当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury.

Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury.

Abstract：

:Factor H is a regulator of the alternative pathway of complement, and genetic studies have shown that patients with mutations in factor H are at increased risk for several types of renal disease. Pathogenic activation of the alternative pathway in acquired diseases, such as ischemic acute kidney injury, suggests that native factor H has a limited capacity to control the alternative pathway in the kidney. Here we found that an absolute deficiency of factor H produced by gene deletion prevented complement activation on tubulointerstitial cells after ischemia/reperfusion (I/R) injury, likely because alternative pathway proteins were consumed in the fluid phase. In contrast, when fluid-phase regulation by factor H was maintained while the interaction of factor H with cell surfaces was blocked by a recombinant inhibitor protein, complement activation after renal I/R increased. Finally, a recombinant form of factor H, specifically targeted to sites of C3 deposition, reduced complement activation in the tubulointerstitium after ischemic injury. Thus, although factor H does not fully prevent activation of the alternative pathway of complement on ischemic tubules, its interaction with the tubule epithelial cell surface is critical for limiting complement activation and attenuating renal injury after ischemia.

journal_name

Kidney Int

journal_title

Kidney international

authors

Renner B,Ferreira VP,Cortes C,Goldberg R,Ljubanovic D,Pangburn MK,Pickering MC,Tomlinson S,Holland-Neidermyer A,Strassheim D,Holers VM,Thurman JM

doi

10.1038/ki.2011.115

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

165-73

issue

2

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)55012-6

journal_volume

80

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • Transcription factor HNF1beta and novel partners affect nephrogenesis.

    abstract：:Heterozygous mutations of the tissue-specific transcription factor hepatocyte nuclear factor (HNF)1beta, cause maturity onset diabetes of the young (MODY5) and kidney anomalies including agenesis, hypoplasia, dysplasia and cysts. Because of these renal anomalies, HNF1beta is classified as a CAKUT (congenital anomalies...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2008.149

    authors： Dudziak K,Mottalebi N,Senkel S,Edghill EL,Rosengarten S,Roose M,Bingham C,Ellard S,Ryffel GU

    更新日期：2008-07-01 00:00:00

  • Calcitriol and doxercalciferol are equivalent in controlling bone turnover, suppressing parathyroid hormone, and increasing fibroblast growth factor-23 in secondary hyperparathyroidism.

    abstract：:We compared the effects of calcitriol and doxercalciferol, in combination with either calcium carbonate or sevelamer, on bone, mineral, and fibroblast growth factor-23 (FGF-23) metabolism in patients with secondary hyperparathyroidism. A total of 60 pediatric patients treated with peritoneal dialysis were randomized t...

    journal_title：Kidney international

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/ki.2010.352

    authors： Wesseling-Perry K,Pereira RC,Sahney S,Gales B,Wang HJ,Elashoff R,Jüppner H,Salusky IB

    更新日期：2011-01-01 00:00:00

  • Severe defect in clearing postprandial chylomicron remnants in dialysis patients.

    abstract：:Lipid abnormalities have been suggested as a major cause of the accelerated atherosclerosis and the high incidence of coronary heart disease in chronic renal failure patients. In the present work the postprandial lipoprotein metabolism was studied in chronic dialysis patients with or without fasting hypertriglyceridem...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1992.411

    authors： Weintraub M,Burstein A,Rassin T,Liron M,Ringel Y,Cabili S,Blum M,Peer G,Iaina A

    更新日期：1992-11-01 00:00:00

  • Targeting the fatty acid transport protein CD36, a class B scavenger receptor, in the treatment of renal disease.

    abstract：:Augmentation of the CD36 pathway, which involves the uptake of several endogenous ligands including free fatty acids and oxidized low-density lipoprotein, contributes to the damage of proximal tubules and podocytes, whereas ablation of CD36 attenuates renal injury. Souza et al. demonstrate that 5A peptide can inhibit ...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1016/j.kint.2016.01.009

    authors： Yokoi H,Yanagita M

    更新日期：2016-04-01 00:00:00

  • Blockade of Angiotensin II type-1 receptor reduces oxidative stress in adipose tissue and ameliorates adipocytokine dysregulation.

