Soluble fibronectin induces chemokine gene expression in renal tubular epithelial cells.

abstract：:X-ray crystal interferometer-based X-ray phase-contrast microtomography (phase-contrast microtomography) is able to image microstructures within soft tissue without the use of a contrast agent. Here we determined the feasibility of using this technique in the non-destructive inspection of formalin-fixed kidney tissue ...

journal_title：Kidney international

authors： Wu J,Takeda T,Lwin TT,Momose A,Sunaguchi N,Fukami T,Yuasa T,Akatsuka T

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Fabry disease is an X-linked generalized progressive debilitating lysosomal storage disorder. The disease usually manifests in childhood, but the diagnosis is often made following the occurrence of late-stage complications such as progressive kidney failure. In order to identify key novel renal diagnostic im...

journal_title：Kidney international

authors： Ries M,Bettis KE,Choyke P,Kopp JB,Austin HA 3rd,Brady RO,Schiffmann R

更新日期：2004-09-01 00:00:00

abstract：:Although case reports link proton-pump inhibitor (PPI) use and hypomagnesemia, no large-scale studies have been conducted. Here we examined the serum magnesium concentration and the likelihood of hypomagnesemia (<1.6 mg/dl) with a history of PPI or histamine-2 receptor antagonist used to reduce gastric acid, or use of...

journal_title：Kidney international

authors： Danziger J,William JH,Scott DJ,Lee J,Lehman LW,Mark RG,Howell MD,Celi LA,Mukamal KJ

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Although several kinds of evidence suggest that glycosaminoglycans (GAGs) and proteoglycans (PGs) may contribute to the development of beta2-microglobulin-related (Abeta2m) amyloidosis, the precise roles of these molecules for the development of Abeta2m amyloidosis are poorly understood. METHODS:We investig...

journal_title：Kidney international

authors： Yamaguchi I,Suda H,Tsuzuike N,Seto K,Seki M,Yamaguchi Y,Hasegawa K,Takahashi N,Yamamoto S,Gejyo F,Naiki H

更新日期：2003-09-01 00:00:00

abstract：:The monitoring of the levels of alloantibodies following transplantation might facilitate early diagnosis of chronic rejection (CR), the leading cause of renal allograft failure. Here, we used serial alloantibody surveillance to monitor patients with preoperative positive flow cytometric crossmatch (FCXM). Sixty-nine ...

journal_title：Kidney international

authors： Kimball PM,Baker MA,Wagner MB,King A

更新日期：2011-05-01 00:00:00

abstract：:Pathological classifications in current use for the assessment of glomerular disease have been typically opinion-based and built on the expert assumptions of renal pathologists about lesions historically thought to be relevant to prognosis. Here we develop a unique approach for the pathological classification of a glo...

journal_title：Kidney international

authors： Working Group of the International IgA Nephropathy Network and the Renal Pathology Society.,Roberts IS,Cook HT,Troyanov S,Alpers CE,Amore A,Barratt J,Berthoux F,Bonsib S,Bruijn JA,Cattran DC,Coppo R,D'Agati V,D'Amico G,Emanci

更新日期：2009-09-01 00:00:00

abstract：:Fibrillary glomerulonephritis (FGN) is a rare glomerular disease. Kidney biopsy is required to establish the diagnosis. Recent studies have identified abundant glomerular deposition of DNAJB9 as a unique histological marker of FGN. We developed an immunoprecipitation-based multiple reaction monitoring method to measur...

journal_title：Kidney international

authors： Nasr SH,Dasari S,Lieske JC,Benson LM,Vanderboom PM,Holtz-Heppelmann CJ,Giesen CD,Snyder MR,Erickson SB,Fervenza FC,Leung N,Kurtin PJ,Alexander MP

更新日期：2019-05-01 00:00:00

abstract：:In this issue, McMahon et al. report that, by combining phenotypic, metabolomic, and genetic data, they could better detect chronic kidney disease at the early stages and provide insight into its pathobiology. The most significant findings of the study are that several urinary metabolites (e.g., glycine and histidine)...

journal_title：Kidney international

authors： Zhang G,Saito R,Sharma K

更新日期：2017-06-01 00:00:00

abstract：:Long-term (5 years) treatment of 20 growth-retarded pre-pubertal children with chronic renal insufficiency (CRI) led to a significant (P < 0.00005) improvement in standardized height from -2.6 at baseline to -0.7 at five years. Eight patients were paused after reaching target height (50th centile midparental height) a...

