Improved assessment of bone turnover by the PTH-(1-84)/large C-PTH fragments ratio in ESRD patients.

abstract：:Serum fibroblast growth factor 23 (FGF23) is a novel phosphaturic factor and important for the regulation of inorganic phosphate (Pi) homeostasis. In this study, we examined an acute effect of oral Pi loading on serum FGF23 levels to clarify the role in rapid adjustment of serum Pi level. We performed a randomized, do...

journal_title：Kidney international

authors： Nishida Y,Taketani Y,Yamanaka-Okumura H,Imamura F,Taniguchi A,Sato T,Shuto E,Nashiki K,Arai H,Yamamoto H,Takeda E

更新日期：2006-12-01 00:00:00

abstract：:Protein and mRNA expression of TGF-beta isoforms, TGF-beta 1, -beta 2 and -beta 3, and deposition of fibronectin containing extra domain A (fibronectin EDA+) and plasminogen activator inhibitor-1 (PAI-1) were studied in human chronic glomerulonephritis and diabetic nephropathy. Normal kidneys showed similar, weak immu...

journal_title：Kidney international

authors： Yamamoto T,Noble NA,Cohen AH,Nast CC,Hishida A,Gold LI,Border WA

更新日期：1996-02-01 00:00:00

abstract：:Many approaches to blocking profibrotic TGFbeta overexpression are under way. Therapeutic targeting of TGFbeta-Smad signaling holds promise for slowing or halting progressive renal disease. In this issue, Fukasawa et al., using the unilateral ureteral obstruction model, provide a new target for therapeutic interventio...

journal_title：Kidney international

authors： Huang Y,Border WA,Noble NA

更新日期：2006-05-01 00:00:00

abstract：:The interaction of 15-hydroxyeicosatetraenoic acid (15-HETE) and cultured MDCK renal tubular epithelial cells was investigated to determine whether incorporation of this lipoxygenase product will affect polyphosphoinositide formation. MDCK cells were incubated with 1 microM [3H]-15-HETE for 15 to 120 minutes. Maximum ...

journal_title：Kidney international

authors： Girton RA,Spector AA,Gordon JA

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:High blood glucose levels play major roles in the pathogenesis of renal diabetic complications through non-enzymatic glycation. For long-lived molecules this leads to formation of advanced glycation end products (AGE), and the renal extracellular matrix appears to be one of the targets for such processes. Us...

journal_title：Kidney international

authors： Bendayan M

更新日期：1998-08-01 00:00:00

abstract：:Studies were conducted to investigate the impact of nitric oxide synthesis inhibition on blood pressure and glomerular hemodynamic adaptations to pregnancy in the rat. In normal pregnancy, urinary excretion of NO2 + NO3 (NOx), reflecting increased nitric oxide (NO) production, progressively increased. Blockade of NO p...

journal_title：Kidney international

authors： Deng A,Engels K,Baylis C

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:We aimed to identify genes with kidney specific, developmentally regulated expression. Here we report the cDNA sequence and expression pattern of KS, a novel kidney-specific rat gene. METHODS:A partial cDNA was identified by differential display polymerase chain reaction (PCR) of a renal cell fraction enric...

journal_title：Kidney international

authors： Hilgers KF,Nagaraj SK,Karginova EA,Kazakova IG,Chevalier RL,Carey RM,Pentz ES,Gomez RA

更新日期：1998-11-01 00:00:00

abstract：:Autophagy is a dynamic and highly regulated process of self-digestion responsible for cell survival and reaction to oxidative stress. As oxidative stress is increased in uremia and is associated with vascular calcification, we studied the role of autophagy in vascular calcification induced by phosphate. In an in vitro...

journal_title：Kidney international

authors： Dai XY,Zhao MM,Cai Y,Guan QC,Zhao Y,Guan Y,Kong W,Zhu WG,Xu MJ,Wang X

更新日期：2013-06-01 00:00:00

abstract：:X-ray films of the hand skeleton (mammography technique), serum chemistry, and quantitative bone histology (micromorphometry of undecalcified sections, iliac crest spongiosa) were compared in 25 patients on maintenance hemodialysis. The X-ray findings correlated better with serum PTH levels than with bone histology. O...

journal_title：Kidney international

authors： Ritz E,Prager P,Krempien B,Bommer J,Malluche HH,Schmidt-Gayk H

更新日期：1978-04-01 00:00:00

abstract：:Tenofovir, a widely prescribed antiretroviral medication for treatment of HIV-1 infection, is infrequently associated with renal dysfunction and biopsy findings of acute tubular necrosis. We examined the clinical and pathological findings in 13 cases of tenofovir nephrotoxicity (7 men and 6 women, mean age of 51.1±9.6...

