当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Azathioprine/methylprednisolone versus cyclophosphamide in proliferative lupus nephritis. A randomized controlled trial.

Azathioprine/methylprednisolone versus cyclophosphamide in proliferative lupus nephritis. A randomized controlled trial.

Abstract：

:Until recently, intravenous cyclophosphamide pulses with oral corticosteroids were regarded standard therapy for proliferative lupus nephritis (LN). Azathioprine, a less toxic alternative, was never proven to be inferior. In the first Dutch lupus nephritis study (enrollment between 1995 and 2001), we randomized 87 proliferative LN patients to either cyclophosphamide pulses (750 mg/m(2), 13 pulses in 2 years) combined with oral prednisone (CY) or to azathioprine (2 mg/kg/day in 2 years) combined with intravenous pulses of methylprednisolone (3 x 3 pulses of 1000 mg) and oral prednisone (AZA). After a median follow-up of 5.7 years (interquartile range 4.1-7.2 years), doubling of serum creatinine was more frequent in the AZA group, although not statistically significant (relative risk (RR): 4.1, with 95% confidence interval (95% CI): 0.8-20.4). Relapses occurred more often in the AZA group (RR: 8.8, 95% CI: 1.5-31.8). Creatinine and proteinuria at last visit did not differ between the two treatment arms. Moreover, 88.4% of the patients in the AZA arm were still free of cyclophosphamide treatment. During the first 2 years, the frequency of remission was not different, but infections, especially herpes zoster virus infections (HZV) were more frequent in the AZA group. Parameters for ovarian function did not differ between the two groups. In conclusion, in this open-label randomized controlled trial, cyclophosphamide was superior to azathioprine with regard to renal relapses and HZV. At last follow-up, there were no differences in serum creatinine or proteinuria between the two groups. However, since our study lacked sufficient power, longer follow-up is needed to reveal putative differences.

journal_name

Kidney Int

journal_title

Kidney international

authors

Grootscholten C,Ligtenberg G,Hagen EC,van den Wall Bake AW,de Glas-Vos JW,Bijl M,Assmann KJ,Bruijn JA,Weening JJ,van Houwelingen HC,Derksen RH,Berden JH,Dutch Working Party on Systemic Lupus Erythematosus.

doi

10.1038/sj.ki.5001630

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

732-42

issue

4

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)52008-5

journal_volume

70

pub_type

杂志文章,随机对照试验

相关文献

KIDNEY INTERNATIONAL文献大全
  • Pharmacokinetics and pharmacodynamics of oral tolvaptan in patients with varying degrees of renal function.

    abstract：:The selective vasopressin V2-receptor antagonist tolvaptan is eliminated almost exclusively by non-renal mechanisms. As renal impairment can influence the pharmacokinetics of drugs even when eliminated by non-renal mechanisms, we evaluated the effect of renal insufficiency on the pharmacokinetics/pharmacodynamics of t...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章

    doi：10.1038/ki.2013.350

    authors： Shoaf SE,Bricmont P,Mallikaarjun S

    更新日期：2014-04-01 00:00:00

  • Renal hemodynamic response to maximal vasodilating stimulus in healthy older subjects.

    abstract：BACKGROUND:It is still unclear whether age per se is associated with preservation of renal functional reserve, that is, of the increase in glomerular filtration rate (GFR) induced by appropriate vasodilating stimulus. METHODS:To gain insights into this issue, we evaluated the renal response to a maximal vasodilating s...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.0590031052.x

    authors： Fuiano G,Sund S,Mazza G,Rosa M,Caglioti A,Gallo G,Natale G,Andreucci M,Memoli B,De Nicola L,Conte G

    更新日期：2001-03-01 00:00:00

  • Long-term comparison of losartan and enalapril on kidney function in hypertensive type 2 diabetics with early nephropathy.

    abstract：BACKGROUND:The objectives of this study were to compare the effects of the angiotensin II receptor blocker, losartan, to those of the angiotensin-converting enzyme inhibitor, enalapril, on albuminuria and renal function in relationship to clinic and ambulatory blood pressure (ABP) in hypertensive type 2 diabetic subjec...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1523-1755.2000.00224.x

    authors： Lacourcière Y,Bélanger A,Godin C,Hallé JP,Ross S,Wright N,Marion J

    更新日期：2000-08-01 00:00:00

  • Effects of 1,25(OH)2D3 in experimental mesangial proliferative nephritis in rats.

    abstract：BACKGROUND:1,25-Dihydroxyvitamin D3 [1,25(OH)2D3], the active form of vitamin D3, is a potent immunomodulatory agent on several cell types such as monocytes and mesangial cells. Recruitment of inflammatory cells, as well as stimulation of resident cells and mesangial matrix accumulation are key features of various expe...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.00775.x

    authors： Panichi V,Migliori M,Taccola D,Filippi C,De Nisco L,Giovannini L,Palla R,Tetta C,Camussi G

