当前位置： SCI文献检索 > KIDNEY INTERNATIONAL期刊下所有文献 > Effects of hyperosmolality on ANP-stimulated cGMP generation in rat inner medullary collecting duct.

Effects of hyperosmolality on ANP-stimulated cGMP generation in rat inner medullary collecting duct.

Abstract：

:The inner medullary collecting duct (IMCD) is a major target site of atrial natriuretic peptide (ANP) for diuresis and natriuresis, and it is in a hypertonic condition made by the renal countercurrent multiplication system. We investigated the effects of hyperosmolality on ANP-stimulated cGMP generation in IMCD and glomerulus. Hypertonic solutions (490 and 690 mOsm/kg.H2O) were made by adding NaCl or urea to isotonic solution (290 mOsm/kg.H2O). Hypertonicity of 490 mOsm/kg.H2O using NaCl reduced both ANP-stimulated guanylate cyclase activity (from 7.7 +/- 1.1 to 4.1 +/- 0.5 fmol/mm/5 min) and cGMP generation (from 1.35 +/- 0.18 to 0.48 +/- 0.20 fmol/mm/3 min) in IMCD. Hypertonicity of 690 mOsm/kg.H2O using NaCl did not further reduce ANP-stimulated cGMP generation in IMCD. Hypertonicity using urea also inhibited ANP-stimulated guanylate cyclase activity and cGMP generation in IMCD. On the other hand, hypertonicity using NaCl stimulated AVP-stimulated cAMP generation in IMCD, while hypertonicity using urea reduced it. In glomeruli, hyperosmolality of 490 mOsm/kg.H2O using NaCl also reduced ANP-stimulated cGMP generation, and hypertonicity of 690 mOsm/kg.H2O using NaCl further reduced it. In summary, hyperosmolality using NaCl and urea inhibited ANP-sensitive guanylate cyclase activity and cGMP generation both in IMCD and glomeruli. However, the mechanisms at work may be different between NaCl and urea.

journal_name

Kidney Int

journal_title

Kidney international

authors

Shinohara M,Nonoguchi H,Ujiie K,Terada Y,Owada A,Tomita K,Marumo F

doi

10.1038/ki.1994.178

subject

Has Abstract

pub_date

1994-05-01 00:00:00

pages

1362-8

issue

5

eissn

0085-2538

issn

1523-1755

pii

S0085-2538(15)58459-7

journal_volume

45

pub_type

杂志文章

相关文献

KIDNEY INTERNATIONAL文献大全
  • Muscle degradation in uremia: 3-methylhistidine release in fed and fasted rats.

    abstract：:The rate of myofibrillar protein degradation was measured by 3-methylhistidine (3MH) release in moderately uremic and sham-operated control rats. The rats were studied in the fed state or after 24 and 48 hours of fasting. When fed, both uremic and control rats gained weight at the same rate. During 48 hours of fasting...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1981.141

    authors： Li JB,Wassner SJ

    更新日期：1981-09-01 00:00:00

  • Nitric oxide enhances paracellular permeability of opossum kidney cells.

    abstract：BACKGROUND:Nitric oxide (NO) has been shown to be a paracrine/autocrine regulator of proximal tubular transport. In this study, we investigated the effect of NO on the paracellular permeability of opossum kidney (OK) cells, a proximal tubule cell line that possesses a leaky paracellular pathway resembling that of the i...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00465.x

    authors： Liang M,Knox FG

    更新日期：1999-06-01 00:00:00

  • Renal transplantation for ethnic minorities in Canada: inequity in access and outcomes?

    abstract：:Among Canadians starting dialysis, patients of East Asian and Indo Asian background are less likely than whites to receive a renal allograft. Although the reasons for such variation are complex, less living donation may contribute significantly. More studies are needed to confirm these differences and to evaluate stra...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/sj.ki.5002437

    authors： Prasad GV

    更新日期：2007-08-01 00:00:00

  • Tubuloglomerular feedback and glomerular morphology in Goldblatt hypertensive rats on varying protein diets.