journal_title：Kidney international

authors： Herlitz LC,Mohan S,Stokes MB,Radhakrishnan J,D'Agati VD,Markowitz GS

更新日期：2010-12-01 00:00:00

abstract：:Recent studies suggest that postnatal neovascularization relies not exclusively on sprouting of preexisting vessels ("angiogenesis"), but also involves the contribution of bone marrow-derived circulating endothelial progenitor cells (EPCs). EPCs can be isolated from peripheral blood or bone marrow mononuclear cells, C...

journal_title：Kidney international

authors： Urbich C,Dimmeler S

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Phenylalanine is converted to para- and ortho-tyrosine by hydroxyl free radical, or to para-tyrosine by the phenylalanine hydroxylase enzyme. The aim of this study was to measure para- and ortho-tyrosine in the urine and plasma of patients with chronic renal disease and/or diabetes, to obtain information on ...

journal_title：Kidney international

authors： Molnár GA,Wagner Z,Markó L,Kó Szegi T,Mohás M,Kocsis B,Matus Z,Wagner L,Tamaskó M,Mazák I,Laczy B,Nagy J,Wittmann I

更新日期：2005-11-01 00:00:00

abstract：:Protein-bound uremic toxins (PBUTs) accumulate in chronic kidney disease (CKD) and are poorly removed by dialysis. Gryp et al. demonstrated that fecal bacteria from patients with CKD do not produce more PBUTs than do those from healthy controls and that the accumulation of PBUTs, as CKD progresses, is mainly due to th...

journal_title：Kidney international

authors： Jourde-Chiche N,Burtey S

更新日期：2020-06-01 00:00:00

abstract：:Nephropathia epidemica (NE) caused by Puumala hantavirus is one type of hemorrhagic fever with renal syndrome (HFRS). There is considerable variability in the clinical severity of NE. Many infections are subclinical but the disease can even be fatal. We questioned whether the wide spectrum in the outcome of NE is depe...

journal_title：Kidney international

authors： Mustonen J,Partanen J,Kanerva M,Pietilä K,Vapalahti O,Pasternack A,Vaheri A

更新日期：1996-01-01 00:00:00

abstract：:To determine whether acute renal failure (ARF) increases the long-term risk of progressive chronic kidney disease (CKD), we studied the outcome of patients whose initial kidney function was normal or near normal but who had an episode of dialysis-requiring ARF and did not develop end-stage renal disease within 30 days...

journal_title：Kidney international

authors： Lo LJ,Go AS,Chertow GM,McCulloch CE,Fan D,Ordoñez JD,Hsu CY

更新日期：2009-10-01 00:00:00

abstract：:The inner medullary collecting duct (IMCD) is a major target site of atrial natriuretic peptide (ANP) for diuresis and natriuresis, and it is in a hypertonic condition made by the renal countercurrent multiplication system. We investigated the effects of hyperosmolality on ANP-stimulated cGMP generation in IMCD and gl...

journal_title：Kidney international

authors： Shinohara M,Nonoguchi H,Ujiie K,Terada Y,Owada A,Tomita K,Marumo F

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:It has been shown that non-congenic mice strains with lower levels of renal meprin develop less renal injury following renal ischemia and reperfusion. We have demonstrated that following ischemia-reperfusion renal injury, there is a rapid shift of meprin localization and intensity from the brush border to th...

journal_title：Kidney international

authors： Carmago S,Shah SV,Walker PD

更新日期：2002-03-01 00:00:00

abstract：:A number of clinical laboratory and biopsy-derived parameters were assessed for their prognostic significance in the short (24 months), intermediate (60 months) and long terms in 45 patients (43 female, 2 male) with diffuse proliferative lupus glomerulonephritis (DPGN). The factors evaluated were serum creatinine (SCr...

journal_title：Kidney international

authors： Magil AB,Puterman ML,Ballon HS,Chan V,Lirenman DS,Rae A,Sutton RA

更新日期：1988-10-01 00:00:00

abstract：:Space medicine and new technology such as magnetic resonance imaging of tissue sodium stores (23NaMRI) have changed our understanding of human sodium homeostasis and pathophysiology. It has become evident that body sodium comprises 3 main components. Two compartments have been traditionally recognized, namely one that...

journal_title：Kidney international

authors： Canaud B,Kooman J,Selby NM,Taal M,Francis S,Kopperschmidt P,Maierhofer A,Kotanko P,Titze J

更新日期：2019-02-01 00:00:00

abstract：:The hormonal responsiveness profile of the cortical collecting duct varies from one species to another. To identify the hormones and agonists that modulate the functions of this tubule segment in the human species, we generated a cell line (HCD) immortalized by SV40 virus. The tubular origin of this cell line was asse...

