Toward a working definition of C3 glomerulopathy by immunofluorescence.

abstract：BACKGROUND:The underlying mechanisms of renal transplant dysfunction are poorly understood. There is little information on tubular function in kidney grafts. The cDNAs encoding kidney-specific cell surface proteins required for renal reabsorption of sodium (sodium cotransporter in thick ascending limb of Henle, rBSC1) ...

journal_title：Kidney international

authors： Michimata M,Wang W,Fujita S,Mizutani H,Fujimori K,Satomi S,Ohta M,Ito S,Kimura T,Araki T,Imai Y,Matsubara M

更新日期：2001-08-01 00:00:00

abstract：:Familial aggregation of non-diabetic end-stage renal disease (ESRD) is found in African Americans and variants in the apolipoprotein L1 gene (APOL1) contribute to this risk. To detect genetic associations with milder forms of nephropathy in the high-risk families, analyses were performed using generalized estimating e...

journal_title：Kidney international

authors： Freedman BI,Langefeld CD,Turner J,Núñez M,High KP,Spainhour M,Hicks PJ,Bowden DW,Reeves-Daniel AM,Murea M,Rocco MV,Divers J

更新日期：2012-10-01 00:00:00

abstract：:Intradialytic hypotension is a most frequent complication of hemodialysis and may contribute to cardiovascular events and high mortality. There is a hypothesis that an increase in adenosine generation during hemodialysis may cause vasodilation and a decrease in cardiac output, which results in systemic hypotension. We...

journal_title：Kidney international

authors： Imai E,Fujii M,Kohno Y,Kageyama H,Nakahara K,Hori M,Tsubakihara Y

更新日期：2006-03-01 00:00:00

abstract：:Interstitial monocytic infiltration of the kidney occurs within hours of acute kidney injury and is an important determinant of functional decline and fibrosis. Li et al. used several surface markers to distinguish between dendritic cells and inflammatory monocytes following acute kidney injury and to identify two che...

journal_title：Kidney international

authors： Swaminathan S,Griffin MD

更新日期：2008-12-01 00:00:00

abstract：:Anticoagulation has been reported to ameliorate antiglomerular basement membrane glomerulonephritis (anti-GBM-GN) while its effect on chronic immune complex glomerulonephritis (IC-GN) as studied in the NZB mouse is unclear. Chronic serum sickness IC-GN was induced in rabbits by injecting bovine serum albumin (BSA) dai...

journal_title：Kidney international

authors： Border WA,Wilson CB,Dixon FJ

更新日期：1975-09-01 00:00:00

abstract：:To evaluate the underlying mechanism of the putative renal protective effects of angiotensin converting enzyme (ACE) inhibitors, the modulatory action of captopril on the angiotensin II (Ang II) and platelet-derived growth factor (PDGF)-induced increase of cytosolic free calcium concentration ([Ca2+]i) was investigate...

journal_title：Kidney international

authors： Tepel M,Heidenreich S,Zhu Z,Walter M,Nofer JR,Zidek W

更新日期：1994-09-01 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is associated with a urine-concentrating defect attributed to renal cystic changes. As PKD genes are expressed in the brain, altered central release of arginine vasopressin could also play a role. In order to help determine this we measured central and nephrogenic c...

journal_title：Kidney international

authors： Ho TA,Godefroid N,Gruzon D,Haymann JP,Maréchal C,Wang X,Serra A,Pirson Y,Devuyst O

更新日期：2012-11-01 00:00:00

abstract：:Hyperinsulinemia can contribute to hypertension through effects on sodium transport. To test whether the stimulatory effect of insulin on renal proximal tubule sodium transport is preserved in insulin resistance, we compared the effects of insulin on abdominal adipocytes and proximal tubules in rats and humans. Insuli...

journal_title：Kidney international

authors： Nakamura M,Yamazaki O,Shirai A,Horita S,Satoh N,Suzuki M,Hamasaki Y,Noiri E,Kume H,Enomoto Y,Homma Y,Seki G

更新日期：2015-03-01 00:00:00

abstract：:Vascular calcification is recognized as a major contributor to cardiovascular disease (CVD) in end stage renal disease (ESRD) patients. Susceptibility to vascular calcification is genetically determined and actively regulated by diverse inducers and inhibitors. One of these inducers, hyperphosphatemia, promotes vascul...

journal_title：Kidney international

authors： Giachelli CM

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:The use of renal Kt/V (r-Kt/V) as an indicator for the need of dialysis initiation has been recommended in the NKF-DOQI guidelines. In analogy to clinical practice in peritoneal dialysis, a fall of r-Kt/V below a threshold of 2.0 per week may indicate inadequate renal toxin elimination. However, there are no...

