Lipoprotein phospholipid composition and LCAT activity in nephrotic and analbuminemic rats.

abstract：:We have previously identified the engulfment and cell motility 1 (ELMO1) as a susceptibility gene for diabetic nephropathy. To elucidate the role of ELMO1 in the pathogenesis of chronic renal injury, we examined the expression of Elmo1 in the kidney of a rat model for chronic glomerulonephritis (uninephrectomy plus an...

journal_title：Kidney international

authors： Shimazaki A,Tanaka Y,Shinosaki T,Ikeda M,Watada H,Hirose T,Kawamori R,Maeda S

更新日期：2006-11-01 00:00:00

abstract：:We previously reported that oxidative stress and renal tubular damage occur in chronic hyperoxaluric rats. However, the in vivo responses of renal epithelial cells after vitamin E administration and their correlations with calcium oxalate (CaOx) crystal formation have not been evaluated. Male Wistar rats received 0.75...

journal_title：Kidney international

authors： Huang HS,Chen J,Chen CF,Ma MC

更新日期：2006-08-01 00:00:00

abstract：:Circulating parathyroid hormone (PTH) shows a complex relationship with hard outcomes in subjects with chronic kidney disease (CKD). Moreover, intervention studies directly targeting PTH failed to yield unequivocal results. Disturbed PTH metabolism, posttranslational modifications of PTH, and end-organ hyporesponsiven...

journal_title：Kidney international

authors： Evenepoel P,Bover J,Ureña Torres P

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:In the United States, infection is second to cardiovascular disease as the leading cause of death in patients with end-stage renal disease (ESRD), and septicemia accounts for more than 75% of this category. This increased susceptibility to infections is partly due to uremia, old age, and comorbid conditions....

journal_title：Kidney international

authors： Sarnak MJ,Jaber BL

更新日期：2000-10-01 00:00:00

abstract：:In organ donation, the donor, recipient, and transplant team must all accept potential health risks to the donor and any uncertainties. To gauge these risks, we surveyed general altruism and risk-taking behaviors in 112 potential donors, 111 potential recipients, and 51 transplant professionals. Next, participants ind...

journal_title：Kidney international

authors： Young A,Karpinski M,Treleaven D,Waterman A,Parikh CR,Thiessen-Philbrook H,Yang RC,Garg AX

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Rats that recover from acute puromycin nephrosis later develop widespread glomerular and tubulointerstitial injury. The current study sought to identify structural changes present in the recovery phase that could precipitate progressive renal disease. METHODS:Stereologic studies were performed 10 weeks afte...

journal_title：Kidney international

authors： Rasch R,Nyengaard JR,Marcussen N,Meyer TW

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:alpha 2 Macroglobulin (alpha 2M), a protease inhibitor, is often increased in plasma of patients with the nephrotic syndrome. Although it has been speculated that synthesis is increased, no direct measurements have been performed. METHODS:alpha 2M synthesis in both normal subjects (N = 4) and nephrotic pati...

journal_title：Kidney international

authors： de Sain-van der Velden MG,Rabelink TJ,Reijngoud DJ,Gadellaa MM,Voorbij HA,Stellaard F,Kaysen GA

更新日期：1998-08-01 00:00:00

abstract：:Inflammation is a protective response to remove dangerous stimuli from the body. The multiprotein complex called the inflammasome regulates inflammation through the cleavage of proinflammatory cytokines into mature forms. Shahzad et al. unravel the importance of the Nlrp3 inflammasome, especially activated in glomerul...

journal_title：Kidney international

authors： Sakai N,Wada T

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Wegener's granulomatosis (WG) is a rare systemic autoimmune disease characterized by small-vessel vasculitis leading to organ damage and the presence of antineutrophil cytoplasmic autoantibodies (ANCAs). ANCAs were shown to be involved in the pathogenesis of the disease by increasing adhesion of polymorphonu...

journal_title：Kidney international

authors： Gencik M,Meller S,Borgmann S,Fricke H

更新日期：2000-12-01 00:00:00

abstract：:Atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura have traditionally been considered separate entities. Defects in the regulation of the complement alternative pathway occur in atypical hemolytic uremic syndrome, and defects in the cleavage of von Willebrand factor (VWF)-multimers arise in thr...

journal_title：Kidney international

authors： Noone DG,Riedl M,Pluthero FG,Bowman ML,Liszewski MK,Lu L,Quan Y,Balgobin S,Schneppenheim R,Schneppenheim S,Budde U,James P,Atkinson JP,Palaniyar N,Kahr WH,Licht C

