Inhibition of platelet-derived growth factor receptor tyrosine kinase by atrial natriuretic peptide.

abstract：:Patients with chronic kidney disease have elevated circulating asymmetric dimethylarginine (ADMA). Recent studies have suggested that ADMA impairs endothelial nitric oxide synthase (eNOS) by effects other than competition with the substrate L-arginine. Here, we sought to identify the molecular mechanism by which incre...

journal_title：Kidney international

authors： Kajimoto H,Kai H,Aoki H,Yasuoka S,Anegawa T,Aoki Y,Ueda S,Okuda S,Imaizumi T

更新日期：2012-04-01 00:00:00

abstract：:We previously reported that oxidative stress and renal tubular damage occur in chronic hyperoxaluric rats. However, the in vivo responses of renal epithelial cells after vitamin E administration and their correlations with calcium oxalate (CaOx) crystal formation have not been evaluated. Male Wistar rats received 0.75...

journal_title：Kidney international

authors： Huang HS,Chen J,Chen CF,Ma MC

更新日期：2006-08-01 00:00:00

abstract：:Calcitonin secretion is stimulated by acute hypercalcemia. Furthermore, in the rat, the calcemic response to parathyroid hormone (PTH) is decreased by calcitonin stimulation. However, in renal failure, it is not known if an increase in the serum calcium concentration within the physiologic range of serum calcium stimu...

journal_title：Kidney international

authors： Torres A,Rodriguez M,Felsenfeld A,Martin-Malo A,Llach F

更新日期：1991-10-01 00:00:00

abstract：:Growth failure is a cardinal feature of chronic renal failure in children. Administration of recombinant human growth hormone (rhGH) ameliorates this problem but may adversely affect the kidney and hasten the progression to end-stage renal disease. We conducted experiments to examine the impact of rhGH on the severity...

journal_title：Kidney international

authors： Trachtman H,Futterweit S,Schwob N,Maesaka J,Valderrama E

更新日期：1993-12-01 00:00:00

abstract：:Major temporal changes in the case mix of patients accepted for renal replacement therapy impede analysis of long-term mortality trends in end-stage renal disease patients. A record linkage study of 2 large electronic hospital inpatient data sets with national mortality data used standardization by age, sex, and comor...

journal_title：Kidney international

authors： Stengel B

更新日期：2018-05-01 00:00:00

abstract：:Emerging evidence of crosstalk between glomerular cells in pathological settings provides opportunities for novel therapeutic discovery. Here we investigated underlying mechanisms of early events leading to filtration barrier defects of podocyte and glomerular endothelial cell crosstalk in the mouse models of primary ...

journal_title：Kidney international

authors： Ebefors K,Wiener RJ,Yu L,Azeloglu EU,Yi Z,Jia F,Zhang W,Baron MH,He JC,Haraldsson B,Daehn I

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:The objectives of this study were to compare the effects of the angiotensin II receptor blocker, losartan, to those of the angiotensin-converting enzyme inhibitor, enalapril, on albuminuria and renal function in relationship to clinic and ambulatory blood pressure (ABP) in hypertensive type 2 diabetic subjec...

journal_title：Kidney international

authors： Lacourcière Y,Bélanger A,Godin C,Hallé JP,Ross S,Wright N,Marion J

更新日期：2000-08-01 00:00:00

abstract：:Atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura have traditionally been considered separate entities. Defects in the regulation of the complement alternative pathway occur in atypical hemolytic uremic syndrome, and defects in the cleavage of von Willebrand factor (VWF)-multimers arise in thr...

journal_title：Kidney international

authors： Noone DG,Riedl M,Pluthero FG,Bowman ML,Liszewski MK,Lu L,Quan Y,Balgobin S,Schneppenheim R,Schneppenheim S,Budde U,James P,Atkinson JP,Palaniyar N,Kahr WH,Licht C

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Nephrotic syndrome is associated with abnormal lipoprotein metabolism and increased risk of coronary heart disease. Endothelial dysfunction, an early phase of atherogenesis that manifests as impaired flow-mediated dilation (FMD) of the peripheral circulation, may link these associations. METHODS:We examined...

journal_title：Kidney international

authors： Watts GF,Herrmann S,Dogra GK,Playford DA,Best JD,Thomas MA,Irish A

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Random, nontimed blood pressure (BP) measurements in the outpatient clinic may fail to provide reliable information on actual daily BP control in renal patients on chronic antihypertensive therapy. METHODS:In a cohort of 163 patients with proteinuric chronic nephropathies followed prospectively with repeate...

journal_title：Kidney international

authors： Ruggenenti P,Perna A,Lesti M,Pisoni R,Mosconi L,Arnoldi F,Ciocca I,Gaspari F,Remuzzi G

更新日期：2000-11-01 00:00:00

abstract：:Nephrin is a slit diaphragm protein critical for structural and functional integrity of visceral glomerular epithelial cells (podocytes) and is known to be tyrosine phosphorylated by Src family kinases. We studied the role of phosphoinositide 3-kinase (PI3K), activated via the phosphorylation of nephrin, in actin cyto...

