Protein microarrays identify antibodies to protein kinase Czeta that are associated with a greater risk of allograft loss in pediatric renal transplant recipients.

abstract：BACKGROUND:Hemodialysis access thrombosis is a significant cause of morbidity for hemodialysis patients and results from decreased access flow caused by venous outflow tract stenosis. Ultrasound dilution (UD) is a practical, noninvasive, and reliable indicator of access flow and is effective in predicting venous stenos...

journal_title：Kidney international

authors： Goldstein SL,Allsteadt A

更新日期：2001-06-01 00:00:00

abstract：:International clinical practice guidelines for the management of anemia in chronic kidney disease suggest target hemoglobin levels ≤ 11.5 g/dl (115 g/l), with individualized consideration of slightly higher hemoglobin targets to improve quality of life. An updated meta-analysis of randomized trials demonstrates no sig...

journal_title：Kidney international

authors： Wyatt CM,Drueke TB

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Clinical studies have shown that the angiotensin-converting enzyme (ACE) inhibitors or angiotensin II (Ang II) receptor antagonists decrease proteinuria and slow the progression of nephropathy in diabetes, indicating that Ang II plays an important role in the development of nephropathy. We have previously re...

journal_title：Kidney international

authors： Zhang SL,Filep JG,Hohman TC,Tang SS,Ingelfinger JR,Chan JS

更新日期：1999-02-01 00:00:00

abstract：:To analyze the role of clusterin in renal diseases involving a regenerative process, we have used a novel rodent model to compare temporal and spatial expression of clusterin mRNA. Thus, renal artery stenosis was used to induce unilateral non-infarctive renal atrophy. After several weeks, when cellular pathology of at...

journal_title：Kidney international

authors： Gobé GC,Buttyan R,Wyburn KR,Etheridge MR,Smith PJ

更新日期：1995-02-01 00:00:00

abstract：:In adults on chronic hemodialysis, achieving a hemoglobin concentration of 12g/dl and above with erythropoiesis stimulating agents leads to increased cardiovascular events and mortality, but this may not be true in children. Therefore, we conducted a retrospective cohort study of pediatric patients (under 18) from the...

journal_title：Kidney international

authors： Rheault MN,Molony JT,Nevins T,Herzog CA,Chavers BM

更新日期：2017-01-01 00:00:00

abstract：:Although case reports link proton-pump inhibitor (PPI) use and hypomagnesemia, no large-scale studies have been conducted. Here we examined the serum magnesium concentration and the likelihood of hypomagnesemia (<1.6 mg/dl) with a history of PPI or histamine-2 receptor antagonist used to reduce gastric acid, or use of...

journal_title：Kidney international

authors： Danziger J,William JH,Scott DJ,Lee J,Lehman LW,Mark RG,Howell MD,Celi LA,Mukamal KJ

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Tubulointerstitial fibrosis is a morphologic hallmark of chronic kidney disease and is a key factor in the prediction of progression to end-stage renal failure. Disruption of tubular basement membrane and interstitial extracellular matrix (ECM) via cytokine-induced alterations in matrix metalloproteinases (M...

journal_title：Kidney international

authors： Nee LE,McMorrow T,Campbell E,Slattery C,Ryan MP

更新日期：2004-10-01 00:00:00

abstract：:We describe a rat model of renal failure that separates catabolic and anabolic states from each other. Muscle protein synthesis was compared during the anabolic period between sham (S) operated and renal failure (RF) rats that were fed different levels of dietary protein. Male rats weighing between 60 and 80 g first h...

journal_title：Kidney international

authors： Baliga R,George VT,Ray PE,Holliday MA

更新日期：1991-05-01 00:00:00

abstract：:NO, a simple molecule synthesized from L-arginine by NO synthases, has been identified to play an important role in cell communication, cell defense and cell injury. The half life of NO is very short because NO either reacts with superoxide anion (O2-), and/or binds to heme molecules or Fe-S groups present in proteins...

journal_title：Kidney international

authors： Raij L,Baylis C

更新日期：1995-07-01 00:00:00

abstract：:Iron is critical for cellular, organismal, and possibly universal existence. Use of iron complexes to treat human diseases is ancient and is described in detail in Ayurveda/Siddha systems of medicine. Old aphorisms from Siddha medicine ("Alavukku Minjinal Amirdhamum Nanjagum," an elixir turns poisonous when taken in e...

journal_title：Kidney international

authors： Swaminathan S

更新日期：2016-07-01 00:00:00

abstract：:The incidence of acute kidney injury (AKI) is high in elderly people, and is difficult to prevent and treat. One of its major causes is renal ischemia-reperfusion injury (IRI). A young systemic environment may prevent the senescence of old organs. However, it is unknown whether a young milieu may reduce renal IRI in t...

