Identification of antigenic epitopes in type IV collagen by use of synthetic peptides.

abstract：BACKGROUND:Although peritoneal dialysis (PD) is a widely accepted form of renal replacement therapy (RRT), concerns remain regarding the bioincompatible nature of standard PD fluid. In order to evaluate whether a newly formulated fluid of neutral pH, and containing low levels of glucose degradation products (GDP), resu...

journal_title：Kidney international

authors： Williams JD,Topley N,Craig KJ,Mackenzie RK,Pischetsrieder M,Lage C,Passlick-Deetjen J,Euro Balance Trial Group.

更新日期：2004-07-01 00:00:00

abstract：:Transgenic rats [TGR; strain name TGR(mRen2)27] harboring the mouse Ren-2 renin gene have been recently generated as a model for the study of primary hypertension that offers the advantage of a clearly-defined genetic alteration. Expression of the mouse Ren-2 gene causes severe hypertension (200 to 260 mm Hg) which is...

journal_title：Kidney international

authors： Bachmann S,Peters J,Engler E,Ganten D,Mullins J

更新日期：1992-01-01 00:00:00

abstract：:Coronary artery stenosis induces renal inflammation and kidney injury in pigs even in the absence of myocardial infarction or clinically significant heart failure. This effect is aggravated by experimentally induced renovascular hypertension. Interestingly, oxidative stress originating from the ischemic myocardium was...

journal_title：Kidney international

authors： Rump LC,Stegbauer J

更新日期：2015-04-01 00:00:00

abstract：:The content of platelet activating factor (PAF) in glomeruli isolated from rats with nephrotoxic serum glomerulonephritis (NSGN) was quantified at various stages of the disease and the role of complement, platelets and neutrophils in mediating changes in glomerular PAF levels was evaluated. PAF content was assessed fo...

journal_title：Kidney international

authors： Lianos EA,Zanglis A

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:While an understanding of the epidemiology and clinical course of HIV-associated nephropathy (HIVAN) is growing, little is known about the risk factors and clinical course of the other renal diseases that may also occur as a complication of HIV infection. This study was undertaken to compare HIVAN to the spe...

journal_title：Kidney international

authors： Szczech LA,Gupta SK,Habash R,Guasch A,Kalayjian R,Appel R,Fields TA,Svetkey LP,Flanagan KH,Klotman PE,Winston JA

更新日期：2004-09-01 00:00:00

abstract：:IgA nephropathy is the most common primary glomerulonephritis worldwide. Its frequent coexistence with inflammatory, infectious, or malignant processes raises the possibility of a pathologic rather than coincidental association. Major strides have been made to elucidate the underlying pathophysiologic events that culm...

journal_title：Kidney international

authors： Saha MK,Julian BA,Novak J,Rizk DV

更新日期：2018-10-01 00:00:00

abstract：:To verify the hypothesis that angiotensin-converting enzyme (ACE) inhibitors possess a unique renoprotective effect in progressive chronic renal disease, we decided to compare the effects of an ACE inhibitor and a calcium antagonist on both hypertension and the progression of non-diabetic renal insufficiency in a long...

journal_title：Kidney international

authors： Zucchelli P,Zuccalà A,Borghi M,Fusaroli M,Sasdelli M,Stallone C,Sanna G,Gaggi R

更新日期：1992-08-01 00:00:00

abstract：:Suramin is a polysulfonated naphthylurea originally designed as a treatment for trypanosomiasis; but that has also been used to treat rodent models of fulminant hepatic failure and focal brain ischemia. In this study, we determined the effects of suramin on renal ischemia/reperfusion-induced acute kidney injury in mic...

journal_title：Kidney international

authors： Zhuang S,Lu B,Daubert RA,Chavin KD,Wang L,Schnellmann RG

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Aldosterone has been known for many years to increase sodium (Na(+)) reabsorption by the distal nephron. The present in vitro experiments investigated the effect of the hormone on calcium (Ca(2+)) transport by the luminal membrane of the rabbit nephron, independent of any systemic influence. METHODS:Proxima...

journal_title：Kidney international

authors： Leclerc M,Brunette MG,Couchourel D

更新日期：2004-07-01 00:00:00

abstract：:In male Wistar rats, renal adenosine triphosphate (ATP), inorganic phosphate (Pi) and intracellular pH were measured by 31phosphorus nuclear magnetic resonance (31P NMR) and correlated with renal function before, during, and for one hour after a period of 30 to 40 minutes hemorrhagic hypotension. In animals which suff...

