Predominant role of FcgammaRIII in the induction of accelerated nephrotoxic glomerulonephritis.

abstract：BACKGROUND:Bone marrow reconstitution using genetically-modified hematopoietic stem cells has been reported to confer resistance to inflammation and prevent renal injury in glomerulonephritis. Although this strategy has potentials for clinical use, taking hematopoietic stem cells from bone marrow is highly stressful fo...

journal_title：Kidney international

authors： Yokoo T,Ohashi T,Utsunomiya Y,Okamoto A,Suzuki T,Shen JS,Tanaka T,Kawamura T,Hosoya T

更新日期：2003-07-01 00:00:00

abstract：:Mesangial cells are known to secrete metalloproteinases that are capable of degrading the constituents of the GBM, and hence are potentially involved not only in the regular maintenance of the ECM components in the glomerulus, but also of contributing to any damage to these components that occurs in disease states. In...

journal_title：Kidney international

authors： Martin J,Knowlden J,Davies M,Williams JD

更新日期：1994-09-01 00:00:00

abstract：:In summary, it is evident that malnutrition is highly prevalent in ESRD patients. This is clearly related to multiple factors encountered during the pre-dialysis stage, as well as during maintenance dialysis therapy. A body of evidence highlights the existence of relationship between malnutrition and outcome in this p...

journal_title：Kidney international

authors： Ikizler TA,Hakim RM

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:In cultured renal epithelial cells, exposure to oxalate, a constituent of many kidney stones, elicits a cascade of responses that often leads to cell death. Oxalate toxicity is mediated via generation of reactive oxygen species (ROS) in a process that depends at least in part upon lipid signaling molecules t...

journal_title：Kidney international

authors： Cao LC,Honeyman TW,Cooney R,Kennington L,Scheid CR,Jonassen JA

更新日期：2004-11-01 00:00:00

abstract：:Hemodynamic factors may play a role in the development of acute renal failure following administration of contrast media (CM). In this study the effect of intravenous injection of contrast media and mannitol on red blood cell velocity (VRBC) and red blood cell aggregation in renal medullary vessels was studied in 58 r...

journal_title：Kidney international

authors： Liss P,Nygren A,Olsson U,Ulfendahl HR,Erikson U

更新日期：1996-05-01 00:00:00

abstract：:We evaluated the contribution of intrarenal factors in the increased renal accumulation of bovine serum albumin (BSA) in chronic serum sickness (CSS). Renal transplantation was used to study 125I BSA uptake (single and paired label techniques) in normal and CSS kidneys exposed to the same immunologic milieu. In CSS, t...

journal_title：Kidney international

authors： Ward DM,Lee S,Wilson CB

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND:Dopamine (DA) is thought to regulate renal proximal transport through the inhibition of the Na+,K+-ATPase and/or Na+/H+ exchanger. Defects in this dopaminergic system are proposed to be a pathogenic factor of genetic hypertension. However, microperfusion studies have not consistently confirmed direct tubular...

journal_title：Kidney international

authors： Kunimi M,Seki G,Hara C,Taniguchi S,Uwatoko S,Goto A,Kimura S,Fujita T

更新日期：2000-02-01 00:00:00

abstract：:Iron is critical for cellular, organismal, and possibly universal existence. Use of iron complexes to treat human diseases is ancient and is described in detail in Ayurveda/Siddha systems of medicine. Old aphorisms from Siddha medicine ("Alavukku Minjinal Amirdhamum Nanjagum," an elixir turns poisonous when taken in e...

journal_title：Kidney international

authors： Swaminathan S

更新日期：2016-07-01 00:00:00

abstract：:Hypocalcemia, hyperphosphatemia, and resistance to the action of PTH are well characterized features in the setting of advanced chronic renal failure (CRF). Although the underlying mechanisms are ill-understood, clinical and experimental evidence points to both PTH receptor down-regulation and post-receptor abnormalit...

journal_title：Kidney international

authors： Ureña P,Kubrusly M,Mannstadt M,Hruby M,Trinh MM,Silve C,Lacour B,Abou-Samra AB,Segre GV,Drüeke T

更新日期：1994-02-01 00:00:00

abstract：:It is unknown whether mild chronic kidney disease (CKD) is associated with adverse cardiovascular (CV) prognosis after accounting for coronary artery disease (CAD). Here we evaluated the interplay between CKD and CAD in predicting CV death or myocardial infarction (MI) and all-cause death. We included 1541 consecutive...

journal_title：Kidney international

authors： Bittencourt MS,Hulten EA,Ghoshhajra B,Abbara S,Murthy VL,Divakaran S,Nasir K,Gowdak LH,Riella LV,Chiumiento M,Hoffmann U,Di Carli MF,Blankstein R