journal_title：Kidney international

authors： Kuhlmann MK,Heckmann M,Riegel W,Köhler H

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Bioimpedance, a noninvasive technique to analyze body composition, has attracted interest in determining body hydration in hemodialysis patients. However, the so-called whole-body (wrist-to-ankle) bioimpedance analysis (WBIA) is sensitive to changes in regional fluid distribution and tends to underestimate f...

journal_title：Kidney international

authors： Zhu F,Schneditz D,Levin NW

更新日期：1999-08-01 00:00:00

abstract：:Changes in macula densa intracellular pH (pHi) were used to monitor the direction of flux mediated by the apical Na:2Cl:K cotransporter. At the macula densa, a decrease in luminal [Cl] ([Cl]1) from 60 to 1 mM produced cellular alkalinization secondary to a cascade of events involving a decrease in apical Na:2Cl:K cotr...

journal_title：Kidney international

authors： Lapointe JY,Laamarti A,Hurst AM,Fowler BC,Bell PD

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:Glucocorticoids (GC) represent the mainstay of treatment of idiopathic nephrotic syndrome (INS) and might be involved in the pathogenesis of the disease. We evaluated basal secretion of cortisol, number and affinity of glucocorticoid receptors, dexamethasone (Dex)-mediated inhibition of concanavalin-A (Con-A...

journal_title：Kidney international

authors： Carlotti AP,Franco PB,Elias LL,Facincani I,Costa EL,Foss N,Moreira AC,de Castro M

更新日期：2004-02-01 00:00:00

abstract：:Antioxidants have been used as therapies to decrease oxidative stress and improve CVD risk in hemodialysis (HD) patients. A systematic search of the Medline database (search date 30 April 2011) found 56 studies investigating the effects of antioxidant therapies on biomarkers of oxidative stress (53 studies) or clinica...

journal_title：Kidney international

authors： Coombes JS,Fassett RG

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:In the rat cortical thick ascending limb (CTAL), intracellular Ca2+ ([Ca2+]i) responses to angiotensin II (Ang II) and angiotensin III (Ang III) were mediated by the Ang II subtype 1A receptor (AT1A-R), whereas the arginine vasopressin (AVP)-dependent cAMP accumulation involved the vasopressin receptor type ...

journal_title：Kidney international

authors： Hus-Citharel A,Marchetti J,Corvol P,Llorens-Cortes C

更新日期：2002-06-01 00:00:00

abstract：:Chronic kidney disease (CKD) remains one of the leading causes of death in the developed world, and acute kidney injury (AKI) is now recognized as a major risk factor in its development. Understanding the factors leading to CKD after acute injury are limited by current animal models of AKI, which concurrently target v...

journal_title：Kidney international

authors： Grgic I,Campanholle G,Bijol V,Wang C,Sabbisetti VS,Ichimura T,Humphreys BD,Bonventre JV

更新日期：2012-07-01 00:00:00

abstract：:Incompatible donor/recipient pairs with broadly sensitized recipients have difficulty finding a crossmatch-compatible match, despite a large kidney paired donation pool. One approach to this problem is to combine kidney paired donation with lower-risk crossmatch-incompatible transplantation with intravenous immunoglob...

journal_title：Kidney international

authors： Blumberg JM,Gritsch HA,Reed EF,Cecka JM,Lipshutz GS,Danovitch GM,McGuire S,Gjertson DW,Veale JL

更新日期：2013-11-01 00:00:00

abstract：:Electron microprobe analysis on freeze-dried cryosections was used to determine the effect of the loop diuretics torasemide and furosemide on intracellular electrolyte concentrations in individual cells of the outer and inner stripe of the outer medulla and on cell rubidium uptake, the latter a measure of basolateral ...

journal_title：Kidney international

authors： Beck FX,Sone M,Dörge A,Thurau K

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:The relationship between low hematocrit and contrast-induced nephropathy has not been investigated. METHODS:Of 6,773 consecutive patients treated with percutaneous coronary intervention, contrast-induced nephropathy (an increase of >/=25% or >/=0.5 mg/dL in preprocedure serum creatinine, at 48 hours postpro...

journal_title：Kidney international

authors： Nikolsky E,Mehran R,Lasic Z,Mintz GS,Lansky AJ,Na Y,Pocock S,Negoita M,Moussa I,Stone GW,Moses JW,Leon MB,Dangas G

更新日期：2005-02-01 00:00:00

abstract：:We evaluated the contribution of intrarenal factors in the increased renal accumulation of bovine serum albumin (BSA) in chronic serum sickness (CSS). Renal transplantation was used to study 125I BSA uptake (single and paired label techniques) in normal and CSS kidneys exposed to the same immunologic milieu. In CSS, t...

