当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Microalbuminuria three years after recovery from Escherichia coli O157 hemolytic uremic syndrome due to municipal water contamination.

Microalbuminuria three years after recovery from Escherichia coli O157 hemolytic uremic syndrome due to municipal water contamination.

Abstract：

BACKGROUND:Knowledge of the long-term renal prognosis of diarrhea associated hemolytic uremic syndrome (HUS) is important for patient counseling and follow-up. However, estimates of long-term risk are highly variable, with previous studies not using a healthy control group. METHODS:A municipal water system in the small rural town of Walkerton, Ontario, became contaminated with Escherichia coli O157:H7 in 2000. A cohort of 19 children who recovered from HUS was randomly age- and sex-matched to 38 children with no symptoms at the time of the outbreak. Both groups had detailed renal function testing 3 years after the outbreak, including a random urine albumin to creatinine, glomerular filtration rate estimated by Schwartz formula, and automated and manual blood pressure measurements. RESULTS:There were no baseline differences between the groups with respect to age (mean 4.8 years, range 1 to 15), sex, or birth weight (mean 3.4 kg). In follow-up there were no differences between the groups in body surface area (mean 1.0 m(2)), or in the methods by which renal function was assessed. Compared to the group with no symptoms, patients with HUS demonstrated more microalbuminuria [32% vs. 5%, relative risk 4.8 (95% CI 1.1 to 22.0)], a nonsignificant trend toward lower GFR (124 vs. 134 mL/min per 1.73 m(2)), and no difference in blood pressure. CONCLUSION:Children may demonstrate microalbuminuria 3 years after recovering from HUS. Longer follow-up is needed to determine if this finding has clinical relevance and utility.

journal_name

Kidney Int

journal_title

Kidney international

authors

Garg AX,Clark WF,Salvadori M,Macnab J,Suri RS,Haynes RB,Matsell D,Walkerton Health Study Investigators.

doi

10.1111/j.1523-1755.2005.00225.x

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

1476-82

issue

4

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)50603-0

journal_volume

67

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • Predictors and consequences of altered mineral metabolism: the Dialysis Outcomes and Practice Patterns Study.

    abstract：BACKGROUND:Altered mineral metabolism contributes to bone disease, cardiovascular disease, and other clinical problems in patients with end-stage renal disease. METHODS:This study describes the recent status, significant predictors, and potential consequences of abnormal mineral metabolism in representative groups of ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00185.x

    authors： Young EW,Albert JM,Satayathum S,Goodkin DA,Pisoni RL,Akiba T,Akizawa T,Kurokawa K,Bommer J,Piera L,Port FK

    更新日期：2005-03-01 00:00:00

  • Glycosaminoglycan and proteoglycan inhibit the depolymerization of beta2-microglobulin amyloid fibrils in vitro.

    abstract：BACKGROUND:Although several kinds of evidence suggest that glycosaminoglycans (GAGs) and proteoglycans (PGs) may contribute to the development of beta2-microglobulin-related (Abeta2m) amyloidosis, the precise roles of these molecules for the development of Abeta2m amyloidosis are poorly understood. METHODS:We investig...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00167.x

    authors： Yamaguchi I,Suda H,Tsuzuike N,Seto K,Seki M,Yamaguchi Y,Hasegawa K,Takahashi N,Yamamoto S,Gejyo F,Naiki H

    更新日期：2003-09-01 00:00:00

  • Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations.

    abstract：BACKGROUND:Hyperhomocysteinemia is a risk factor for atherosclerosis that is common in chronic renal failure (CRF), but its cause is unknown. Homocysteine metabolism is linked to betaine-homocysteine methyl transferase (BHMT), a zinc metalloenzyme that converts glycine betaine (GB) to N,N dimethylglycine (DMG). DMG is ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.00743.x

    authors： McGregor DO,Dellow WJ,Lever M,George PM,Robson RA,Chambers ST

    更新日期：2001-06-01 00:00:00

  • Atrial fibrillation in incident dialysis patients.

    abstract：:Despite the importance of cardiovascular disease in dialysis patients, the frequency of atrial fibrillation in incident dialysis patients has not been determined. We analyzed the prevalence of atrial fibrillation in patients starting dialysis over a 4-year period, its occurrence over the course of dialysis, and its in...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2009.185

    authors： Vazquez E,Sanchez-Perales C,Garcia-Garcia F,Castellano P,Garcia-Cortes MJ,Liebana A,Lozano C

    更新日期：2009-08-01 00:00:00

  • Renal CD14 expression correlates with the progression of cystic kidney disease.

    abstract：:Monocyte and macrophage markers are among the most highly overexpressed genes in cpk mouse kidneys with severely progressive renal cystic disease. We show here that one of these markers, CD14, is abnormally transcribed, activated and shed in cystic kidneys. However, these abnormalities were not associated with an incr...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2010.175

    authors： Zhou J,Ouyang X,Cui X,Schoeb TR,Smythies LE,Johnson MR,Guay-Woodford LM,Chapman AB,Mrug M

