Effect of angiotensin on the filtration of protein in the rat kidney: a micropuncture study.

abstract：:Podocytes are highly differentiated cells that play an important role in maintaining glomerular filtration barrier integrity; a function regulated by small GTPase proteins of the Rho family. To investigate the role of Rho A in podocyte biology, we created transgenic mice expressing doxycycline-inducible constitutively...

journal_title：Kidney international

authors： Wang L,Ellis MJ,Gomez JA,Eisner W,Fennell W,Howell DN,Ruiz P,Fields TA,Spurney RF

更新日期：2012-06-01 00:00:00

abstract：:Clinical and experimental studies have shown that serum aluminum (Al) is bound to transferrin and that cellular uptake of Al appears to be mediated by transferrin receptors. Based on these findings it is widely believed that intestinal Al absorption occurs via iron-specific, transferrin-dependent pathways and that iro...

journal_title：Kidney international

authors： Ittel TH,Kinzel S,Ortmanns A,Sieberth HG

更新日期：1996-12-01 00:00:00

abstract：:The homocysteine hypothesis states that circulating homocysteine is a vascular toxin in concentrations that occur in the general population and in renal failure. This hypothesis is currently being tested in the Kidney and End State Renal Disease Study (HOST), but data have emerged since the HOST began that suggest its...

journal_title：Kidney international

authors： Hoffer LJ

更新日期：2006-05-01 00:00:00

abstract：:Transepithelial fluid secretion promotes the progressive enlargement of cysts in autosomal dominant polycystic kidney disease (ADPKD). Recent indirect evidence indicated that active chloride transport may drive net fluid secretion in cultures of epithelia derived from ADPKD cysts. We now report that forskolin, which s...

journal_title：Kidney international

authors： Davidow CJ,Maser RL,Rome LA,Calvet JP,Grantham JJ

更新日期：1996-07-01 00:00:00

abstract：:The microcirculation is regulated by oxygen gradients and by endothelial release of nitric oxide, which can react with hemoglobin to form S-nitroso derivatives. Here we induced flow-mediated dilatation of the brachial artery in response to ischemia in 141 non-diabetic patients with stage 3-4 chronic kidney disease who...

journal_title：Kidney international

authors： Yilmaz MI,Sonmez A,Saglam M,Gulec M,Kilic S,Eyileten T,Caglar K,Oguz Y,Vural A,Yenicesu M,Zoccali C

更新日期：2009-06-01 00:00:00

abstract：:Recent studies of timing of dialysis initiation have challenged the recent trend to earlier initiation of therapy. The observed outcomes though are a consequence of the balance between the risks of advanced uremia versus the inherent dangers relating to dialysis therapy itself. Many of these risks are inherent in how ...

journal_title：Kidney international

authors： McIntyre CW,Rosansky SJ

更新日期：2012-08-01 00:00:00

abstract：:Previous studies from our laboratory have demonstrated that metabolic clearance rate (MCR) of calcitriol is decreased in experimental renal failure. In this experiment, we examined the effects of calcitriol, 25-hydroxyvitamin D3 (25(OH)D3) and 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) on the MCR of calcitriol in renal ...

journal_title：Kidney international

authors： Patel S,Simpson RU,Hsu CH

更新日期：1989-08-01 00:00:00

abstract：:Intravenous conjugated estrogens reduce the prolonged bleeding time in uremic patients and in a rat model of uremia. However, estrogens have major side effects related to their hormonal activity. We investigated whether a beta-resorcylic acid lactone, zeranol (a compound with close spatial similarity to estrogens but ...

journal_title：Kidney international

authors： Zoja C,Viganò G,Corna D,Salmona M,Remuzzi G,Garattini S

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Diabetic nephropathy is commonly associated with renal salt and water retention and hypertension. The molecular mechanisms involved and how the kidney responds to this volume expansion, in terms of renal transporter regulation, are not understood. METHODS:Targeted proteomics employing semiquantitative immun...

journal_title：Kidney international

authors： Bickel CA,Knepper MA,Verbalis JG,Ecelbarger CA

更新日期：2002-06-01 00:00:00

abstract：:Protein misfolding in the endoplasmic reticulum (ER) leads to ER stress. The unfolded protein response and ER-associated degradation (ERAD) interact in a coordinated manner with the ubiquitin-proteasome system and autophagy to alleviate protein misfolding or its consequences. The intersecting actions of these processe...

