De novo pyrimidine nucleotide biosynthesis in isolated rat glomeruli.

abstract：BACKGROUND:Interleukin-6 (IL-6) exerts its actions through a cell-surface receptor system that consists of two transmembrane subunits: the IL-6 binding glycoprotein gp 80 (IL-6R) and the signal-transducing component (gp 130). Soluble forms of the IL-6R (sIL-6R) are generated by shedding of the membrane-associated prote...

journal_title：Kidney international

authors： Memoli B,Postiglione L,Cianciaruso B,Bisesti V,Cimmaruta C,Marzano L,Minutolo R,Cuomo V,Guida B,Andreucci M,Rossi G

更新日期：2000-07-01 00:00:00

abstract：:Progression of diabetic nephropathy appears directly related to renal tubulointerstitial injury, but the involved genes are incompletely delineated. To identify such genes, DNA microarray analysis was performed with RNA from renal proximal tubules (RPTs) of streptozotocin-induced diabetic Wistar rats, spontaneously di...

journal_title：Kidney international

authors： Hsieh TJ,Chen R,Zhang SL,Liu F,Brezniceanu ML,Whiteside CI,Fantus IG,Ingelfinger JR,Hamet P,Chan JS

更新日期：2006-03-01 00:00:00

abstract：:To determine the prognosis and risk factors for ischemic heart disease in chronic uremia, a cohort of 432 dialysis patients were followed prospectively from start of dialysis therapy until death or renal transplantation. Baseline demographic, clinical and echocardiographic data were obtained. After the initiation of d...

journal_title：Kidney international

authors： Parfrey PS,Foley RN,Harnett JD,Kent GM,Murray D,Barre PE

更新日期：1996-05-01 00:00:00

abstract：:The safety of dietary protein and phosphorous restriction was evaluated in the Modification of Diet in Renal Disease (MDRD) Study. In Study A, 585 patients with a glomerular filtration rate (GFR) of 25 to 55 ml/min/1.73 m2 were randomly assigned to a usual-protein diet (1.3 g/kg/day) or a low-protein diet (0.58 g/kg/d...

journal_title：Kidney international

authors： Kopple JD,Levey AS,Greene T,Chumlea WC,Gassman JJ,Hollinger DL,Maroni BJ,Merrill D,Scherch LK,Schulman G,Wang SR,Zimmer GS

更新日期：1997-09-01 00:00:00

abstract：:Albuminuria and a reduced glomerular filtration rate are conventional predictors of a future decline in kidney function in patients with type 2 diabetes mellitus. Using a nested case-control study we assessed whether circulating transforming growth factor-β1 (TGF-β1) and bone morphogenetic protein-7 (BMP-7) levels mor...

journal_title：Kidney international

authors： Wong MG,Perkovic V,Woodward M,Chalmers J,Li Q,Hillis GS,Yaghobian Azari D,Jun M,Poulter N,Hamet P,Williams B,Neal B,Mancia G,Cooper M,Pollock CA

更新日期：2013-02-01 00:00:00

abstract：:To investigate whether alpha (alpha)-adrenoceptor agonists have a stimulatory effect on the expression of the angiotensinogen (Ang) gene in opossum kidney (OK) cells, we used OK 27 cells with a fusion gene containing the 5'-flanking regulatory sequence of the rat angiotensinogen gene fused with a human growth hormone ...

journal_title：Kidney international

authors： Wang TT,Lachance S,Delalandre A,Carrière S,Chan JS

更新日期：1995-07-01 00:00:00

abstract：:When patients develop acute kidney injury, a small fraction of them will develop end-stage renal disease later. The severity of renal impairment in the remaining patients is uncertain because studies have not carefully examined renal function over time or the precise timing of entry into a late stage of chronic kidney...

journal_title：Kidney international

authors： Amdur RL,Chawla LS,Amodeo S,Kimmel PL,Palant CE

更新日期：2009-11-01 00:00:00

abstract：:Progressive renal vascular sclerosis is a key feature of chronic kidney disease (CKD). Adiponectin, an adipokine with potent anti-inflammatory and antiatherosclerotic properties, is associated with insulin resistance, type II diabetes and cardiovascular disease. In this study, we evaluated the predictive value of adip...

journal_title：Kidney international

authors： Kollerits B,Fliser D,Heid IM,Ritz E,Kronenberg F,MMKD Study Group.

