Abstract：
:Despite the importance of cardiovascular disease in dialysis patients, the frequency of atrial fibrillation in incident dialysis patients has not been determined. We analyzed the prevalence of atrial fibrillation in patients starting dialysis over a 4-year period, its occurrence over the course of dialysis, and its influence on ischemic stroke and mortality. Factors predisposing to atrial fibrillation were noted, as was the influence of arrhythmia on mortality and presentation of ischemic stroke. Of the 256 patients studied, 31 had atrial fibrillation at the start of dialysis. Increased age, larger left atrium, and female gender were independently related to the presence of atrial fibrillation at dialysis inception. Of the 225 patients who were in sinus rhythm at the start of dialysis, 28 developed atrial fibrillation during a mean follow-up time of 2 years. The presence of valvular calcifications, bundle branch block, previous ischemic stroke, lower ejection fraction, higher pulse pressure, and lower hemoglobin concentration were predictors of the clinical evolution of atrial fibrillation. Overall, atrial fibrillation increased mortality risk 1.72-fold and ischemic stroke risk 9.8-fold. Therefore, it appears that atrial fibrillation is quite prevalent and its presence is associated with significant risk.
journal_name
Kidney Intjournal_title
Kidney internationalauthors
Vazquez E,Sanchez-Perales C,Garcia-Garcia F,Castellano P,Garcia-Cortes MJ,Liebana A,Lozano Cdoi
10.1038/ki.2009.185subject
Has Abstractpub_date
2009-08-01 00:00:00pages
324-30issue
3eissn
0085-2538issn
1523-1755pii
S0085-2538(15)53966-5journal_volume
76pub_type
杂志文章abstract：:To maintain nitrogen equilibrium when prescribed a low protein diet (LPD), metabolic adaptations occur involving a reduction protein turnover, principally decreased muscle protein degradation. Studies suggest that in patients with chronic renal failure (CRF) uncomplicated by metabolic acidosis (MA), these adaptive res...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1991.275
更新日期：1991-10-01 00:00:00
abstract：:With a lifetime incidence of up to 12% in man and 6% in woman, nephrolithiasis is a major health problem worldwide. Approximately, 80% of kidney stones are composed of calcium and hypercalciuria is found in up to 40% of stone-formers. Although the mechanisms resulting in precipitation and growth of calcium crystals in...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/sj.ki.5002441
更新日期：2007-11-01 00:00:00
abstract：BACKGROUND:Knowledge of the long-term renal prognosis of diarrhea associated hemolytic uremic syndrome (HUS) is important for patient counseling and follow-up. However, estimates of long-term risk are highly variable, with previous studies not using a healthy control group. METHODS:A municipal water system in the smal...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2005.00225.x
更新日期：2005-04-01 00:00:00
abstract：:We examined the process of receptor-mediated endocytosis in A-9 lung fibroblast and chinese hamster ovary (CHO) cells transfected with the recently cloned vasopressin V1a receptor (51). We used a fluorescent labeled vasopressin analog (rhodamine-mercaptopropionic acid lysine vasopressin) and radiolabeled vasopressin t...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1993.119
更新日期：1993-04-01 00:00:00
abstract：:Antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) commonly results in glomerulonephritis, in which neutrophils and monocytes have important roles. The heterodimer calprotectin (S100A8/S100A9, mrp8/14) is a Toll-like receptor-4 ligand found in neutrophils and monocytes and is elevated in inflammatory...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2013.2
更新日期：2013-06-01 00:00:00
abstract：:Class IV-S lupus nephritis is often associated with more necrosis and fewer subendothelial immune deposits compared to class IV-G lupus nephritis, suggestive of necrotising glomerular inflammation found in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. ANCAs are present in a significant proportion o...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2017.04.029
更新日期：2017-11-01 00:00:00
abstract：:Healthy male rats were exposed to a chronic ingesta of an isotonic NaCl solution during a period of four months. Two different preparations were utilized to study the effect of this treatment on the active mechanisms of Na+ reabsorption of kidney proximal tubular cells: outermost kidney cortex slices (rich in proximal...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1986.216
更新日期：1986-10-01 00:00:00