journal_title：Kidney international

authors： Cybulsky AV

更新日期：2013-07-01 00:00:00

abstract：:Patients with chronic kidney disease (CKD) have a high risk of hyperkalemia, which increases mortality and can lead to renin-angiotensin-aldosterone system inhibitor (RAASi) dose reduction or discontinuation. Patiromer, a nonabsorbed potassium binder, has been shown to normalize serum potassium in patients with CKD an...

journal_title：Kidney international

authors： Bushinsky DA,Williams GH,Pitt B,Weir MR,Freeman MW,Garza D,Stasiv Y,Li E,Berman L,Bakris GL

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Tubular transepithelial reabsorption of chloride along the nephron is a major determinant of body salt and water homeostasis and blood pressure regulation. About 40% of the glomerulary filtered sodium chloride are reabsorbed in the distal nephrons. Vectorial transepithelial sodium chloride transport is criti...

journal_title：Kidney international

authors： Jeck N,Waldegger P,Doroszewicz J,Seyberth H,Waldegger S

更新日期：2004-01-01 00:00:00

abstract：:E-64d, a membrane-permeable cysteine protease inhibitor, was tested for its ability to inhibit PTH-induced contraction in intact mouse MC-3T3-E1 osteoblastic cells. Incubation of MC-3T3-E1 cells with vehicle (DMSO) or E-64c, a nonpermeant cysteine protease inhibitor, in the presence or in the absence of PTH had no eff...

journal_title：Kidney international

authors： Tram KK,Murray SS,Lee DB,Murray EJ

更新日期：1993-03-01 00:00:00

abstract：:The highly amiloride-sensitive epithelial sodium channel (ENaC) is an apical membrane constituent of cells of many salt-absorbing epithelia. In the kidney, the functional relevance of ENaC expression has been well established. ENaC mediates the aldosterone-dependent sodium reabsorption in the distal nephron and is inv...

journal_title：Kidney international

authors： Bonny O,Hummler E

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Although apoptosis has been linked to the renal cell deletion and ensuing renal fibrosis, its regulating mechanisms remain obscure. Of the known regulators of apoptosis, the best characterized is the Bax to Bcl-2 ratio. However, its importance in controlling apoptosis in glomerulonephritis is unclear. Here, ...

journal_title：Kidney international

authors： Yang B,Johnson TS,Thomas GL,Watson PF,Wagner B,Furness PN,El Nahas AM

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Intrauterine growth retardation (IUGR) is associated with higher morbidity and mortality not only in perinatal life but also in later life. The purpose of our study was to determine whether IUGR has any effect on the course of minimal change nephrotic syndrome (MCNS) in children. METHODS:Forty children who ...

journal_title：Kidney international

authors： Zidar N,Avgustin Cavić M,Kenda RB,Ferluga D

更新日期：1998-10-01 00:00:00

abstract：:Cystinosis as a clinical entity is a progressive dysfunction of multiple organs caused by the accumulation of cystine in the tissues, leading, for example, to end-stage renal failure, diabetes, hypothyroidism, myopathy, and central nervous system deterioration. Brodin-Sartorius and colleagues present a long-term study...

journal_title：Kidney international

authors： Cherqui S

更新日期：2012-01-01 00:00:00

abstract：:Epigenetic mechanisms have been the focus of intensive research. De Marinis et al. demonstrated that high glucose levels exert stimulatory effects on activation histone marks, leading to the upregulation of thioredoxin-interacting protein (TXNIP) gene expression, which is proinflammatory. They also showed that the eff...

journal_title：Kidney international

authors： Mimura I

更新日期：2016-02-01 00:00:00

abstract：:Previous work has documented an acceleration of proteolysis and branched-chain amino acid oxidation when muscles from rats with chronic metabolic acidosis were incubated in vitro. The present study examines the impact of chronic metabolic acidosis on whole body amino acid turnover and oxidation in chronically catheter...

journal_title：Kidney international

authors： May RC,Masud T,Logue B,Bailey J,England B

更新日期：1992-06-01 00:00:00

abstract：:We examined the process of receptor-mediated endocytosis in A-9 lung fibroblast and chinese hamster ovary (CHO) cells transfected with the recently cloned vasopressin V1a receptor (51). We used a fluorescent labeled vasopressin analog (rhodamine-mercaptopropionic acid lysine vasopressin) and radiolabeled vasopressin t...