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Recent clinical trials of mycophenolate mofetil (MMF) in chronic allograft nephropathy (CAN) demonstrated that the dose of cyclosporine A (CsA) is one of the critical factors in determining graft function in CAN, but the effect of MMF on chronic CsA nephropathy is undetermined. We undertook this study to eva...

journal_title：Kidney international

authors： Yang CW,Ahn HJ,Kim WY,Li C,Kim HW,Choi BS,Cha JH,Kim YS,Kim J,Bang BK

更新日期：2002-07-01 00:00:00

abstract：:Substantial evidence implicates impaired renal excretion of sodium as the major culprit in the pathogenesis of hypertension. The key question is: How does the impairment of Na+ excretion lead to increased peripheral vascular resistance and elevation of the blood pressure? Here we describe the evidence that elevated le...

journal_title：Kidney international

authors： Blaustein MP

更新日期：1996-06-01 00:00:00

abstract：:Renal blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) is a noninvasive fast technique to characterize renal function. Here we evaluated the impact of renal function on the relaxation rate (R2(*)) in the cortex and medulla to provide baseline data for further use of renal BOLD-MRI. This parameter was...

journal_title：Kidney international

authors： Michaely HJ,Metzger L,Haneder S,Hansmann J,Schoenberg SO,Attenberger UI

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:The relationship between blood pressure (BP) and mortality in hemodialysis patients has remained controversial. Some studies suggested that a lower pre- or postdialysis BP was associated with excess mortality, while others showed poorer outcome in patients with uncontrolled hypertension. We conducted a multi...

journal_title：Kidney international

authors： Shoji T,Tsubakihara Y,Fujii M,Imai E

更新日期：2004-09-01 00:00:00

abstract：:Acute elevations in intracellular adenosine 3',5'-cyclic monophosphate (cAMP) concentrations are known to increase ionic chloride permeability in diverse tissues. To determine if chronic endogenous increases in cAMP are associated with sustained alterations in membrane ionic permeabilities, renal cortical brush border...

journal_title：Kidney international

authors： London RD,Lipkowitz MS,Abramson RG

更新日期：1992-08-01 00:00:00

abstract：:How much dialysis is required for optimal well-being and long-term survival? The Frequent Hemodialysis Network completed two prospective trials examining the effect of more frequent, short hours and, now, of nocturnal hemodialysis compared with standard thrice-weekly treatments. Whereas the short-hours trial reported ...

journal_title：Kidney international

authors： Davenport A

更新日期：2011-11-01 00:00:00

abstract：:Circulating parathyroid hormone (PTH) shows a complex relationship with hard outcomes in subjects with chronic kidney disease (CKD). Moreover, intervention studies directly targeting PTH failed to yield unequivocal results. Disturbed PTH metabolism, posttranslational modifications of PTH, and end-organ hyporesponsiven...

journal_title：Kidney international

authors： Evenepoel P,Bover J,Ureña Torres P

更新日期：2016-12-01 00:00:00

abstract：:Indomethacin has been used to lower proteinuria in human glomerular diseases with controversial results. The mechanism of indomethacin beneficial effects has not been established. A possible explanation is that indomethacin reduces proteinuria by inhibiting the synthesis of renal prostaglandins (PGs); however, appropr...

journal_title：Kidney international

authors： Zoja C,Benigni A,Verroust P,Ronco P,Bertani T,Remuzzi G

更新日期：1987-06-01 00:00:00

abstract：:Albumin is an acceptor of lysophosphatidylcholine (LPC), product of the lecithin:cholesterol acyl transferase (LCAT) reaction, and it has been suggested that low LCAT activity and reduced cholesterol esterification rate in patients with the nephrotic syndrome may be linked to depletion of albumin. Effects of low plasm...

journal_title：Kidney international

authors： Joles JA,Willekes-Koolschijn N,Scheek LM,Koomans HA,Rabelink TJ,van Tol A

更新日期：1994-07-01 00:00:00

abstract：:Progressive glomerulonephritis and attendant end-stage renal disease (ESRD) result from antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. The optimum time of kidney transplantation in patients with ESRD due to ANCA-associated vasculitis (AAV) and the risk of renal or nonrenal recurrence of vasculitis a...

journal_title：Kidney international

authors： Gera M,Griffin MD,Specks U,Leung N,Stegall MD,Fervenza FC

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Proteomic techniques have recently become available for large-scale protein analysis. The utility of these techniques in identification of urinary proteins is poorly defined. We constructed a proteome map of normal human urine as a reference protein database by using two differential fractionated techniques ...

journal_title：Kidney international

authors： Thongboonkerd V,McLeish KR,Arthur JM,Klein JB

更新日期：2002-10-01 00:00:00

abstract：:Insulin and growth factors activate the phosphatidylinositide-3-kinase pathway, leading to stimulation of several kinases including serum- and glucocorticoid-inducible kinase isoform SGK3, a transport regulating kinase. Here, we explored the contribution of SGK3 to the regulation of renal tubular phosphate transport. ...

