Compensatory renal growth in uninephrectomized adult mice is growth hormone dependent.

abstract：:Acute phosphate nephropathy (APhN) is a clinical pathological entity characterized by acute and subsequent chronic renal failure following exposure to oral sodium phosphate (OSP) bowel purgatives. Renal biopsy findings include acute and chronic tubular injury with prominent tubular and interstitial calcium phosphate d...

journal_title：Kidney international

authors： Markowitz GS,Perazella MA

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:The benefit of the potent chemotherapeutic agent cisplatin in treating neoplasms is limited by nephrotoxicity. We tested the hypothesis that CD54 [intercellular adhesion molecule-1 (ICAM-1)] is an important mediator in cisplatin-mediated renal failure. METHODS:The effect of a monoclonal anti-CD54 antibody w...

journal_title：Kidney international

authors： Kelly KJ,Meehan SM,Colvin RB,Williams WW,Bonventre JV

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Metabolic acidosis caused by increased rates of fixed acid production is associated with increased urinary excretion of Ca and negative Ca balances. Metabolic acidosis caused by a reduced capacity of the kidneys to excrete acid contributes to the development of bone disease in the course of chronic renal fai...

journal_title：Kidney international

authors： Lemann J Jr,Adams ND,Wilz DR,Brenes LG

更新日期：2000-09-01 00:00:00

abstract：:Mutations in the inverted formin 2 gene (INF2) have recently been identified as the most common cause of autosomal dominant focal and segmental glomerulosclerosis (FSGS). To quantify the contribution of various genes contributing to FSGS, we sequenced INF2 where all mutations have previously been described (exons 2 to...

journal_title：Kidney international

authors： Barua M,Brown EJ,Charoonratana VT,Genovese G,Sun H,Pollak MR

更新日期：2013-02-01 00:00:00

abstract：:Because of high risk of cardiovascular disease, patients with chronic kidney disease may benefit from cholesterol-lowering therapy beyond statins. A cost-effectiveness analysis of adding ezetimibe to high-dose statins for primary cardiovascular disease prevention in patients with non-dialysis-dependent chronic kidney ...

journal_title：Kidney international

authors： Walther CP,Erickson KF

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:It is known that inhibition of cyclooxygenase (COX) impairs the renal actions of loop diuretics. Recently, we found that cyclosporine A (CsA) inhibits renal COX-2 expression. Therefore, we examined the interferences of CsA with the renal actions of loop diuretics. METHOD:We investigated the renal effects of...

journal_title：Kidney international

authors： Höcherl K,Kees F,Krämer BK,Kurtz A

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Macrophage (Mphi) infiltration may contribute to chronic renal injury. We therefore sought to examine the expression of genes associated with Mphi recruitment in the rat remnant kidney model. METHODS:Male Munich Wistar rats underwent 5/6 nephrectomy or sham operation (SHM, N = 18) and received no treatment ...

journal_title：Kidney international

authors： Taal MW,Zandi-Nejad K,Weening B,Shahsafaei A,Kato S,Lee KW,Ziai F,Jiang T,Brenner BM,MacKenzie HS

更新日期：2000-10-01 00:00:00

abstract：:Neutrophil gelatinase-associated lipocalin (Ngal, 24p3, SIP24, lipocalin 2, or siderocalin) was originally purified from neutrophils, but with unknown function. Recently, it was identified that Ngal activates nephron formation in the embryonic kidney, is rapidly and massively induced in renal failure and possesses kid...

journal_title：Kidney international

authors： Mori K,Nakao K

更新日期：2007-05-01 00:00:00

abstract：:Substrate oxidation was assessed by measuring 14CO2 production from 14C-labeled substrates in proximal convoluted tubules (PCT), medullary (MTAL), and cortical (CTAL) thick ascending limb of Henle, nephron segments rich in mitochondria and characterized by active solute transport. PCT, MTAL, and CTAL were dissected fr...

journal_title：Kidney international

authors： Klein KL,Wang MS,Torikai S,Davidson WD,Kurokawa K

更新日期：1981-07-01 00:00:00

abstract：:Experimental studies have demonstrated the cardinal role played by the mononuclear phagocyte system in the removal of antigen-antibody complexes. To assess the functional capacity of phagocytes in patients with renal disease, 33 normal subjects, 10 patients with mesangial proliferative glomerulonephritis, 8 patients w...

journal_title：Kidney international

authors： Ooi YM,Ooi BS

更新日期：1983-06-01 00:00:00

abstract：:Copy number variations associate with different developmental phenotypes and represent a major cause of congenital anomalies of the kidney and urinary tract (CAKUT). Because rare pathogenic copy number variations are often large and contain multiple genes, identification of the underlying genetic drivers has proven to...

