Severe defect in clearing postprandial chylomicron remnants in dialysis patients.

abstract：:To investigate whether the administration of cimetidine can improve the reliability of creatinine as a marker of GFR, we compared the creatinine clearance (CCr) to the clearance of the true filtration markers 51Cr-EDTA (CEDTA) and inulin (CIn), after oral ingestion of cimetidine in 10 healthy men and 29 patients with ...

journal_title：Kidney international

authors： Hilbrands LB,Artz MA,Wetzels JF,Koene RA

更新日期：1991-12-01 00:00:00

abstract：:The proportion of deceased donor kidneys procured for transplant but subsequently discarded has been growing steadily in the United States, but factors contributing to the rising discard rate remain unclear. To assess the reasons for and probability of organ discard we assembled a cohort of 212,305 deceased donor kidn...

journal_title：Kidney international

authors： Mohan S,Chiles MC,Patzer RE,Pastan SO,Husain SA,Carpenter DJ,Dube GK,Crew RJ,Ratner LE,Cohen DJ

更新日期：2018-07-01 00:00:00

abstract：:Mutations in the complement regulatory proteins are associated with several different diseases. Although these mutations cause dysregulated alternative pathway activation throughout the body, the kidneys are the most common site of injury. The susceptibility of the kidney to alternative pathway-mediated injury may be ...

journal_title：Kidney international

authors： Laskowski J,Renner B,Le Quintrec M,Panzer S,Hannan JP,Ljubanovic D,Ruseva MM,Borza DB,Antonioli AH,Pickering MC,Holers VM,Thurman JM

更新日期：2016-07-01 00:00:00

abstract：:Stimulation of interleukin-1 beta (IL-1 beta) and tumor necrosis factor (TNF alpha) production was studied during in vitro hemodialysis (HD) of whole blood using cuprammonium (Cup) or polysulfone (PS) dialyzers. In the absence of LPS, circulation of whole blood for two hours through Cup or PS dialyzers was not suffici...

journal_title：Kidney international

authors： Schindler R,Lonnemann G,Shaldon S,Koch KM,Dinarello CA

更新日期：1990-01-01 00:00:00

abstract：:Functional and morphological changes developed rapidly in rats after the intravenous administration of the organic nephrotoxin p-aminophenol. Proximal intratubular pressure remained close to its mean control value of 14.9 +/- 0.9 mm Hg up to 40 min after injection of the nephrotoxin then rose rapidly over the followin...

journal_title：Kidney international

authors： Davis JM,Emslie KR,Sweet RS,Walker LL,Naughton RJ,Skinner SL,Tange JD

更新日期：1983-12-01 00:00:00

abstract：BACKGROUND:Mast cells are growth factor-rich, bone marrow-derived cells that infiltrate injured tissue where they have been implicated in the pathogenesis of progressive fibrosis. METHODS:Mast cell infiltration and the expression of related chemoattractants was examined following 5/6 nephrectomy, a model of progressiv...

journal_title：Kidney international

authors： Jones SE,Kelly DJ,Cox AJ,Zhang Y,Gow RM,Gilbert RE

更新日期：2003-09-01 00:00:00

abstract：:Aminopeptidase A is one of the most potent enzymes within the renin-angiotensin system in terms of angiotensin II degradation. Here, we examined whether there is a kidney phenotype and any compensatory changes in other renin angiotensin system enzymes involved in the metabolism of angiotensin II associated with aminop...

journal_title：Kidney international

authors： Marahrens B,Schulze A,Wysocki J,Lin MH,Ye M,Kanwar YS,Bader M,Velez JCQ,Miner JH,Batlle D

更新日期：2020-12-11 00:00:00

abstract：:The improvement in the anemia in patients with end-stage renal disease (ESRD) on continuous ambulatory peritoneal dialysis (CAPD) suggests that dialyzable substances present in the sera of uremic patients either inhibit erythropoiesis directly or inactivate erythropoietin (EPO). In the present study predialysis sera f...

journal_title：Kidney international

authors： Kushner D,Beckman B,Nguyen L,Chen S,Della Santina C,Husserl F,Rice J,Fisher JW

更新日期：1991-04-01 00:00:00

abstract：:E-64d, a membrane-permeable cysteine protease inhibitor, was tested for its ability to inhibit PTH-induced contraction in intact mouse MC-3T3-E1 osteoblastic cells. Incubation of MC-3T3-E1 cells with vehicle (DMSO) or E-64c, a nonpermeant cysteine protease inhibitor, in the presence or in the absence of PTH had no eff...

journal_title：Kidney international

authors： Tram KK,Murray SS,Lee DB,Murray EJ

更新日期：1993-03-01 00:00:00

abstract：:Autophagy is a dynamic and highly regulated process of self-digestion responsible for cell survival and reaction to oxidative stress. As oxidative stress is increased in uremia and is associated with vascular calcification, we studied the role of autophagy in vascular calcification induced by phosphate. In an in vitro...