    abstract：:Dysregulated production of adipocytokines may be involved in the development of atherosclerotic cardiovascular disease in metabolic syndrome and chronic kidney disease (CKD) associated with metabolic syndrome. The aim of this study was to determine the effects of treatment with angiotensin II (Ang II) type-1 receptor ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5001810

    authors： Kurata A,Nishizawa H,Kihara S,Maeda N,Sonoda M,Okada T,Ohashi K,Hibuse T,Fujita K,Yasui A,Hiuge A,Kumada M,Kuriyama H,Shimomura I,Funahashi T

    更新日期：2006-11-01 00:00:00

  • Localization of glutamine accumulation and tubular reabsorption in rat nephron.

    abstract：:Glutamine accumulation in rat kidney was investigated by giving large loads of gluta, mate and aspartate and measuring glutamine changes in seven completely defined portions of the nephron and in small patches from the thin limb area and from the papilla. Both glutamate and aspartate (which is partly coverted to gluta...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1978.145

    authors： Burch HB,Chan AW,Alvey TR,Lowry OH

    更新日期：1978-11-01 00:00:00

  • G protein beta3 subunit C825T polymorphism in primary IgA nephropathy.

    abstract：BACKGROUND:The T allele of the G protein beta3 subunit (GNB3) C825T polymorphism has been associated with increased signal transduction, increased activity of the kidney Na+/H+ exchanger, and also with late-onset essential hypertension. Hypertension is a strong independent risk factor for progression in IgA nephropathy...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00734.x

    authors： Thibaudin L,Berthoux P,Thibaudin D,Mariat C,Berthoux F

    更新日期：2004-07-01 00:00:00

  • Patients with hypertension-associated thrombotic microangiopathy may present with complement abnormalities.

    abstract：:Thrombotic microangiopathy (TMA) is a pattern of endothelial damage that can be found in association with diverse clinical conditions such as malignant hypertension. Although the pathophysiological mechanisms differ, accumulating evidence links complement dysregulation to various TMA syndromes and in particular the at...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2016.12.009

    authors： Timmermans SAMEG,Abdul-Hamid MA,Vanderlocht J,Damoiseaux JGMC,Reutelingsperger CP,van Paassen P,Limburg Renal Registry.

    更新日期：2017-06-01 00:00:00

  • Increased nitric oxide inactivation by reactive oxygen species in lead-induced hypertension.

    abstract：BACKGROUND:We have recently found evidence for increased reactive oxygen species (ROS) in rats with lead-induced hypertension. We hypothesized that increased ROS activity may contribute to hypertension by enhancing inactivation of nitric oxide (NO) in this model. METHODS:Rats were treated for 12 weeks with either lead...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00670.x

    authors： Vaziri ND,Liang K,Ding Y

    更新日期：1999-10-01 00:00:00

  • Antioxidant therapy in hemodialysis patients: a systematic review.

    abstract：:Antioxidants have been used as therapies to decrease oxidative stress and improve CVD risk in hemodialysis (HD) patients. A systematic search of the Medline database (search date 30 April 2011) found 56 studies investigating the effects of antioxidant therapies on biomarkers of oxidative stress (53 studies) or clinica...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1038/ki.2011.341

    authors： Coombes JS,Fassett RG

    更新日期：2012-02-01 00:00:00

  • Toxic acute tubular necrosis following treatment with zoledronate (Zometa).