    abstract：:The present experiments were performed to examine the effect of variation in protein intake on renal function and morphology in the non-clipped kidneys of Goldblatt hypertensive rats. After renal artery clipping, rats were put on diets containing 5 (LP), 17.5 (NP), or 51% (HP) protein. After 4 to 5 weeks, all rats had...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1986.30

    authors： Schnermann J,Gokel M,Weber PC,Schubert G,Briggs JP

    更新日期：1986-02-01 00:00:00

  • The IL-4 receptor α has a critical role in bone marrow-derived fibroblast activation and renal fibrosis.

    abstract：:Renal fibrosis is a common pathway leading to the progression of chronic kidney disease, and bone marrow-derived fibroblasts contribute significantly to the development of renal fibrosis. However, the signaling mechanisms underlying the activation of these fibroblasts are not completely understood. Here, we examined t...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2017.04.021

    authors： Liang H,Zhang Z,Yan J,Wang Y,Hu Z,Mitch WE,Wang Y

    更新日期：2017-12-01 00:00:00

  • Estimation of fluid volumes in hemodialysis patients: comparing bioimpedance with isotopic and dilution methods.

    abstract：:Both single-frequency bioimpedance and multiple-frequency spectroscopy are equally accurate in measuring total-body water and intracellular fluid. Estimates are consistent at a population level but not at the individual level, because of wide limits of agreement. There is no real 'gold standard' method providing estim...

    journal_title：Kidney international

    pub_type： 评论,杂志文章

    doi：10.1038/ki.2013.434

    authors： Piccoli A

    更新日期：2014-04-01 00:00:00

  • Patiromer induces rapid and sustained potassium lowering in patients with chronic kidney disease and hyperkalemia.

    abstract：:Patients with chronic kidney disease (CKD) have a high risk of hyperkalemia, which increases mortality and can lead to renin-angiotensin-aldosterone system inhibitor (RAASi) dose reduction or discontinuation. Patiromer, a nonabsorbed potassium binder, has been shown to normalize serum potassium in patients with CKD an...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2015.270

    authors： Bushinsky DA,Williams GH,Pitt B,Weir MR,Freeman MW,Garza D,Stasiv Y,Li E,Berman L,Bakris GL

    更新日期：2015-12-01 00:00:00

  • The prognosis of segmental glomerulonephritis in systemic lupus erythematosus.

    abstract：:Severe segmental glomerulonephritis (Seg GN) (greater than or equal to 50% involvement) in systemic lupus erythematosus (SLE) is classified as diffuse GN (DPGN) in the WHO classification. We tested the validity of the assumption that severe Seg GN and DPGN have the same prognosis by determining the proportion of glome...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1987.203

    authors： Schwartz MM,Kawala KS,Corwin HL,Lewis EJ

    更新日期：1987-08-01 00:00:00

  • Toward a working definition of C3 glomerulopathy by immunofluorescence.

    abstract：:Precise immunofluorescence criteria for C3 glomerulopathy remain to be defined. Here we tested hierarchical immunofluorescence criteria with varying stringency for C3 glomerulopathy in a cohort with dense deposit disease as the gold standard and then applied these criteria to analyze the incidence of C3 glomerulopathy...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2013.340

    authors： Hou J,Markowitz GS,Bomback AS,Appel GB,Herlitz LC,Barry Stokes M,D'Agati VD

    更新日期：2014-02-01 00:00:00

  • Expression of leucocyte and lymphocyte adhesion molecules in the human kidney.

    abstract：:Leucocyte interaction with other cells is facilitated by the adhesion molecules, leucocyte function-associated antigen-1 (LFA-1)-binding to intercellular adhesion molecule-1 (ICAM-1) and for T cells and natural killer (NK) cells the binding of LFA-2 (CD2) to LFA-3. As these interactions are critical for the mediation ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1989.303

    authors： Bishop GA,Hall BM

    更新日期：1989-12-01 00:00:00

  • A nationwide evaluation of deceased donor kidney transplantation indicates detrimental consequences of early graft loss.