    更新日期：2010-09-01 00:00:00

  • Elevated cysteinyl leukotriene excretion in experimental glomerulonephritis.

    abstract：:The involvement of cysteinyl leukotrienes (LT) in the etiology of glomerulonephritis (GN) was investigated in a rat model of nephrotoxic serum nephritis in which renal function, morphology, LTC4 synthase activity and urinary cysteinyl LT excretion were monitored over seven days. Significant alterations in renal functi...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1994.401

    authors： Petric R,Ford-Hutchinson AW

    更新日期：1994-11-01 00:00:00

  • If you lose your nerves, at least you will not get kidney fibrosis!

    abstract：:Kidney fibrosis is one of the most promising treatment targets in nephrology. To design effective treatment approaches, a detailed understanding of the initiating mechanisms is of great importance. Kim and Pandanilam now find that renal nerves are a major trigger for renal fibrosis. Both afferent and efferent nerve fi...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2014.327

    authors： Boor P,Papasotiriou ME

    更新日期：2015-02-01 00:00:00

  • Role of excess volume in the pathophysiology of hypertension in chronic kidney disease.

    abstract：BACKGROUND:The pathophysiology of hypertension in patients with chronic kidney disease (CKD) is largely attributed to positive sodium balance. It is unclear how loop diuretics affect fluid volume compartments, especially with respect to their antihypertensive effect. METHODS:Subjects with CKD were administered a singl...

    journal_title：Kidney international

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1523-1755.2003.00273.x

    authors： Vasavada N,Agarwal R

    更新日期：2003-11-01 00:00:00

  • Antioxidant therapy in hemodialysis patients: a systematic review.

    abstract：:Antioxidants have been used as therapies to decrease oxidative stress and improve CVD risk in hemodialysis (HD) patients. A systematic search of the Medline database (search date 30 April 2011) found 56 studies investigating the effects of antioxidant therapies on biomarkers of oxidative stress (53 studies) or clinica...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/ki.2011.341

    authors： Coombes JS,Fassett RG

    更新日期：2012-02-01 00:00:00

  • Cell senescence in rat kidneys in vivo increases with growth and age despite lack of telomere shortening.

    abstract：BACKGROUND:Somatic cells in vitro have a finite life expectancy before entering a state of senescence, but it is unclear whether this state occurs in vivo in kidney development, growth, and aging. We previously showed that human kidney cortex displays telomere shortening with age. In this study, we compared the structu...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00032.x

    authors： Melk A,Kittikowit W,Sandhu I,Halloran KM,Grimm P,Schmidt BM,Halloran PF

    更新日期：2003-06-01 00:00:00

  • Transplant approach establishes that kidneys are responsible for serum CSF-1 but require a stimulus in MRL-lpr mice.

    abstract：:Colony stimulating factor-1 (CSF-1) is a chemoattractant and growth factor for macrophages. In autoimmune MRL-lpr mice, CSF-1 is detected in the circulation and there is an increase in CSF-1 transcripts and macrophages in the kidney. The purpose of this study was to establish whether the MRL-lpr kidney is responsible ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1996.9

    authors： Naito T,Griffiths RC,Coffman TM,Kelley VR

    更新日期：1996-01-01 00:00:00

  • Myofibroblastic conversion of mesothelial cells.

    abstract：BACKGROUND:The continuous chemical, physical, and inflammatory insults of prolonged continuous ambulatory peritoneal dialysis (CAPD) incite mesothelial cell responses, which may result in peritoneal fibrosis. The transforming growth factor-beta (TGF-beta), especially the isoform TGF-beta 1, has long been known to play ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00861.x

    authors： Yang AH,Chen JY,Lin JK

    更新日期：2003-04-01 00:00:00

  • National trend of the incidence of urolithiasis in Japan from 1965 to 1995.

    abstract：BACKGROUND:A nationwide survey of urolithiasis in Japan was made in order to evaluate the chronological trend of upper urinary tract stones in the Japanese. It succeeded previous studies done in 1955, 1966, 1979, and 1990. METHODS:All outpatient visits to urologists that resulted in a diagnosis of first-episode upper ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00754.x

    authors： Yoshida O,Terai A,Ohkawa T,Okada Y

    更新日期：1999-11-01 00:00:00

  • Effect of valproate on renal metabolism in the intact dog.

    abstract：:Valproate is an antiepileptic drug known to induce hyperammonemia in humans. This hyperammonemia might result from a reduced detoxification of ammonium in the liver and/or from an accelerated renal ammoniagenesis. Six dogs with normal acid-base equilibrium and eight dogs with chronic metabolic acidosis were infused wi...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1988.229

    authors： Rengel-Aranda M,Gougoux A,Vinay P,Lopez-Novoa JM

    更新日期：1988-11-01 00:00:00

  • Non-muscle myosin IIA is required for the development of the zebrafish glomerulus.