journal_title：Kidney international

authors： Ward DM,Lee S,Wilson CB

更新日期：1986-11-01 00:00:00

abstract：:From September 9 to October 3, 1994, five patients on maintenance hemodialysis in a dialysis unit in Tokyo contracted hepatitis B virus (HBV) infection successively, and four of them died of fulminant hepatitis. The unit treated 181 patients three times a week on eight shifts, and all five afflicted patients were on t...

journal_title：Kidney international

authors： Tanaka S,Yoshiba M,Iino S,Fukuda M,Nakao H,Tsuda F,Okamoto H,Miyakawa Y,Mayumi M

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Cold ischemia and reperfusion during kidney transplantation are associated with release of free oxygen radicals and damage of renal tubular cells. Bioflavonoids may diminish cold storage-induced injury due to antioxidant and iron chelating activities. This study was designed to delineate the renoprotective m...

journal_title：Kidney international

authors： Ahlenstiel T,Burkhardt G,Köhler H,Kuhlmann MK

更新日期：2003-02-01 00:00:00

abstract：:Acute kidney injury (AKI) is a critical condition with a mortality rate as high as 50% and significantly contributes to the burden of end-stage renal disease (ESRD) requiring renal replacement therapy. The incidence and prognosis of AKI have been shown to vary with patient age, with younger individuals being more resi...

journal_title：Kidney international

authors： Fan H,Yang HC,You L,Wang YY,He WJ,Hao CM

更新日期：2013-03-01 00:00:00

abstract：:Adiponectin levels are increased in patients with type I diabetes especially in the presence of microangiopathy. Here we determined the predictive value of serum adiponectin levels and 8 adiponectin gene polymorphisms for mortality, cardiovascular events and end-stage renal disease in type I diabetic patients. This pr...

journal_title：Kidney international

authors： Jorsal A,Tarnow L,Frystyk J,Lajer M,Flyvbjerg A,Parving HH,Vionnet N,Rossing P

更新日期：2008-09-01 00:00:00

abstract：:The high serum fibroblast growth factor 23 (FGF23) levels in patients with acute kidney injury (AKI) and chronic kidney disease (CKD) are associated with increased morbidity and mortality. Mice with folic acid-induced AKI had an increase in bone FGF23 mRNA expression together with an increase in serum FGF23 and severa...

journal_title：Kidney international

authors： Durlacher-Betzer K,Hassan A,Levi R,Axelrod J,Silver J,Naveh-Many T

更新日期：2018-08-01 00:00:00

abstract：:The processes of growth and remodeling that characterize growing bone are vulnerable to the biochemical effects of uremia. These processes are affected by the alterations in vitamin D metabolism and hyperparathyroidism that commonly occur with chronic renal insufficiency. Uremia interferes with cartilaginous developme...

journal_title：Kidney international

authors： Avioli LV

更新日期：1978-10-01 00:00:00

abstract：:Urinary proteomics is a promising tool for biomarker investigation, particularly in complex kidney diseases. Fabris and colleagues report that urinary laminin subunit alpha-2 is a potential diagnostic marker of medullary sponge kidney (MSK) disease by using a label-free quantitative proteomics platform and a clinicall...

journal_title：Kidney international

authors： Chutipongtanate S

更新日期：2017-02-01 00:00:00

abstract：:Acute urinary obstruction causes interstitial inflammation with leukocyte accumulation and the secretion of soluble mediators. Here we show that unilateral ureteral ligation caused a progressive increase in renal F4/80(+) and F4/80(-) dendritic cells, monocytes, neutrophils and T-cells 24-72 h following obstruction. D...

journal_title：Kidney international

authors： Dong X,Bachman LA,Miller MN,Nath KA,Griffin MD

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Population-genetic studies investigating genetic polymorphisms of Mendelian inheritance should always test whether the measured genotype frequencies deviate from the expected one. For this purpose Hardy-Weinberg (HW) criteria are generally used. If genotype distribution of control population misses HW equili...

journal_title：Kidney international

authors： Kocsis I,Györffy B,Németh E,Vásárhelyi B

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:It is not known whether angiotensin-converting-enzyme (ACE) inhibitors slow the progression of polycystic kidney disease (PKD). We performed a patient-level meta-analysis to compare the effect of antihypertensive regimens, including ACE inhibitors, to those without ACE inhibitors (controls) on kidney disease...

journal_title：Kidney international

authors： Jafar TH,Stark PC,Schmid CH,Strandgaard S,Kamper AL,Maschio G,Becker G,Perrone RD,Levey AS,ACE Inhibition in Progressive Renal Disease (AIPRD) Study Group.

更新日期：2005-01-01 00:00:00