journal_title：Kidney international

authors： Liu D,Lun L,Huang Q,Ning Y,Zhang Y,Wang L,Yin Z,Zhang Y,Xia L,Yin Z,Fu B,Cai G,Sun X,Chen X

更新日期：2018-08-01 00:00:00

abstract：:Podocyte injury and loss contribute to the progression of glomerular diseases, including diabetic kidney disease. We previously found that the glomerular expression of Sirtuin-1 (SIRT1) is reduced in human diabetic glomeruli and that the podocyte-specific loss of SIRT1 aggravated albuminuria and worsened kidney diseas...

journal_title：Kidney international

authors： Hong Q,Zhang L,Das B,Li Z,Liu B,Cai G,Chen X,Chuang PY,He JC,Lee K

更新日期：2018-06-01 00:00:00

abstract：:Parathyroid suppression by intraperitoneal calcitriol (1,25(OH)2D3) during peritoneal dialysis. The purpose of this study was to determine if parathyroid hormone (PTH) suppression could be achieved by increasing calcium mass transfer (Ca MT) with high dialysate Ca (4 mEq/liter) or via intraperitoneal (i.p.) 1,25(OH)2D...

journal_title：Kidney international

authors： Delmez JA,Dougan CS,Gearing BK,Rothstein M,Windus DW,Rapp N,Slatopolsky E

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:Rho proteins are small guanine 5'-triphosphate (GTP)-binding proteins felt to be important regulators of several aspects of cell function, including the organization of the actin cytoskeleton. The effects of Rho proteins on the regulation of renal tubular epithelial cell function are not known. METHODS:Sele...

journal_title：Kidney international

authors： Anderson RJ,Ray CJ,Popoff MR

更新日期：2000-11-01 00:00:00

abstract：:The terminally differentiated podocyte, also called glomerular visceral epithelial cell, are highly specialized cells. They function as a critical size and charge barrier to prevent proteinuria. Podocytes are injured in diabetic and non-diabetic renal diseases. The clinical signature of podocyte injury is proteinuria,...

journal_title：Kidney international

authors： Shankland SJ

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:It is suggested that either arginine or its metabolites, nitric oxide and polyamines play a role in the renal hemodynamic alterations observed in the early stages of diabetes. Yet, the regulation of arginine transport in diabetic kidneys has never been studied. METHODS:Arginine uptake was determined in glom...

journal_title：Kidney international

authors： Schwartz IF,Iaina A,Benedict Y,Wollman Y,Chernichovski T,Brasowski E,Misonzhnik F,Ben-Dor A,Blum M,Levo Y,Schwartz D

更新日期：2004-04-01 00:00:00

abstract：:The purpose of this study was to explore risk factors affecting the incidence of chronic kidney disease (CKD) in general population. We conducted a 10-year follow-up study with 123 764 (male: 41 012, female: 82 752) adults aged 40 years and over who received community-based annual examinations. The primary outcome for...

journal_title：Kidney international

authors： Yamagata K,Ishida K,Sairenchi T,Takahashi H,Ohba S,Shiigai T,Narita M,Koyama A

更新日期：2007-01-01 00:00:00

abstract：:Suramin is a polysulfonated naphthylurea originally designed as a treatment for trypanosomiasis; but that has also been used to treat rodent models of fulminant hepatic failure and focal brain ischemia. In this study, we determined the effects of suramin on renal ischemia/reperfusion-induced acute kidney injury in mic...

journal_title：Kidney international

authors： Zhuang S,Lu B,Daubert RA,Chavin KD,Wang L,Schnellmann RG

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Nephrotoxic glomerulonephritis is induced by the administration of antibody against the glomerular basement membrane (GBM). We demonstrated previously that Fc receptors for immunoglobulin G (IgG) (FcgammaR) play crucial roles in the induction of accelerated nephrotoxic glomerulonephritis by using FcRgamma-de...

journal_title：Kidney international

authors： Fujii T,Hamano Y,Ueda S,Akikusa B,Yamasaki S,Ogawa M,Saisho H,Verbeek JS,Taki S,Saito T

更新日期：2003-10-01 00:00:00

abstract：:Sirtuin 6 (SIRT6) is a NAD+-dependent deacetylase associated with numerous aspects of health and physiology. Overexpression of SIRT6 has emerged as a protector in cardiac tissues against pathologic cardiac hypertrophy. However, the mechanism of this protective effect is not fully understood. Here, both in vivo and in ...

