Sodium and water handling during hemodialysis: new pathophysiologic insights and management approaches for improving outcomes in end-stage kidney disease.

abstract：BACKGROUND:Non-(1-84) parathyroid hormone (PTH) fragments are large circulating carboxyl-terminal (C) fragments with a partially preserved amino-terminal (N) structure. hPTH (7-84), a synthetic surrogate, has been demonstrated to exert biologic effects in vivo and in vitro which are opposite to those of hPTH (1-34) on ...

journal_title：Kidney international

authors： D'Amour P,Brossard JH,Rousseau L,Nguyen-Yamamoto L,Nassif E,Lazure C,Gauthier D,Lavigne JR,Zahradnik RJ

更新日期：2005-09-01 00:00:00

abstract：:Extracellular fluid volume expansion is known to produce exaggerated natriuresis in essential hypertension. In order to assess the role of hemodynamic and intrarenal physical factors upon natriuretic response to central volume expansion, two hour water immersion (WI) experiments were made in six uncomplicated essentia...

journal_title：Kidney international

authors： Coruzzi P,Musiari L,Biggi A,Ravanetti C,Vallisa D,Montanari A,Novarini A

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:Elevated glucose levels and glomerular hypertension (Pgc) are considered to contribute to the elaboration of matrix protein by mesangial cells (MCs) in diabetic glomeruli. MCs grown in 30 mM of glucose produce excessive matrix protein, as do MCs exposed to cyclic strain, and the combination of the two exacer...

journal_title：Kidney international

authors： Ingram AJ,Ly H,Thai K,Kang MJ,Scholey JW

更新日期：1999-11-01 00:00:00

abstract：:We have recently presented evidence that endogenous nitric oxide (NO) and prostaglandins (PGs) modulate angiotensin II (Ang II) action in microperfused afferent arterioles (Af-Arts). Because flow may be a physiological stimulus of endothelial release of NO and PGs, we tested the hypothesis that flow through the lumen ...

journal_title：Kidney international

authors： Juncos LA,Ren Y,Arima S,Garvin J,Carretero OA,Ito S

更新日期：1996-02-01 00:00:00

abstract：:The kidney is a likely source for some urinary epinephrine (E) since adrenalectomized animals and humans continue to excrete urinary E and the human kidney contains E synthesizing enzymes. We studied subjects during an intravenous infusion of 3H-E to determine the fraction of urinary E derived from the kidney. Eight n...

journal_title：Kidney international

authors： Ziegler MG,Aung M,Kennedy B

更新日期：1997-01-01 00:00:00

abstract：:Glomerular podocytes are terminally differentiated cells, and podocyte loss is a common feature of progressive renal pathologies. In this issue, Romoli et al. focus on podocyte progenitors that were proposed to reside in the Bowman's capsule. They demonstrate that suppression of CXCL12/CXCR4 signaling activates pariet...

journal_title：Kidney international

authors： Massa F,Schedl A

更新日期：2018-12-01 00:00:00

abstract：:Vascular calcification is prevalent in dialysis patients and is associated with a high burden of cardiovascular disease. Fetuin-A is a potent inhibitor of vascular calcification, but the precise mechanism by which it mediates vascular calcification in uremia is unclear. Matsui and colleagues demonstrate that circulati...

journal_title：Kidney international

authors： Komaba H,Fukagawa M

更新日期：2009-05-01 00:00:00

abstract：:Systemic AA type amyloidosis with renal involvement is the major cause of morbidity and mortality in patients with familial Mediterranean fever (FMF). A histopathological examination is essential to achieve a definite diagnosis in systemic amyloidosis. The diagnostic yield of the procedure varies according to the biop...

journal_title：Kidney international

authors： Sungur C,Sungur A,Ruacan S,Arik N,Yasavul U,Turgan C,Caglar S

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:Mesangial immunoglobulin A (IgA) deposition is incidentally encountered in asymptomatic individuals, but its precise frequency and significance had not been clarified. The background of the latent IgA deposition is related to the epidemiology and pathogenesis of IgA nephropathy. METHODS:Zero-hour allograft ...

journal_title：Kidney international

authors： Suzuki K,Honda K,Tanabe K,Toma H,Nihei H,Yamaguchi Y

更新日期：2003-06-01 00:00:00

abstract：:Recent evidence suggests that glomerular hypertrophy is a key event in the development of focal and segmental glomerulosclerosis and hyalinosis (FSGS) in humans and in many experimental models of FSGS. The initial aim of the present study was to determine if glomerular hypertrophy occurs in a puromycin aminonucleoside...