journal_title：Kidney international

authors： Zhu J,Sun N,Aoudjit L,Li H,Kawachi H,Lemay S,Takano T

更新日期：2008-03-01 00:00:00

abstract：:Chronic inflammation contributes to increased mortality in hemodialysis (HD) patients. YKL-40 is a novel marker of inflammation, tissue remodeling, and highly expressed in macrophages inside vascular lesions. Elevated levels of YKL-40 have been reported for HD patients but how it integrates into the proinflammatory me...

journal_title：Kidney international

authors： Lorenz G,Schmalenberg M,Kemmner S,Haller B,Steubl D,Pham D,Schreiegg A,Bachmann Q,Schmidt A,Haderer S,Huber M,Angermann S,Günthner R,Braunisch M,Hauser C,Reichelt AL,Matschkal J,Suttmann Y,Moog P,Stock K,Küchle C

更新日期：2018-01-01 00:00:00

abstract：:Despite the high costs of treatment of people with kidney disease and associated comorbid conditions, the amount of reliable information available to guide the care of such patients is very limited. Some treatments have been assessed in randomized trials, but most such trials have been too small to detect treatment ef...

journal_title：Kidney international

authors： Baigent C,Herrington WG,Coresh J,Landray MJ,Levin A,Perkovic V,Pfeffer MA,Rossing P,Walsh M,Wanner C,Wheeler DC,Winkelmayer WC,McMurray JJV,KDIGO Controversies Conference on Challenges in the Conduct of Clinical Trials in Nephr

更新日期：2017-08-01 00:00:00

abstract：:The impact of dialysis on cognitive trends is uncertain. Kurella Tamura et al. evaluated cognitive trajectories in 212 participants from the Chronic Renal Insufficiency Cohort study and found that dialysis initiation was associated with a decline in executive function. This is consistent with a cerebrovascular basis f...

journal_title：Kidney international

authors： Iyasere O,Brown EA

更新日期：2017-04-01 00:00:00

abstract：:Apoptosis mediated by verotoxins (VTs) has been identified in a renal carcinoma cell line, ACHN cells, which are an in vitro model of renal tubular epithelial cells. ACHN cells express the renal tubular marker CD24 as well as globotriaosyl ceramide/CD77, the receptor for VTs. VT binding to the ACHN cell surface was co...

journal_title：Kidney international

authors： Taguchi T,Uchida H,Kiyokawa N,Mori T,Sato N,Horie H,Takeda T,Fujimoto J

更新日期：1998-06-01 00:00:00

abstract：:Defective cholesterol metabolism primarily linked to reduced ATP-binding cassette transporter A1 (ABCA1) expression is closely associated with the pathogenesis and progression of kidney diseases, including diabetic kidney disease and Alport Syndrome. However, whether the accumulation of free or esterified cholesterol ...

journal_title：Kidney international

authors： Liu X,Ducasa GM,Mallela SK,Kim JJ,Molina J,Mitrofanova A,Wilbon SS,Ge M,Fontanella A,Pedigo C,Santos JV,Nelson RG,Drexler Y,Contreras G,Al-Ali H,Merscher S,Fornoni A

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Hyperphagic obese Zucker rats develop glomerular injury and die of renal disease, an outcome prevented by food restriction at an early age. We examined the effects of food restriction imposed at different ages on systemic, renal hemodynamic, and hormonal changes to gain insight into the mechanisms of obesity...

journal_title：Kidney international

authors： Maddox DA,Alavi FK,Santella RN,Zawada ET Jr

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:IgA nephropathy is the most common glomerular disease. Mechanisms leading to its occurrence and controlling the evolution of the disease remain largely unknown. Various genetic factors have been found, mostly implicating immunologically relevant genes (IgH, TCR, human lymphocyte antigen, and complement loci)...

journal_title：Kidney international

authors： Aupetit C,Drouet M,Pinaud E,Denizot Y,Aldigier JC,Bridoux F,Cogné M

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Low dialysate calcium (LdCa) concentration is used to prevent or treat hemodialysis (HD)-induced hypercalcemia, but its use has been complicated by intradialytic hypotension in some patients. Our goal was to explore the possibility that dialysis calcium profiling (dCaP) can ameliorate intradialytic hypotensi...

journal_title：Kidney international

authors： Kyriazis J,Glotsos J,Bilirakis L,Smirnioudis N,Tripolitou M,Georgiakodis F,Grimani I

更新日期：2002-01-01 00:00:00

abstract：:The normal pattern of mRNA metabolism almost certainly becomes altered after uninephrectomy, especially during the first day when ribosomes accumulate in the proximal tubular cells of the remaining kidney. For example, within the first hour after nephrectomy, the fraction of newly synthesized poly(A)-deficient mRNA in...

