Sigmoidal relationship between calcitonin and calcium: studies in normal, parathyroidectomized, and azotemic rats.

abstract：:Renal cell carcinoma (RCC) is the most common kidney malignancy and has a poor prognosis owing to its resistance to chemotherapy. RCC cells overexpress the transcription factor, PAX2, normally expressed in fetal kidney but downregulated at birth. Since Pax2 suppresses apoptosis during renal development, we reasoned th...

journal_title：Kidney international

authors： Hueber PA,Waters P,Clark P,Eccles M,Goodyer P

更新日期：2006-04-01 00:00:00

abstract：:T lymphocytes modulate early ischemia-reperfusion injury in the kidney; however, their role during repair is unknown. We studied the role of TCRbeta(+)CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs), known to blunt immune responses, in repair after ischemia-reperfusion injury to the kidney. Using a murine model of is...

journal_title：Kidney international

authors： Gandolfo MT,Jang HR,Bagnasco SM,Ko GJ,Agreda P,Satpute SR,Crow MT,King LS,Rabb H

更新日期：2009-10-01 00:00:00

abstract：:Recent studies have shown renoprotective effects of the peroxisome proliferator-activated receptor-α (PPAR-α), but its role in kidney fibrosis is unknown. In order to gain insight into this, we examined the effect of a novel PPAR-α agonist, BAY PP1, in two rat models of renal fibrosis: unilateral ureteral obstruction ...

journal_title：Kidney international

authors： Boor P,Celec P,Martin IV,Villa L,Hodosy J,Klenovicsová K,Esposito C,Schäfer S,Albrecht-Küpper B,Ostendorf T,Heidland A,Šebeková K

更新日期：2011-12-01 00:00:00

abstract：:Antibodies to human leukocyte antigens (HLAs) are a risk factor for acute renal allograft rejection and loss. The role of non-HLAs and their significance to allograft rejection have gained recent attention. Here, we applied protein microarray technology, with the capacity to simultaneously identify 5056 potential anti...

journal_title：Kidney international

authors： Sutherland SM,Li L,Sigdel TK,Wadia PP,Miklos DB,Butte AJ,Sarwal MM

更新日期：2009-12-01 00:00:00

abstract：:Tamm-Horsfall protein (THP), a monomeric glycoprotein (M(r) 80 to 100 kDa), is produced by the mammalian kidney's thick ascending limb of Henle cells and excreted into the urine. The function of THP is uncertain. Here we report that a high molecular weight contaminant in sheep THP (sTHP) preparations was identified as...

journal_title：Kidney international

authors： Rhodes DC,Hinsman EJ,Rhodes JA

更新日期：1993-11-01 00:00:00

abstract：:The renal effects of a single intravenous dose of two different E. coli lipopolysaccharides (LPS 0111:B4 and LPS 0127:B8), at the same dose of 100 micrograms/kg, were evaluated in euvolemic Munich-Wistar (MW) rats by whole kidney clearance techniques and micropuncture studies. Following LPS infusion, a significant dec...

journal_title：Kidney international

authors： Lugon JR,Boim MA,Ramos OL,Ajzen H,Schor N

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:Nuclear factor-kappaB (NF-kappaB) and activated protein-1 (AP-1) are transcription factors that regulate many genes involved in the progression of renal disease. Recent data have shown that NF-kappaB is activated in tubules and glomeruli in various experimental models of renal injury. In vitro studies also s...

journal_title：Kidney international

authors： Mezzano SA,Barría M,Droguett MA,Burgos ME,Ardiles LG,Flores C,Egido J

更新日期：2001-10-01 00:00:00

abstract：:Renal para-aminohippurate (PAH) clearances were predicted in 16 kidneys of eight hypertensive patients with renal artery stenosis, pyelonephritis, or obstructive nephropathy, without individual ureteral catheterization. Predictions of left or right kidney clearance (CL or CR) were based on roentgenographic renal front...

journal_title：Kidney international

authors： Gutkin M,Perl W,Das BN,Chin B,Modlinger RS

更新日期：1977-03-01 00:00:00

abstract：:To determine whether acute renal failure (ARF) increases the long-term risk of progressive chronic kidney disease (CKD), we studied the outcome of patients whose initial kidney function was normal or near normal but who had an episode of dialysis-requiring ARF and did not develop end-stage renal disease within 30 days...

journal_title：Kidney international

authors： Lo LJ,Go AS,Chertow GM,McCulloch CE,Fan D,Ordoñez JD,Hsu CY

更新日期：2009-10-01 00:00:00

abstract：:We evaluated short- and long-term effects of high-dose recombinant human erythropoietin (rHuEPO) in kidney transplantation in a prospective double-blind, placebo-controlled study. Patients with chronic kidney disease following receipt of a deceased donor kidney allograft were randomized to 3 doses of 40,000 units rHuE...

