kidney international

authors： Monier-Faugere MC,Geng Z,Mawad H,Friedler RM,Gao P,Cantor TL,Malluche HH

更新日期：2001-10-01 00:00:00

abstract：:Renal stone disease, which affects 12% of males and 5% of females by the seventh decade, occurs as an inherited disorder in 45% of patients and is most commonly associated with hypercalciuria. The biochemical basis for hereditary nephrolithiasis and hypercalciuria is unknown, and this has therefore been investigated b...

journal_title：Kidney international

authors： Thakker RV

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Inbred miniature swine treated for 12 days with high-dose cyclosporine A develop tolerance to histocompatibility complex (MHC) class I-mismatched renal allografts. When this protocol was modified by adding thymectomy before transplant, all animals developed acute rejection. Thereafter, by day 100, one half d...

journal_title：Kidney international

authors： Shimizu A,Yamada K,Sachs DH,Colvin RB

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:This study examined the effects of stent placement for renal artery stenosis on the function of treated and contralateral kidneys. METHODS:Eighteen patients who underwent stent placement for unilateral renal artery stenosis presenting with hypertension and/or renal failure were studied before angiography an...

journal_title：Kidney international

authors： Leertouwer TC,Derkx FH,Pattynama PM,Deinum J,van Dijk LC,Schalekamp MA

更新日期：2002-08-01 00:00:00

abstract：:The profibrotic adhesion molecule, osteopontin (OPN), is upregulated in kidneys of humans and mice with diabetes. The thiazolidinedione (TZD) insulin sensitizers decrease albuminuria in diabetic nephropathy (DN) and reduce OPN expression in vascular and cardiac tissue. To examine whether OPN is a critical mediator of ...

journal_title：Kidney international

authors： Nicholas SB,Liu J,Kim J,Ren Y,Collins AR,Nguyen L,Hsueh WA

更新日期：2010-04-01 00:00:00

abstract：:Intradialytic hypotension is a most frequent complication of hemodialysis and may contribute to cardiovascular events and high mortality. There is a hypothesis that an increase in adenosine generation during hemodialysis may cause vasodilation and a decrease in cardiac output, which results in systemic hypotension. We...

journal_title：Kidney international

authors： Imai E,Fujii M,Kohno Y,Kageyama H,Nakahara K,Hori M,Tsubakihara Y

更新日期：2006-03-01 00:00:00

abstract：:To test the hypothesis that systemic administration of immunoglobulin might reduce glomerular injury in membranous nephropathy through mechanisms involving inhibition of complement activation, we studied the passive Heymann nephritis (PHN) model of membranous nephropathy in rats. The daily administration of immunoglob...

journal_title：Kidney international

authors： Nangaku M,Pippin J,Richardson CA,Schulze M,Young BA,Alpers CE,Gordon KL,Johnson RJ,Couser WG

更新日期：1996-12-01 00:00:00