更新日期：2016-07-01 00:00:00

abstract：:A morphometric technique is used to estimate the absolute and relative surface areas of the brush border microvilli and cell walls bordering lateral intercellular spaces. In isolated, perfused proximal tubule from rabbit, the luminal and lateral surfaces are equal in area. For proximal convoluted tubules (PCT) each su...

journal_title：Kidney international

authors： Welling LW,Welling DJ

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND:Tacrolimus has a narrow therapeutic window, and bioavailability is known to vary considerably between renal transplant recipients. Most centers still rely on measurement of trough levels, but there are conflicting reports on the correlation between tacrolimus trough levels and systemic exposure, as measured ...

journal_title：Kidney international

authors： Scholten EM,Cremers SC,Schoemaker RC,Rowshani AT,van Kan EJ,den Hartigh J,Paul LC,de Fijter JW

更新日期：2005-06-01 00:00:00

abstract：:Pain is a common complaint in patients with autosomal-dominant polycystic kidney disease, and a systematic approach is needed to differentiate the etiology of the pain and define an approach to management. A thorough history is the best clue to the multifactorial causes of the pain, superimposed upon an understanding ...

journal_title：Kidney international

authors： Bajwa ZH,Gupta S,Warfield CA,Steinman TI

更新日期：2001-11-01 00:00:00

abstract：:Congenital chloride diarrhea is due to mutations in the intestinal Cl(-)/HCO(3)(-) exchange (SLC26A3) which results in sodium chloride and fluid depletion leading to hypochloremic and hypokalemic metabolic alkalosis. Although treatment with sodium and potassium chloride offers protection from renal involvement in chil...

journal_title：Kidney international

authors： Wedenoja S,Ormälä T,Berg UB,Halling SF,Jalanko H,Karikoski R,Kere J,Holmberg C,Höglund P

更新日期：2008-10-01 00:00:00

abstract：:The adaptation of erythropoietin production to oxygen supply is determined by the abundance of hypoxia-inducible factor (HIF), a regulation that is induced by a prolyl hydroxylase. To identify cells that express HIF subunits (HIF-1alpha and HIF-2alpha) and erythropoietin, we treated Sprague-Dawley rats with the prolyl...

journal_title：Kidney international

authors： Paliege A,Rosenberger C,Bondke A,Sciesielski L,Shina A,Heyman SN,Flippin LA,Arend M,Klaus SJ,Bachmann S

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:The pathophysiology of hypertension in patients with chronic kidney disease (CKD) is largely attributed to positive sodium balance. It is unclear how loop diuretics affect fluid volume compartments, especially with respect to their antihypertensive effect. METHODS:Subjects with CKD were administered a singl...

journal_title：Kidney international

authors： Vasavada N,Agarwal R

更新日期：2003-11-01 00:00:00

abstract：:Pain was surveyed via structured interview and the McGill Pain Questionnaire in 53 dialysis and 27 transplant patients. Increased patient control over the dialysis procedure was not associated with a reduction in pain though perceived control may have been. Compliance with the dialysis regimen did not predict pain and...

journal_title：Kidney international

authors： Binik YM,Baker AG,Kalogeropoulos D,Devins GM,Guttmann RD,Hollomby DJ,Barré PE,Hutchison T,Prud'Homme M,McMullen L

更新日期：1982-06-01 00:00:00

abstract：:Obesity could affect associations between creatinine generation, estimated body surface area, and excretory burden, with effects on chronic kidney disease assessment. We therefore examined the impact of obesity on the performances of estimated glomerular filtration rate (eGFR), the urine albumin:creatinine ratio (ACR)...

journal_title：Kidney international

authors： Fotheringham J,Weatherley N,Kawar B,Fogarty DG,Ellam T

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus-associated nephropathy (HIVAN) has become the third leading cause of end-stage renal disease (ESRD) in African Americans, and is expected to grow exponentially. Highly active antiretroviral therapy (HAART) has significantly prolonged the survival of patients with HIV infection. D...

journal_title：Kidney international

authors： Kumar MS,Sierka DR,Damask AM,Fyfe B,McAlack RF,Heifets M,Moritz MJ,Alvarez D,Kumar A

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Long-term graft function is the result of multiple parameters, including both immune and non-immune components, which have a beneficial or detrimental potential. Among these, despite its frequency and theoretical interest (expression of "danger signals" in the graft itself), the effects of acute graft pyelon...

journal_title：Kidney international

authors： Giral M,Pascuariello G,Karam G,Hourmant M,Cantarovich D,Dantal J,Blancho G,Coupel S,Josien R,Daguin P,Méchineau S,Soulillou JP

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Little information is available regarding cardiac morbidity and mortality in children with end-stage renal disease. We sought to determine the incidence of cardiac morbidity and mortality in pediatric chronic dialysis patients. METHODS:Medicare incident pediatric (0 to 19 years) dialysis patients from 1991 ...