journal_title：Kidney international

authors： Hafer C,Becker T,Kielstein JT,Bahlmann E,Schwarz A,Grinzoff N,Drzymala D,Bonnard I,Richter N,Lehner F,Klempnauer J,Haller H,Traeder J,Fliser D

更新日期：2012-02-01 00:00:00

abstract：:The loss of interstitial capillaries is a feature of several experimental models of renal disease and this contributes to secondary kidney injury. Angiopoietin-1 is a secreted growth factor which binds to Tie-2 present on endothelia to enhance cell survival thereby stabilizing capillary architecture in-vitro. Previous...

journal_title：Kidney international

authors： Long DA,Price KL,Ioffe E,Gannon CM,Gnudi L,White KE,Yancopoulos GD,Rudge JS,Woolf AS

更新日期：2008-08-01 00:00:00

abstract：:Fourteen Center hemodialysis (CHD) patients, 13 continuous ambulatory peritoneal dialysis (CAPD) patients, and 10 normals matched by group for age and sex were compared using a battery of evoked (EP) and event-related (ERP) brain potential measures to determine the effects on central nervous system (CNS) functioning o...

journal_title：Kidney international

authors： Marsh JT,Brown WS,Wolcott D,Landsverk J,Nissenson AR

更新日期：1986-12-01 00:00:00

abstract：:The relative importance of sarcopenia and its individual components as independent predictors of mortality in the dialysis population has not been determined. We estimated whole-body muscle mass using pre-dialysis bioimpedance spectroscopy measurements in 645 ACTIVE/ADIPOSE-enrolled prevalent hemodialysis patients fro...

journal_title：Kidney international

authors： Kittiskulnam P,Chertow GM,Carrero JJ,Delgado C,Kaysen GA,Johansen KL

更新日期：2017-07-01 00:00:00

abstract：:VLDL receptor (VLDL-R) is a novel member of the LDL receptor gene family with distinct tissue distribution and function. It binds and internalizes VLDL particles and is primarily expressed in skeletal muscle, heart, brain and adipose tissue, which use fatty acids for energy production or storage. CRF is associated wit...

journal_title：Kidney international

authors： Vaziri ND,Liang K

更新日期：1997-03-01 00:00:00

abstract：:The X-linked Hyp and Gy mutations are murine homologues of X-linked hypophosphatemia (XLH), a dominant disorder of phosphate (Pi) homeostasis characterized by growth retardation, rickets, hypophosphatemia and decreased renal tubular maximum for Pi reabsorption relative to glomerular filtration rate (Tmp/GFR). In Hyp a...

journal_title：Kidney international

authors： Tenenhouse HS,Beck L

更新日期：1996-04-01 00:00:00

abstract：:Tremendous progress has been made over recent years in the understanding of the mechanisms regulating calcium, phosphorus, vitamin D, and parathyroid hormone homeostasis in the normal human body and in patients with different degrees of renal failure. In addition, some of these findings have been translated into clini...

journal_title：Kidney international

authors： De Broe ME

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:We have recently found evidence for increased reactive oxygen species (ROS) in rats with lead-induced hypertension. We hypothesized that increased ROS activity may contribute to hypertension by enhancing inactivation of nitric oxide (NO) in this model. METHODS:Rats were treated for 12 weeks with either lead...

journal_title：Kidney international

authors： Vaziri ND,Liang K,Ding Y

更新日期：1999-10-01 00:00:00

abstract：:Recent reports indicate a decreased mortality risk for patients on chronic peritoneal dialysis in the United States. We sought to determine whether a higher use of automated versus continuous ambulatory peritoneal dialysis was associated with this improvement. Analyses were carried out using data from the United State...

journal_title：Kidney international

authors： Mehrotra R,Chiu YW,Kalantar-Zadeh K,Vonesh E

更新日期：2009-07-01 00:00:00

abstract：:E-64d, a membrane-permeable cysteine protease inhibitor, was tested for its ability to inhibit PTH-induced contraction in intact mouse MC-3T3-E1 osteoblastic cells. Incubation of MC-3T3-E1 cells with vehicle (DMSO) or E-64c, a nonpermeant cysteine protease inhibitor, in the presence or in the absence of PTH had no eff...

journal_title：Kidney international

authors： Tram KK,Murray SS,Lee DB,Murray EJ

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:The prevalence of cardiovascular disease (CVD) and inflammation is high in patients with end-stage renal disease (ESRD). Adiponectin is an adipocytokine that may have significant anti-inflammatory and anti-atherosclerotic effects. Low adiponectin levels have previously been found in patients with high risk f...

journal_title：Kidney international

authors： Stenvinkel P,Marchlewska A,Pecoits-Filho R,Heimbürger O,Zhang Z,Hoff C,Holmes C,Axelsson J,Arvidsson S,Schalling M,Barany P,Lindholm B,Nordfors L

