Reversal of adynamic bone disease by lowering of dialysate calcium.

abstract：BACKGROUND:Intrauterine growth retardation (IUGR) is associated with higher morbidity and mortality not only in perinatal life but also in later life. The purpose of our study was to determine whether IUGR has any effect on the course of minimal change nephrotic syndrome (MCNS) in children. METHODS:Forty children who ...

journal_title：Kidney international

authors： Zidar N,Avgustin Cavić M,Kenda RB,Ferluga D

更新日期：1998-10-01 00:00:00

abstract：:Efficacy and safety of antibiotic 'locks', in prevention of thrombotic and infectious complication-related morbidity and mortality, among diabetics dialyzed through tunneled-cuffed catheters (TCCs) has not been effectively investigated. This trial was designed to investigate the outcome of TCCs (n = 109), inserted amo...

journal_title：Kidney international

authors： Saxena AK,Panhotra BR,Sundaram DS,Al-Hafiz A,Naguib M,Venkateshappa CK,Abu-Oun BA,Hussain SM,Al-Ghamdi AA

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:The rat renal proximal tubule cells contain a large amount of monoamine oxidase, which catalyzes the oxidative deamination of catecholamines such as dopamine (DA). The aim of this study is to investigate the potential role of hydrogen peroxide (H2O2) produced by monoamine oxidase (MAO) isoform on regulation ...

journal_title：Kidney international

authors： Vindis C,Séguélas MH,Lanier S,Parini A,Cambon C

更新日期：2001-01-01 00:00:00

abstract：:The risk of death in hemodialysis patients treated with calcium-containing phosphate binders or sevelamer is not known. We assessed all-cause mortality in 127 patients new to hemodialysis assigned to calcium-containing binders or sevelamer after a median follow-up of 44 months from randomization. This was a predetermi...

journal_title：Kidney international

authors： Block GA,Raggi P,Bellasi A,Kooienga L,Spiegel DM

更新日期：2007-03-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF)-D, a specific PDGF receptor β (PDGFR-β) ligand, mediates mesangial proliferation in vitro and in vivo. However, its role in renal development, physiology, and fibrosis is relatively unknown. In healthy murine kidneys, PDGF-D was found to be expressed on renal mesenchymal cells (me...

journal_title：Kidney international

authors： Buhl EM,Djudjaj S,Babickova J,Klinkhammer BM,Folestad E,Borkham-Kamphorst E,Weiskirchen R,Hudkins K,Alpers CE,Eriksson U,Floege J,Boor P

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Cux-1 is a murine homeodomain protein that functions as a cell cycle-dependent transcriptional repressor in proliferating cells. Targets of Cux-1 repression include the cyclin kinase inhibitors p21 and p27. In the kidney, Cux-1 is spatially and temporally regulated, and ectopic expression of Cux-1 in transge...

journal_title：Kidney international

authors： Sharma M,Brantley JG,Alcalay NI,Zhou J,Heystek E,Maser RL,Vanden Heuvel GB

更新日期：2005-02-01 00:00:00

abstract：:Starting from observations in intact cells and extending to studies in native membranes and solubilized membrane proteins, a significant body of evidence has been accumulated to indicate that some of the short-term regulatory influences on the Na+-H+ exchanger in the apical membrane of the proximal convoluted tubule a...

journal_title：Kidney international

authors： Weinman EJ,Dubinsky W,Shenolikar S

更新日期：1989-10-01 00:00:00

abstract：:Cytokines are important modulators of inflammation. The balance between pro- and anti-inflammatory cytokines determines whether the intensity of inflammatory response is within physiological limits or in the pathological range. The cytokine network is highly complex, containing interactive cascades of gene activation ...

journal_title：Kidney international

authors： Rao M,Wong C,Kanetsky P,Girndt M,Stenvinkel P,Reilly M,Raj DS

更新日期：2007-09-01 00:00:00

abstract：:The widths of slit diaphragms in rat glomeruli were quantitatively measured on electron micrographs obtained by the rapid-freezing and freeze-substitution (FS) fixation method and compared to those prepared by conventional chemical fixation procedures, such as tannic acid, glutaraldehyde and osmium tetroxide (TGO) or ...

journal_title：Kidney international

authors： Furukawa T,Ohno S,Oguchi H,Hora K,Tokunaga S,Furuta S

更新日期：1991-10-01 00:00:00

abstract：:Adenosine is known to be a potent inhibitor of renin release from the kidneys. The aim of this study was to investigate the transmembrane signalling avenue that the second messenger of adenosine causes inhibition of renal renin release. Using short term cultures of juxtaglomerular cells isolated from rat kidneys, we f...