journal_title：Kidney international

authors： Chavers BM,Li S,Collins AJ,Herzog CA

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:The debate on the association between nonphenacetin-containing combined analgesics and renal disease has lasted for several years. METHOD:A peer review committee of scientists, selected jointly by the regulatory authorities of Germany, Switzerland, and Austria and the pharmaceutical industry was asked to cr...

journal_title：Kidney international

authors： Feinstein AR,Heinemann LA,Curhan GC,Delzell E,Deschepper PJ,Fox JM,Graf H,Luft FC,Michielsen P,Mihatsch MJ,Suissa S,Van Der Woude F,Willich S

更新日期：2000-12-01 00:00:00

abstract：:The kidneys excrete the daily acid load mainly by generating and excreting ammonia but the underlying molecular mechanisms are not fully understood. Here we evaluated the role of the inwardly rectifying potassium channel subunit Kir4.2 (Kcnj15 gene product) in this process. In mice, Kir4.2 was present exclusively at t...

journal_title：Kidney international

authors： Bignon Y,Pinelli L,Frachon N,Lahuna O,Figueres L,Houillier P,Lourdel S,Teulon J,Paulais M

更新日期：2020-02-01 00:00:00

abstract：:Our findings indicate that hypoaldosteronism occurs commonly (23/31 patients) in hyperkalemic patients with chronic renal insufficiency and that the deficiency of aldosterone contributes to the pathogenesis of the hyperkalemia. In most patients (83%), hypoaldosteronism could be accounted for by deficient renal secreti...

journal_title：Kidney international

authors： Schambelan M,Sebastian A,Biglieri EG

更新日期：1980-01-01 00:00:00

abstract：:The influence of transforming growth factor beta 1 (TGF-beta 1) and of dexamethasone on fibronectin (FN) synthesis of human renal tubular epithelial cells in culture (TEC) was studied. Cocultivation with TGF-beta 1 increased the steady state level of FN RNA within 24 to 48 hours. By PCR and Northern blotting it was fo...

journal_title：Kidney international

authors： Viedt C,Bürger A,Hänsch GM

更新日期：1995-12-01 00:00:00

abstract：:Levels of prepro epidermal growth factor (EGF) mRNA in renal cortical tissue and urinary EGF excretion have been determined during cisplatin and ischemia-induced acute renal failure in the rat. Northern analysis of polyadenylated RNAs of kidney cortical tissue showed diminished renal preproEGF mRNA in rats injected wi...

journal_title：Kidney international

authors： Safirstein R,Zelent AZ,Price PM

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Podocyte loss contributes to the development of glomerulosclerosis. Although podocytes have been detected in the urine in certain glomerular diseases, the viability of detached cells is not known. METHODS:Urine was collected from rats with experimental membranous nephropathy [passive Heymann nephritis (PHN)...

journal_title：Kidney international

authors： Petermann AT,Krofft R,Blonski M,Hiromura K,Vaughn M,Pichler R,Griffin S,Wada T,Pippin J,Durvasula R,Shankland SJ

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:The peritoneum is progressively denuded of its mesothelial cell monolayer in patients on continuous ambulatory peritoneal dialysis (CAPD). These alterations of the mesothelium cause membrane dysfunction and progressive peritoneal fibrosis. Integrins regulate cell motility and play an important role in wound ...

journal_title：Kidney international

authors： Tamura M,Osajima A,Nakayamada S,Anai H,Kabashima N,Kanegae K,Ota T,Tanaka Y,Nakashima Y

更新日期：2003-02-01 00:00:00

abstract：:Intravenous conjugated estrogens reduce the prolonged bleeding time in uremic patients and in a rat model of uremia. However, estrogens have major side effects related to their hormonal activity. We investigated whether a beta-resorcylic acid lactone, zeranol (a compound with close spatial similarity to estrogens but ...

journal_title：Kidney international

authors： Zoja C,Viganò G,Corna D,Salmona M,Remuzzi G,Garattini S

更新日期：1990-07-01 00:00:00

abstract：:Clofibrate, a peroxisome proliferator-activated receptor-alpha (PPAR alpha) agonist, increases renal tubular cytochrome P450 4a (Cyp4a) expression thereby increasing 20-hydroxyeicosatetraenoic acid (20-HETE) production. To determine if clofibrate affects blood pressure regulation we studied mice with DOCA-salt induced...

journal_title：Kidney international

authors： Zhou Y,Luo P,Chang HH,Huang H,Yang T,Dong Z,Wang CY,Wang MH

更新日期：2008-10-01 00:00:00