Morphologic alterations in the rat medullary collecting duct following potassium depletion.

abstract：:Although case reports link proton-pump inhibitor (PPI) use and hypomagnesemia, no large-scale studies have been conducted. Here we examined the serum magnesium concentration and the likelihood of hypomagnesemia (<1.6 mg/dl) with a history of PPI or histamine-2 receptor antagonist used to reduce gastric acid, or use of...

journal_title：Kidney international

authors： Danziger J,William JH,Scott DJ,Lee J,Lehman LW,Mark RG,Howell MD,Celi LA,Mukamal KJ

更新日期：2013-04-01 00:00:00

abstract：:Early kidney transplant results in children lagged behind corresponding results in adults. Multiple advances over the past three decades have eliminated that gap. Most children now have equal or superior long-term allograft and patient survival compared with adult recipients. However, black children in the United Stat...

journal_title：Kidney international

authors： Dharnidharka VR,Seifert ME

更新日期：2015-03-01 00:00:00

abstract：:Primary hyperoxaluria is characterized by severe urolithiasis, nephrocalcinosis, and early renal failure. As treatment options are scarce, we aimed for a new therapeutic tool using colonic degradation of endogenous oxalate by Oxalobactor formigenes. Oxalobacter was orally administered for 4 weeks as frozen paste (IxOC...

journal_title：Kidney international

authors： Hoppe B,Beck B,Gatter N,von Unruh G,Tischer A,Hesse A,Laube N,Kaul P,Sidhu H

更新日期：2006-10-01 00:00:00

abstract：UNLABELLED:Compensatory renal growth in uninephrectomized adult mice is growth hormone dependent. BACKGROUND:Growth hormone (GH) and insulin-like growth factors (IGFs) have been implicated as pathogenic factors in compensatory renal growth (CRG) following unilateral nephrectomy in rodents. CRG in adult rats has been s...

journal_title：Kidney international

authors： Flyvbjerg A,Bennett WF,Rasch R,van Neck JW,Groffen CA,Kopchick JJ,Scarlett JA

更新日期：1999-12-01 00:00:00

abstract：:Recent insights have defined the central role of podocytes both in rare genetic diseases and as a general determinant of the progression of human glomerular diseases. In a recent issue of Nature, Weavers et al. described a podocyte-like cell type in Drosophila, the nephrocyte, that closely resembles mammalian podocyte...

journal_title：Kidney international

authors： Simons M,Huber TB

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Epithelial cells in the renal inner medulla accumulate osmolytes such as betaine to maintain normal cell volume during prolonged extracellular hypertonic stress. Betaine accumulation is the result of activation of transcription of the BGT1 transporter gene followed by increased betaine transport. METHODS:We...

journal_title：Kidney international

authors： Basham JC,Chabrerie A,Kempson SA

更新日期：2001-06-01 00:00:00

abstract：:The remnant kidney model was produced in mice by unilateral nephrectomy and partial infarction of the remaining kidney. Control mice underwent laparotomy only. The mice were studied for up to 44 weeks. No quantitative differences were noted in systolic arterial pressure, proteinuria, or histopathology between control ...

journal_title：Kidney international

authors： Kren S,Hostetter TH

更新日期：1999-07-01 00:00:00

abstract：:To determine the effect of an acute load of potassium on potassium reabsorption by the loop of Henle in chronic renal failure, the right kidney was removed and branches of the left renal artery were ligated in 17 rats. One week later and after 2 days of a potassium-free diet, rats were studied before (period 1) and af...

journal_title：Kidney international

authors： Milanes CL,Jamison RL

更新日期：1985-06-01 00:00:00

abstract：BACKGROUND:Acute renal failure (ARF) has a high morbidity and mortality. Many therapies have worked in animals but were unsuccessful in clinical trials. The inability to diagnose ARF early may have impaired the success of these trials. METHOD:We screened a subtraction library to search for potential disease markers th...

journal_title：Kidney international

authors： Muramatsu Y,Tsujie M,Kohda Y,Pham B,Perantoni AO,Zhao H,Jo SK,Yuen PS,Craig L,Hu X,Star RA

更新日期：2002-11-01 00:00:00

abstract：:The primary hyperoxalurias are diseases of overproduction of oxalate. The immediate precursor of oxalate is glyoxylate. Metabolism of hydroxyproline, derived from collagen turnover or the diet, appears to be a major source of glyoxylate, and a potential target for a therapeutic strategy of substrate depletion. ...