journal_title：Kidney international

authors： Cahill MM,Ryan GB,Bertram JF

更新日期：1996-09-01 00:00:00

abstract：:Using in situ hybridization and immunocytochemistry we describe the renal localization of the PDGF alpha-receptor. PDGF alpha-receptor mRNA was uniformly present in human metanephric kidney in interstitial cells and vascular arcades that course through the blastema. PDGF alpha-receptor mRNA was present in some mesangi...

journal_title：Kidney international

authors： Floege J,Hudkins KL,Seifert RA,Francki A,Bowen-Pope DF,Alpers CE

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:The plasma concentrations of total homocysteine (tHcy) and total cysteine (tCys) are determined by intracellular metabolism and by renal plasma clearance, and we hypothesized that glomerular filtration is a major determinant of plasma tHcy and tCys. We studied the relationships between the glomerular filtrat...

journal_title：Kidney international

authors： Wollesen F,Brattström L,Refsum H,Ueland PM,Berglund L,Berne C

更新日期：1999-03-01 00:00:00

abstract：:Peptides representing potential antigenic regions of the NC-1 and 7-S domains of the human alpha 1 and alpha 2, and bovine alpha 3 chains of type IV collagen were synthesized either chemically or by the recombinant DNA technique and tested by ELISA using antibodies raised in rabbits against the whole type IV collagen ...

journal_title：Kidney international

authors： Kefalides NA,Ohno N,Wilson CB,Fillit H,Zabriski J,Rosenbloom J

更新日期：1993-01-01 00:00:00

abstract：:Isotomic fluid reabsorption (JV) of rat renal proximal tubules was examined by the shrinking droplet method in combination with simulatneous perfusion of blood capillaries. Sensitivity of JV measurement was improved by using each punctured tubule for control measurements: 1) Parathyroid hormoen (PTH) on the contralumi...

journal_title：Kidney international

authors： Baumann K,Chan YL,Bode F,Papavassiliou F

更新日期：1977-02-01 00:00:00

abstract：BACKGROUND:Our preliminary studies indicate that chronic caffeine consumption has adverse renal effects in nephropathy associated with high blood pressure and insulin resistance. The purpose of this study was to investigate the effects of early (beginning at 8 weeks of age) and long-term (30 weeks) caffeine treatment (...

journal_title：Kidney international

authors： Tofovic SP,Kost CK Jr,Jackson EK,Bastacky SI

更新日期：2002-04-01 00:00:00

abstract：:A major factor contributing to failure of arteriovenous fistulas (AVFs) is migration of smooth muscle cells into the forming neointima. To identify the source of smooth muscle cells in neointima, we created end-to-end AVFs by anastomosing the common carotid artery to the jugular vein and studied neural crest-derived s...

journal_title：Kidney international

authors： Liang M,Wang Y,Liang A,Mitch WE,Roy-Chaudhury P,Han G,Cheng J

更新日期：2015-09-01 00:00:00

abstract：:This report of the NIH-supported National Continuous Ambulatory Peritoneal Dialysis (CAPD) Registry summarizes data on 7,404 patients treated with CAPD during the three-year period 1981 through 1983, or nearly one-half of patients treated in the USA who were treated with CAPD during this time. While age and diabetes m...

journal_title：Kidney international

authors： Nolph KD,Cutler SJ,Steinberg SM,Novak JW

更新日期：1985-08-01 00:00:00

abstract：:Protein energy wasting is a common feature of patients with chronic kidney disease (CKD) and is associated with poor outcomes. Protein energy wasting and cachexia, a severe form of protein energy wasting, are characterized by increased resting energy expenditure but the underlying mechanisms are unclear. Browning corr...

journal_title：Kidney international

authors： Luce M,Barba C,Yi D,Mey A,Roussel D,Bres E,Benoit B,Pastural M,Granjon S,Szelag JC,Laville M,Arkouche W,Bouchara A,Nyam E,Fouque D,Soulage CO,Koppe L

更新日期：2020-09-01 00:00:00

abstract：:This study was undertaken to test the hypothesis that, given equal arterial pressure reductions, the combination of an angiotensin converting enzyme (ACE) inhibitor and calcium antagonist slows declines in renal function and yields greater reductions in albuminuria over either agent alone. This hypothesis was evaluate...

journal_title：Kidney international

authors： Bakris GL,Barnhill BW,Sadler R

更新日期：1992-04-01 00:00:00

abstract：:As an alternative to classical immunosuppressants in experimental lupus nephritis, we looked at bindarit, 2-methyl-2-[[1-phenylmethyl)-1H-indazol-3-y1]methoxy]propanoic acid, a novel molecule devoid of immunosuppressive effects, which selectively reduces chronic inflammation in rat adjuvant arthritis. Two groups of NZ...

journal_title：Kidney international

authors： Zoja C,Corna D,Benedetti G,Morigi M,Donadelli R,Guglielmotti A,Pinza M,Bertani T,Remuzzi G

