Effect of a high NaCl diet on the active mechanisms of Na+ extrusion in rat kidney.

abstract：BACKGROUND:The genetic dissection of a polygenic, multifactorial, quantitative disease such as arterial hypertension is hampered by a large environmental variance and by genetic heterogeneity. METHODS:To reduce the environmental variance, we measured the pressor response to a saline load (PRSL) and the basal plasma re...

journal_title：Kidney international

authors： Barlassina C,Schork NJ,Manunta P,Citterio L,Sciarrone M,Lanella G,Bianchi G,Cusi D

更新日期：2000-03-01 00:00:00

abstract：:Although angiotensin-converting enzyme (ACE) inhibitors are well-established drugs in the treatment of hypertension, they are not supposed to be sufficient in the inhibition of aldosterone formation. The present study analyzes the effect of aldosterone receptor antagonist, spironolactone and ACE inhibitor, captopril o...

journal_title：Kidney international

authors： Pechanova O,Matuskova J,Capikova D,Jendekova L,Paulis L,Simko F

更新日期：2006-07-01 00:00:00

abstract：:Kidney cancer, although relatively rare when compared to other malignancies, occurs not uncommonly in patients with renal disease and is often discovered incidentally during the initial nephrologic work-up, or by the savvy clinician who is familiar with the paraneoplastic signs. While surgical approaches are generally...

journal_title：Kidney international

authors： Weiss RH,Lin PY

更新日期：2006-01-01 00:00:00

abstract：:The homocysteine hypothesis states that circulating homocysteine is a vascular toxin in concentrations that occur in the general population and in renal failure. This hypothesis is currently being tested in the Kidney and End State Renal Disease Study (HOST), but data have emerged since the HOST began that suggest its...

journal_title：Kidney international

authors： Hoffer LJ

更新日期：2006-05-01 00:00:00

abstract：UNLABELLED:The paracellular permeability of opossum kidney cells, a proximal tubule cell line. BACKGROUND:The regulation of the unusually leaky paracellular pathway of the proximal tubule is poorly understood partially because of the lack of an appropriate in vitro cell model. In this study, we determined whether the ...

journal_title：Kidney international

authors： Liang M,Ramsey CR,Knox FG

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Patients with thin basement membrane disease (TBMD) are often from families where hematuria segregates with the COL4A3 and COL4A4 genes. These genes also are affected in autosomal recessive Alport syndrome. The aim of this study was to demonstrate COL4A4 mutations in TBMD. METHODS:Forty-eight unrelated indi...

journal_title：Kidney international

authors： Buzza M,Dagher H,Wang YY,Wilson D,Babon JJ,Cotton RG,Savige J

更新日期：2003-02-01 00:00:00

abstract：:The Executive Summary of the KDIGO Clinical Practice Guideline for the Care of Kidney Transplant Recipients is presented in this issue of Kidney International. This guideline will require careful attention for implementation in the context of available resources within each country, especially those with underdevelope...

journal_title：Kidney international

authors： Delmonico FL

更新日期：2010-02-01 00:00:00

abstract：:We have studied the effect of neutralizing the surface charge of rat glomerular epithelial cells (GEC) in culture on prostanoid production. Incubation of rat GEC with polycations poly-L-lysine (PL) resulted in a dose dependent increase of 6-keto-PGF1 alpha (up to 8 to 10-fold) and PGE2 (up to 7 to 8-fold) production. ...

journal_title：Kidney international

authors： Pugliese F,Singh AK,Kasinath BS,Kreisberg JI,Lewis EJ

更新日期：1987-07-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase. Its activation results in beneficial or detrimental consequences, depending on the particular setting. Earlier studies in the animal model of acute kidney injury showed that EGFR activation promotes renal tubular cell proliferation. Activation of E...

journal_title：Kidney international

authors： Tang J,Liu N,Zhuang S

更新日期：2013-05-01 00:00:00

abstract：:Hyperinsulinemia can contribute to hypertension through effects on sodium transport. To test whether the stimulatory effect of insulin on renal proximal tubule sodium transport is preserved in insulin resistance, we compared the effects of insulin on abdominal adipocytes and proximal tubules in rats and humans. Insuli...

journal_title：Kidney international

authors： Nakamura M,Yamazaki O,Shirai A,Horita S,Satoh N,Suzuki M,Hamasaki Y,Noiri E,Kume H,Enomoto Y,Homma Y,Seki G