更新日期：2015-07-01 00:00:00

abstract：:The effects of intravenous (i.v.) and intracarotid (IC) angiotensin II (AII) infusion on systemic and renal hemodynamics, renal water excretion, and plasma antidiuretic hormone (ADH) levels were examined in six conscious dogs under water loaded and hydropenic conditions. In the first group of seven studies, AII in a m...

journal_title：Kidney international

authors： Henrich WL,Walker BR,Handelman WA,Erickson AL,Arnold PE,Schrier RW

更新日期：1986-10-01 00:00:00

abstract：BACKGROUND:Fructose is a nutrient as well as a potent agent for the formation of advanced glycation end product in diabetes. GLUT5 is a facilitated-diffusion fructose transporter expressed in the small intestine and kidney. Previous reports on the localization of GLUT5 by in situ hybridization and immunohistochemistry ...

journal_title：Kidney international

authors： Sugawara-Yokoo M,Suzuki T,Matsuzaki T,Naruse T,Takata K

更新日期：1999-09-01 00:00:00

abstract：:We report the stepwise application of the RIFLE classification in 155,624 admissions in the UK Intensive Care National Audit & Research Centre Case Mix Programme database. The assumptions required to define RIFLE and their relationship with renal replacement therapy (RRT) and ICU mortality were assessed. Previous repo...

journal_title：Kidney international

authors： Harris SK,Lewington AJ,Harrison DA,Rowan KM

更新日期：2015-08-01 00:00:00

abstract：:Increasing evidence points to the importance of aberrant O-glycosylated immunoglobulin A1 (IgA1) in the pathogenesis of IgA nephropathy (IgAN), a disease widely considered to be a polygenic disorder. We earlier found that haplotypes in two key glycosyltransferase genes, C1GALT1 and ST6GALNAC2, were associated with sus...

journal_title：Kidney international

authors： Zhu L,Tang W,Li G,Lv J,Ding J,Yu L,Zhao M,Li Y,Zhang X,Shen Y,Zhang H,Wang H

更新日期：2009-07-01 00:00:00

abstract：:Chronic kidney disease (CKD) has received increased attention as a leading public health problem worldwide. Globally surveillance systems for kidney disease are still lacking, especially in developing countries like China, which constitutes an obstacle to develop effective preventive strategies. China Kidney Disease N...

journal_title：Kidney international

authors： Wang F,Yang C,Long J,Zhao X,Tang W,Zhang D,Bai K,Su Z,Gao B,Chu H,Wang J,Sun X,Wang S,Zuo L,Wang Y,Yu F,Wang H,Zhang L,Zhao MH

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Prolactin (PRL), originally identified as an anterior pituitary hormone exhibiting lactogenic activity, is now recognized as a versatile hormone expressed in a wide variety of tissues. METHODS:In this study, the expression of PRL in the mouse kidney was investigated by solution-phase and in situ reverse tra...

journal_title：Kidney international

authors： Sakai Y,Hiraoka Y,Ogawa M,Takeuchi Y,Aiso S

更新日期：1999-03-01 00:00:00

abstract：:Insulin-like growth factor I (IGF-I) has been found in the kidney, particularly in the collecting duct in the rat. Since cultured rabbit collecting duct cells constitute a convenient system for in vitro studies, we have examined whether these cells secrete IGF-I. Culture medium conditioned by collecting duct cells was...

journal_title：Kidney international

authors： Aron DC,Saadi HF,Nye CN,Douglas JG

更新日期：1991-01-01 00:00:00

abstract：:To determine the effect of an acute load of potassium on potassium reabsorption by the loop of Henle in chronic renal failure, the right kidney was removed and branches of the left renal artery were ligated in 17 rats. One week later and after 2 days of a potassium-free diet, rats were studied before (period 1) and af...

journal_title：Kidney international

authors： Milanes CL,Jamison RL

更新日期：1985-06-01 00:00:00

abstract：:IgM in the blood of normal individuals consists mainly of 'natural' polyreactive antibodies. Natural IgM is thought to provide an initial defense against infection and to promote the healing of wounded cells. Yet, as Panzer and colleagues show, these benefits can be eclipsed when the IgM binds to damaged cells of the ...

journal_title：Kidney international

authors： Platt JL,Cascalho M

更新日期：2015-09-01 00:00:00

abstract：:Our genetic hypercalciuric (GH) rats have been selected and inbred for 29 generations to maximize urine calcium (UCa) excretion compared to identical gender controls (Ctl). To determine the effect of the increased UCa on urinary supersaturation and stone formation, we pair fed 15 GH and 15 Ctl rats a standard 1.2% cal...

journal_title：Kidney international

authors： Bushinsky DA,Grynpas MD,Nilsson EL,Nakagawa Y,Coe FL

更新日期：1995-12-01 00:00:00

abstract：:The biological action of calcitriol is mediated through a hormone-receptor complex interacting with nuclear chromatin. Interaction of the calcitriol receptor (VDR) with VDR response elements produces bioactive proteins which carry out the physiological actions of calcitriol. Since biological response to calcitriol app...