journal_title：Kidney international

authors： Lutz W,Sanders M,Salisbury J,Lolait S,O'Carroll AM,Kumar R

更新日期：1993-04-01 00:00:00

abstract：:In seven patients on maintenance hemodialysis, de novo recurrent renal stone formation was observed. In all patients, the underlying disease was glomerulonephritis, with or without the nephrotic syndrome. All patients had considerable persistent proteinuria. The stones consisted predominantly of protein, as revealed b...

journal_title：Kidney international

authors： Bommer J,Ritz E,Tschöpe W,Waldherr R,Gebhardt M

更新日期：1979-12-01 00:00:00

abstract：:Augmentation of the CD36 pathway, which involves the uptake of several endogenous ligands including free fatty acids and oxidized low-density lipoprotein, contributes to the damage of proximal tubules and podocytes, whereas ablation of CD36 attenuates renal injury. Souza et al. demonstrate that 5A peptide can inhibit ...

journal_title：Kidney international

authors： Yokoi H,Yanagita M

更新日期：2016-04-01 00:00:00

abstract：:This study was undertaken to test the hypothesis that, given equal arterial pressure reductions, the combination of an angiotensin converting enzyme (ACE) inhibitor and calcium antagonist slows declines in renal function and yields greater reductions in albuminuria over either agent alone. This hypothesis was evaluate...

journal_title：Kidney international

authors： Bakris GL,Barnhill BW,Sadler R

更新日期：1992-04-01 00:00:00

abstract：:Isotomic fluid reabsorption (JV) of rat renal proximal tubules was examined by the shrinking droplet method in combination with simulatneous perfusion of blood capillaries. Sensitivity of JV measurement was improved by using each punctured tubule for control measurements: 1) Parathyroid hormoen (PTH) on the contralumi...

journal_title：Kidney international

authors： Baumann K,Chan YL,Bode F,Papavassiliou F

更新日期：1977-02-01 00:00:00

abstract：:In order to study the effects of acute ureteral obstruction on glomerular hemodynamics, glomerular hydrostatic capillary pressure (PG), pressure in the first-order peritubular capillaries (EAP), and intratubular pressure (PT) were directly measured in superficial nephrons on Munich-Wistar rats by micropuncture with a ...

journal_title：Kidney international

authors： Dal Canton A,Stanziale R,Corradi A,Andreucci VE,Migone L

更新日期：1977-12-01 00:00:00

abstract：BACKGROUND:The genetic dissection of a polygenic, multifactorial, quantitative disease such as arterial hypertension is hampered by a large environmental variance and by genetic heterogeneity. METHODS:To reduce the environmental variance, we measured the pressor response to a saline load (PRSL) and the basal plasma re...

journal_title：Kidney international

authors： Barlassina C,Schork NJ,Manunta P,Citterio L,Sciarrone M,Lanella G,Bianchi G,Cusi D

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:The interaction between tubular epithelial cells and calcium oxalate crystals or oxalate ions is a very precarious event in the lithogenesis. Urine contains ions, glycoproteins and glycosaminoglycans that inhibit the crystallization process and may protect the kidney against lithogenesis. We examined the eff...

journal_title：Kidney international

authors： Borges FT,Michelacci YM,Aguiar JA,Dalboni MA,Garófalo AS,Schor N

更新日期：2005-10-01 00:00:00

abstract：:In male Wistar rats, renal adenosine triphosphate (ATP), inorganic phosphate (Pi) and intracellular pH were measured by 31phosphorus nuclear magnetic resonance (31P NMR) and correlated with renal function before, during, and for one hour after a period of 30 to 40 minutes hemorrhagic hypotension. In animals which suff...

journal_title：Kidney international

authors： Ratcliffe PJ,Moonen CT,Holloway PA,Ledingham JG,Radda GK

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND:Population-genetic studies investigating genetic polymorphisms of Mendelian inheritance should always test whether the measured genotype frequencies deviate from the expected one. For this purpose Hardy-Weinberg (HW) criteria are generally used. If genotype distribution of control population misses HW equili...

journal_title：Kidney international

authors： Kocsis I,Györffy B,Németh E,Vásárhelyi B

更新日期：2004-05-01 00:00:00

abstract：:Starting from observations in intact cells and extending to studies in native membranes and solubilized membrane proteins, a significant body of evidence has been accumulated to indicate that some of the short-term regulatory influences on the Na+-H+ exchanger in the apical membrane of the proximal convoluted tubule a...

journal_title：Kidney international

authors： Weinman EJ,Dubinsky W,Shenolikar S

更新日期：1989-10-01 00:00:00