journal_title：Kidney international

authors： Prié D,Friedlander G,Coureau C,Vandewalle A,Cassingéna R,Ronco PM

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:The substitution of tryptophan for glycine at amino acid 460 (Gly460Trp polymorphism) of the alpha-subunit of the heterodimeric cytoskeleton protein adducin increases renal sodium reabsorption and may be involved in the pathophysiology of essential hypertension. In the present study, we investigated in multi...

journal_title：Kidney international

authors： Wang JG,Staessen JA,Barlassina C,Fagard R,Kuznetsova T,Struijker-Boudier HA,Zagato L,Citterio L,Messaggio E,Bianchi G

更新日期：2002-12-01 00:00:00

abstract：:Vascular calcification is recognized as a major contributor to cardiovascular disease (CVD) in end stage renal disease (ESRD) patients. Susceptibility to vascular calcification is genetically determined and actively regulated by diverse inducers and inhibitors. One of these inducers, hyperphosphatemia, promotes vascul...

journal_title：Kidney international

authors： Giachelli CM

更新日期：2009-05-01 00:00:00

abstract：:Patients receiving hemodialysis have high rates of cardiovascular morbidity and mortality that may be related to the hemodynamic effects of rapid ultrafiltration. Here we tested whether higher dialytic ultrafiltration rates are associated with greater all-cause and cardiovascular mortality, and hospitalization for car...

journal_title：Kidney international

authors： Flythe JE,Kimmel SE,Brunelli SM

更新日期：2011-01-01 00:00:00

abstract：:Pain is a common complaint in patients with autosomal-dominant polycystic kidney disease, and a systematic approach is needed to differentiate the etiology of the pain and define an approach to management. A thorough history is the best clue to the multifactorial causes of the pain, superimposed upon an understanding ...

journal_title：Kidney international

authors： Bajwa ZH,Gupta S,Warfield CA,Steinman TI

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Nitric oxide (NO) has been shown to be a paracrine/autocrine regulator of proximal tubular transport. In this study, we investigated the effect of NO on the paracellular permeability of opossum kidney (OK) cells, a proximal tubule cell line that possesses a leaky paracellular pathway resembling that of the i...

journal_title：Kidney international

authors： Liang M,Knox FG

更新日期：1999-06-01 00:00:00

abstract：:Growth failure is a cardinal feature of chronic renal failure in children. Administration of recombinant human growth hormone (rhGH) ameliorates this problem but may adversely affect the kidney and hasten the progression to end-stage renal disease. We conducted experiments to examine the impact of rhGH on the severity...

journal_title：Kidney international

authors： Trachtman H,Futterweit S,Schwob N,Maesaka J,Valderrama E

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Hyperuricemia has been linked to cardiovascular and renal diseases, possibly through the generation of reactive oxygen species (ROS) and subsequent endothelial dysfunction. The enzymatic effect of xanthine oxidase is the production of ROS and uric acid. Studies have shown that inhibiting xanthine oxidase wit...

journal_title：Kidney international

authors： Khosla UM,Zharikov S,Finch JL,Nakagawa T,Roncal C,Mu W,Krotova K,Block ER,Prabhakar S,Johnson RJ

更新日期：2005-05-01 00:00:00

abstract：:Increasing evidence points to the importance of aberrant O-glycosylated immunoglobulin A1 (IgA1) in the pathogenesis of IgA nephropathy (IgAN), a disease widely considered to be a polygenic disorder. We earlier found that haplotypes in two key glycosyltransferase genes, C1GALT1 and ST6GALNAC2, were associated with sus...

journal_title：Kidney international

authors： Zhu L,Tang W,Li G,Lv J,Ding J,Yu L,Zhao M,Li Y,Zhang X,Shen Y,Zhang H,Wang H

更新日期：2009-07-01 00:00:00

abstract：:Suramin is a polysulfonated naphthylurea originally designed as a treatment for trypanosomiasis; but that has also been used to treat rodent models of fulminant hepatic failure and focal brain ischemia. In this study, we determined the effects of suramin on renal ischemia/reperfusion-induced acute kidney injury in mic...

journal_title：Kidney international

authors： Zhuang S,Lu B,Daubert RA,Chavin KD,Wang L,Schnellmann RG

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:While tubular cell death is a characteristic of acute renal failure (ARF), the molecular mechanisms that modulate this cell death are unclear. Cell fate in acute renal failure hinges on a balance of survival and mortality factors in a changing environment. We further explored this issue by studying selected ...

journal_title：Kidney international

authors： Ortiz A,Lorz C,Catalán MP,Danoff TM,Yamasaki Y,Egido J,Neilson EG

更新日期：2000-03-01 00:00:00