journal_title：Kidney international

authors： Ratcliffe PJ,Moonen CT,Holloway PA,Ledingham JG,Radda GK

更新日期：1986-09-01 00:00:00

abstract：:Elevated serum levels of uric acid consistently correlate with hypertension, but the directionality of the association remains debated. To help define this relationship, we used a controlled setting within a homogeneous Amish community and the Mendelian randomization of a nonsynonymous coding single-nucleotide polymor...

journal_title：Kidney international

authors： Parsa A,Brown E,Weir MR,Fink JC,Shuldiner AR,Mitchell BD,McArdle PF

更新日期：2012-03-01 00:00:00

abstract：:There is a paucity of studies describing malignancy-related mortality after kidney transplantation. To help quantify this, we extracted data for all kidney-alone transplant procedures performed in England between April 2001 and March 2012. Data linkage analysis was performed between Hospital Episode Statistics and the...

journal_title：Kidney international

authors： Farrugia D,Mahboob S,Cheshire J,Begaj I,Khosla S,Ray D,Sharif A

更新日期：2014-06-01 00:00:00

abstract：:The microcirculation is regulated by oxygen gradients and by endothelial release of nitric oxide, which can react with hemoglobin to form S-nitroso derivatives. Here we induced flow-mediated dilatation of the brachial artery in response to ischemia in 141 non-diabetic patients with stage 3-4 chronic kidney disease who...

journal_title：Kidney international

authors： Yilmaz MI,Sonmez A,Saglam M,Gulec M,Kilic S,Eyileten T,Caglar K,Oguz Y,Vural A,Yenicesu M,Zoccali C

更新日期：2009-06-01 00:00:00

abstract：:Mineral metabolism in chronic kidney disease is attracting intense interest and unprecedented levels of research. The pharmaceutical industry has responded by developing various new agents. Bervoets et al. report the use of an unusual combination of basic-science techniques to increase understanding of the kinetics of...

journal_title：Kidney international

authors： Hutchison AJ

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease is the most frequent cause of mortality in chronic renal failure (CRF). Therefore, it is important to identify appropriate treatment measures. The antioxidant N-acetylcysteine (NAC) has been shown to reduce cardiovascular events in hemodialysis patients. Here we examine a possible dire...

journal_title：Kidney international

authors： Ivanovski O,Szumilak D,Nguyen-Khoa T,Ruellan N,Phan O,Lacour B,Descamps-Latscha B,Drüeke TB,Massy ZA

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:There is accumulating evidence that adult bone marrow (BM) cells show unexpected plasticity, and can differentiate into a wide range of specialized cells. In the case of intrinsic renal glomerular cells, BM-derived cells have been reported to differentiate into both mesangial cells and podocytes. However, th...

journal_title：Kidney international

authors： Ikarashi K,Li B,Suwa M,Kawamura K,Morioka T,Yao J,Khan F,Uchiyama M,Oite T

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:The rat renal proximal tubule cells contain a large amount of monoamine oxidase, which catalyzes the oxidative deamination of catecholamines such as dopamine (DA). The aim of this study is to investigate the potential role of hydrogen peroxide (H2O2) produced by monoamine oxidase (MAO) isoform on regulation ...

journal_title：Kidney international

authors： Vindis C,Séguélas MH,Lanier S,Parini A,Cambon C

更新日期：2001-01-01 00:00:00

abstract：:Previous studies in living animals have suggested that variations in the serum concentrations of calcium and phosphate directly affect renal tubular bicarbonate transport. To examine this area more directly, we measured the bicarbonate and the fluid transport in isolated rabbit proximal convoluted and straight tubules...

journal_title：Kidney international

authors： McKinney TD,Myers P

更新日期：1982-03-01 00:00:00

abstract：:This study examined the utility of interleukin-10 (IL-10), a cytokine with potent anti-macrophage and anti-Th1 activity, in the treatment of experimental anti-glomerular basement membrane (GBM) nephritis in the rat. Accelerated anti-GBM disease was induced in Sprague-Dawley rats by immunization with rabbit IgG, follow...

journal_title：Kidney international

authors： Chadban SJ,Tesch GH,Lan HY,Atkins RC,Nikolic-Paterson DJ

更新日期：1997-06-01 00:00:00

abstract：:Mitochondria are critical in determining a cell's energy homeostasis and fate, and mitochondrial dysfunction has been implicated in the pathogenesis of chronic kidney disease (CKD). We sought to identify causative mitochondrial microRNAs. A microarray screen of kidney tissue from healthy mice identified 97 microRNAs t...