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Studies in animal models have shown that the alternative pathway of complement is activated in the kidney after ischemia/reperfusion. In addition, mice deficient in complement factor B, a necessary component of the alternative pathway, are protected from ischemic acute renal failure. The purpose of this stud...

journal_title：Kidney international

authors： Thurman JM,Lucia MS,Ljubanovic D,Holers VM

更新日期：2005-02-01 00:00:00

abstract：:Suramin is a polysulfonated naphthylurea originally designed as a treatment for trypanosomiasis; but that has also been used to treat rodent models of fulminant hepatic failure and focal brain ischemia. In this study, we determined the effects of suramin on renal ischemia/reperfusion-induced acute kidney injury in mic...

journal_title：Kidney international

authors： Zhuang S,Lu B,Daubert RA,Chavin KD,Wang L,Schnellmann RG

更新日期：2009-02-01 00:00:00

abstract：:Recently, 4 new risk scores for the prediction of mortality and cardiovascular events were especially tailored for hemodialysis patients; these scores performed much better than previous scores. Tripepi et al. found that these risk scores were even more predictive for all-cause and cardiovascular death than the measur...

journal_title：Kidney international

authors： Kronenberg F,Schwaiger JP

更新日期：2017-03-01 00:00:00

abstract：:Recent evidence suggesting a strong interplay between components of the renin-angiotensin system and key mediators of fibrosis led us to hypothesize that renin, independent of its enzymatic action to enhance angiotensin (Ang) II synthesis, directly increases production of the fibrogenic cytokine transforming growth fa...

journal_title：Kidney international

authors： Huang Y,Wongamorntham S,Kasting J,McQuillan D,Owens RT,Yu L,Noble NA,Border W

更新日期：2006-01-01 00:00:00

abstract：:Neuropilin1 (Nrp1) is a co-receptor best known to regulate the development of endothelial cells and is a target of anticancer therapies. However, its role in other vascular cells including pericytes is emergent. The kidney is an organ with high pericyte density and cancer patients develop severe proteinuria following ...

journal_title：Kidney international

authors： Wnuk M,Anderegg MA,Graber WA,Buergy R,Fuster DG,Djonov V

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Chronic cyclosporine (CsA) nephrotoxicity is characterized by interstitial fibrosis and afferent arteriolar hyalinosis. L-arginine (L-Arg), the substrate for nitric oxide (NO) synthase and N-nitro-L-arginine-methyl ester (L-NAME), the NO synthase inhibitor, were shown to modulate acute CsA nephrotoxicity. Ho...

journal_title：Kidney international

authors： Shihab FS,Yi H,Bennett WM,Andoh TF

更新日期：2000-09-01 00:00:00

abstract：:In the present study we assessed the prevalence of thin glomerular basement membrane (TGBM) in a large group of native kidney biopsies done for evaluation of renal disease. TGBM was present in 54 of 1078 biopsies (5%). In 12 of 54 biopsies (24%), TGBM was the only abnormality present. In the remaining biopsies TGBM wa...

journal_title：Kidney international

authors： Cosio FG,Falkenhain ME,Sedmak DD

更新日期：1994-08-01 00:00:00

abstract：:To define the pattern of recovery from postischemic acute renal failure (ARF), we performed clearance and micropuncture studies at intervals of 1, 2, 4, and 8 weeks following 60 min of complete unilateral renal artery occlusion in the rat. At 1 week, the inulin clearance (CIn) of the postischemic kidney was less than ...

journal_title：Kidney international

authors： Finn WF,Chevalier RL

更新日期：1979-08-01 00:00:00

abstract：:VLDL receptor (VLDL-R) is a novel member of the LDL receptor gene family with distinct tissue distribution and function. It binds and internalizes VLDL particles and is primarily expressed in skeletal muscle, heart, brain and adipose tissue, which use fatty acids for energy production or storage. CRF is associated wit...

journal_title：Kidney international

authors： Vaziri ND,Liang K

更新日期：1997-03-01 00:00:00

abstract：:Gene expression differs substantially among individual cells of the same type. We speculate that genes that are expressed in all but a portion of cells of a given cell type would be likely essential and required for either the cell survival (housekeeping) or for the cell type's unique structure and function, enabling ...

journal_title：Kidney international

authors： Lu Y,Ye Y,Bao W,Yang Q,Wang J,Liu Z,Shi S

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Optimal nutrient intake is important in the maintenance of a positive nitrogen balance in hemodialysis (HD) patients. The objectives of this study were (1) to assess the influence of two levels of protein intakes on nitrogen balance in stable adult HD patients, and (2) to identify a minimum level of protein ...