abstract：:Early graft loss (EGL) is a feared outcome of kidney transplantation. Consequently, kidneys with an anticipated risk of EGL are declined for transplantation. In the most favorable scenario, with optimal use of available donor kidneys, the donor pool size is balanced by the risk of EGL, with a tradeoff dictated by the ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2020.01.043
更新日期：2020-06-01 00:00:00
abstract：:The risk of developing contrast media-induced acute renal failure was studied in 49 randomly selected nonazotemic type 2 adult diabetic patients subjected to IVU. There were 19 men and 30 women in the group whose mean age was 62 +/- 10 years (range, 38 to 82 years). In preparation for IVU, patients were neither dehydr...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1982.91
更新日期：1982-05-01 00:00:00
abstract：:Progressive kidney fibrosis precedes end-stage renal failure in up to a third of patients with diabetes mellitus. Elevated intra-renal transforming growth factor-beta (TGF-beta) is thought to underlie disease progression by promoting deposition of extracellular matrix and epithelial-mesenchymal transition. GW788388 is...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5002717
更新日期：2008-03-01 00:00:00
abstract：:Loss of hypoxic vasodilation has been proposed as a causative factor in the development of hypertension in dialysis patients treated with recombinant human erythropoietin (rHuEPO). Venous occlusion plethysmography was therefore performed on 22 dialysis patients (aged 23 to 71 years, dialysis duration 6 to 260 months, ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1992.376
更新日期：1992-10-01 00:00:00
abstract：:Myeloproliferative neoplasms are clonal hematopoietic stem cell disorders that can produce an undefined glomerulopathy. To better characterize the glomerular disease associated with myeloproliferative neoplasms, we evaluated features of 11 patients with myeloproliferative neoplasm-related glomerulopathy that included ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2011.147
更新日期：2011-10-01 00:00:00
abstract：:Incompatible donor/recipient pairs with broadly sensitized recipients have difficulty finding a crossmatch-compatible match, despite a large kidney paired donation pool. One approach to this problem is to combine kidney paired donation with lower-risk crossmatch-incompatible transplantation with intravenous immunoglob...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2013.206
更新日期：2013-11-01 00:00:00
abstract：:Healthy volunteers (N = 9) and patients with varying degrees of renal insufficiency (N = 36) were given a low dose of dopamine and/or amino acids intravenously during a simultaneous measurement of the glomerular filtration rate and the effective renal plasma flow. Dopamine infusion led to a rise in the glomerular filt...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1986.79
更新日期：1986-04-01 00:00:00
abstract：BACKGROUND:Tubulointerstitial fibrosis is a morphologic hallmark of chronic kidney disease and is a key factor in the prediction of progression to end-stage renal failure. Disruption of tubular basement membrane and interstitial extracellular matrix (ECM) via cytokine-induced alterations in matrix metalloproteinases (M...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2004.00900.x
更新日期：2004-10-01 00:00:00
abstract：:31P NMR as a descriptive technique is of interest to nephrologists. Particular contributions of 31P NMR to our understanding of renal function may be enumerated.: "Free" metabolite levels are different from those classically accepted; in particular, ADP and Pi are low with implications for the control of renal metabol...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/ki.1986.15
更新日期：1986-01-01 00:00:00
abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia emerged in Wuhan, China in December 2019. Unfortunately, there is a lack of evidence about the optimal management of novel coronavirus disease 2019 (COVID-19), and even less is available in patients on maintenance hemodialysis therapy than in the g...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2020.04.031
更新日期：2020-07-01 00:00:00
abstract：:Fibroblast growth factor-23 (FGF23), a regulator of mineral metabolism, has been linked to cardiovascular disease in chronic kidney disease. As community-based data of the longitudinal association between FGF23 and cardiovascular events are lacking, we investigated a possible relationship in 727 men of the Uppsala Lon...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2012.327
更新日期：2013-01-01 00:00:00
abstract：:Protein energy wasting is a common feature of patients with chronic kidney disease (CKD) and is associated with poor outcomes. Protein energy wasting and cachexia, a severe form of protein energy wasting, are characterized by increased resting energy expenditure but the underlying mechanisms are unclear. Browning corr...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2020.03.027
