Effects of contrast media and mannitol on renal medullary blood flow and red cell aggregation in the rat kidney.

Abstract:

:Hemodynamic factors may play a role in the development of acute renal failure following administration of contrast media (CM). In this study the effect of intravenous injection of contrast media and mannitol on red blood cell velocity (VRBC) and red blood cell aggregation in renal medullary vessels was studied in 58 rats. Renal medullary blood flow was investigated by a cross-correlation technique and by a visual aggregation score. The CM, namely diatrizoate, iopromide, iohexol, ioxaglate, iotrolan, were given in iodine equivalent doses (1600 mg/kg body wt). Mannitol (950 mOsm/liter) and Ringer's solution were used as controls. The same vessels were studied 30 minutes before and 30 minutes after injections. VRBC decreased significantly after injection of diatrizoate, iopromide, iohexol, iotrolan and mannitol. Ringer's solution and ioxaglate did not significantly alter medullary blood flow, while iotrolan and mannitol caused the largest decreases in VRBC. All CM and mannitol caused both red cell aggregation and cessation of blood flow. The decrease in blood flow and increase in red blood cell aggregation after injection of CM and mannitol may partly explain the occurrence of contrast medium-induced acute renal failure.

journal_name

Kidney Int

journal_title

Kidney international

authors

Liss P,Nygren A,Olsson U,Ulfendahl HR,Erikson U

doi

10.1038/ki.1996.181

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

1268-75

issue

5

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)59475-1

journal_volume

49

pub_type

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