    abstract：:Early graft loss (EGL) is a feared outcome of kidney transplantation. Consequently, kidneys with an anticipated risk of EGL are declined for transplantation. In the most favorable scenario, with optimal use of available donor kidneys, the donor pool size is balanced by the risk of EGL, with a tradeoff dictated by the ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1016/j.kint.2020.01.043

    authors： de Kok MJ,Schaapherder AF,Mensink JW,de Vries AP,Reinders ME,Konijn C,Bemelman FJ,van de Wetering J,van Zuilen AD,Christiaans MH,Baas MC,Nurmohamed AS,Berger SP,Ploeg RJ,Alwayn IP,Lindeman JH

    更新日期：2020-06-01 00:00:00

  • A clinico-pathologic study of crescentic glomerulonephritis in 50 children. A report of the Southwest Pediatric Nephrology Study Group.

    abstract：:In this study, we have evaluated 50 children (30 girls and 20 boys; mean age, 10.1 years) with a variety of renal diseases in whom renal biopsy specimens showed crescents in greater than or equal to 50% of glomeruli. Initial clinical features included edema in 61%; hypertension in 51%; gross hematuria in 73%; 3 to 4+ ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1985.30

    authors：

    更新日期：1985-02-01 00:00:00

  • Angiotensin II action in isolated microperfused rabbit afferent arterioles is modulated by flow.

    abstract：:We have recently presented evidence that endogenous nitric oxide (NO) and prostaglandins (PGs) modulate angiotensin II (Ang II) action in microperfused afferent arterioles (Af-Arts). Because flow may be a physiological stimulus of endothelial release of NO and PGs, we tested the hypothesis that flow through the lumen ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1996.55

    authors： Juncos LA,Ren Y,Arima S,Garvin J,Carretero OA,Ito S

    更新日期：1996-02-01 00:00:00

  • Signal regulatory protein-α interacts with the insulin receptor contributing to muscle wasting in chronic kidney disease.

    abstract：:Insulin resistance from chronic kidney disease (CKD) stimulates muscle protein wasting but mechanisms causing this resistance are controversial. To help resolve this, we used microarray analyses to identify initiators of insulin resistance in the muscles of mice with CKD, glucose intolerance, and insulin resistance. C...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2013.97

    authors： Thomas SS,Dong Y,Zhang L,Mitch WE

    更新日期：2013-08-01 00:00:00

  • Pathophysiologic basis for normouricosuric uric acid nephrolithiasis.

    abstract：BACKGROUND:Low urinary pH is the commonest and by far the most important factor in uric acid nephrolithiasis but the reason(s) for this defect is (are) unknown. Patients with uric acid nephrolithaisis have normal acid-base parameters according conventional clinical tests. METHODS:We studied steady-state plasma and uri...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2002.00508.x

    authors： Sakhaee K,Adams-Huet B,Moe OW,Pak CY

    更新日期：2002-09-01 00:00:00

  • Factors in the dialysis regimen which contribute to alterations in the abnormalities of uremia.

    abstract：:While hemodialysis therapy in its present form is capable of sustaining life, dialysis patients are not metabolically normal and we are unable to say what technical factors contribute adequate therapy. Recent efforts to resolve these problems have led to the assumption that substances in the molecular weight range of ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1976.126

    authors： Lowrie EG,Steinberg SM,Galen MA,Gagneux SA,Lazarus JM,Gottlieb MN,Merrill JP

    更新日期：1976-11-01 00:00:00

  • Epidemiology of atherosclerotic renal artery stenosis as a mirror of prospective trials.

    abstract：:Diagnosis and treatment of atherosclerotic renal artery stenosis (ARAS) in the elderly is a never-ending challenge for every nephrologist. Kalra et al. report that adjusted hazard ratios for ARAS increased threefold from 1992 to 2004 in 16 million United States Renal Data System participants aged 66 years or older. Ho...