journal_title：Kidney international

authors： Coulter-Mackie MB

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Proteoglycans are integral components of the mesangial matrix and glomerular permeability barrier. Recent studies have shown that changes in glomerular proteoglycan expression may play a major role in the pathogenesis of renal disease. Steroid hormones are used as first-choice therapy for the treatment of gl...

journal_title：Kidney international

authors： Kuroda M,Sasamura H,Shimizu-Hirota R,Mifune M,Nakaya H,Kobayashi E,Hayashi M,Saruta T

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:In the rat cortical thick ascending limb (CTAL), intracellular Ca2+ ([Ca2+]i) responses to angiotensin II (Ang II) and angiotensin III (Ang III) were mediated by the Ang II subtype 1A receptor (AT1A-R), whereas the arginine vasopressin (AVP)-dependent cAMP accumulation involved the vasopressin receptor type ...

journal_title：Kidney international

authors： Hus-Citharel A,Marchetti J,Corvol P,Llorens-Cortes C

更新日期：2002-06-01 00:00:00

abstract：:A high frequency (25%) of anti-hepatitis C virus (HCV) antibodies is observed in French hemodialyzed patients; this is associated with detectable viremia in 85% and results in chronic hepatitis in more than 90%. We conducted a pilot study to examine the tolerance and efficacy of alpha-2b Interferon therapy upon HCV in...

journal_title：Kidney international

authors： Pol S,Thiers V,Carnot F,Zins B,Romeo R,Berthelot P,Bréchot C

更新日期：1995-05-01 00:00:00

abstract：:Insulin resistance has been associated with kidney disease even in the absence of diabetes; however, pathways linking insulin resistance to kidney disease are unclear. The purpose of this study was to determine if transforming growth factor (TGF)-beta1, a key cytokine associated with kidney disease, responds to circul...

journal_title：Kidney international

authors： Huan Y,DeLoach S,Daskalakis C,Dunn SR,Sharma K,Falkner B

更新日期：2010-08-01 00:00:00

abstract：:It is no a secret that we are confronted by an alarmingly increasing number of patients with progressive renal disease. There is ample evidence for the notion that angiotensin II (Ang II) is a major culprit in progression. The vasopeptide Ang II turned out to have also multiple nonhemodynamic pathophysiologic actions ...

journal_title：Kidney international

authors： Wolf G,Ritz E

更新日期：2005-03-01 00:00:00

abstract：:Higher diet-dependent nonvolatile acid load is associated with faster chronic kidney disease (CKD) progression, but most studies have used estimated acid load or measured only components of the gold standard, net acid excretion (NAE). Here we measured NAE as the sum of urine ammonium and titratable acidity in 24-hour ...

journal_title：Kidney international

authors： Scialla JJ,Asplin J,Dobre M,Chang AR,Lash J,Hsu CY,Kallem RR,Hamm LL,Feldman HI,Chen J,Appel LJ,Anderson CA,Wolf M,Chronic Renal Insufficiency Cohort Study Investigators.

更新日期：2017-01-01 00:00:00

abstract：:The nature of the light chains in mesangial IgA deposits and serum IgA was studied in patients with IgA nephropathy. Immunofluorescence (IF) studies using murine monoclonal antibodies, rabbit and goat anti-human monospecific antisera were performed in kidney sections from 15 IgA nephritic patients with only IgA isotyp...

journal_title：Kidney international

authors： Lai KN,Chui SH,Lai FM,Lam CW

更新日期：1988-02-01 00:00:00

abstract：:Pathologic calcification is a significant cause of increased morbidity and mortality in patients with chronic kidney disease. The precise mechanisms of ectopic calcification are not fully elucidated, but it is known to be caused by an imbalance of procalcific and anticalcific factors. In the chronic kidney disease pop...

journal_title：Kidney international

authors： Paloian NJ,Leaf EM,Giachelli CM

更新日期：2016-05-01 00:00:00

abstract：:Spontaneous polycystic kidney and liver disease in an inbred herd of Springbok (Antidorcas marsupialis) was studied by light microscopy, transmission electron microscopy, and microdissection. Springbok are a small species of gazelle of the family Bovidae native to South Africa. Since 1976, 18% of all live calves born ...

journal_title：Kidney international

authors： Iverson WO,Fetterman GH,Jacobson ER,Olsen JH,Senior DF,Schobert EE

更新日期：1982-08-01 00:00:00

abstract：:Residual kidney function (RKF) may confer a variety of benefits to patients on maintenance dialysis. RKF provides continuous clearance of middle molecules and protein-bound solutes. Whereas the definition of RKF varies across studies, interdialytic urine volume may emerge as a pragmatic alternative to more cumbersome ...