journal_title：Kidney international

authors： Westland R,Verbitsky M,Vukojevic K,Perry BJ,Fasel DA,Zwijnenburg PJ,Bökenkamp A,Gille JJ,Saraga-Babic M,Ghiggeri GM,D'Agati VD,Schreuder MF,Gharavi AG,van Wijk JA,Sanna-Cherchi S

更新日期：2015-12-01 00:00:00

abstract：:The inner medullary collecting duct (IMCD) is a major target site of atrial natriuretic peptide (ANP) for diuresis and natriuresis, and it is in a hypertonic condition made by the renal countercurrent multiplication system. We investigated the effects of hyperosmolality on ANP-stimulated cGMP generation in IMCD and gl...

journal_title：Kidney international

authors： Shinohara M,Nonoguchi H,Ujiie K,Terada Y,Owada A,Tomita K,Marumo F

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Children with chronic renal failure (CRF) exhibit growth retardation and a disturbed growth hormone/insulin-like growth factor-I (GH/IGF-I) axis. Treatment of children with CRF with GH or GH/IGF-I can partially restore linear growth. The molecular basis for decreased longitudinal growth is not known but may ...

journal_title：Kidney international

authors： Edmondson SR,Baker NL,Oh J,Kovacs G,Werther GA,Mehls O

更新日期：2000-07-01 00:00:00

abstract：:An expression profile is a list based on a large scale sequencing of 1000 cDNA clones, showing the expressed genes and the abundance of their transcripts in a given cell or tissue (Okubo K et al: Nature Genet 2:173, 1992). We constructed an expression profile of mouse renal proximal tubules (PT) carefully isolated by ...

journal_title：Kidney international

authors： Takenaka M,Imai E,Kaneko T,Ito T,Moriyama T,Yamauchi A,Hori M,Kawamoto S,Okubo K

更新日期：1998-03-01 00:00:00

abstract：:Circulating parathyroid hormone (PTH) shows a complex relationship with hard outcomes in subjects with chronic kidney disease (CKD). Moreover, intervention studies directly targeting PTH failed to yield unequivocal results. Disturbed PTH metabolism, posttranslational modifications of PTH, and end-organ hyporesponsiven...

journal_title：Kidney international

authors： Evenepoel P,Bover J,Ureña Torres P

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Unilateral ureteral obstruction (UUO) leads to interstitial fibrosis of the obstructed kidney, and TGF-beta is considered to play an important role in this fibrotic process. Smad7 has been recently identified as an antagonist of TGF-beta signaling. To investigate whether this novel molecule can be exploited ...

journal_title：Kidney international

authors： Terada Y,Hanada S,Nakao A,Kuwahara M,Sasaki S,Marumo F

更新日期：2002-01-01 00:00:00

abstract：:Renal sodium reabsorption is a key determinant of final urine concentration. Our aim was to determine whether differences existed between aged and young rats in their response to water restriction with regard to the regulation of abundance of any of the major distal renal sodium transporter proteins. Male Fisher 344 x...

journal_title：Kidney international

authors： Tian Y,Riazi S,Khan O,Klein JD,Sugimura Y,Verbalis JG,Ecelbarger CA

更新日期：2006-01-01 00:00:00

abstract：:The nature of the light chains in mesangial IgA deposits and serum IgA was studied in patients with IgA nephropathy. Immunofluorescence (IF) studies using murine monoclonal antibodies, rabbit and goat anti-human monospecific antisera were performed in kidney sections from 15 IgA nephritic patients with only IgA isotyp...

journal_title：Kidney international

authors： Lai KN,Chui SH,Lai FM,Lam CW

更新日期：1988-02-01 00:00:00

abstract：:Uracil ribonucleotide-sugars and aminosugars are required for glomerular basement membrane (GBM) biosynthesis. Since these nucleotides are metabolic derivatives of uridine 5'-triphosphate (UTP), we have studied the cellular pools of uridine 5'-diphosphoglucose (UDPG), uridine 5'-diphosphoglucuronic acid (UDPGA), uridi...

journal_title：Kidney international

authors： Cortes P,Dumler F,Levin NW

更新日期：1986-07-01 00:00:00

abstract：:The International Pediatric Peritonitis Registry (IPPR) was created to assess and evaluate the validity of the pediatric peritonitis treatment guidelines issued by the International Society for Peritoneal Dialysis. The study by Schaefer et al., one of the first to emerge from the IPPR, describes regional variability i...