journal_title：Kidney international

authors： Ouellette AJ

更新日期：1983-04-01 00:00:00

abstract：:Low density lipoprotein (LDL) deposition and local oxidation play a key role in the pathogenesis of atherosclerosis and may likewise contribute to glomerular injury. These studies were designed to determine whether cultured human mesangial cells oxidize homologous LDL and to compare the effects of unmodified and oxidi...

journal_title：Kidney international

authors： Wheeler DC,Chana RS,Topley N,Petersen MM,Davies M,Williams JD

更新日期：1994-06-01 00:00:00

abstract：:Risk factors for disease states are rigorously defined. This analysis considers the definition of a risk factor as applied to the question of whether the serum phosphorus level is a risk factor for cardiovascular disease. Observational studies strongly suggest that phosphorus is associated with cardiovascular risk, an...

journal_title：Kidney international

authors： Hruska K,Mathew S,Lund R,Fang Y,Sugatani T

更新日期：2011-04-01 00:00:00

abstract：:Vascular calcification is prevalent in dialysis patients and is associated with a high burden of cardiovascular disease. Fetuin-A is a potent inhibitor of vascular calcification, but the precise mechanism by which it mediates vascular calcification in uremia is unclear. Matsui and colleagues demonstrate that circulati...

journal_title：Kidney international

authors： Komaba H,Fukagawa M

更新日期：2009-05-01 00:00:00

abstract：:Unilateral progressive Masugi nephritis was produced in rabbits and studied by microangiography as well as light and immunofluorescence microscopy. The following five groups were studied: Group 1. Heparin was started simultaneously with nephrotoxic serum (NTS) and was given for one week. The animals were then sacrific...

journal_title：Kidney international

authors： Nakamoto Y,Dohi K,Fujike H,Yuri T,Shinoda A,Takeuchi J

更新日期：1978-04-01 00:00:00

abstract：:The effects of acidosis on renal function and morphology were examined in the isolated perfused rat kidney (IPK). Kidneys were perfused with oxygenated Krebs-Henseleit-albumin medium for 60 minutes at pH 7.4 or pH 7.0. At the lower pH, GFR was reduced by 25%, TRNa by 32% and oxygen consumption by 41% as compared to pe...

journal_title：Kidney international

authors： Shanley PF,Shapiro JI,Chan L,Burke TJ,Johnson GC

更新日期：1988-12-01 00:00:00

abstract：:The effects of two models of chronic hypercalcemia on renal acid-base metabolism were studied in rats. In the first series of experiments, rats were rendered hyperparathyroid by the autologous grafting of 20 to 24 parathyroid glands into a single recipient. Hypercalcemia (5.48 +/- 0.03 mEq/liter in high PTH animals, 4...

journal_title：Kidney international

authors： Mitnick P,Greenberg A,Coffman T,Kelepouris E,Wolf CJ,Goldfarb S

更新日期：1982-04-01 00:00:00

abstract：:Hypocalcemia, hyperphosphatemia, and resistance to the action of PTH are well characterized features in the setting of advanced chronic renal failure (CRF). Although the underlying mechanisms are ill-understood, clinical and experimental evidence points to both PTH receptor down-regulation and post-receptor abnormalit...

journal_title：Kidney international

authors： Ureña P,Kubrusly M,Mannstadt M,Hruby M,Trinh MM,Silve C,Lacour B,Abou-Samra AB,Segre GV,Drüeke T

更新日期：1994-02-01 00:00:00

abstract：:Nephronophthisis is an autosomal recessive chronic tubulointerstitial disease that progresses to end-stage renal disease (ESRD) in about 10% of cases during infancy. Mutations in the INVS (NPHP2) gene were found in a few patients with infantile nephronophthisis. Mutations of NPHP3, known to be associated with adolesce...

journal_title：Kidney international

authors： Tory K,Rousset-Rouvière C,Gubler MC,Morinière V,Pawtowski A,Becker C,Guyot C,Gié S,Frishberg Y,Nivet H,Deschênes G,Cochat P,Gagnadoux MF,Saunier S,Antignac C,Salomon R

更新日期：2009-04-01 00:00:00

abstract：:Hypercalciuria is one of the early manifestations of diabetic nephropathy. We explored here the role of α-Klotho, a protein expressed predominantly in distal convoluted tubules that has a role in calcium reabsorption. We studied 31 patients with early diabetic nephropathy and compared them with 31 patients with IgA ne...

journal_title：Kidney international

authors： Asai O,Nakatani K,Tanaka T,Sakan H,Imura A,Yoshimoto S,Samejima K,Yamaguchi Y,Matsui M,Akai Y,Konishi N,Iwano M,Nabeshima Y,Saito Y

更新日期：2012-03-01 00:00:00

abstract：:Since the kidney medulla was reported to generate platelet activating factor (PAF), we investigated a possible effect of this agent on the reabsorptive function of in vitro microperfused medullary thick ascending limbs from mouse kidney (mTAL). PAF, 10(-7) M in the bath, significantly decreased the net chloride flux (...

journal_title：Kidney international

authors： Bailly C,Barlet-Bas C,Amiel C

更新日期：1992-02-01 00:00:00