journal_title：Kidney international

authors： Kurtz A,Della Bruna R,Pfeilschifter J,Bauer C

更新日期：1988-04-01 00:00:00

abstract：UNLABELLED:The paracellular permeability of opossum kidney cells, a proximal tubule cell line. BACKGROUND:The regulation of the unusually leaky paracellular pathway of the proximal tubule is poorly understood partially because of the lack of an appropriate in vitro cell model. In this study, we determined whether the ...

journal_title：Kidney international

authors： Liang M,Ramsey CR,Knox FG

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Increasing proteinuria in kidney disease is associated with an increased risk of renal failure. Urinary proteins such as albumin induce inflammatory signaling and gene expression in tubular epithelial cells (TECs). Fibronectin is an extracellular matrix protein that can exist in soluble form and is excreted ...

journal_title：Kidney international

authors： Ren L,Blanchette JB,White LR,Clark SA,Heffner DJ,Tibbles LA,Muruve DA

更新日期：2005-11-01 00:00:00

abstract：:Melamine, a widely used chemical found in many products in daily use, became a public health concern due to melamine-associated urinary stone formation in children. In adults, it is still unknown whether low-dose melamine exposure may also cause urolithiasis. To address this question, we studied 211 Taiwanese patients...

journal_title：Kidney international

authors： Liu CC,Wu CF,Chen BH,Huang SP,Goggins W,Lee HH,Chou YH,Wu WJ,Huang CH,Shiea J,Lee CH,Wu KY,Wu MT

更新日期：2011-10-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) is known to suppress platelet-derived growth factor (PDGF)-stimulated proliferation of rat cultured vascular smooth muscle cells. The present study examined whether ANP inhibits the PDGF receptor (PDGFR) tyrosine kinase activation, an initial event for PDGF cellular signaling. ANP redu...

journal_title：Kidney international

authors： Awazu M

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND:The characteristic feature of Goodpasture disease is the occurrence of an autoantibody response to the noncollagenous domain of the alpha3 chain of type IV collagen [alpha3(IV)NC1] in the alveolar and glomerular basement membrane. These antibodies are associated with the development of a rapidly progressive ...

journal_title：Kidney international

authors： Hellmark T,Segelmark M,Unger C,Burkhardt H,Saus J,Wieslander J

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Rho proteins are small guanine 5'-triphosphate (GTP)-binding proteins felt to be important regulators of several aspects of cell function, including the organization of the actin cytoskeleton. The effects of Rho proteins on the regulation of renal tubular epithelial cell function are not known. METHODS:Sele...

journal_title：Kidney international

authors： Anderson RJ,Ray CJ,Popoff MR

更新日期：2000-11-01 00:00:00

abstract：:Insulin resistance has been associated with kidney disease even in the absence of diabetes; however, pathways linking insulin resistance to kidney disease are unclear. The purpose of this study was to determine if transforming growth factor (TGF)-beta1, a key cytokine associated with kidney disease, responds to circul...

journal_title：Kidney international

authors： Huan Y,DeLoach S,Daskalakis C,Dunn SR,Sharma K,Falkner B

更新日期：2010-08-01 00:00:00

abstract：:Risk factors for disease states are rigorously defined. This analysis considers the definition of a risk factor as applied to the question of whether the serum phosphorus level is a risk factor for cardiovascular disease. Observational studies strongly suggest that phosphorus is associated with cardiovascular risk, an...

journal_title：Kidney international

authors： Hruska K,Mathew S,Lund R,Fang Y,Sugatani T

更新日期：2011-04-01 00:00:00

abstract：:Atypical hemolytic uremic syndrome (aHUS) is a form of thrombotic microangiopathy (TMA) caused by dysregulated complement activation. Clinically, aHUS is effectively treated by an anti-C5 monoclonal antibody (mAb) but whether the disease is mediated by the C5a receptor (C5aR) or C5b-9 pathway, or both, is unknown. Her...

journal_title：Kidney international

authors： Ueda Y,Miwa T,Ito D,Kim H,Sato S,Gullipalli D,Zhou L,Golla M,Song D,Dunaief JL,Palmer MB,Song WC

更新日期：2019-07-01 00:00:00

abstract：:Cells from RCCT-28A cell line, which exhibited the highest peanut-lectin binding capacity [RCCT-28A(P+)] were separated and cultured attempting to obtain a population of HCO3- secreting cells. The mechanisms of apical solution acid or base extrusion were studied in confluent monolayers. In RCCT-28A (P+) cells net H+ f...