更新日期：2020-09-01 00:00:00
abstract：:The recent identification of RPGRIP1L as a Joubert syndrome gene brings the total of known genes to five. Three of these are also associated with the lethal Meckel syndrome, and two with Senior-Løken syndrome; both of these disorders share Joubert syndrome phenotypes, illustrating the genetic complexity of this. ...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/sj.ki.5002577
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND:Low birth weight is an important risk factor for hypertension and unfavorable prognoses of a number of renal diseases. It is also associated with reduced kidney size and nephron number. A differentiation between the effects of low birth weight versus being born premature or small for gestational age has, how...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2005.00451.x
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND:Recently, the in vivo pathogenic role of anti-neutrophil cytoplasm autoantibodies (ANCA) in ANCA-associated vasculitis has been challenged by Abdel-Salam et al. In their report, they observed that ANCA directed against proteinase 3 (PR3) cannot bind to their target autoantigen PR3 on circulating neutrophils ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2005.00431.x
更新日期：2005-08-01 00:00:00
abstract：:The incidence of malnutrition disorders in chronic kidney disease (CKD) appears unchanged over time, whereas patient-care and dialysis techniques continue to progress. Despite some evidence for cost-effective treatments, there are numerous caveats to applying these research findings on a daily care basis. There is a s...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/ki.2011.118
更新日期：2011-08-01 00:00:00
abstract：:This NIH-funded multicenter randomized study of focal segmental glomerulosclerosis (FSGS) treatment compared the efficacy of a 12-month course of cyclosporine to a combination of oral pulse dexamethasone and mycophenolate mofetil in children and adults with steroid-resistant primary FSGS. Of the 192 patients enrolled,...
journal_title：Kidney international
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/ki.2011.195
更新日期：2011-10-01 00:00:00
abstract：:In seven patients on maintenance hemodialysis, de novo recurrent renal stone formation was observed. In all patients, the underlying disease was glomerulonephritis, with or without the nephrotic syndrome. All patients had considerable persistent proteinuria. The stones consisted predominantly of protein, as revealed b...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1979.188
更新日期：1979-12-01 00:00:00
abstract：:Chronic cyclosporine nephrotoxicity is a poorly understood drug side-effect characterized by renal cortical interstitial scarring. To evaluate procollagen mRNA levels as an early factor in the development of this form of renal fibrosis, we measured renal procollagen alpha 1 (I), alpha 1 (III), alpha 1 (IV) and beta-ac...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1991.75
更新日期：1991-04-01 00:00:00
abstract：BACKGROUND:A family history increases the risk of kidney stone passage independent of dietary risk factors. However, the metabolic basis for familial aggregation of urolithiasis is unknown. METHODS:We evaluated metabolic risk factors in families with at least two sibs with a history of calcium stones. Sibs underwent o...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2001.0600031141.x
更新日期：2001-09-01 00:00:00
abstract：BACKGROUND:Low urinary pH is the commonest and by far the most important factor in uric acid nephrolithiasis but the reason(s) for this defect is (are) unknown. Patients with uric acid nephrolithaisis have normal acid-base parameters according conventional clinical tests. METHODS:We studied steady-state plasma and uri...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2002.00508.x
更新日期：2002-09-01 00:00:00
abstract：:Recent advances have led to a greater appreciation of how mitochondrial dysfunction contributes to diverse acute and chronic pathologies. Indeed, mitochondria have received increasing attention as a therapeutic target in a variety of diseases because they serve as key regulatory hubs uniquely situated at crossroads be...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1016/j.kint.2017.05.034
更新日期：2017-11-01 00:00:00
abstract：:Hydrogen sulfide has recently been found decreased in chronic kidney disease. Here we determined the effect and underlying mechanisms of hydrogen sulfide on a rat model of unilateral ureteral obstruction. Compared with normal rats, obstructive injury decreased the plasma hydrogen sulfide level. Cystathionine-β-synthas...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2013.449
更新日期：2014-06-01 00:00:00