    abstract：BACKGROUND:Renal failure and toxic acute tubular necrosis (ATN) may be seen following exposure to a variety of therapeutic agents. Zoledronate (Zometa) is a new, highly potent bisphosphonate used in the treatment of hypercalcemia of malignancy. We report the first clinical-pathologic study of nephrotoxicity associated ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00071.x

    authors： Markowitz GS,Fine PL,Stack JI,Kunis CL,Radhakrishnan J,Palecki W,Park J,Nasr SH,Hoh S,Siegel DS,D'Agati VD

    更新日期：2003-07-01 00:00:00

  • Pressure diuresis and natriuresis in DOCA-salt mice.

    abstract：:The increasing use of mice in renal and cardiovascular studies has necessitated adapting physiological methods used for rats to mice, which are far smaller in size. We have adapted measurements of continuous renal blood flow, pressure natriuresis and diuresis, and laser-Doppler cortical and medullary flow to 40 g mice...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1997.462

    authors： Gross V,Lippoldt A,Luft FC

    更新日期：1997-11-01 00:00:00

  • Histopathology and surgical anatomy of patients with primary hyperparathyroidism and calcium phosphate stones.

    abstract：:Using a combination of intra-operative digital photography and micro-biopsy we measured renal cortical and papillary changes in five patients with primary hyperparathyroidism and abundant calcium phosphate kidney stones. Major tissue changes were variable papillary flattening and retraction, dilation of the ducts of B...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2008.161

    authors： Evan AE,Lingeman JE,Coe FL,Miller NL,Bledsoe SB,Sommer AJ,Williams JC,Shao Y,Worcester EM

    更新日期：2008-07-01 00:00:00

  • Significance of the tissue kallikrein promoter and transforming growth factor-beta1 polymorphisms with renal progression in children with vesicoureteral reflux.

    abstract：BACKGROUND:Tissue kallikrein regulates blood circulation. Low urinary kallikrein excretion was associated with hypertension and renal disease in blacks. The polymorphic KLK1 promoter includes -130 GN coupled with multiple single base substitutions. The -130 G12 allele in the KLK1 promoter was associated with lower tran...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2004.00526.x

    authors： Lee-Chen GJ,Liu KP,Lai YC,Juang HS,Huang SY,Lin CY

    更新日期：2004-04-01 00:00:00

  • High glucose levels inhibit focal adhesion kinase-mediated wound healing of rat peritoneal mesothelial cells.

    abstract：BACKGROUND:The peritoneum is progressively denuded of its mesothelial cell monolayer in patients on continuous ambulatory peritoneal dialysis (CAPD). These alterations of the mesothelium cause membrane dysfunction and progressive peritoneal fibrosis. Integrins regulate cell motility and play an important role in wound ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00772.x

    authors： Tamura M,Osajima A,Nakayamada S,Anai H,Kabashima N,Kanegae K,Ota T,Tanaka Y,Nakashima Y

    更新日期：2003-02-01 00:00:00

  • Decreased sensitivity to heparin in vitro in steroid-responsive nephrotic syndrome.

    abstract：:The in vitro heparin sensitivity of 18 nephrotic children was compared with that of 10 normal children and 13 children with other renal diseases. The influence of age on the heparin sensitivity of 52 normal subjects (aged 12 to 85 years) was also studied. The heparin sensitivity was calculated from the dose-response c...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1987.155

    authors： Vermylen CG,Levin M,Lanham JG,Hardisty RM,Barratt TM

    更新日期：1987-06-01 00:00:00

  • Importance of angiogenic action of angiotensin II in the glomerular growth of maturing kidneys.

    abstract：:We studied the effect of three antihypertensive drugs on the growth of glomeruli in four- to five-week-old Munich-Wistar rats (N = 24), which were undergoing rapid maturation processes. Young rats were given an angiotensin converting enzyme inhibitor (ACEI, enalapril, 50 mg/liter drinking water), verapamil (50 mg/lite...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1990.314

    authors： Fogo A,Yoshida Y,Yared A,Ichikawa I

    更新日期：1990-12-01 00:00:00

  • Distribution of MHC class II alleles in primary systemic vasculitis.