journal_title：Kidney international

authors： Dai XY,Zhao MM,Cai Y,Guan QC,Zhao Y,Guan Y,Kong W,Zhu WG,Xu MJ,Wang X

更新日期：2013-06-01 00:00:00

abstract：:The purpose of these studies was to clarify the basis of the relationship between the urine bicarbonate concentration and the urine minus blood PCO2 difference in alkaline urine (U-B PCO2) and hence shed light on factors that influence hydrogen ion secretion in the collecting duct in vivo. The U-B PCO2 was used to mon...

journal_title：Kidney international

authors： Tam SC,Goldstein MB,Stinebaugh BJ,Chen CB,Gougoux A,Halperin ML

更新日期：1981-11-01 00:00:00

abstract：:Polycystic renal disease was induced in rats by feeding 2-amino-4,5-diphenylthiazole. Tubular (TBM) and glomerular basement membranes (GBM) were purified and analyzed for possible structural changes that may be a factor in the development of the tubular dilations and cysts. Changes in the relative quantities of TBM po...

journal_title：Kidney international

authors： Butkowski RJ,Carone FA,Grantham JJ,Hudson BG

更新日期：1985-11-01 00:00:00

abstract：:Ischemia-reperfusion injury (IRI) is the outcome of an inflammatory process that is triggered when an organ undergoes a transient reduction or cessation of blood flow, followed by re-establishment of perfusion. In the clinical setting, IRI contributes to significant acute kidney injury, patient morbidity and mortality...

journal_title：Kidney international

authors： Pefanis A,Ierino FL,Murphy JM,Cowan PJ

更新日期：2019-08-01 00:00:00

abstract：:Tamm-Horsfall protein (THP), a monomeric glycoprotein (M(r) 80 to 100 kDa), is produced by the mammalian kidney's thick ascending limb of Henle cells and excreted into the urine. The function of THP is uncertain. Here we report that a high molecular weight contaminant in sheep THP (sTHP) preparations was identified as...

journal_title：Kidney international

authors： Rhodes DC,Hinsman EJ,Rhodes JA

更新日期：1993-11-01 00:00:00

abstract：:Transepithelial fluid secretion promotes the progressive enlargement of cysts in autosomal dominant polycystic kidney disease (ADPKD). Recent indirect evidence indicated that active chloride transport may drive net fluid secretion in cultures of epithelia derived from ADPKD cysts. We now report that forskolin, which s...

journal_title：Kidney international

authors： Davidow CJ,Maser RL,Rome LA,Calvet JP,Grantham JJ

更新日期：1996-07-01 00:00:00

abstract：:Compelling evidence indicates that vascular endothelial growth factor (VEGF) is a fundamental regulator of normal and abnormal angiogenesis. The loss of a single VEGF allele results in defective vascularization and early embryonic lethality. VEGF plays also a critical role in kidney development, and its inactivation d...

journal_title：Kidney international

authors： Ferrara N

更新日期：1999-09-01 00:00:00

abstract：:Reliable estimates of the long-term outcomes of acute kidney injury (AKI) are needed to inform clinical practice and guide allocation of health care resources. This systematic review and meta-analysis aimed to quantify the association between AKI and chronic kidney disease (CKD), end-stage kidney disease (ESKD), and d...

journal_title：Kidney international

authors： See EJ,Jayasinghe K,Glassford N,Bailey M,Johnson DW,Polkinghorne KR,Toussaint ND,Bellomo R

更新日期：2019-01-01 00:00:00

abstract：:Among patients with proteinuric chronic kidney disease (CKD), current guideline recommendations mandate the use of agents blocking the renin angiotensin aldosterone system (RAAS) as first-line antihypertensive therapy based on randomized trials demonstrating that RAAS inhibitors are superior to other antihypertensive ...

journal_title：Kidney international

authors： Georgianos PI,Agarwal R

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF-A) is expressed constitutively in the adult glomerular podocytes at high levels; however, the regulation of its production is unclear. Recent data from podocyte-specific knockout mice suggest that VPF/VEGF-A is critical for the proper ...

journal_title：Kidney international

authors： Datta K,Li J,Karumanchi SA,Wang E,Rondeau E,Mukhopadhyay D

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Left ventricular enlargement is very common at the inception of dialysis therapy, and highly predictive of future cardiac morbidity and mortality. It is not known whether cardiac size increases further while on dialysis therapy and whether potentially reversible risk factors for later progression can be iden...

journal_title：Kidney international

authors： Foley RN,Parfrey PS,Kent GM,Harnett JD,Murray DC,Barre PE

更新日期：1998-11-01 00:00:00

abstract：:As the worldwide prevalence of end-stage renal disease increases it is important to evaluate the rate of living kidney donation in various countries; however there is no comprehensive global assessment of these rates. To measure this, we compiled data from representatives, renal registries, transplant networks, publis...

journal_title：Kidney international

authors： Horvat LD,Shariff SZ,Garg AX,Donor Nephrectomy Outcomes Research (DONOR) Network.