更新日期：1998-03-01 00:00:00

abstract：:We have analyzed the protein content of proximal tubular fluid (PTF) by ultramicro disc electrophoresis and measured total protein excretion rates both in control conditions and during angiotensin infusion to the rat. Under control conditions PTF albumin concentration was 1.49 +/- 1.12 (SD) mg/100 ml and did not incre...

journal_title：Kidney international

authors： Eisenbach GM,Liew JB,Boylan JW,Manz N,Muir P

更新日期：1975-08-01 00:00:00

abstract：BACKGROUND:Gene expression profiling of nephropathies may facilitate development of diagnostic strategies for complex renal diseases as well as provide insight into the molecular pathogenesis of kidney diseases. To test molecular based renal disease categorization, differential gene expression profiles were compared be...

journal_title：Kidney international

authors： Henger A,Kretzler M,Doran P,Bonrouhi M,Schmid H,Kiss E,Cohen CD,Madden S,Porubsky S,Gröne EF,Schlöndorff D,Nelson PJ,Gröne HJ

更新日期：2004-03-01 00:00:00

abstract：:Factor H is a regulator of the alternative pathway of complement, and genetic studies have shown that patients with mutations in factor H are at increased risk for several types of renal disease. Pathogenic activation of the alternative pathway in acquired diseases, such as ischemic acute kidney injury, suggests that ...

journal_title：Kidney international

authors： Renner B,Ferreira VP,Cortes C,Goldberg R,Ljubanovic D,Pangburn MK,Pickering MC,Tomlinson S,Holland-Neidermyer A,Strassheim D,Holers VM,Thurman JM

更新日期：2011-07-01 00:00:00

abstract：:Kidney-targeted gene therapy could be an ideal treatment for renal diseases since the therapeutic molecule is limited in the kidney and the systemic effect may be minimized. The technical development of the gene delivery to kidney and the identification of the responsive gene for a particular disease encourage the cha...

journal_title：Kidney international

authors： Imai E,Takabatake Y,Mizui M,Isaka Y

更新日期：2004-05-01 00:00:00

abstract：:The contractile properties of recombinant human erythropoietin (rHuEPO) on isolated resistance vessels of renal and mesenteric vascular beds were studied in an in vitro model using a small vessel myograph. Under isometric conditions, rHuEPO caused a contraction of this vasculature in a concentration range between 10 U...

journal_title：Kidney international

authors： Heidenreich S,Rahn KH,Zidek W

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:Fractalkine is a newly identified T-cell and monocyte/macrophage (Mphi) chemokine with a transmembrane domain and is a cell-surface protein on activated endothelium. It can mediate adhesion of cells expressing the fractalkine receptor CX3CR1. These unique features make fractalkine well suited for leukocyte r...

journal_title：Kidney international

authors： Feng L,Chen S,Garcia GE,Xia Y,Siani MA,Botti P,Wilson CB,Harrison JK,Bacon KB

更新日期：1999-08-01 00:00:00

abstract：:How much dialysis is required for optimal well-being and long-term survival? The Frequent Hemodialysis Network completed two prospective trials examining the effect of more frequent, short hours and, now, of nocturnal hemodialysis compared with standard thrice-weekly treatments. Whereas the short-hours trial reported ...

journal_title：Kidney international

authors： Davenport A

更新日期：2011-11-01 00:00:00

abstract：:Macrophages are inflammatory cells with important roles in the propagation of renal injury. More recently they have also been shown to be important in the resolution of inflammation. Wang et al. show that macrophages can be modulated ex vivo by cytokine stimulation, localize to renal tissue, and slow progression of ex...

journal_title：Kidney international

authors： Kluth DC

更新日期：2007-08-01 00:00:00

abstract：:Human mesangial cells (MC) in culture, when stimulated by interleukin 1 alpha(IL-1 alpha) or tumour necrosis factor (TNF alpha), but not with lipopolysaccharide (LPS), express interleukin 8 (IL-8) mRNA, and both cell associated and extracellular IL-8. Dexamethasone treatment of mesangial cells induced partial inhibiti...

journal_title：Kidney international

authors： Brown Z,Strieter RM,Chensue SW,Ceska M,Lindley I,Neild GH,Kunkel SL,Westwick J

更新日期：1991-07-01 00:00:00

abstract：:Amylin (islet amyloid peptide) plays a critical role in islet amyloidosis and in the development of beta-cell dysfunction in patients with diabetes; however, the involvement of amylin in renal amyloidosis has not been studied. For this reason, we surveyed 149 patients with biopsy-proven diabetic nephropathy (DN). The ...

journal_title：Kidney international

authors： Gong W,Liu ZH,Zeng CH,Peng A,Chen HP,Zhou H,Li LS

更新日期：2007-07-01 00:00:00