journal_title：Kidney international

authors： Bello-Reuss E

更新日期：1993-01-01 00:00:00

abstract：:Cholesterol conversion to and biliary excretion of bile acids represents the principal pathway of cholesterol catabolism in mammals. Cholesterol 7 alpha-hydroxylase (Ch-7 alpha-H) is the first and the rate limiting step in bile acid production. Recently, Ch-7 alpha-H enzymatic activity has been shown to be normal in r...

journal_title：Kidney international

authors： Liang KH,Oveisi F,Vaziri ND

更新日期：1996-03-01 00:00:00

abstract：:Transgenic rats [TGR; strain name TGR(mRen2)27] harboring the mouse Ren-2 renin gene have been recently generated as a model for the study of primary hypertension that offers the advantage of a clearly-defined genetic alteration. Expression of the mouse Ren-2 gene causes severe hypertension (200 to 260 mm Hg) which is...

journal_title：Kidney international

authors： Bachmann S,Peters J,Engler E,Ganten D,Mullins J

更新日期：1992-01-01 00:00:00

abstract：:Hydrogen sulfide has recently been found decreased in chronic kidney disease. Here we determined the effect and underlying mechanisms of hydrogen sulfide on a rat model of unilateral ureteral obstruction. Compared with normal rats, obstructive injury decreased the plasma hydrogen sulfide level. Cystathionine-β-synthas...

journal_title：Kidney international

authors： Song K,Wang F,Li Q,Shi YB,Zheng HF,Peng H,Shen HY,Liu CF,Hu LF

更新日期：2014-06-01 00:00:00

abstract：:Circulating immune complexes (CIC), measured by the solid-phase Clq method, were found to be in abnormal concentration in about half of 39 patients with membranoproliferative glomerulonephritis (MPGN). In contrast, they were present, usually in higher concentration, in nearly all patients with active lupus nephritis. ...

journal_title：Kidney international

authors： Davis CA,Marder H,West CD

更新日期：1981-12-01 00:00:00

abstract：BACKGROUND:We have previously reported that the serum concentration of 2-(alpha-mannopyranosyl)-L-tryptophan (MPT), tryptophan glycoconjugate, is a more accurate measure of renal function than that of serum creatinine concentration. The aim of the present study was to compare the diagnostic value of serum concentration...

journal_title：Kidney international

authors： Yonemura K,Takahira R,Yonekawa O,Wada N,Hishida A

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Endothelium-derived nitric oxide and reactive oxygen species (ROS) have been proposed to regulate vascular tone by complex mechanisms, including the modulation of ion channel function. In endothelial function itself, activation of Ca2+-activated K+ channels (KCa) plays a crucial role by inducing hyperpolariz...

journal_title：Kidney international

authors： Brakemeier S,Eichler I,Knorr A,Fassheber T,Köhler R,Hoyer J

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate the renoprotective effect as reflected by short-term changes in albuminuria of ultrahigh doses of irbesartan in type 2 diabetic patients with microalbuminuria. METHODS:This double-masked randomized crossover trial included 52 (41 males) hypertensive type 2 diabetic ...

journal_title：Kidney international

authors： Rossing K,Schjoedt KJ,Jensen BR,Boomsma F,Parving HH

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:The plasma concentrations of total homocysteine (tHcy) and total cysteine (tCys) are determined by intracellular metabolism and by renal plasma clearance, and we hypothesized that glomerular filtration is a major determinant of plasma tHcy and tCys. We studied the relationships between the glomerular filtrat...

journal_title：Kidney international

authors： Wollesen F,Brattström L,Refsum H,Ueland PM,Berglund L,Berne C

更新日期：1999-03-01 00:00:00

abstract：:Podocyte injury and loss contribute to the progression of glomerular diseases, including diabetic kidney disease. We previously found that the glomerular expression of Sirtuin-1 (SIRT1) is reduced in human diabetic glomeruli and that the podocyte-specific loss of SIRT1 aggravated albuminuria and worsened kidney diseas...

journal_title：Kidney international

authors： Hong Q,Zhang L,Das B,Li Z,Liu B,Cai G,Chen X,Chuang PY,He JC,Lee K

更新日期：2018-06-01 00:00:00

abstract：:Osteonectin (SPARC, culture shock protein, BM-40) is a widely distributed glycoprotein which binds calcium and several extracellular matrix proteins, including interstitial collagens and thrombospondin, but whose physiologic role remains undefined. In the present studies, we have demonstrated that immunoreactive osteo...

journal_title：Kidney international

authors： Kopp JB,Bianco P,Young MF,Termine JD,Robey PG

更新日期：1992-01-01 00:00:00