journal_title：Kidney international

authors： Fine RN,Kohaut E,Brown D,Kuntze J,Attie KM

更新日期：1996-03-01 00:00:00

abstract：:Intravital multiphoton microscopy is a powerful tool to study kidney physiology in living animals. However, certain technical issues have curbed its usage to date, including limited depth of tissue penetration and high background emission of endogenous signals. Most previous studies have used the excitation range 700–...

journal_title：Kidney international

authors： Schuh CD,Haenni D,Craigie E,Ziegler U,Weber B,Devuyst O,Hall AM

更新日期：2016-03-01 00:00:00

abstract：:Long-term complications of continuous immunosuppression still remain a serious threat and are currently drawing the attention of transplant physicians. Wimmer et al. show that malignancy occurs approximately fourfold more frequently in renal-transplant recipients than in a normal control population. Besides immunosupp...

journal_title：Kidney international

authors： Bosmans JL,Verpooten GA

更新日期：2007-06-01 00:00:00

abstract：:Mutations in the NPHS2 gene, encoding podocin, are responsible for familial autosomal recessive and sporadic cases of steroid-resistant nephrotic syndrome. We have successfully generated a mouse model in which the common p.R138Q mutation found in nephrotic patients is expressed in the kidney. Homozygous mice express t...

journal_title：Kidney international

authors： Philippe A,Weber S,Esquivel EL,Houbron C,Hamard G,Ratelade J,Kriz W,Schaefer F,Gubler MC,Antignac C

更新日期：2008-05-01 00:00:00

abstract：:Unilateral ureteral obstruction results in marked changes in renal function throughout the nephron, including impaired acid and potassium secretion and salt wastage. The nephron site believed responsible for the acidification defect is the collecting duct. It has been presumed, although not demonstrated, that the cell...

journal_title：Kidney international

authors： Sabatini S,Kurtzman NA

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Although renal protective effect of interrupting the inflammatory process is well established, it is still controversial if it also prevents the glomerular hemodynamic disturbances that initiate renal injury. We investigated the effects of suppressing inflammation with mycophenolate mofetil (MMF) on glomerul...

journal_title：Kidney international

authors： Tapia E,Franco M,Sánchez-Lozada LG,Soto V,Avila-Casado C,Santamaría J,Quiroz Y,Rodríguez-Iturbe B,Herrera-Acosta J

更新日期：2003-03-01 00:00:00

abstract：:The formation of the non-sulphated glycosaminoglycan hyaluronan by cells of the renal glomerulus in diabetes may contribute to altered matrix composition. We describe an increased production of hyaluronan from mesangial cell-enriched glomerular cores from diabetic animals, and further show that increased hyaluronan pr...

journal_title：Kidney international

authors： Dunlop ME,Clark S,Mahadevan P,Muggli E,Larkins RG

更新日期：1996-07-01 00:00:00

abstract：:The erythropoietin analogs have been an important advance for the treatment of the anemia of kidney disease, resulting in reduced need for blood transfusion and improved quality of life. Recent studies, however, have indicated risks associated with targeting higher levels of hemoglobin (Hb). As a result, in March 2007...

journal_title：Kidney international

authors： Fishbane S,Nissenson AR

更新日期：2007-10-01 00:00:00

abstract：:Many subjects nowadays present with end-stage renal failure and its attendant cardiovascular complications without known prior renal damage. In this report we review the evidence available to strongly suggest that the present practice of secondary prevention in those with known prior renal disease should be extended t...

journal_title：Kidney international

authors： de Jong PE,Brenner BM

更新日期：2004-12-01 00:00:00

abstract：:In six healthy males on a fixed sodium/potassium (Na/K) intake, we studied the relation between plasma K and urine K and Na excretion after an oral K load. Studies were repeated during fludrocortisone (0.5 mg bid) or spironolactone (50 mg qid), that is, after escape from the Na-retaining and Na-excreting effects of th...

journal_title：Kidney international

authors： Hené RJ,Koomans HA,Rabelink AJ,Boer P,Dorhout Mees EJ

更新日期：1988-11-01 00:00:00

abstract：:Here we studied a possible association between low parathyroid hormone (PTH) status and mortality in incident patients undergoing hemodialysis . A total of 1983 patients were included at baseline and prospectively followed for 24 months. Patients were classified according to their Kidney Disease: Improving Global Outc...

journal_title：Kidney international

authors： Merle E,Roth H,London GM,Jean G,Hannedouche T,Bouchet JL,Drüeke T,Fouque D,Daugas E,French Calcium and Phosphate Observatory.

