Abstract：
:Acute kidney injury (AKI) activates pathways of cell death and cell proliferation. Although seemingly discrete and unrelated mechanisms, these pathways can now be shown to be connected and even to be controlled by similar pathways. The dependence of the severity of renal-cell injury on cell cycle pathways can be used to control and perhaps to prevent acute kidney injury. This review is written to address the correlation between cellular life and death in kidney tubules, especially in acute kidney injury.
journal_name
Kidney Intjournal_title
Kidney internationalauthors
Price PM,Safirstein RL,Megyesi Jdoi
10.1038/ki.2009.224subject
Has Abstractpub_date
2009-09-01 00:00:00pages
604-13issue
6eissn
0085-2538issn
1523-1755pii
S0085-2538(15)54026-Xjournal_volume
76pub_type
杂志文章,评审abstract：BACKGROUND:While metabolically generated oxidants are produced locally in experimental glomerular diseases, little is still known of their significance and the respective scavenger systems in human glomerular diseases. METHODS:Here we studied kidneys from patients with congenital nephrotic syndrome of the Finnish type...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2001.059002481.x
更新日期：2001-02-01 00:00:00
abstract：:Protein misfolding in the endoplasmic reticulum (ER) leads to ER stress. The unfolded protein response and ER-associated degradation (ERAD) interact in a coordinated manner with the ubiquitin-proteasome system and autophagy to alleviate protein misfolding or its consequences. The intersecting actions of these processe...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/ki.2012.390
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:Little information is available regarding cardiac morbidity and mortality in children with end-stage renal disease. We sought to determine the incidence of cardiac morbidity and mortality in pediatric chronic dialysis patients. METHODS:Medicare incident pediatric (0 to 19 years) dialysis patients from 1991 ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2002.00472.x
更新日期：2002-08-01 00:00:00
abstract：BACKGROUND:Wegener's granulomatosis (WG) is a rare systemic autoimmune disease characterized by small-vessel vasculitis leading to organ damage and the presence of antineutrophil cytoplasmic autoantibodies (ANCAs). ANCAs were shown to be involved in the pathogenesis of the disease by increasing adhesion of polymorphonu...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2000.00430.x
更新日期：2000-12-01 00:00:00
abstract：:The International Pediatric Peritonitis Registry (IPPR) was created to assess and evaluate the validity of the pediatric peritonitis treatment guidelines issued by the International Society for Peritoneal Dialysis. The study by Schaefer et al., one of the first to emerge from the IPPR, describes regional variability i...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/sj.ki.5002529
更新日期：2007-12-01 00:00:00
abstract：:The effect of intravenous infusion of angiotensin II on microvascular parameters of the renal microcirculation of rats was studied. With the aid of fluorescence microscopy and a high sensitivity video system we observed the passage of fluorescence-labeled erythrocytes through single glomerular capillaries on the surfa...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1985.4
更新日期：1985-01-01 00:00:00
abstract：:Prior studies reported associations of APOL1 nephropathy risk variants with subclinical atherosclerosis. However, these findings were limited to older individuals with high comorbidities. To evaluate this in younger individuals, we calculated associations of APOL1 risk variants (high risk [2 risk variants] vs. low ris...
journal_title：Kidney international
pub_type： 杂志文章,多中心研究
doi：10.1016/j.kint.2017.08.019
更新日期：2018-03-01 00:00:00
abstract：BACKGROUND:The podocyte is the focus of much research into the mechanisms of renal disease progression, and the number of podocytes per glomerulus has thus become a parameter of much interest. When counting podocytes, the actual particle counted is the cell nucleus. The majority of published studies estimating podocyte...
journal_title：Kidney international
pub_type： 临床试验,杂志文章
doi：10.1111/j.1523-1755.2004.00787.x
更新日期：2004-08-01 00:00:00
abstract：:It has been shown that somatostatin inhibits the antidiuretic action of vasopressin in toad urinary bladder in vitro and in dogs and rats in vivo. The presence of somatostatin-like immunoreactivity (SLI) in the urinary bladder and kidney of the toad has suggested the possibility that somatostatin may act as a local pa...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1983.223
更新日期：1983-12-01 00:00:00
abstract：BACKGROUND:The feasibility of simultaneously infusing glucose and amino acid (AA)-based peritoneal dialysis solutions was tested to determine whether peritoneal dialysis patients could achieve an adequate nonprotein calorie/nitrogen ratio while preventing a marked increase in blood urea nitrogen (BUN), which is usually...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2001.0590051967.x
更新日期：2001-05-01 00:00:00
abstract：:The homocysteine hypothesis states that circulating homocysteine is a vascular toxin in concentrations that occur in the general population and in renal failure. This hypothesis is currently being tested in the Kidney and End State Renal Disease Study (HOST), but data have emerged since the HOST began that suggest its...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5000279
更新日期：2006-05-01 00:00:00
abstract：:Although it has been recognized for more than 140 years that the pacemaker driving pyeloureteric peristalsis resides within the kidney, the cellular mechanisms underlying this autorhythmicity have been little investigated. The demonstration by Hurtado et al. of a role of hyperpolarization-activated cation channels in ...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1038/ki.2009.485
更新日期：2010-03-01 00:00:00
abstract：:The plasmin protease system may have a role in maintaining the patency of renal tubules and in regulating matrix degradation within the glomerulus. Urokinase-plasminogen activator (u-PA) is a serine protease which plays an important part in the regulation of plasmin production from plasminogen. The synthesis of u-PA b...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1994.5
更新日期：1994-01-01 00:00:00
abstract：:Experimental studies have demonstrated the cardinal role played by the mononuclear phagocyte system in the removal of antigen-antibody complexes. To assess the functional capacity of phagocytes in patients with renal disease, 33 normal subjects, 10 patients with mesangial proliferative glomerulonephritis, 8 patients w...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1983.105