    journal_title：Kidney international

    pub_type： 信件

    doi：10.1038/ki.2009.326

    authors： Krumme B

    更新日期：2010-01-01 00:00:00

  • Intraerythrocytic pH variations during hemodialysis: a 31P NMR study.

    abstract：:Before hemodialysis, patients have an intraerythrocytic pH (pHi) and an extracellular pH, measured in whole blood (pHo), which are lower than those of healthy controls. During bicarbonate hemodialysis, pHi values continuously increase, approaching a normal value at the end of the session. Concomitantly, pHo values fol...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1989.66

    authors： Monti JP,Gallice P,Baz M,Murisasco A,Crevat A,Elsen R

    更新日期：1989-03-01 00:00:00

  • Functional effects of renal artery stent placement on treated and contralateral kidneys.

    abstract：BACKGROUND:This study examined the effects of stent placement for renal artery stenosis on the function of treated and contralateral kidneys. METHODS:Eighteen patients who underwent stent placement for unilateral renal artery stenosis presenting with hypertension and/or renal failure were studied before angiography an...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2002.00456.x

    authors： Leertouwer TC,Derkx FH,Pattynama PM,Deinum J,van Dijk LC,Schalekamp MA

    更新日期：2002-08-01 00:00:00

  • Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstruction.

    abstract：:Progressive renal fibrosis is the final common pathway leading to renal failure irrespective of the initiating cause. Clinical studies of renal fibrosis found that prominent mast cell accumulation correlated with worse outcomes. Mast cells are pluripotent innate immune cells that synthesize and secrete profibrotic med...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.2012.211

    authors： Summers SA,Gan PY,Dewage L,Ma FT,Ooi JD,O'Sullivan KM,Nikolic-Paterson DJ,Kitching AR,Holdsworth SR

    更新日期：2012-09-01 00:00:00

  • A novel lysozyme mutation Phe57Ile associated with hereditary renal amyloidosis.

    abstract：BACKGROUND:Variant forms of lysozyme, a ubiquitous bacteriolytic enzyme, are known to lead to hereditary non-neuropathic renal amyloidosis and, so far, three different mutations of the lysozyme gene have been reported. In this study, we report a novel lysozyme variant, Phe57Ile, associated with renal amyloidosis in thr...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2003.00904.x

    authors： Yazaki M,Farrell SA,Benson MD

    更新日期：2003-05-01 00:00:00

  • Continuous ambulatory peritoneal dialysis in the United States: a three-year study.

    abstract：:This report of the NIH-supported National Continuous Ambulatory Peritoneal Dialysis (CAPD) Registry summarizes data on 7,404 patients treated with CAPD during the three-year period 1981 through 1983, or nearly one-half of patients treated in the USA who were treated with CAPD during this time. While age and diabetes m...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1985.141

    authors： Nolph KD,Cutler SJ,Steinberg SM,Novak JW

    更新日期：1985-08-01 00:00:00

  • A network thermodynamic model of glomerular dynamics: application in the rat.

    abstract：:A model of glomerular dynamics has been developed by using network thermodynamics and the SPICE 2 computer program to further explore the determinants of glomerular filtration. The model is designed to be holistic and self-adjusting, taking cognizance of and permitting quantitation of the secondary alterations in indi...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1981.27

    authors： Oken DE,Thomas SR,Mikulecky DC

    更新日期：1981-02-01 00:00:00

  • The role of urinary peptidomics in kidney disease research.

    abstract：:Urinary peptidomics focuses on endogenous urinary peptide content. Many studies now show the usefulness of this approach for the discovery and validation of biomarkers in kidney diseases that are as varied as chronic kidney disease, acute kidney injury, congenital anomalies of the kidney and the urinary tract, and pol...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1016/j.kint.2015.10.010

    authors： Klein J,Bascands JL,Mischak H,Schanstra JP

    更新日期：2016-03-01 00:00:00

  • Presence of fructose transporter GLUT5 in the S3 proximal tubules in the rat kidney.