更新日期：2016-03-01 00:00:00

abstract：:We have described a simple technique for the measurement of picomoles or nanomoles of ammonium. Samples can be easily processed on the day of an experiment. analysis of 14C-glutamate can be done at a later date by an accurate sensitive and reliable method. We can readily process 50 samples per day. The sensitivity can...

journal_title：Kidney international

authors： Cheema-Dhadli S,Hamat R,Sonnenberg H,Halperin M

更新日期：1981-01-01 00:00:00

abstract：:Cultures of human proximal tubule cells were exposed to elevated concentrations of glucose and dome formation was assessed over a 22 day period of growth. Cultures grown on 5.5 mM glucose formed five domes per microscopic field while those exposed to elevated glucose concentrations (11.0 mM to 27.5 mM) formed only two...

journal_title：Kidney international

authors： Hazen-Martin DJ,Sens MA,Detrisac CJ,Blackburn JG,Sens DA

更新日期：1989-01-01 00:00:00

abstract：:Acute kidney injury (AKI) activates pathways of cell death and cell proliferation. Although seemingly discrete and unrelated mechanisms, these pathways can now be shown to be connected and even to be controlled by similar pathways. The dependence of the severity of renal-cell injury on cell cycle pathways can be used ...

journal_title：Kidney international

authors： Price PM,Safirstein RL,Megyesi J

更新日期：2009-09-01 00:00:00

abstract：:The Institute of Medicine's recent report, Organ Donation: Opportunities for Action, studies the current problems facing organ donation in the USA, making suggestions for quality improvement and analyzing various proposals of incentivized donation and presumed consent (PC). Although the report deals with the donation ...

journal_title：Kidney international

authors： Das KK,Lerner BH

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:There is accumulating evidence that adult bone marrow (BM) cells show unexpected plasticity, and can differentiate into a wide range of specialized cells. In the case of intrinsic renal glomerular cells, BM-derived cells have been reported to differentiate into both mesangial cells and podocytes. However, th...

journal_title：Kidney international

authors： Ikarashi K,Li B,Suwa M,Kawamura K,Morioka T,Yao J,Khan F,Uchiyama M,Oite T

更新日期：2005-05-01 00:00:00

abstract：:Initiation of dialysis is associated with increased morbidity and mortality. However, a question could be asked whether these events are caused by initiation of dialysis or whether dialysis serves as a trigger unveiling or worsening underlying preexisting cardiovascular comorbidities that could be pre-treated. ...

journal_title：Kidney international

authors： Zareba W

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:We have previously reported that the serum concentration of 2-(alpha-mannopyranosyl)-L-tryptophan (MPT), tryptophan glycoconjugate, is a more accurate measure of renal function than that of serum creatinine concentration. The aim of the present study was to compare the diagnostic value of serum concentration...

journal_title：Kidney international

authors： Yonemura K,Takahira R,Yonekawa O,Wada N,Hishida A

更新日期：2004-04-01 00:00:00

abstract：:Alterations in red blood cell sodium (Na) transport have been described in chronic renal failure. This study examines the possible impact of uremia on two ouabain-insensitive pathways, the Na/H antiporter and the Cl-/NaCO3- anion exchanger. The Vmax of Na/H antiporter measured as Na influx driven by outward H gradient...

journal_title：Kidney international

authors： Corry DB,Tuck ML,Nicholas S,Weinman EJ

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:While the association of complement activation and glomerulonephritis has been recognized for decades, the pathogenic mechanisms of complement-mediated glomerular damage are incompletely understood. Expression of the C5a receptor in the kidney suggests that C5a could play a direct role in initiating or promo...

journal_title：Kidney international

authors： Braun M,Davis AE 3rd

更新日期：1998-11-01 00:00:00

abstract：:The kidneys excrete the daily acid load mainly by generating and excreting ammonia but the underlying molecular mechanisms are not fully understood. Here we evaluated the role of the inwardly rectifying potassium channel subunit Kir4.2 (Kcnj15 gene product) in this process. In mice, Kir4.2 was present exclusively at t...

journal_title：Kidney international

authors： Bignon Y,Pinelli L,Frachon N,Lahuna O,Figueres L,Houillier P,Lourdel S,Teulon J,Paulais M

更新日期：2020-02-01 00:00:00

abstract：:We evaluated the contribution of intrarenal factors in the increased renal accumulation of bovine serum albumin (BSA) in chronic serum sickness (CSS). Renal transplantation was used to study 125I BSA uptake (single and paired label techniques) in normal and CSS kidneys exposed to the same immunologic milieu. In CSS, t...

journal_title：Kidney international

authors： Ward DM,Lee S,Wilson CB

更新日期：1986-11-01 00:00:00