journal_title：Kidney international

authors： Rao M,Sharma M,Juneja R,Jacob S,Jacob CK

更新日期：2000-07-01 00:00:00

abstract：:Tubulointerstitial nephritis (TIN) is a disease pattern with heterogeneous causes. Recently a specific subtype of autoimmune TIN, IgG4-related TIN, has been identified that is part of systemic IgG4-related disease/ autoimmune pancreatitis. On biopsy, this TIN shows an IgG4+ plasma cell-rich infiltrate, akin to the pan...

journal_title：Kidney international

authors： Cornell LD

更新日期：2010-11-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is the most common kidney malignancy and has a poor prognosis owing to its resistance to chemotherapy. RCC cells overexpress the transcription factor, PAX2, normally expressed in fetal kidney but downregulated at birth. Since Pax2 suppresses apoptosis during renal development, we reasoned th...

journal_title：Kidney international

authors： Hueber PA,Waters P,Clark P,Eccles M,Goodyer P

更新日期：2006-04-01 00:00:00

abstract：:Patients receiving cadaveric kidney transplants often experience delayed graft function. As iodinated contrast media injection (ICMI), necessary for cerebral angiography, which is often used to diagnose brain death, can be nephrotoxic, we compared renal function recovery (RFR) and 1-year and long-term graft survival a...

journal_title：Kidney international

authors： Vigneau C,Fulgencio JP,Godier A,Chalem Y,El Metaoua S,Rondeau E,Tuppin P,Bonnet F

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:This study evaluated the effects of dietary sodium manipulation in dogs on the regulation of canine angiotensin receptors (cAT1 and cAT2) in the kidney and adrenal. METHODS:Isolated glomeruli and membranes from renal medulla and the adrenal gland were used in radioligand binding assays from two groups of do...

journal_title：Kidney international

authors： Zheng W,Ji H,Szabo Z,Brown PR,Yoo SE,Sandberg K

更新日期：2001-05-01 00:00:00

abstract：:The primary hyperoxalurias are diseases of overproduction of oxalate. The immediate precursor of oxalate is glyoxylate. Metabolism of hydroxyproline, derived from collagen turnover or the diet, appears to be a major source of glyoxylate, and a potential target for a therapeutic strategy of substrate depletion. ...

journal_title：Kidney international

authors： Coulter-Mackie MB

更新日期：2006-12-01 00:00:00

abstract：:The candidacidal activity of kidneys, liver, and spleen's phagocytic systems was studied in mouse. Different strains of mice were inoculated intravenously (i.v.) with 1 to 2.6 x 10(4) viable Candida albicans. Elimination of the microorganisms from the kidneys, liver, and spleen were evaluated by enumeration of colony ...

journal_title：Kidney international

authors： Baghian A,Lee KW

更新日期：1991-09-01 00:00:00

abstract：:The members of the matrix metalloproteinase gene family play critical roles in numerous physiologic events, including cellular migration, tissue remodeling in wound healing and development, as well as in the evolution of the inflammatory process. The 72 kDa gelatinase A (formerly denoted 72 kDa Type IV collagenase) is...

journal_title：Kidney international

authors： Turck J,Pollock AS,Lovett DH

更新日期：1997-05-01 00:00:00

abstract：:Protein energy wasting is a common feature of patients with chronic kidney disease (CKD) and is associated with poor outcomes. Protein energy wasting and cachexia, a severe form of protein energy wasting, are characterized by increased resting energy expenditure but the underlying mechanisms are unclear. Browning corr...

journal_title：Kidney international

authors： Luce M,Barba C,Yi D,Mey A,Roussel D,Bres E,Benoit B,Pastural M,Granjon S,Szelag JC,Laville M,Arkouche W,Bouchara A,Nyam E,Fouque D,Soulage CO,Koppe L

更新日期：2020-09-01 00:00:00

abstract：:The role of calcitonin on the calcemic response to parathyroid hormone (PTH) in renal failure has not been evaluated previously. Often animal studies evaluating the calcemic response to PTH in renal failure are performed in thyroparathyroidectomized (TPTX) animals, and thus eliminate any potential physiologic effect o...

journal_title：Kidney international

authors： Rodriguez M,Felsenfeld AJ,Torres A,Pederson L,Llach F

更新日期：1991-08-01 00:00:00