Abstract：
:The processes of growth and remodeling that characterize growing bone are vulnerable to the biochemical effects of uremia. These processes are affected by the alterations in vitamin D metabolism and hyperparathyroidism that commonly occur with chronic renal insufficiency. Uremia interferes with cartilaginous developments as well. These changes, which are similar radiographically to vitamin-D-deficiency rickets, differ in their basic histological and biochemical evolution. They account for growth failure and deformity of long bones, which contribute to the short stature of children with renal insufficiency.
journal_name
Kidney Intjournal_title
Kidney internationalauthors
Avioli LVdoi
10.1038/ki.1978.136subject
Has Abstractpub_date
1978-10-01 00:00:00pages
355-60issue
4eissn
0085-2538issn
1523-1755pii
S0085-2538(15)31973-6journal_volume
14pub_type
杂志文章,评审abstract：:Cholesterol conversion to and biliary excretion of bile acids represents the principal pathway of cholesterol catabolism in mammals. Cholesterol 7 alpha-hydroxylase (Ch-7 alpha-H) is the first and the rate limiting step in bile acid production. Recently, Ch-7 alpha-H enzymatic activity has been shown to be normal in r...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1996.118
更新日期：1996-03-01 00:00:00
abstract：:Rare mutations in the LRP2 gene encoding for the endocytic receptor megalin cause developmental abnormalities and kidney disease. However, the mechanisms governing the dysfunction of mutant megalin remain unclear. A new study utilizing patient-derived induced pluripotent stem cells is now putting the endolysosomal sys...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2020.04.033
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:Children with chronic renal failure (CRF) exhibit growth retardation and a disturbed growth hormone/insulin-like growth factor-I (GH/IGF-I) axis. Treatment of children with CRF with GH or GH/IGF-I can partially restore linear growth. The molecular basis for decreased longitudinal growth is not known but may ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2000.00141.x
更新日期：2000-07-01 00:00:00
abstract：BACKGROUND:In cultured renal epithelial cells, exposure to oxalate, a constituent of many kidney stones, elicits a cascade of responses that often leads to cell death. Oxalate toxicity is mediated via generation of reactive oxygen species (ROS) in a process that depends at least in part upon lipid signaling molecules t...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2004.00963.x
更新日期：2004-11-01 00:00:00
abstract：BACKGROUND:Epithelial cells in the renal inner medulla accumulate osmolytes such as betaine to maintain normal cell volume during prolonged extracellular hypertonic stress. Betaine accumulation is the result of activation of transcription of the BGT1 transporter gene followed by increased betaine transport. METHODS:We...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2001.00733.x
更新日期：2001-06-01 00:00:00
abstract：:This very brief summary of the various possible contributions of PG to normal and abnormal renal function should highlight the problem of assigning a specific role to PG in overall renal physiology and pathophysiology. PG produced in specific segments of the nephron will affect specific functions occurring in this seg...