journal_title：Kidney international

authors： Li Z,Xu K,Zhang N,Amador G,Wang Y,Zhao S,Li L,Qiu Y,Wang Z

更新日期：2018-04-01 00:00:00

abstract：:Increasing evidence points to the importance of aberrant O-glycosylated immunoglobulin A1 (IgA1) in the pathogenesis of IgA nephropathy (IgAN), a disease widely considered to be a polygenic disorder. We earlier found that haplotypes in two key glycosyltransferase genes, C1GALT1 and ST6GALNAC2, were associated with sus...

journal_title：Kidney international

authors： Zhu L,Tang W,Li G,Lv J,Ding J,Yu L,Zhao M,Li Y,Zhang X,Shen Y,Zhang H,Wang H

更新日期：2009-07-01 00:00:00

abstract：:Insulin resistance from chronic kidney disease (CKD) stimulates muscle protein wasting but mechanisms causing this resistance are controversial. To help resolve this, we used microarray analyses to identify initiators of insulin resistance in the muscles of mice with CKD, glucose intolerance, and insulin resistance. C...

journal_title：Kidney international

authors： Thomas SS,Dong Y,Zhang L,Mitch WE

更新日期：2013-08-01 00:00:00

abstract：:The International Pediatric Peritonitis Registry (IPPR) was created to assess and evaluate the validity of the pediatric peritonitis treatment guidelines issued by the International Society for Peritoneal Dialysis. The study by Schaefer et al., one of the first to emerge from the IPPR, describes regional variability i...

journal_title：Kidney international

authors： Teitelbaum I

更新日期：2007-12-01 00:00:00

abstract：:In vitro metabolic acidosis (Met) induces greater bone mineral resorption than respiratory acidosis (Resp). Met, but not Resp, inhibits osteoblasts which control many aspects of osteoclastic function. To determine whether at a similar decrement in extracellular pH, Met and Resp would induce different changes in intrac...

journal_title：Kidney international

authors： Ori Y,Lee SG,Krieger NS,Bushinsky DA

更新日期：1995-06-01 00:00:00

abstract：:We have analyzed the protein content of proximal tubular fluid (PTF) by ultramicro disc electrophoresis and measured total protein excretion rates both in control conditions and during angiotensin infusion to the rat. Under control conditions PTF albumin concentration was 1.49 +/- 1.12 (SD) mg/100 ml and did not incre...

journal_title：Kidney international

authors： Eisenbach GM,Liew JB,Boylan JW,Manz N,Muir P

更新日期：1975-08-01 00:00:00

abstract：:The binding of albumin to the glomerular capillary wall was studied using albumin-gold in perfused kidneys, the interaction of [3H]albumin with isolated glomeruli at 37 degrees C and 4 degrees C and the interaction at [3H]albumin with purified basement membrane. The albumin-gold was found to bind predominantly to the ...

journal_title：Kidney international

authors： Adal Y,Smit MF,Osicka TM,Comper WD

更新日期：1995-04-01 00:00:00

abstract：:In previous studies from this laboratory it has been shown that ATP-ase activity in situ in the glomerular basement membrane (GBM) is clearly reduced in rats rendered nephrotic after treatment with adriamycin (ADR). The question was raised whether this reduction of ATP-ase activity in the GBM is due to toxic activity ...

journal_title：Kidney international

authors： Bakker WW,Kalicharan D,Donga J,Hulstaert CE,Hardonk MJ

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:Recent clinical trials of mycophenolate mofetil (MMF) in chronic allograft nephropathy (CAN) demonstrated that the dose of cyclosporine A (CsA) is one of the critical factors in determining graft function in CAN, but the effect of MMF on chronic CsA nephropathy is undetermined. We undertook this study to eva...

journal_title：Kidney international

authors： Yang CW,Ahn HJ,Kim WY,Li C,Kim HW,Choi BS,Cha JH,Kim YS,Kim J,Bang BK

更新日期：2002-07-01 00:00:00

abstract：:In rats undergoing renal mass reduction (RMR) oral supplementation with the nitric oxide (NO) precursor L-arginine increases glomerular filtration rate and ameliorates signs of glomerular injury, suggesting that chronic renal failure in the rats is a condition of low NO formation in the kidney. On the contrary, data a...

journal_title：Kidney international

authors： Aiello S,Noris M,Todeschini M,Zappella S,Foglieni C,Benigni A,Corna D,Zoja C,Cavallotti D,Remuzzi G

更新日期：1997-07-01 00:00:00

abstract：:In organ transplantation, ischemia/reperfusion (I/R) results in damage that may affect cell viability and lead to organ failure. I/R injury involves a complex cascade of events, including loss of energy, derangement of the ionic hemostasis, production of reactive oxygen species, and cell death. In this context, mitoch...

journal_title：Kidney international

authors： Jassem W,Heaton ND

更新日期：2004-08-01 00:00:00