journal_title：Kidney international

authors： Mathew AT,Fishbane S,Obi Y,Kalantar-Zadeh K

更新日期：2016-08-01 00:00:00

abstract：:Hypoxia in the embryo is a frequent cause of intra-uterine growth retardation, low birth weight, and multiple organ defects. In the kidney, this can lead to low nephron endowment, predisposing to chronic kidney disease and arterial hypertension. A key component in cellular adaptation to hypoxia is the hypoxia-inducibl...

journal_title：Kidney international

authors： Kobayashi H,Liu J,Urrutia AA,Burmakin M,Ishii K,Rajan M,Davidoff O,Saifudeen Z,Haase VH

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:The debate on the association between nonphenacetin-containing combined analgesics and renal disease has lasted for several years. METHOD:A peer review committee of scientists, selected jointly by the regulatory authorities of Germany, Switzerland, and Austria and the pharmaceutical industry was asked to cr...

journal_title：Kidney international

authors： Feinstein AR,Heinemann LA,Curhan GC,Delzell E,Deschepper PJ,Fox JM,Graf H,Luft FC,Michielsen P,Mihatsch MJ,Suissa S,Van Der Woude F,Willich S

更新日期：2000-12-01 00:00:00

abstract：:We studied binding and degradation of vasoactive intestinal peptide (VIP) by highly purified brush border and basolateral membranes from rabbit kidney cortex. Brush border and basolateral membranes were capable of 73 and 49% degradation of VIP after 20 minutes, and the degradation was totally prevented by bacitracin. ...

journal_title：Kidney international

authors： Kniaz D,Pahlavan P,Valaitis D,Arruda JA

更新日期：1991-02-01 00:00:00

abstract：:Vascular calcification (VC) is an important reason for the high burden of vascular disease among chronic dialysis patients. Chronic kidney disease (CKD) is associated with increased promoters and decreased inhibitors of VC. The circulating levels of fetuin-A, a well-described inhibitor of calcification, regulate the c...

journal_title：Kidney international

authors： Mehrotra R

更新日期：2007-07-01 00:00:00

abstract：:Space medicine and new technology such as magnetic resonance imaging of tissue sodium stores (23NaMRI) have changed our understanding of human sodium homeostasis and pathophysiology. It has become evident that body sodium comprises 3 main components. Two compartments have been traditionally recognized, namely one that...

journal_title：Kidney international

authors： Canaud B,Kooman J,Selby NM,Taal M,Francis S,Kopperschmidt P,Maierhofer A,Kotanko P,Titze J

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:In the United States, infection is second to cardiovascular disease as the leading cause of death in patients with end-stage renal disease (ESRD), and septicemia accounts for more than 75% of this category. This increased susceptibility to infections is partly due to uremia, old age, and comorbid conditions....

journal_title：Kidney international

authors： Sarnak MJ,Jaber BL

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Genetic polymorphisms of the angiotensinogen (AGT) and angiotensin-converting enzyme (ACE) genes are associated with increased risk of hypertension and left ventricular hypertrophy (LVH) in hypertensive subjects. However, the extent to which these polymorphisms are related to LVH and remodeling in dialysis p...

journal_title：Kidney international

authors： Wang AY,Chan JC,Wang M,Poon E,Lui SF,Li PK,Sanderson J

更新日期：2003-05-01 00:00:00

abstract：:Electron microprobe analysis on freeze-dried cryosections was used to determine the effect of the loop diuretics torasemide and furosemide on intracellular electrolyte concentrations in individual cells of the outer and inner stripe of the outer medulla and on cell rubidium uptake, the latter a measure of basolateral ...

journal_title：Kidney international

authors： Beck FX,Sone M,Dörge A,Thurau K

更新日期：1992-10-01 00:00:00

abstract：:The incidence of acute kidney injury (AKI) is high in elderly people, and is difficult to prevent and treat. One of its major causes is renal ischemia-reperfusion injury (IRI). A young systemic environment may prevent the senescence of old organs. However, it is unknown whether a young milieu may reduce renal IRI in t...

journal_title：Kidney international

authors： Liu D,Lun L,Huang Q,Ning Y,Zhang Y,Wang L,Yin Z,Zhang Y,Xia L,Yin Z,Fu B,Cai G,Sun X,Chen X

更新日期：2018-08-01 00:00:00

abstract：:In summary, the three major segments of the collecting duct subserve three different functions in the urinary concentrating mechanism. The main function of the cortical collecting tubule is to raise the fractional solute contribution and absolute concentration of urea in fluid that it delivers to the outer medullary c...

journal_title：Kidney international

authors： Kokko JP

更新日期：1987-02-01 00:00:00