journal_title：Kidney international

authors： Bai M,Chen H,Ding D,Song R,Lin J,Zhang Y,Guo Y,Chen S,Ding G,Zhang Y,Jia Z,Huang S,He JC,Yang L,Zhang A

更新日期：2019-06-01 00:00:00

abstract：:[Arg(8)]-vasopressin (AVP) has several functions via its three distinct receptors, V1a, V1b, and V2. The V1a vasopressin receptor (V1aR) is expressed in blood vessels and involved in vascular contraction. Recently, we generated V1a receptor-deficient (V1aR(-/-)) mice and found that they were hypotensive. In addition, ...

journal_title：Kidney international

authors： Aoyagi T,Koshimizu TA,Tanoue A

更新日期：2009-11-01 00:00:00

abstract：:Experiments were performed to study the mechanism of the compensatory increase in the excretion of metabolic acid by residual nephrons after reduction in renal mass. Despite a decrease in nephron population to 20% of control, total excretion of acid remained similar to pair-fed controls due to an increase in nephron e...

journal_title：Kidney international

authors： MacClean AJ,Hayslett JP

更新日期：1980-05-01 00:00:00

abstract：:Residual kidney function (RKF) may confer a variety of benefits to patients on maintenance dialysis. RKF provides continuous clearance of middle molecules and protein-bound solutes. Whereas the definition of RKF varies across studies, interdialytic urine volume may emerge as a pragmatic alternative to more cumbersome ...

journal_title：Kidney international

authors： Mathew AT,Fishbane S,Obi Y,Kalantar-Zadeh K

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Tubulointerstitial fibrosis is a morphologic hallmark of chronic kidney disease and is a key factor in the prediction of progression to end-stage renal failure. Disruption of tubular basement membrane and interstitial extracellular matrix (ECM) via cytokine-induced alterations in matrix metalloproteinases (M...

journal_title：Kidney international

authors： Nee LE,McMorrow T,Campbell E,Slattery C,Ryan MP

更新日期：2004-10-01 00:00:00

abstract：:Donor pretreatment of 100 mg/kg each of cyclophosphamide (CY) and methylprednisolone (P) infused 5 hours before nephrectomy invariably prolongs the survival of DLA mismatched, MLC incompatible nonlittermate Beagle renal allografts as well as the survival of mongrel renal allografts. The effect of donor pretreatment ap...

journal_title：Kidney international

authors： Brom HL,van Breda Vriesman PJ,Terpstra JL

更新日期：1982-02-01 00:00:00

abstract：:The binding of albumin to the glomerular capillary wall was studied using albumin-gold in perfused kidneys, the interaction of [3H]albumin with isolated glomeruli at 37 degrees C and 4 degrees C and the interaction at [3H]albumin with purified basement membrane. The albumin-gold was found to bind predominantly to the ...

journal_title：Kidney international

authors： Adal Y,Smit MF,Osicka TM,Comper WD

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Many studies have reported that blocking the renin-angiotensin-system (RAS) with an angiotensin-converting enzyme (ACE) inhibitor or an angiotensin receptor blocker in the patient with diabetes mellitus leads to an increase in renal plasma flow (RPF), no change in glomerular filtration rate (GFR), and a fall...

journal_title：Kidney international

authors： Hollenberg NK,Price DA,Fisher ND,Lansang MC,Perkins B,Gordon MS,Williams GH,Laffel LM

更新日期：2003-01-01 00:00:00

abstract：:Inflammation is the immune system's response to infectious or noninfectious sources of danger. Danger recognition is facilitated by various innate immune receptor families including the Toll-like receptors (TLRs), which detect danger signals in extracellular and intracellular compartments. It is an evolving concept th...

journal_title：Kidney international

authors： Anders HJ,Schlondorff DO

更新日期：2010-07-01 00:00:00

abstract：:The ability to pursue gene therapy has been limited by the availability of an effective and safe system for gene delivery, especially to the kidney. Electroporation is an efficient method to transfer physiologically the gene to the cells without complicated preparation. Given that the systemic delivery of the function...

journal_title：Kidney international

authors： Imai E,Isaka Y

更新日期：2002-01-01 00:00:00

abstract：:Vitamin D deficiency is common in patients with chronic kidney disease after renal transplantation. Vitamin D, essential for mineral and bone metabolism, also has myriad beneficial autocrine effects on intact immune responses and defense against infection, as well as suppression of malignant changes. Supplementation w...

journal_title：Kidney international

authors： Levi R,Silver J

更新日期：2009-03-01 00:00:00