journal_title：Kidney international

authors： Bhandaru M,Kempe DS,Rotte A,Capuano P,Pathare G,Sopjani M,Alesutan I,Tyan L,Huang DY,Siraskar B,Judenhofer MS,Stange G,Pichler BJ,Biber J,Quintanilla-Martinez L,Wagner CA,Pearce D,Föller M,Lang F

更新日期：2011-07-01 00:00:00

abstract：:The erythropoietin analogs have been an important advance for the treatment of the anemia of kidney disease, resulting in reduced need for blood transfusion and improved quality of life. Recent studies, however, have indicated risks associated with targeting higher levels of hemoglobin (Hb). As a result, in March 2007...

journal_title：Kidney international

authors： Fishbane S,Nissenson AR

更新日期：2007-10-01 00:00:00

abstract：:Sodium depletion has a protective effect on target-organ damage in hypertension independent of blood pressure. Here we tested whether chronic dietary sodium restriction may prevent the development of renal alterations associated with insulin resistance by reducing the inflammatory and oxidant state. Rats were fed norm...

journal_title：Kidney international

authors： Oudot C,Lajoix AD,Jover B,Rugale C

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Assessment of mRNA levels has the potential to predict renal outcome. The objective of this study was to optimize several steps in the protocol for obtaining cDNA from routine clinical kidney biopsy material. METHODS:RNA integrity was compared between different methods for extraction of RNA, synthesis of cD...

journal_title：Kidney international

authors： Roos-van Groningen MC,Eikmans M,Baelde HJ,de Heer E,Bruijn JA

更新日期：2004-01-01 00:00:00

abstract：:We present a new hypothesis to explain the development of salt-dependent hypertension in humans. We propose that hypertension has two phases: an early phase in which elevations in blood pressure (BP) are mainly episodic and are mediated by a hyperactive sympathetic nervous or renin-angiotensin system, and a second pha...

journal_title：Kidney international

authors： Johnson RJ,Schreiner GF

更新日期：1997-11-01 00:00:00

abstract：:Polycystic kidney disease progresses more rapidly in men than in women. To investigate the basis for this sexual dimorphism, we exposed Madin-Darby canine kidney (MDCK) cells grown on collagen-coated cell culture inserts to control media, or to estradiol or testosterone (1 nM-1 microM). Compared to control and estradi...

journal_title：Kidney international

authors： Sandhu S,Silbiger SR,Lei J,Neugarten J

更新日期：1997-05-01 00:00:00

abstract：:The role of glutathione (GSH) in the preservation of renal function and the pathogenesis of renal injury has been investigated using the isolated perfused rat kidney as a model. In kidneys perfused for 80 min with 5 mM glucose as the only exogenous substrate, tissue GSH becomes depleted, renal function deteriorates, a...

journal_title：Kidney international

authors： Brezis M,Rosen S,Silva P,Epstein FH

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND:While metabolically generated oxidants are produced locally in experimental glomerular diseases, little is still known of their significance and the respective scavenger systems in human glomerular diseases. METHODS:Here we studied kidneys from patients with congenital nephrotic syndrome of the Finnish type...

journal_title：Kidney international

authors： Solin ML,Ahola H,Haltia A,Ursini F,Montine T,Roveri A,Kerjaschki D,Holthöfer H

更新日期：2001-02-01 00:00:00

abstract：:We report the stepwise application of the RIFLE classification in 155,624 admissions in the UK Intensive Care National Audit & Research Centre Case Mix Programme database. The assumptions required to define RIFLE and their relationship with renal replacement therapy (RRT) and ICU mortality were assessed. Previous repo...

journal_title：Kidney international

authors： Harris SK,Lewington AJ,Harrison DA,Rowan KM

更新日期：2015-08-01 00:00:00

abstract：:Polycystic renal disease was induced in rats by feeding 2-amino-4,5-diphenylthiazole. Tubular (TBM) and glomerular basement membranes (GBM) were purified and analyzed for possible structural changes that may be a factor in the development of the tubular dilations and cysts. Changes in the relative quantities of TBM po...

journal_title：Kidney international

authors： Butkowski RJ,Carone FA,Grantham JJ,Hudson BG

更新日期：1985-11-01 00:00:00

abstract：:A substantial body of evidence has accumulated linking an increased incidence of cardiovascular disease in patients with acute kidney injury (AKI), chronic kidney disease (CKD), and end-stage renal disease (ESRD). A multitude of novel risk factors related to decreased kidney function might interact with the renal and ...

journal_title：Kidney international

authors： Swaminathan S,Shah SV

更新日期：2011-09-01 00:00:00