    更新日期：2001-07-01 00:00:00

  • Breaking the ice: urine proteomics of medullary sponge kidney disease.

    abstract：:Urinary proteomics is a promising tool for biomarker investigation, particularly in complex kidney diseases. Fabris and colleagues report that urinary laminin subunit alpha-2 is a potential diagnostic marker of medullary sponge kidney (MSK) disease by using a label-free quantitative proteomics platform and a clinicall...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2016.10.032

    authors： Chutipongtanate S

    更新日期：2017-02-01 00:00:00

  • Platelet-derived growth factor receptors in the kidney--upregulated expression in inflammation.

    abstract：:Major features of a long-standing inflammation in the kidney are vascular proliferation, glomerulosclerosis, interstitial fibrosis and tubular atrophy, leading to a gradual deterioration of the renal function. In this study we have investigated the expression of B-type receptors for platelet-derived growth factor (PDG...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1989.306

    authors： Fellström B,Klareskog L,Heldin CH,Larsson E,Rönnstrand L,Terracio L,Tufveson G,Wahlberg J,Rubin K

    更新日期：1989-12-01 00:00:00

  • Adaptive change in ammonia excretion in renal insufficiency.

    abstract：:Experiments were performed to study the mechanism of the compensatory increase in the excretion of metabolic acid by residual nephrons after reduction in renal mass. Despite a decrease in nephron population to 20% of control, total excretion of acid remained similar to pair-fed controls due to an increase in nephron e...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1980.70

    authors： MacClean AJ,Hayslett JP

    更新日期：1980-05-01 00:00:00

  • Impaired in vivo antibody production in CRF rats: role of secondary hyperparathyroidism.

    abstract：:Antibody responses to antigens are impaired in humans and animals with chronic renal failure (CRF), and parathyroid hormone (PTH) inhibits Staphylococcus aureus Cowan I (SAC) or pokeweed mitogen (PWM)-induced antibody production by B cells from normal subjects. Since CRF is associated with secondary hyperparathyroidis...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1991.286

    authors： Gaciong Z,Alexiewicz JM,Massry SG

    更新日期：1991-11-01 00:00:00

  • Effect of Schiff base formation on the function of the calcitriol receptor.

    abstract：:The genomic action of calcitriol is mediated through the interaction of the calcitriol receptor (VDR) with vitamin D response elements (VDREs) of the target genes. We have shown that the interaction of VDRs with VDREs is inhibited by uremic toxins. We hypothesize that uremic toxins form Schiff bases with the lysine re...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1996.469

    authors： Patel SR,Koenig RJ,Hsu CH

    更新日期：1996-11-01 00:00:00

  • Atrial fibrillation in incident dialysis patients.

    abstract：:Despite the importance of cardiovascular disease in dialysis patients, the frequency of atrial fibrillation in incident dialysis patients has not been determined. We analyzed the prevalence of atrial fibrillation in patients starting dialysis over a 4-year period, its occurrence over the course of dialysis, and its in...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2009.185

    authors： Vazquez E,Sanchez-Perales C,Garcia-Garcia F,Castellano P,Garcia-Cortes MJ,Liebana A,Lozano C

    更新日期：2009-08-01 00:00:00

  • Hereditary systemic amyloidosis associated with a new apolipoprotein AII stop codon mutation Stop78Arg.

    abstract：UNLABELLED:Hereditary systemic amyloidosis associated with a new apolipoprotein AII stop codon mutation Stop78Arg. BACKGROUND:Mutations in the gene for apolipoprotein AII (apoAII) have recently been found to cause hereditary renal amyloidosis. In each case amyloid deposition has been associated with a peptide extensio...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00047.x

    authors： Yazaki M,Liepnieks JJ,Barats MS,Cohen AH,Benson MD

    更新日期：2003-07-01 00:00:00

  • Testing the homocysteine hypothesis in end-stage renal disease: Problems and a possible solution.

    abstract：:The homocysteine hypothesis states that circulating homocysteine is a vascular toxin in concentrations that occur in the general population and in renal failure. This hypothesis is currently being tested in the Kidney and End State Renal Disease Study (HOST), but data have emerged since the HOST began that suggest its...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5000279

    authors： Hoffer LJ

    更新日期：2006-05-01 00:00:00

  • Effect of valproate on renal metabolism in the intact dog.

    abstract：:Valproate is an antiepileptic drug known to induce hyperammonemia in humans. This hyperammonemia might result from a reduced detoxification of ammonium in the liver and/or from an accelerated renal ammoniagenesis. Six dogs with normal acid-base equilibrium and eight dogs with chronic metabolic acidosis were infused wi...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1988.229

    authors： Rengel-Aranda M,Gougoux A,Vinay P,Lopez-Novoa JM

    更新日期：1988-11-01 00:00:00

  • Poor accordance to a DASH dietary pattern is associated with higher risk of ESRD among adults with moderate chronic kidney disease and hypertension.