    abstract：BACKGROUND:Fructose is a nutrient as well as a potent agent for the formation of advanced glycation end product in diabetes. GLUT5 is a facilitated-diffusion fructose transporter expressed in the small intestine and kidney. Previous reports on the localization of GLUT5 by in situ hybridization and immunohistochemistry ...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.1999.00635.x

    authors： Sugawara-Yokoo M,Suzuki T,Matsuzaki T,Naruse T,Takata K

    更新日期：1999-09-01 00:00:00

  • Activation of Na:2Cl:K cotransport by luminal chloride in macula densa cells.

    abstract：:Changes in macula densa intracellular pH (pHi) were used to monitor the direction of flux mediated by the apical Na:2Cl:K cotransporter. At the macula densa, a decrease in luminal [Cl] ([Cl]1) from 60 to 1 mM produced cellular alkalinization secondary to a cascade of events involving a decrease in apical Na:2Cl:K cotr...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/ki.1995.115

    authors： Lapointe JY,Laamarti A,Hurst AM,Fowler BC,Bell PD

    更新日期：1995-03-01 00:00:00

  • Role of different dialysis membranes in the release of interleukin-6-soluble receptor in uremic patients.

    abstract：BACKGROUND:Interleukin-6 (IL-6) exerts its actions through a cell-surface receptor system that consists of two transmembrane subunits: the IL-6 binding glycoprotein gp 80 (IL-6R) and the signal-transducing component (gp 130). Soluble forms of the IL-6R (sIL-6R) are generated by shedding of the membrane-associated prote...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1046/j.1523-1755.2000.00181.x

    authors： Memoli B,Postiglione L,Cianciaruso B,Bisesti V,Cimmaruta C,Marzano L,Minutolo R,Cuomo V,Guida B,Andreucci M,Rossi G

    更新日期：2000-07-01 00:00:00

  • Shedding of endothelial protein C receptor contributes to vasculopathy and renal injury in lupus: in vivo and in vitro evidence.

    abstract：BACKGROUND:Candidate biomarkers for vasculopathy in systemic lupus erythematosus (SLE) include circulating endothelial cells and the recently identified endothelial protein C receptor (EPCR) which, when shed, promotes a thrombotic diathesis. This study sought correlation between plasma levels of soluble EPCR and diseas...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1111/j.1523-1755.2005.00385.x

    authors： Sesin CA,Yin X,Esmon CT,Buyon JP,Clancy RM

    更新日期：2005-07-01 00:00:00

  • Catch-up growth follows an abnormal pattern in experimental renal insufficiency and growth hormone treatment normalizes it.

    abstract：:The primary goal of this study was to determine if the ability to undergo catch-up growth following a transient injury is preserved in an experimental model of moderate chronic renal failure (CRF) and the effect of growth hormone (GH) administration on such phenomenon. Young rats were subtotally nephrectomized (days 0...

    journal_title：Kidney international

    pub_type： 杂志文章

    doi：10.1038/sj.ki.5001949

    authors： Molinos I,Santos F,Carbajo-Perez E,Garcia E,Rodriguez J,Garcia-Alvarez O,Gil H,Ordoñez FA,Loredo V,Mallada L

    更新日期：2006-12-01 00:00:00

  • Pain management in polycystic kidney disease.

    abstract：:Pain is a common complaint in patients with autosomal-dominant polycystic kidney disease, and a systematic approach is needed to differentiate the etiology of the pain and define an approach to management. A thorough history is the best clue to the multifactorial causes of the pain, superimposed upon an understanding ...

    journal_title：Kidney international

    pub_type： 杂志文章,评审

    doi：10.1046/j.1523-1755.2001.00985.x

    authors： Bajwa ZH,Gupta S,Warfield CA,Steinman TI

    更新日期：2001-11-01 00:00:00