    abstract：:Previous studies have shown a number of different associations between major histocompatibility complex (MHC) alleles and primary systemic vasculitis. Disease heterogeneity and the lack of specificity of certain MHC typing techniques may have contributed to the lack of consistency in those studies. We therefore studie...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.37

    authors： Zhang L,Jayne DR,Zhao MH,Lockwood CM,Oliveira DB

    更新日期：1995-01-01 00:00:00

  • Limited urinary concentration and damaged tubules in rats with a syngeneic kidney graft.

    abstract：BACKGROUND:The underlying mechanisms of renal transplant dysfunction are poorly understood. There is little information on tubular function in kidney grafts. The cDNAs encoding kidney-specific cell surface proteins required for renal reabsorption of sodium (sodium cotransporter in thick ascending limb of Henle, rBSC1) ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2001.060002672.x

    authors： Michimata M,Wang W,Fujita S,Mizutani H,Fujimori K,Satomi S,Ohta M,Ito S,Kimura T,Araki T,Imai Y,Matsubara M

    更新日期：2001-08-01 00:00:00

  • Treatment of experimental renal osteodystrophy with pamidronate.

    abstract：:We evaluated the effects of the bisphosphonate pamidronate on bone histomorphometry, structure and strength in male rats with uninephrectomy or with chronic renal disease induced by 5/6 nephrectomy. In rats with chronic renal disease the plasma urea, phosphate and parathyroid hormone levels were significantly increase...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2008.180

    authors： Jokihaara J,Pörsti IH,Kööbi P,Jolma PM,Mustonen JT,Saha HH,Sievänen H,Kannus P,Iwaniec UT,Turner RT,Järvinen TL

    更新日期：2008-08-01 00:00:00

  • Polycystic kidney and liver disease in Springbok: I. Morphology of the lesions.

    abstract：:Spontaneous polycystic kidney and liver disease in an inbred herd of Springbok (Antidorcas marsupialis) was studied by light microscopy, transmission electron microscopy, and microdissection. Springbok are a small species of gazelle of the family Bovidae native to South Africa. Since 1976, 18% of all live calves born ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1982.146

    authors： Iverson WO,Fetterman GH,Jacobson ER,Olsen JH,Senior DF,Schobert EE

    更新日期：1982-08-01 00:00:00

  • Revisiting RAAS blockade in CKD with newer potassium-binding drugs.

    abstract：:Among patients with proteinuric chronic kidney disease (CKD), current guideline recommendations mandate the use of agents blocking the renin angiotensin aldosterone system (RAAS) as first-line antihypertensive therapy based on randomized trials demonstrating that RAAS inhibitors are superior to other antihypertensive ...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1016/j.kint.2017.08.038

    authors： Georgianos PI,Agarwal R

    更新日期：2018-02-01 00:00:00

  • Human anti-neutrophil cytoplasm autoantibodies to proteinase 3 (PR3-ANCA) bind to neutrophils.

    abstract：BACKGROUND:Recently, the in vivo pathogenic role of anti-neutrophil cytoplasm autoantibodies (ANCA) in ANCA-associated vasculitis has been challenged by Abdel-Salam et al. In their report, they observed that ANCA directed against proteinase 3 (PR3) cannot bind to their target autoantigen PR3 on circulating neutrophils ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00431.x

    authors： Van Rossum AP,van der Geld YM,Limburg PC,Kallenberg CG

    更新日期：2005-08-01 00:00:00

  • Partial biochemical and physicochemical characterization of organic macromolecules in urine from patients with renal stones and control subjects.