journal_title：Kidney international

authors： Teitelbaum I

更新日期：2007-12-01 00:00:00

abstract：:To evaluate the effect of continuous ambulatory peritoneal dialysis (CAPD) on the anemia of endstage renal disease, serial measurements of red cell mass and other hematological parameters were performed in 34 patients. Twenty-five patients were measured at the start and at 6 months (group 1), 13 at the start, at 6 and...

journal_title：Kidney international

authors： De Paepe MB,Schelstraete KH,Ringoir SM,Lameire NH

更新日期：1983-05-01 00:00:00

abstract：:We studied the effect of three antihypertensive drugs on the growth of glomeruli in four- to five-week-old Munich-Wistar rats (N = 24), which were undergoing rapid maturation processes. Young rats were given an angiotensin converting enzyme inhibitor (ACEI, enalapril, 50 mg/liter drinking water), verapamil (50 mg/lite...

journal_title：Kidney international

authors： Fogo A,Yoshida Y,Yared A,Ichikawa I

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:While tubular cell death is a characteristic of acute renal failure (ARF), the molecular mechanisms that modulate this cell death are unclear. Cell fate in acute renal failure hinges on a balance of survival and mortality factors in a changing environment. We further explored this issue by studying selected ...

journal_title：Kidney international

authors： Ortiz A,Lorz C,Catalán MP,Danoff TM,Yamasaki Y,Egido J,Neilson EG

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Chronic cyclosporine (CsA) nephrotoxicity is characterized by interstitial fibrosis and afferent arteriolar hyalinosis. L-arginine (L-Arg), the substrate for nitric oxide (NO) synthase and N-nitro-L-arginine-methyl ester (L-NAME), the NO synthase inhibitor, were shown to modulate acute CsA nephrotoxicity. Ho...

journal_title：Kidney international

authors： Shihab FS,Yi H,Bennett WM,Andoh TF

更新日期：2000-09-01 00:00:00

abstract：:In seven patients on maintenance hemodialysis, de novo recurrent renal stone formation was observed. In all patients, the underlying disease was glomerulonephritis, with or without the nephrotic syndrome. All patients had considerable persistent proteinuria. The stones consisted predominantly of protein, as revealed b...

journal_title：Kidney international

authors： Bommer J,Ritz E,Tschöpe W,Waldherr R,Gebhardt M

更新日期：1979-12-01 00:00:00

abstract：:The possibility that the rabbit collecting tubule is heterogeneous with respect to electrical and morphologic properties was examined in isolated segments. Collecting tubules from rabbits treated with desoxycorticosterone acetate were dissected from various locations within the cortex and outer medulla, and the transe...

journal_title：Kidney international

authors： Stokes JB,Tisher CC,Kokko JP

更新日期：1978-12-01 00:00:00

abstract：BACKGROUND:Renal disease is commonly associated with hyperlipidemia and correlates with glomerular accumulation of atherogenic lipoproteins, for example, lipoprotein(a) [Lp(a)], and mesangial hypercellularity. Specific binding of Lp(a) to mesangial cells and induction of c-myc and c-fos expression has been demonstrated...

journal_title：Kidney international

authors： Mondorf UF,Piiper A,Herrero M,Olbrich HG,Bender M,Gross W,Scheuermann E,Geiger H

更新日期：1999-04-01 00:00:00

abstract：:In rats undergoing renal mass reduction (RMR) oral supplementation with the nitric oxide (NO) precursor L-arginine increases glomerular filtration rate and ameliorates signs of glomerular injury, suggesting that chronic renal failure in the rats is a condition of low NO formation in the kidney. On the contrary, data a...

journal_title：Kidney international

authors： Aiello S,Noris M,Todeschini M,Zappella S,Foglieni C,Benigni A,Corna D,Zoja C,Cavallotti D,Remuzzi G

更新日期：1997-07-01 00:00:00

abstract：:Vascular calcification is prevalent in dialysis patients and is associated with a high burden of cardiovascular disease. Fetuin-A is a potent inhibitor of vascular calcification, but the precise mechanism by which it mediates vascular calcification in uremia is unclear. Matsui and colleagues demonstrate that circulati...

journal_title：Kidney international

authors： Komaba H,Fukagawa M

更新日期：2009-05-01 00:00:00

abstract：:Progranulin (PGRN), an autocrine growth factor, has multiple physiological functions and is widely involved in the pathogenesis of many types of diseases. The pivotal anti-inflammatory function of PGRN in rheumatoid arthritis encouraged us to examine the role of PGRN in acute kidney injury (AKI). We found that levels ...

journal_title：Kidney international

authors： Zhou M,Tang W,Fu Y,Xu X,Wang Z,Lu Y,Liu F,Yang X,Wei X,Zhang Y,Liu J,Geng X,Zhang C,Wan Q,Li N,Yi F

更新日期：2015-05-01 00:00:00