    abstract：:Mutations in the MYH9 gene, coding for the non-muscle myosin heavy chain IIA (NMHC-IIA), are responsible for syndromes characterized by macrothrombocytopenia associated with deafness, cataracts, and severe glomerular disease. Electron microscopy of renal biopsies from these patients found glomerular abnormalities char...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2011.256

    authors： Müller T,Rumpel E,Hradetzky S,Bollig F,Wegner H,Blumenthal A,Greinacher A,Endlich K,Endlich N

    更新日期：2011-11-01 00:00:00

  • Genomic and clinical profiling of a national nephrotic syndrome cohort advocates a precision medicine approach to disease management.

    abstract：:Steroid Resistant Nephrotic Syndrome (SRNS) in children and young adults has differing etiologies with monogenic disease accounting for 2.9-30% in selected series. Using whole exome sequencing we sought to stratify a national population of children with SRNS into monogenic and non-monogenic forms, and further define t...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2016.10.013

    authors： Bierzynska A,McCarthy HJ,Soderquest K,Sen ES,Colby E,Ding WY,Nabhan MM,Kerecuk L,Hegde S,Hughes D,Marks S,Feather S,Jones C,Webb NJ,Ognjanovic M,Christian M,Gilbert RD,Sinha MD,Lord GM,Simpson M,Koziell AB,Welsh

    更新日期：2017-04-01 00:00:00

  • Endostatin and transglutaminase 2 are involved in fibrosis of the aging kidney.

    abstract：:Endostatin (EST), an antiangiogenic factor, is enriched in aging kidneys. EST is also an interactive partner of transglutaminase 2 (TG2), an enzyme that cross-links extracellular matrix proteins. Here we tested whether EST and TG2 play a role in the fibrosis of aging. In wild-type mice, aging kidneys exhibited a 2- to...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2016.01.030

    authors： Lin CH,Chen J,Zhang Z,Johnson GV,Cooper AJ,Feola J,Bank A,Shein J,Ruotsalainen HJ,Pihlajaniemi TA,Goligorsky MS

    更新日期：2016-06-01 00:00:00

  • Reversal of adynamic bone disease by lowering of dialysate calcium.

    abstract：:Adynamic bone disease (ABD) is increasingly recognized, especially in dialysis patients treated with oral calcium carbonate, vitamin D supplements, or supraphysiological dialysate calcium. We undertook this study to assess the effect of lowering dialysate calcium on episodes of hypercalcemia, serum parathyroid hormone...

    journal_title：Kidney international

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/sj.ki.5001666

    authors： Haris A,Sherrard DJ,Hercz G

    更新日期：2006-09-01 00:00:00

  • Parenteral iron treatment induces MCP-1 accumulation in plasma, normal kidneys, and in experimental nephropathy.

    abstract：INTRODUCTION:Monocyte chemoattractant protein-1 (MCP-1) promotes renal inflammation, thereby contributing to acute and chronic nephropathies. Its production is stimulated by oxidative stress. Thus, this study tested whether pro-oxidant iron/carbohydrate complexes, used to treat iron deficiency, induce MCP-1 in renal/ex...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00565.x

    authors： Zager RA

    更新日期：2005-10-01 00:00:00

  • Role of the 11beta-hydroxysteroid dehydrogenase type 2 in blood pressure regulation.

    abstract：:The renal 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) enzyme inactivates 11-hydroxy steroids in the kidney, thus protecting the nonselective mineralocorticoid receptor (MR) from occupation by glucocorticoids. The gene is highly expressed in all sodium-transporting epithelia, but also in human placenta, pan...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1046/j.1523-1755.2000.00978.x

    authors： Ferrari P,Krozowski Z

    更新日期：2000-04-01 00:00:00

  • Intraerythrocytic pH variations during hemodialysis: a 31P NMR study.

    abstract：:Before hemodialysis, patients have an intraerythrocytic pH (pHi) and an extracellular pH, measured in whole blood (pHo), which are lower than those of healthy controls. During bicarbonate hemodialysis, pHi values continuously increase, approaching a normal value at the end of the session. Concomitantly, pHo values fol...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1989.66

    authors： Monti JP,Gallice P,Baz M,Murisasco A,Crevat A,Elsen R

    更新日期：1989-03-01 00:00:00

  • A new model of diabetic nephropathy with progressive renal impairment in the transgenic (mRen-2)27 rat (TGR).