    abstract：:From the urine of patients with calcium nephrolithiasis, and of control subjects, we isolated organic substances according to molecular size and tested them for effects on calcium oxalate precipitation. Nine subgroup materials of varying sizes were prepared by ultrafiltration and Sephadex G-200 column chromatography f...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1982.33

    authors： Kitamura T,Zerwekh JE,Pak CY

    更新日期：1982-02-01 00:00:00

  • Antiproteinuric effect of the calcium channel blocker cilnidipine added to renin-angiotensin inhibition in hypertensive patients with chronic renal disease.

    abstract：:Cilnidipine, a dual L-/N-type calcium channel blocker, dilates both efferent and afferent arterioles and is renoprotective. Our multi-center, open-labeled, and randomized trial compared the antiproteinuric effect of cilnidipine with that of amlodipine in hypertensive patients with kidney disease. A group of 339 patien...

    journal_title：Kidney international

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1038/sj.ki.5002623

    authors： Fujita T,Ando K,Nishimura H,Ideura T,Yasuda G,Isshiki M,Takahashi K,Cilnidipine versus Amlodipine Randomised Trial for Evaluation in Renal Desease(CARTER) Study Investigators.

    更新日期：2007-12-01 00:00:00

  • Sodium balance and renin regulation in rats: role of intrinsic renal mechanisms.

    abstract：:Renin secretion was compared in vivo and in vitro among five groups of rats, each group subjected to a different sodium balance for 10 to 14 days. The state of the renin-angiotensin system in vivo was evaluated by measuring the renal renin (RR) and the plasma renin concentration (PRC) in both anesthetized and nonanest...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1980.71

    authors： Nakane H,Nakane Y,Corvol P,Menard J

    更新日期：1980-05-01 00:00:00

  • Protective role of selectin ligand inhibition in a large animal model of kidney ischemia-reperfusion injury.

    abstract：:Experiments in rodents have demonstrated an important role for selectins in kidney ischemia-reperfusion injury (IRI). However, the relevance of this in larger mammals, as well as the impact on long-term structure and function is unknown. We tested the hypothesis that small molecule selectin ligand inhibition attenuate...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5000335

    authors： Jayle C,Milinkevitch S,Favreau F,Doucet C,Richer JP,Deretz S,Mauco G,Rabb H,Hauet T

    更新日期：2006-05-01 00:00:00

  • Vascular access calcification predicts mortality in hemodialysis patients.

    abstract：:Vascular calcification is a recognized risk factor for cardiovascular mortality in patients with end-stage renal disease. The aim of this study was to identify risk factors for vascular access calcification and to determine if patients with this disorder are at increased risk of death. Vascular access calcification wa...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2008.458

    authors： Schlieper G,Krüger T,Djuric Z,Damjanovic T,Markovic N,Schurgers LJ,Brandenburg VM,Westenfeld R,Dimkovic S,Ketteler M,Grootendorst DC,Dekker FW,Floege J,Dimkovic N

    更新日期：2008-12-01 00:00:00

  • Alleles of the alpha1 immunoglobulin gene 3' enhancer control evolution of IgA nephropathy toward renal failure.

    abstract：BACKGROUND:IgA nephropathy is the most common glomerular disease. Mechanisms leading to its occurrence and controlling the evolution of the disease remain largely unknown. Various genetic factors have been found, mostly implicating immunologically relevant genes (IgH, TCR, human lymphocyte antigen, and complement loci)...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00253.x

    authors： Aupetit C,Drouet M,Pinaud E,Denizot Y,Aldigier JC,Bridoux F,Cogné M

    更新日期：2000-09-01 00:00:00

  • Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-κB-mediated inflammatory response.

    abstract：:The generation of reactive oxygen species has a pivotal role in both acute and chronic glomerular injuries in patients with lupus nephritis. As the transcription factor Nrf2 is a major regulator of the antioxidant response and is a primary cellular defense mechanism, we sought to determine a role of Nrf2 in the progre...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2013.343

    authors： Jiang T,Tian F,Zheng H,Whitman SA,Lin Y,Zhang Z,Zhang N,Zhang DD

    更新日期：2014-02-01 00:00:00