更新日期：2004-01-01 00:00:00

abstract：:Chronic kidney disease (CKD) remains one of the leading causes of death in the developed world, and acute kidney injury (AKI) is now recognized as a major risk factor in its development. Understanding the factors leading to CKD after acute injury are limited by current animal models of AKI, which concurrently target v...

journal_title：Kidney international

authors： Grgic I,Campanholle G,Bijol V,Wang C,Sabbisetti VS,Ichimura T,Humphreys BD,Bonventre JV

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:In a prior study the 21-aminosteroid (lazaroid) U74389F provided in vivo protection from oxidative stress when used as a preventive therapy in ischemia-reperfusion injury in the kidney. As the cell membrane is the principal site for lipoperoxidation, in the current study the very lipophilic 2-methylaminochro...

journal_title：Kidney international

authors： De Vecchi E,Lubatti L,Beretta C,Ferrero S,Rinaldi P,Galli Kienle M,Trazzi R,Paroni R

更新日期：1998-09-01 00:00:00

abstract：:Stimulation of interleukin-1 beta (IL-1 beta) and tumor necrosis factor (TNF alpha) production was studied during in vitro hemodialysis (HD) of whole blood using cuprammonium (Cup) or polysulfone (PS) dialyzers. In the absence of LPS, circulation of whole blood for two hours through Cup or PS dialyzers was not suffici...

journal_title：Kidney international

authors： Schindler R,Lonnemann G,Shaldon S,Koch KM,Dinarello CA

更新日期：1990-01-01 00:00:00

abstract：:Chronic metabolic acidosis (CMA) is a major cause of growth defect, implying disturbances of protein metabolism. Previously, in vivo studies performed in the fasting state showed enhanced whole body protein turnover, whereas in vitro studies showed unchanged muscle protein synthesis. The present study is the first to ...

journal_title：Kidney international

authors： Maniar S,Laouari D,Dechaux M,Motel V,Yvert JP,Mathian B,Kleinknecht C

更新日期：1994-12-01 00:00:00

abstract：:Australia's Indigenous people have high rates of chronic kidney disease and kidney failure. To define renal disease among these people, we reviewed 643 renal biopsies on Indigenous people across Australia, and compared them with 249 biopsies of non-Indigenous patients. The intent was to reach a consensus on pathologic...

journal_title：Kidney international

authors： Hoy WE,Samuel T,Mott SA,Kincaid-Smith PS,Fogo AB,Dowling JP,Hughson MD,Sinniah R,Pugsley DJ,Kirubakaran MG,Douglas-Denton RN,Bertram JF

更新日期：2012-12-01 00:00:00

abstract：:Ischemia-reperfusion injury (IRI) is the outcome of an inflammatory process that is triggered when an organ undergoes a transient reduction or cessation of blood flow, followed by re-establishment of perfusion. In the clinical setting, IRI contributes to significant acute kidney injury, patient morbidity and mortality...

journal_title：Kidney international

authors： Pefanis A,Ierino FL,Murphy JM,Cowan PJ

更新日期：2019-08-01 00:00:00

abstract：:Cyanate is a uremic toxin responsible for the carbamylation of proteins, which has been implicated as playing a key role in accelerating the progression of atherosclerosis in patients with chronic kidney disease. El-Gamal et al. report that while cyanate promotes protein carbamylation in vivo, the resulting endothelia...

journal_title：Kidney international

authors： Hawkins CL

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:The characteristic feature of Goodpasture disease is the occurrence of an autoantibody response to the noncollagenous domain of the alpha3 chain of type IV collagen [alpha3(IV)NC1] in the alveolar and glomerular basement membrane. These antibodies are associated with the development of a rapidly progressive ...

journal_title：Kidney international

authors： Hellmark T,Segelmark M,Unger C,Burkhardt H,Saus J,Wieslander J

更新日期：1999-03-01 00:00:00

abstract：:Although the pathogenesis of steroid-sensitive nephrotic syndrome (SSNS) remains elusive, multiple epidemiologic, clinical, and experimental studies converge on the common theme of immune dysregulation. Initially, T-cell adaptive immunity was solely emphasized; however, the role of humoral immunity in nephrotic syndro...

journal_title：Kidney international

authors： Chambers ET,Gbadegesin RA

更新日期：2019-10-01 00:00:00

abstract：:Alterations in red blood cell sodium (Na) transport have been described in chronic renal failure. This study examines the possible impact of uremia on two ouabain-insensitive pathways, the Na/H antiporter and the Cl-/NaCO3- anion exchanger. The Vmax of Na/H antiporter measured as Na influx driven by outward H gradient...

journal_title：Kidney international

authors： Corry DB,Tuck ML,Nicholas S,Weinman EJ

更新日期：1993-09-01 00:00:00