更新日期：2009-05-01 00:00:00

abstract：:Heterozygous mutations of the tissue-specific transcription factor hepatocyte nuclear factor (HNF)1beta, cause maturity onset diabetes of the young (MODY5) and kidney anomalies including agenesis, hypoplasia, dysplasia and cysts. Because of these renal anomalies, HNF1beta is classified as a CAKUT (congenital anomalies...

journal_title：Kidney international

authors： Dudziak K,Mottalebi N,Senkel S,Edghill EL,Rosengarten S,Roose M,Bingham C,Ellard S,Ryffel GU

更新日期：2008-07-01 00:00:00

abstract：:Steroid Resistant Nephrotic Syndrome (SRNS) in children and young adults has differing etiologies with monogenic disease accounting for 2.9-30% in selected series. Using whole exome sequencing we sought to stratify a national population of children with SRNS into monogenic and non-monogenic forms, and further define t...

journal_title：Kidney international

authors： Bierzynska A,McCarthy HJ,Soderquest K,Sen ES,Colby E,Ding WY,Nabhan MM,Kerecuk L,Hegde S,Hughes D,Marks S,Feather S,Jones C,Webb NJ,Ognjanovic M,Christian M,Gilbert RD,Sinha MD,Lord GM,Simpson M,Koziell AB,Welsh

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:The genetic dissection of a polygenic, multifactorial, quantitative disease such as arterial hypertension is hampered by a large environmental variance and by genetic heterogeneity. METHODS:To reduce the environmental variance, we measured the pressor response to a saline load (PRSL) and the basal plasma re...

journal_title：Kidney international

authors： Barlassina C,Schork NJ,Manunta P,Citterio L,Sciarrone M,Lanella G,Bianchi G,Cusi D

更新日期：2000-03-01 00:00:00

abstract：:The application of our evolving knowledge of adhesion receptors to experimental models of immune complex glomerulonephritis has led to substantial advances in our understanding of how leukocytes emigrate from the vasculature into glomeruli and produce glomerular dysfunction. With respect to neutrophil (PMN) migration ...

journal_title：Kidney international

authors： Lefkowith JB

更新日期：1997-05-01 00:00:00

abstract：:Because the size of renal cysts in the native kidneys of patients with ADPKD who have been transplanted was found to be reduced when rapamycin was the immunosuppressant, we tested the involvement of the mTOR pathway in cyst enlargement. Here, male pcy mice, with mutation in one of the nephronophthisis genes, were trea...

journal_title：Kidney international

authors： Gattone VH 2nd,Sinders RM,Hornberger TA,Robling AG

更新日期：2009-07-01 00:00:00

abstract：:The aging process in humans and in the rat is associated with an impairment in renal tubular reabsorption of Pi and renal tubular adaptation to a low Pi diet. The purposes of the present study were to determine whether changes in the abundance of type II Na-Pi contransporter (NaPi-2) protein and/or mRNA play a role in...

journal_title：Kidney international

authors： Sorribas V,Lötscher M,Loffing J,Biber J,Kaissling B,Murer H,Levi M

更新日期：1996-09-01 00:00:00

abstract：:Fibrates, the PPAR alpha ligand-like compounds increase the expression of proximal tubule liver fatty acid binding protein (L-FABP) and significantly decrease cisplatin-induced acute kidney injury. To study whether the bezafibrate-mediated upregulation of renal L-FABP was involved in this cytoprotective effect we trea...

journal_title：Kidney international

authors： Negishi K,Noiri E,Maeda R,Portilla D,Sugaya T,Fujita T

更新日期：2008-06-01 00:00:00

abstract：:Freeze-fracture and thin-section electron microscopy and morphometry were used to characterize further the response of the rat medullary collecting duct to potassium depletion. In freeze-fracture replicas, principal cells and intercalated cells were identified based on the assumption that intercalated cells possess a ...

journal_title：Kidney international

authors： Stetson DL,Wade JB,Giebisch G

更新日期：1980-01-01 00:00:00

abstract：:Using a combination of intra-operative digital photography and micro-biopsy we measured renal cortical and papillary changes in five patients with primary hyperparathyroidism and abundant calcium phosphate kidney stones. Major tissue changes were variable papillary flattening and retraction, dilation of the ducts of B...

journal_title：Kidney international

authors： Evan AE,Lingeman JE,Coe FL,Miller NL,Bledsoe SB,Sommer AJ,Williams JC,Shao Y,Worcester EM

更新日期：2008-07-01 00:00:00