    abstract：BACKGROUND:The tissue renin-angiotensin system (RAS) may modulate the structural and functional changes that occur in the diabetic kidney. METHODS:Hypertensive transgenic (mREN-2)27 rat (TGR) that exhibit increased tissue renin expression were administered streptozotocin (STZ, diabetic) or citrate buffer (non-diabetic...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1998.00019.x

    authors： Kelly DJ,Wilkinson-Berka JL,Allen TJ,Cooper ME,Skinner SL

    更新日期：1998-08-01 00:00:00

  • DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition.

    abstract：BACKGROUND:Tubulointerstitial inflammation and fibrosis are pathologic hallmarks of end-stage renal disease (ESRD). Here we have used DNA microarray technology to monitor the transcriptomic responses to murine unilateral ureteral obstruction (UUO) with a view to identifying molecular modulators of tubulointerstitial fi...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00306.x

    authors： Higgins DF,Lappin DW,Kieran NE,Anders HJ,Watson RW,Strutz F,Schlondorff D,Haase VH,Fitzpatrick JM,Godson C,Brady HR

    更新日期：2003-12-01 00:00:00

  • Autosomal-dominant medullary cystic kidney disease type 1: clinical and molecular findings in six large Cypriot families.

    abstract：BACKGROUND:Autosomal-dominant medullary cystic kidney disease (ADMCKD), a hereditary chronic interstitial nephropathy, recently attracted attention because of the cloning or mapping of certain gene loci, namely NPHP1, NPHP2 and NPHP3 for familial juvenile nephronophthisis (NPH) and MCKD1 and MCKD2 for the adult form of...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2002.kid581.x

    authors： Stavrou C,Koptides M,Tombazos C,Psara E,Patsias C,Zouvani I,Kyriacou K,Hildebrandt F,Christofides T,Pierides A,Deltas CC

    更新日期：2002-10-01 00:00:00

  • Migration of smooth muscle cells from the arterial anastomosis of arteriovenous fistulas requires Notch activation to form neointima.

    abstract：:A major factor contributing to failure of arteriovenous fistulas (AVFs) is migration of smooth muscle cells into the forming neointima. To identify the source of smooth muscle cells in neointima, we created end-to-end AVFs by anastomosing the common carotid artery to the jugular vein and studied neural crest-derived s...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2015.73

    authors： Liang M,Wang Y,Liang A,Mitch WE,Roy-Chaudhury P,Han G,Cheng J

    更新日期：2015-09-01 00:00:00

  • Pressure diuresis and natriuresis in DOCA-salt mice.

    abstract：:The increasing use of mice in renal and cardiovascular studies has necessitated adapting physiological methods used for rats to mice, which are far smaller in size. We have adapted measurements of continuous renal blood flow, pressure natriuresis and diuresis, and laser-Doppler cortical and medullary flow to 40 g mice...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1997.462

    authors： Gross V,Lippoldt A,Luft FC

    更新日期：1997-11-01 00:00:00

  • Cellular and molecular pathways of renal repair after acute kidney injury.

    abstract：:The acutely injured mammalian kidney mounts a cellular and molecular response to repair itself. However, in patchy regions such intrinsic processes are impaired and dysregulated leading to chronic kidney disease. Currently, no therapy exists to treat established acute kidney injury per se. Strategies to augment human ...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1016/j.kint.2017.07.030

    authors： Kumar S

    更新日期：2018-01-01 00:00:00

  • Beneficial impact of spironolactone in diabetic nephropathy.

    abstract：BACKGROUND:Aldosterone has been suggested to play a role in the initiation and progression of diabetic nephropathy. Currently recommended treatment with angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers [renin-angiotensin system (RAS) blockade] does not suppress circulating aldosterone ...

    journal_title：Kidney international

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1523-1755.2005.00756.x

    authors： Schjoedt KJ,Rossing K,Juhl TR,Boomsma F,Rossing P,Tarnow L,Parving HH

    更新日期：2005-12-01 00:00:00

  • Furosemide-induced vasodilation: importance of the state of hydration and filtration.

    abstract：:The circumstances under which furosemide increases renal blood flow was examined in mongrel dogs as it may relate to a tubuloglomerular feedback mechanism. Two maneuvers, desoxycorticosterone (DOCA) plus salt treatment and inhibition of tubular fluid flow, were used in the dogs to evaluate the renal vascular effects o...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1980.158

    authors： Gerber JG,Nies AS

    更新日期：1980-10-01 00:00:00

  • Evaluation of renal Kt/V as a marker of renal function in predialysis patients.

    abstract：BACKGROUND:The use of renal Kt/V (r-Kt/V) as an indicator for the need of dialysis initiation has been recommended in the NKF-DOQI guidelines. In analogy to clinical practice in peritoneal dialysis, a fall of r-Kt/V below a threshold of 2.0 per week may indicate inadequate renal toxin elimination. However, there are no...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.00957.x

    authors： Kuhlmann MK,Heckmann M,Riegel W,Köhler H

    更新日期：2001-10-01 00:00:00