journal_title：Kidney international
pub_type： 杂志文章,评审
doi：10.1038/ki.1986.13
更新日期：1986-01-01 00:00:00
abstract：:Renal blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) is a noninvasive fast technique to characterize renal function. Here we evaluated the impact of renal function on the relaxation rate (R2(*)) in the cortex and medulla to provide baseline data for further use of renal BOLD-MRI. This parameter was...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2011.455
更新日期：2012-04-01 00:00:00
abstract：:Osteopontin is an arginine-glycine-aspartate (RGD) containing secreted phosphoprotein recently shown to stimulate a local macrophage influx when injected subcutaneously in mice. We examined the effect of angiotensin II infusion on renal injury and osteopontin expression in the rat kidney by in situ hybridization and i...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1994.67
更新日期：1994-02-01 00:00:00
abstract：:Chronic kidney disease (CKD) accelerates muscle protein degradation by stimulating the ubiquitin proteasome system through activation of the E3 ligases, Atrogin-1/MAFbx and MuRF-1. Forkhead transcription factors (FoxOs) can control the expression of these E3 ligases, but the contribution of individual FoxOs to muscle ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2012.84
更新日期：2012-08-01 00:00:00
abstract：:Chronic cyclosporine (CsA) nephrotoxicity is a major complication of heart, bone marrow, and renal transplantation, and is characterized in humans by striped interstitial fibrosis, tubular dilatation and atrophy, and hyalinization of hilar arterioles. This last feature is highly specific for cyclosporine injury and ha...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1995.311
更新日期：1995-08-01 00:00:00
abstract：:The contractile properties of recombinant human erythropoietin (rHuEPO) on isolated resistance vessels of renal and mesenteric vascular beds were studied in an in vitro model using a small vessel myograph. Under isometric conditions, rHuEPO caused a contraction of this vasculature in a concentration range between 10 U...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1991.31
更新日期：1991-02-01 00:00:00
abstract：:To investigate whether alpha (alpha)-adrenoceptor agonists have a stimulatory effect on the expression of the angiotensinogen (Ang) gene in opossum kidney (OK) cells, we used OK 27 cells with a fusion gene containing the 5'-flanking regulatory sequence of the rat angiotensinogen gene fused with a human growth hormone ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1995.277
更新日期：1995-07-01 00:00:00
abstract：:Renal sodium reabsorption is a key determinant of final urine concentration. Our aim was to determine whether differences existed between aged and young rats in their response to water restriction with regard to the regulation of abundance of any of the major distal renal sodium transporter proteins. Male Fisher 344 x...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5000076
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:The mechanisms of cyclosporine (CsA)-induced nephrotoxicity are not fully understood. While hemodynamic changes may be involved in vivo, there is also some evidence for tubular involvement. We previously showed direct toxicity of CsA in the LLC-PK1 renal tubular cell line. In the current study we examined me...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.1998.00202.x
更新日期：1998-12-01 00:00:00
abstract：:Because of high risk of cardiovascular disease, patients with chronic kidney disease may benefit from cholesterol-lowering therapy beyond statins. A cost-effectiveness analysis of adding ezetimibe to high-dose statins for primary cardiovascular disease prevention in patients with non-dialysis-dependent chronic kidney ...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1016/j.kint.2019.02.029
更新日期：2019-07-01 00:00:00
abstract：:Vitamin D deficiency is common in patients with chronic kidney disease after renal transplantation. Vitamin D, essential for mineral and bone metabolism, also has myriad beneficial autocrine effects on intact immune responses and defense against infection, as well as suppression of malignant changes. Supplementation w...
journal_title：Kidney international
pub_type： 评论,杂志文章,评审
doi：10.1038/ki.2008.492
更新日期：2009-03-01 00:00:00
abstract：:The survival of patients with diabetes mellitus in the general population has improved in recent years. Here we assessed whether similar trends have occurred in 1688 kidney recipients, including 413 with diabetes prior to transplant between 1996 and 2007. Compared to patients without diabetes, the 5-year mortality was...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2014.70
更新日期：2014-09-01 00:00:00
abstract：:In this study, we have evaluated 50 children (30 girls and 20 boys; mean age, 10.1 years) with a variety of renal diseases in whom renal biopsy specimens showed crescents in greater than or equal to 50% of glomeruli. Initial clinical features included edema in 61%; hypertension in 51%; gross hematuria in 73%; 3 to 4+ ...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1985.30
更新日期：1985-02-01 00:00:00