    abstract：:The Dietary Approaches to Stop Hypertension (DASH) diet lowers blood pressure, an important risk factor for chronic kidney disease (CKD) and end-stage renal disease (ESRD). However, it is unclear whether adherence to a DASH diet confers protection against future ESRD, especially among those with pre-existing CKD and h...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2018.12.027

    authors： Banerjee T,Crews DC,Tuot DS,Pavkov ME,Burrows NR,Stack AG,Saran R,Bragg-Gresham J,Powe NR,Centers for Disease Control and Prevention Chronic Kidney Disease Surveillance Team.

    更新日期：2019-06-01 00:00:00

  • Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury.

    abstract：:Mutations in the complement regulatory proteins are associated with several different diseases. Although these mutations cause dysregulated alternative pathway activation throughout the body, the kidneys are the most common site of injury. The susceptibility of the kidney to alternative pathway-mediated injury may be ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2016.02.036

    authors： Laskowski J,Renner B,Le Quintrec M,Panzer S,Hannan JP,Ljubanovic D,Ruseva MM,Borza DB,Antonioli AH,Pickering MC,Holers VM,Thurman JM

    更新日期：2016-07-01 00:00:00

  • Glucose absorption during continuous ambulatory peritoneal dialysis.

    abstract：:Patients undergoing continuous ambulatory peritoneal dialysis (CAPD) are exposed to a continuous infusion of glucose via their peritoneal cavity. We performed studies to quantitate the amount of energy derived from dialysate glucose. Net glucose absorption averaged 182 +/- (SD) 61 g/day in 19 studies with a dialysate ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1981.53

    authors： Grodstein GP,Blumenkrantz MJ,Kopple JD,Moran JK,Coburn JW

    更新日期：1981-04-01 00:00:00

  • Normalizing the peritoneal dialysis dose-have we got it right?

    abstract：:How the dialysis dose is normalized is just one of several assumptions that clinicians need to take into account when prescribing peritoneal dialysis. El-Kateb et al. confirm that estimating the volume of urea distribution is associated with significant error and show that energy expenditure is not linearly related to...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2016.09.020

    authors： Davies SJ

    更新日期：2016-12-01 00:00:00

  • Endothelin-1 induction of cyclooxygenase-2 expression in rat mesangial cells.

    abstract：:Prostaglandin E2 (PGE2) may be an important negative feedback modulator of endothelin-1 (ET-1)-stimulated mesangial cell proliferation and contraction. Recent studies suggest that ET-1 may induce prolonged mesangial cell PGE2 production, however the mechanism of this effect is unknown. The current study was undertaken...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.6

    authors： Hughes AK,Padilla E,Kutchera WA,Michael JR,Kohan DE

    更新日期：1995-01-01 00:00:00

  • Diagnosis of renovascular disease by intra- and extrarenal Doppler scanning.

    abstract：:The purpose of this prospective, angiographically controlled study was to determine the diagnostic value of color Doppler sonography with two differing approaches of scanning in patients with clinical clues for renal artery stenosis (RAS). In 135 hypertensive patients peak systolic velocity in the main renal arteries ...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章

    doi：10.1038/ki.1996.440

    authors： Krumme B,Blum U,Schwertfeger E,Flügel P,Höllstin F,Schollmeyer P,Rump LC

    更新日期：1996-10-01 00:00:00

  • Mechanisms of altered renal perfusion in the early stage of obstructive jaundice.

    abstract：:Mechanisms responsible for renal hemodynamic alterations were studied in jaundiced (by bile-duct ligation) rabbits (BDL) 10 days after ligation of the biliary tract, in comparison with sham-operated rabbits (SO). Arterial hematocrit, plasma volume, blood pressure, abdominal inferior vena cava pressure, and heart rate ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1980.25

    authors： Hishida A,Honda N,Sudo M,Nagase M

    更新日期：1980-02-01 00:00:00

  • Structure of non-(1-84) PTH fragments secreted by parathyroid glands in primary and secondary hyperparathyroidism.

    abstract：BACKGROUND:Non-(1-84) parathyroid hormone (PTH) fragments are large circulating carboxyl-terminal (C) fragments with a partially preserved amino-terminal (N) structure. hPTH (7-84), a synthetic surrogate, has been demonstrated to exert biologic effects in vivo and in vitro which are opposite to those of hPTH (1-34) on ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00493.x

    authors： D'Amour P,Brossard JH,Rousseau L,Nguyen-Yamamoto L,Nassif E,Lazure C,Gauthier D,Lavigne JR,Zahradnik RJ

    更新日期：2005-09-01 00:00:00

  • What is the place of peritoneal dialysis in the integrated treatment of renal failure?