更新日期：1983-06-01 00:00:00
abstract：:Fibroblast growth factor 23 (FGF23) is a phosphate-regulating hormone that acts primarily on the kidney and parathyroid. With declining kidney function there is an increase in circulating FGF23 levels, which is associated with vascular calcification and mortality in chronic kidney disease. Whether FGF23 exerts direct ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2013.332
更新日期：2014-05-01 00:00:00
abstract：:Transcriptome analysis of a rat polycystic kidney disease (PKD) model: importance of genes involved in extracellular matrix metabolism. PKD is a common genetic cause of chronic renal failure, and is characterized by the accumulation of fluid-filled cysts in the kidneys and other organs. Abnormalities in the expression...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5000309
更新日期：2006-05-01 00:00:00
abstract：:The autoregulatory ability of the renal vascular system in the split hydronephrotic kidney was quantitated with intravital microscopy. The luminal diameters of the arcuate and interlobular arteries as well as the afferent and efferent arterioles were measured. Glomerular blood flow was determined by the dual slit tech...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1989.104
更新日期：1989-05-01 00:00:00
abstract：:Effect of varying concentrations (0 to 800 microM) of three different light chains on sodium-dependent L-(14C)alanine and D-(14C)glucose uptake by rat renal brush border membrane vesicles were studied. One kappa and two lambda type light chains (lambda-1 and lambda-2) were isolated from urines of patients with multipl...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1986.237
更新日期：1986-11-01 00:00:00
abstract：:Dialysis patients have a high risk of cardiovascular disease. Cardiac rehabilitation is recommended in the general population as a standard component of care and covered by Medicare for those who have undergone coronary artery bypass grafting (CABG). Here we determined the impact of cardiac rehabilitation on Medicare ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2008.381
更新日期：2008-10-01 00:00:00
abstract：:Isotomic fluid reabsorption (JV) of rat renal proximal tubules was examined by the shrinking droplet method in combination with simulatneous perfusion of blood capillaries. Sensitivity of JV measurement was improved by using each punctured tubule for control measurements: 1) Parathyroid hormoen (PTH) on the contralumi...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1977.12
更新日期：1977-02-01 00:00:00
abstract：:Mitochondrial diseases represent a significant clinical challenge. Substantial efforts have been devoted to identifying therapeutic strategies for mitochondrial disorders, but effective interventions have remained elusive. Recently, we reported attenuation of disease in a mouse model of the human mitochondrial disease...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2018.08.038
更新日期：2019-02-01 00:00:00
abstract：:The kidneys excrete the daily acid load mainly by generating and excreting ammonia but the underlying molecular mechanisms are not fully understood. Here we evaluated the role of the inwardly rectifying potassium channel subunit Kir4.2 (Kcnj15 gene product) in this process. In mice, Kir4.2 was present exclusively at t...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2019.09.028
更新日期：2020-02-01 00:00:00
abstract：:Studies were undertaken to examine the mechanism whereby changes in intraluminal flow rates after reabsorption in the isolated perfused proximal tubule of the rabbit. All protocols employed the technique of in vitro perfusion of isolated segments of the proximal convoluted tubule. Stepwise elimination of d-glucose and...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1977.3
更新日期：1977-01-01 00:00:00
abstract：:Space medicine and new technology such as magnetic resonance imaging of tissue sodium stores (23NaMRI) have changed our understanding of human sodium homeostasis and pathophysiology. It has become evident that body sodium comprises 3 main components. Two compartments have been traditionally recognized, namely one that...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1016/j.kint.2018.09.024
更新日期：2019-02-01 00:00:00
abstract：:The proportion of deceased donor kidneys procured for transplant but subsequently discarded has been growing steadily in the United States, but factors contributing to the rising discard rate remain unclear. To assess the reasons for and probability of organ discard we assembled a cohort of 212,305 deceased donor kidn...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2018.02.016
更新日期：2018-07-01 00:00:00
abstract：:The enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) is thought to be a protective enzyme of the mineralocorticoid receptor (MR). We have previously demonstrated (Bonvalet et al, J Clin Invest 86:832-837, 1990) that 11 beta-OHSD is colocalized with MR along the rabbit nephron. In the present study, we examin...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1992.260
更新日期：1992-07-01 00:00:00
abstract：:The kinetics of formaldehyde washout in new and reused dialyzers with 2% (w/v) and 4% formaldehyde solution was studied. Using a standard method of rinsing, the concentration of formaldehyde decreases exponentially, but the rate of decrease and the steady-state level depends on the type of dialyzer. The residual quant...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1985.221
更新日期：1985-12-01 00:00:00
abstract：:Protein energy wasting is a common feature of patients with chronic kidney disease (CKD) and is associated with poor outcomes. Protein energy wasting and cachexia, a severe form of protein energy wasting, are characterized by increased resting energy expenditure but the underlying mechanisms are unclear. Browning corr...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2020.03.027
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:The alteration of renal cell growth is one of the early abnormalities in the diabetic nephropathy. However, the effects of high glucose and its action mechanism in renal proximal tubule cell (PTC) proliferation have not been elucidated. METHODS:The effects of 25 mmol/L glucose on cell proliferation, thymidi...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2001.0590051695.x
更新日期：2001-05-01 00:00:00
abstract：:Mice chronically infected with the virus of lymphocytic choriomeningitis (LCM) develop immune complex glomerulonephritis. Others have shown that adoptive immunization of these mice by the i.p. injection of syngeneic immune spleen cells terminates the chronic viral carrier state. The present studies were designed to de...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1977.49
更新日期：1977-05-01 00:00:00