abstract：:The remnant kidney (RK) exhibits an enhanced fractional excretion of phosphate (FEPi) even in the absence of parathyroid hormone (PTH). Thus, factors other than PTH contribute to this adaptive phosphaturia. Dopamine (DA) infusion is phosphaturic, whereas stimulation of adrenoreceptors is antiphosphaturic. Therefore, t...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1993.144
更新日期：1993-05-01 00:00:00
abstract：BACKGROUND:Podocyte loss contributes to the development of glomerulosclerosis. Although podocytes have been detected in the urine in certain glomerular diseases, the viability of detached cells is not known. METHODS:Urine was collected from rats with experimental membranous nephropathy [passive Heymann nephritis (PHN)...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2003.00217.x
更新日期：2003-10-01 00:00:00
abstract：:Iron is critical for cellular, organismal, and possibly universal existence. Use of iron complexes to treat human diseases is ancient and is described in detail in Ayurveda/Siddha systems of medicine. Old aphorisms from Siddha medicine ("Alavukku Minjinal Amirdhamum Nanjagum," an elixir turns poisonous when taken in e...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1016/j.kint.2016.02.035
更新日期：2016-07-01 00:00:00
abstract：:Patients with chronic kidney disease have elevated circulating asymmetric dimethylarginine (ADMA). Recent studies have suggested that ADMA impairs endothelial nitric oxide synthase (eNOS) by effects other than competition with the substrate L-arginine. Here, we sought to identify the molecular mechanism by which incre...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2011.476
更新日期：2012-04-01 00:00:00
abstract：:Idiopathic retroperitoneal fibrosis (IRF) is a rare disease often causing obstructive uropathy. We evaluated the clinicopathologic features of 24 patients with IRF to characterize the histopathology of the disease and to provide a framework for the differential diagnosis with other retroperitoneal fibrosing conditions...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/sj.ki.5002427
更新日期：2007-09-01 00:00:00
abstract：:The possibility that the rabbit collecting tubule is heterogeneous with respect to electrical and morphologic properties was examined in isolated segments. Collecting tubules from rabbits treated with desoxycorticosterone acetate were dissected from various locations within the cortex and outer medulla, and the transe...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1978.167
更新日期：1978-12-01 00:00:00
abstract：:IgG4-related disease is a recently recognized multi-organ disorder characterized by high levels of serum IgG4 and dense infiltration of IgG4-positive cells into several organs. Although the pancreas was the first organ recognized to be affected by IgG4-related disorder in the syndrome of autoimmune pancreatitis, we pr...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.2010.271
更新日期：2010-11-01 00:00:00
abstract：:A cyclical corticosteroid-cyclophosphamide regimen is recommended for patients with primary membranous nephropathy at high risk of progression. We hypothesized that sequential therapy with tacrolimus and rituximab is superior to cyclical alternating treatment with corticosteroids and cyclophosphamide in inducing persi...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1016/j.kint.2020.10.014
更新日期：2020-11-07 00:00:00
abstract：BACKGROUND:Hyperuricemia has been linked to cardiovascular and renal diseases, possibly through the generation of reactive oxygen species (ROS) and subsequent endothelial dysfunction. The enzymatic effect of xanthine oxidase is the production of ROS and uric acid. Studies have shown that inhibiting xanthine oxidase wit...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1111/j.1523-1755.2005.00273.x
更新日期：2005-05-01 00:00:00
abstract：:The following bone density measurements have limited utility in determining bone strength because they do not include bone quality: microarchitecture, mineralization, ability to repair damage, collagen structure, crystal size, or marrow composition. Patients with kidney disease have poor bone quality. Newman et al. no...
journal_title：Kidney international
pub_type： 评论,杂志文章
doi：10.1016/j.kint.2015.11.004
更新日期：2016-01-01 00:00:00
abstract：:We analyzed clinical and pathologic data from 36 recipients of 38 renal allografts who developed nephrotic syndrome following transplantation. Three groups were identified on the basis of histologic changes in the graft, and each group had a distinct clinical course. Nine grafts (23.7%) had recurrent glomerulonephriti...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1038/ki.1980.146
更新日期：1980-09-01 00:00:00
abstract：BACKGROUND:Long-term graft function is the result of multiple parameters, including both immune and non-immune components, which have a beneficial or detrimental potential. Among these, despite its frequency and theoretical interest (expression of "danger signals" in the graft itself), the effects of acute graft pyelon...
journal_title：Kidney international
pub_type： 杂志文章
doi：10.1046/j.1523-1755.2002.00323.x
更新日期：2002-05-01 00:00:00