journal_title：Kidney international

authors： Patel SR,Ke HQ,Vanholder R,Hsu CH

更新日期：1994-07-01 00:00:00

abstract：:To determine whether acute renal failure (ARF) increases the long-term risk of progressive chronic kidney disease (CKD), we studied the outcome of patients whose initial kidney function was normal or near normal but who had an episode of dialysis-requiring ARF and did not develop end-stage renal disease within 30 days...

journal_title：Kidney international

authors： Lo LJ,Go AS,Chertow GM,McCulloch CE,Fan D,Ordoñez JD,Hsu CY

更新日期：2009-10-01 00:00:00

abstract：:To investigate mechanisms underlying GFR control in diabetes mellitus, renal hemodynamics and segmental tubular handling of sodium, using lithium clearance, were assessed in 41 insulin-dependent diabetics (IDD) treated by insulin for 11 +/- 8 days, and in 19 normal controls. Average GFR and effective renal plasma flow...

journal_title：Kidney international

authors： Hannedouche TP,Delgado AG,Gnionsahe DA,Boitard C,Lacour B,Grünfeld JP

更新日期：1990-04-01 00:00:00

abstract：BACKGROUND:Autosomal-dominant medullary cystic kidney disease type 2 (MCKD2) is a tubulointerstitial nephropathy that causes renal salt wasting, hyperuricemia, gout, and end-stage renal failure in the fifth decade of life. The chromosomal locus for MCKD2 was localized on chromosome 16p12. Within this chromosomal region...

journal_title：Kidney international

authors： Wolf MT,Mucha BE,Attanasio M,Zalewski I,Karle SM,Neumann HP,Rahman N,Bader B,Baldamus CA,Otto E,Witzgall R,Fuchshuber A,Hildebrandt F

更新日期：2003-11-01 00:00:00

abstract：:Until recently, intravenous cyclophosphamide pulses with oral corticosteroids were regarded standard therapy for proliferative lupus nephritis (LN). Azathioprine, a less toxic alternative, was never proven to be inferior. In the first Dutch lupus nephritis study (enrollment between 1995 and 2001), we randomized 87 pro...

journal_title：Kidney international

authors： Grootscholten C,Ligtenberg G,Hagen EC,van den Wall Bake AW,de Glas-Vos JW,Bijl M,Assmann KJ,Bruijn JA,Weening JJ,van Houwelingen HC,Derksen RH,Berden JH,Dutch Working Party on Systemic Lupus Erythematosus.

更新日期：2006-08-01 00:00:00

abstract：:Mesangial cells are essential for the structure and function of glomeruli, but the mechanisms underlying these roles are not well understood. Here, we performed a single-cell RNA-sequence (RNA-seq) analysis of mouse mesangial cells using the Fluidigm C1 platform. We found that gene expression in individual mesangial c...

journal_title：Kidney international

authors： Lu Y,Ye Y,Yang Q,Shi S

更新日期：2017-08-01 00:00:00

abstract：:We have analyzed the protein content of proximal tubular fluid (PTF) by ultramicro disc electrophoresis and measured total protein excretion rates both in control conditions and during angiotensin infusion to the rat. Under control conditions PTF albumin concentration was 1.49 +/- 1.12 (SD) mg/100 ml and did not incre...

journal_title：Kidney international

authors： Eisenbach GM,Liew JB,Boylan JW,Manz N,Muir P

更新日期：1975-08-01 00:00:00

abstract：:Rare mutations in the LRP2 gene encoding for the endocytic receptor megalin cause developmental abnormalities and kidney disease. However, the mechanisms governing the dysfunction of mutant megalin remain unclear. A new study utilizing patient-derived induced pluripotent stem cells is now putting the endolysosomal sys...

journal_title：Kidney international

authors： Luciani A,Freedman BS

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Podocytes play an important role in the development of proteinuria and focal glomerulosclerosis. Previously we have demonstrated that a combination of two monoclonal antibodies (mAb) against aminopeptidase A (APA), an enzyme present on podocytes, induces a massive acute albuminuria in mice. The present study...

journal_title：Kidney international

authors： Assmann KJ,van Son JP,Dïjkman HB,Mentzel S,Wetzels JF

更新日期：2002-07-01 00:00:00

abstract：:The involvement of cysteinyl leukotrienes (LT) in the etiology of glomerulonephritis (GN) was investigated in a rat model of nephrotoxic serum nephritis in which renal function, morphology, LTC4 synthase activity and urinary cysteinyl LT excretion were monitored over seven days. Significant alterations in renal functi...

journal_title：Kidney international

authors： Petric R,Ford-Hutchinson AW

更新日期：1994-11-01 00:00:00