    abstract：:The role of peritoneal dialysis (PD) in renal replacement therapy (RRT) remains unclear. There are no controlled trials to provide hard evidence of its efficacy. Comparative studies with haemodialysis from different centres and countries have given conflicting results even when allowing for case mix. Data from the Uni...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1046/j.1523-1755.1998.00183.x

    authors： Coles GA,Williams JD

    更新日期：1998-12-01 00:00:00

  • A micropuncture study of renal sodium retention in nephrotic syndrome in rats: evidence for increased resistance to tubular fluid flow.

    abstract：:Micropuncture studies were carried out in surface nephrons of rats with nephrotoxic-serum (NTS)-induced nephrotic syndrome during a period of active sodium and water retention. It was found that hydrostatic pressure and tubular diameter were increased in the proximal tubules (13.4 +/- 0.2 vs. 10.4 +/- 0.2 mm Hg; 31.3 ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1979.166

    authors： Kuroda S,Aynedjian HS,Bank N

    更新日期：1979-11-01 00:00:00

  • Inherited complement component deficiencies in membranoproliferative glomerulonephritis.

    abstract：:Anecdotal reports of complement component deficiencies in patients with immune complex disease led to a systematic study of the levels of seven complement components in serum specimens from 178 patients with glomerulonephritis and 163 normal subjects. Deficiencies were found with significantly higher frequency (22.7%)...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1983.211

    authors： Coleman TH,Forristal J,Kosaka T,West CD

    更新日期：1983-11-01 00:00:00

  • T-cell deficiency in immune complex glomerulonephritis.

    abstract：:Mice chronically infected with the virus of lymphocytic choriomeningitis (LCM) develop immune complex glomerulonephritis. Others have shown that adoptive immunization of these mice by the i.p. injection of syngeneic immune spleen cells terminates the chronic viral carrier state. The present studies were designed to de...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1977.49

    authors： Hoffsten PE,Villalobos R,Hill C,Klahr S

    更新日期：1977-05-01 00:00:00

  • Polycystic kidney and liver disease in Springbok: I. Morphology of the lesions.

    abstract：:Spontaneous polycystic kidney and liver disease in an inbred herd of Springbok (Antidorcas marsupialis) was studied by light microscopy, transmission electron microscopy, and microdissection. Springbok are a small species of gazelle of the family Bovidae native to South Africa. Since 1976, 18% of all live calves born ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1982.146

    authors： Iverson WO,Fetterman GH,Jacobson ER,Olsen JH,Senior DF,Schobert EE

    更新日期：1982-08-01 00:00:00

  • Prevalence of raised sodium-lithium countertransport activity in type 1 diabetic patients.

    abstract：:The prevalence of raised Na+/Li+ countertransport (CT) activity (greater than 0.41 mmol/liter RBC/hr) was assessed in 185 consecutive insulin-dependent diabetic patients attending an outpatient diabetic clinic. Normoalbuminuria was defined as an overnight albumin excretion rate (AER) of less than 20 micrograms/min (N ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1992.134

    authors： Lopes de Faria JB,Friedman R,Tariq T,Viberti G

    更新日期：1992-04-01 00:00:00

  • Influence of systemically applied angiotensin II on the microcirculation of glomerular capillaries in the rat.

    abstract：:The effect of intravenous infusion of angiotensin II on microvascular parameters of the renal microcirculation of rats was studied. With the aid of fluorescence microscopy and a high sensitivity video system we observed the passage of fluorescence-labeled erythrocytes through single glomerular capillaries on the surfa...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1985.4

    authors： Zimmerhackl B,Parekh N,Kücherer H,Steinhausen M

    更新日期：1985-01-01 00:00:00

  • Mesenchymal, but not hematopoietic, stem cells can be mobilized and differentiate into cardiomyocytes after myocardial infarction in mice.

    abstract：:Bone marrow (BM) cells are reported to contribute to the process of regeneration following myocardial infarction. The present study examined two independent clonal studies to determine the origin of bone marrow (BM)-derived cardiomyocytes. First, we transplanted single CD34(-)c-kit(+)Sca-1(+)lineage(-) side population...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1111/j.1523-1755.2005.00624.x

    authors： Fukuda K,Fujita J

    更新日期：2005-11-01 00:00:00

  • IL-1beta, TNF-alpha, TGF-beta, and bFGF expression in bone biopsies before and after parathyroidectomy.

    abstract：BACKGROUND:There is growing evidence pointing to an involvement of cytokines and growth factors in renal osteodystrophy. In this study, the expression of interleukin-l beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-beta (TGF-beta), and basic fibroblast growth factor (bFGF) in bone...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00835.x

    authors： Santos FR,Moysés RM,Montenegro FL,Jorgetti V,Noronha IL

    更新日期：2003-03-01 00:00:00